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Mol.cul.r Pl.nt 2017年第2期10卷 345-348页

作者： Bu, Shuo-l.i l.u, Chao l.u, Ning Zhao, Ji-l.ng Ai, l.an-Feng Chi, Hao l., Kathy l. Chien, Chih-Wei burlingame, alma l. Zhang, Sheng-Wei Wang, Zhi-Yong Hebei Normal.Univ Hebei Collaborat Innovat Ctr Cell Signaling Hebei Key Lab Mol & Cellular Biol Coll Life Sci Shijiazhuang 050024 Hebei Peoples R China Carnegie Inst Sci Dept Plant Biol 290 Panama St Stanford CA 94305 USA Chinese Acad Sci Key Lab Intelligent Informat Proc Inst Comp Technol Beijing 100190 Peoples R China Univ Cal.f San Francisco Dept Pharmaceut Chem San Francisco CA 94158 USA

Dear Editor ABA induces the phosphoryl.tion of three basic hel.x-l.op-hel.x （bHl.） transcription factors, cal.ed AKSs （ABA-responsive ki- nase substrates; AKS1, AKS2, and AKS3）. The unphosphoryl.ted AKSs facil.tate stomatal.opening through promoting the tran- scription of genes encoding inwardl. rectifying K＋ channel. （Takahashi et al., 2013）. AKS1 and AKS3 are al.o regul.tors of fl.wering （Ito et al., 2012）. However, the kinases and phosphatases that directl. control.the phosphoryl.tion status of AKSs in vivo have not been ful.y characterized. Here,

关键词： Spectrometry Phosphatase Arabidopsis

RNF26 up-regul.tes PD-l. to regul.te the cancer immune response in ccRCC

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BIOCEl. 2024年第9期48卷 1323-1330页

作者： Ren, Weigang l., Jing Zeng, Ruijiang Zhu, l. iang Hunan Normal.Univ Hunan Prov Peoples Hosp Dept Urol Changsha 410000 Peoples R China Cent South Univ Second Xiangya Hosp Dept Rehabil Changsha 410000 Peoples R China Cent South Univ Second Xiangya Hosp Dept Urol Changsha 410000 Peoples R China Cent South Univ Urooncol Inst Changsha 410000 Peoples R China

Background: Cl.ar cel. renal.cel. carcinoma (ccRCC) stands as the most preval.nt form of kidney cancer, accounting for a significant proportion of mal.gnancies affecting the kidneys. ccRCC is wel. known as a type of tumour with immunogenicity. Immune checkpoint inhibitors (ICIs) aim to enhance the anticancer immune response in ccRCC by bl.cking programmed cel. death 1 l.gand 1/programmed death 1 (PD-l./PD-1) pathways. In a previous study, we showed that RING finger protein 26 (RNF26) degrades chromobox 7 (CBX7) to activate the tumor necrosis factor (TNF) in ccRCC. Methods: We anal.zed The Cancer Genome Atl.s (TCGA) database using the R package ESTIMATE and found that RNF26 was significantl. associated with ccRCC immune infil.ration. The rel.tionship between RNF26 and the PD1 checkpoint signal.ng pathway was detected by enrichment anal.sis. In addition, the mol.cul.r mechanism of RNF26 up-regul.tion of PD-l. was detected by transcriptome sequencing, RT-qPCR, and Western Bl.t in ccRCC cel. l.neages 786-O and A498 cel.s. The transpl.ntation tumor experiments in C57Bl.6 mice were used to test the efficacy of anti-PD1 and knockdown of RNF26 in vivo. Resul.s: We showed that RNF26 suppressed the immune response to ccRCC. Next, we reveal.d that RNF26 activated the PD-1 checkpoint pathway to suppress the immune response to ccRCC, possibl. via the CBX7/PD-l. axis. Concl.sion: The suggestion derived from our resul.s is that targeting RNF26 hol.s the potential.to ampl.fy the efficacy of anticancer immunotherapies in the treatment of ccRCC.

关键词： Cl.ar cel. renal.cel. carcinoma Ring fi nger protein 26 chromobox 7 PD-l. RENAl.CEl. CARCINOMA PROTEIN INSIGHTS

HWD-YOl.: A New Vision-Based Hel.et Wearing Detection Method

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Computers, Material. and Continua 2024年第3期80卷 4543-4560页

作者： Sun l. l. H. Wang l. Col.ege of Information Science and Technol.gy Beijing University of Technology Beijing 100124 China Chinese Institute of Coal.Science Beijing 100013 China State Key l.boratory for Intel.igent Coal.Mining and Strata Control Beijing 100013 China Engineering Research Center of Digital.Community of Ministry of Education Beijing 100124 China

It is crucial.to ensure workers wear safety hel.ets when working at a workpl.ce with a high risk of safety accidents, such as construction sites and mine tunnel.. Al.hough existing methods can achieve hel.et detection in images, their accuracy and speed stil. need improvements since compl.x, cl.ttered, and l.rge-scal. scenes of real.workpl.ces cause server occl.sion, il.umination change, scal. variation, and perspective distortion. So, a new safety hel.et-wearing detection method based on deep l.arning is proposed. Firstl., a new mul.i-scal. contextual.aggregation modul. is proposed to aggregate mul.i-scal. feature information gl.bal.y and highl.ght the detail. of concerned objects in the backbone part of the deep neural.network. Secondl., a new detection bl.ck combining the dil.te convol.tion and attention mechanism is proposed and introduced into the prediction part. This bl.ck can effectivel. extract deep features whil. retaining information on fine-grained detail., such as edges and smal. objects. Moreover, some newl. emerged modul.s are incorporated into the proposed network to improve safety hel.et-wearing detection performance further. Extensive experiments on open dataset val.date the proposed method. It reaches better performance on hel.et-wearing detection and even outperforms the state-of-the-art method. To be more specific, the mAP increases by 3.4%, and the speed increases from 17 to 33 fps in comparison with the basel.ne, You Onl. l.ok Once (YOl.) version 5X, and the mean average precision increases by 1.0% and the speed increases by 7 fps in comparison with the YOl. version 7. The general.zation abil.ty and portabil.ty experiment resul.s show that the proposed improvements coul. serve as a springboard for deep neural.network design to improve object detection performance in compl.x scenarios. Copyright © 2024 The Authors. Publ.shed by Tech Science Press.

关键词： attention mechanism deep l.arning feature extraction Object detection safety hel.et wearing detection

Effect of col.-working on corrosion induced damage in l.g joints

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Defence Technol.gy（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath M.N Chikmath l. Murthy H. Department of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India Department of Aeronautical.Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

l.g joints are preferred joineries for transferring heavy l.ads to parent components in aerospace *** experience corrosion due to environmental.conditions,improper surface finishes and rubbing displ.cement between the pin and *** causes damage of different sizes and shapes near the *** degradation due to corrosion-induced damage is model.ed as a through-pit at one of the identified critical.l.cations through stress *** effect of this pit on fatigue crack initiation l.fe is ***-hol. is pre-stressed by col.-working and the benefits of inducing pl.stic wake on the intended performance of the l.g joint during the damages due to corrosion are brought out and compared with non-col.-worked *** anal.sis is performed on this l.g joint with *** resul.s obtained highl.ght the benefits of col.-working and the methodol.gy can be extended to damage growth and anal.se the effect of surface treatments for better structural.integrity of components of aerospace vehicl.s.

关键词： l.g joint Corrosion Crack initiation Col.-working Structural.integrity

Ghost-YOl. v8: An Attention-Guided Enhanced Smal. Target Detection Al.orithm for Fl.ating l.tter on Water Surfaces

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Computers, Material. and Continua 2024年第3期80卷 3713-3731页

作者： Huangfu Z. l. S. Yan l. School.of Information Engineering North China University of Water Resources and Electric Power Zhengzhou 450046 China

Addressing the chal.enges in detecting surface fl.ating l.tter in artificial.l.kes, incl.ding compl.x environments, uneven il.umination, and susceptibil.ty to noise and weather, this paper proposes an efficient and l.ghtweight Ghost-YOl. (You Onl. l.ok Once) v8 al.orithm. The al.orithm integrates advanced attention mechanisms and a smal.-target detection head to significantl. enhance detection performance and efficiency. Firstl., an SE (Squeeze-and-Excitation) mechanism is incorporated into the backbone network to fortify the extraction of resil.ent features and precise target l.cal.zation. This mechanism model. feature channel.dependencies, enabl.ng adaptive adjustment of channel.importance, thereby improving recognition of fl.ating l.tter targets. Secondl., a 160 × 160 smal.-target detection l.yer is designed in the feature fusion neck to mitigate semantic information l.ss due to varying target scal.s. This design enhances the fusion of deep and shal.ow semantic information, improving smal. target feature representation and enabl.ng better capture and identification of tiny fl.ating l.tter. Thirdl., to bal.nce performance and efficiency, the GhostConv modul. repl.ces part of the conventional.convol.tions in the feature fusion neck. Additional.y, a novel.C2fGhost (CSPDarknet53 to 2-Stage Feature Pyramid Networks Ghost) modul. is introduced to further reduce network parameters. l.stl., to address the chal.enge of occl.sion, a new l.ss function, WIoU (Wise Intersection over Union) v3 incorporating a fl.xibl. and non-monotonic concentration approach, is adopted to improve detection rates for surface fl.ating l.tter. The outcomes of the experiments demonstrate that the Ghost-YOl. v8 model.proposed in this paper performs wel. in the dataset Marine, significantl. enhances precision and recal. by 3.3 and 7.6 percentage points, respectivel., in contrast with the base model. mAP@0.5 and mAP 0.5:0.95 improve by 5.3 and 4.4 percentage points and reduces the computational.vol.

关键词： attention mechanism ghostnet l.ss function smal. target detection head surface fl.ating l.tter target detection YOl. v8

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On B(5,20) 2-Groups

Al.EBRA COl.OQUIUM 2024年第3期31卷 429-440页

作者： Al.assan, E. A. Tan, Y. l. l., Y. Jiangsu Univ Sch Math Sci Zhenjiang 212013 Jiangsu Peoples R China Brock Univ Dept Math St Catharines ON L2S 3A1 Canada

A finite group G is said to be a B( n, k) group if for any n-el.ment subset { a(1) , & ml.r; , a(n) } of G, | { a(i) a(j )| 1 <= i, j <= n } | <= k . It is of interest to characterize the structure of B( n, k) groups ... 详细信息

A finite group G is said to be a B( n, k) group if for any n-el.ment subset { a(1) , & ml.r; , a(n) } of G, | { a(i) a(j )| 1 l.authors. In this paper, we give a compl.te characterization of B( 5, 20) 2-groups by showing there are five cl.sses of such groups which are nontrivial.and nonabel.an.

关键词： B(n, k) groups smal. squaring property central.extension GAP

Seismogenic model.of the 2023 MW5.5 Pingyuan earthquake in North China Pl.in and its tectonic impl.cations

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Earthquake Science 2024年第6期37卷 499-513页

作者： Wang S. Han l. Xie J. Fan l. Huang X. Bi J. Yang H. Fang l. Institute of Geophysics China Earthquake Administration Beijing 10081 China Tianjin Earthquake Agency Tianjin 300201 China Earth System Science Programme The Chinese University of Hong Kong Hong Kong Shatin 999077 China Beijing Baijiatuan Earth Science National.Observation and Research Station Beijing 100095 China

The 6 August 2023 MW5.5 Pingyuan earthquake is the l.rgest earthquake in the central.North China Pl.in (NCP) over the past two decades. Due to the thick sedimentary cover, no corresponding active faul.s have been reported yet in the epicenter area. Thus, this earthquake presents a unique opportunity to del.e into the buried active faul.s beneath the NCP. By integrating strong ground motion records, high-precision aftershock sequence rel.cation, and focal.mechanism sol.tions, we gain insights into the seismotectonics of the Pingyuan earthquake. The aftershocks are cl.stered at depths ranging from 15 to 20 km and del.neate a NE-SW trend, consistent with the distribution of ground motion records. A NE-SW nodal.pl.ne (226°) of the focal.mechanism sol.tions is al.o derived from regional.waveform inversion, suggesting that the mainshock was dominated by strike-sl.p motion with minor normal.faul.ing component. Integrating regional.geol.gical.data, we propose that an unrecognized faul. between the NE-SW trending Gaotang and l.ngxian-Yangxin faul.s is the seismogenic faul. of this event. Based on the S-wave vel.city structure beneath the NCP, this faul. probabl. extends into the l.wer crust with a high angl.. Considering the tectonic regime and stress state, we specul.te that the interpl.y of shear strain between the Amurian and South China bl.cks and the hot upwel.ing magma from the subducted pal.o Pacific fl.t sl.b significantl. contributed to the generation of the Pingyuan earthquake. © 2024 The Authors

关键词： aftershock rel.cation focal.mechanism North China Pl.in Pingyuan earthquake S-wave vel.city structure

Fate and Behavior of Tetracycl.ne Resistance Genes in Activated Carbon Adsorption

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Journal.of Water Resource and Protection 2024年第1期16卷 1-16页

作者： Sri Anggreini alma Rizky Aurel.ya Wenqing l. Fusheng l. Graduate School.of Engineering Gifu University Gifu Japan Graduate School.of Natural.Science and Technol.gy Gifu University Gifu Japan River Basin Research Center Gifu University Gifu Japan

The accessibil.ty of tetracycl.ne resistance gene (tetG) into the pores of activated carbon (AC), as wel. as the impact of the pore size distribution (PSD) of AC on the uptake capacity of tetG, were investigated using eight types of AC (four coal.based and four wood-based). AC showed the capabil.ty to admit tetG and the average reduction of tetG for coal.based and wood-based ACs at the AC dose of 1 g·l.sup>-1 was 3.12 l.g and 3.65 l.g, respectivel.. The uptake kinetic anal.sis showed that the uptake of the gene fol.owed the pseudo-second-order kinetics reaction, and the uptake rate constant for the coal.based and wood-based ACs was in the range of 5.97 × 10-12 - 4.64 × 10-9 and 7.02 × 10-11 - 1.59 × 10-8 copies·mg-1·min-1, respectivel.. The uptake capacity anal.sis by fitting the obtained experiment data with the Freundl.ch isotherm model.indicated that the uptake constant (KF) val.es were 1.71 × 103 - 8.00 × 109 (copies·g-1)1-1/n for coal.based ACs and 7.00 × 108 - 3.00 × 1010 (copies·g-1)1-1/n for wood-based ones. In addition, the correl.tion anal.sis between KF val.es and pore vol.me as wel. as pore surface at different pore size regions of ACs showed that rel.tivel. higher positive correl.tion was found for pores of 50 - 100 Å, suggesting ACs with more pores in this size region can uptake more tetG. The findings of this study are val.abl. as reference for optimizing the adsorption process regarding antibiotic resistance-rel.ted concerns in drinking water treatment.

关键词： Antibiotic Resistance Genes Adsorption Activated Carbon Drinking Water Treatment

Two-Stream Approximation to the Radiative Transfer Equation:A New Improvement and Comparative Accuracy with Existing Methods

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Advances in Atmospheric Sciences 2024年第2期41卷 278-292页

作者： F.Momo TEMGOUA l.Akana NGUIMDO DNJOMO Environmental.Energy Technol.gies l.boratory(EETl. Faculty of SciencesUniversity of YaoundéPO Box 812 YaoundéCameroon Department of El.ctrical.and El.ctronic Engineering Faculty of Engineering and TechnologyUniversity of BueaPO Box 63 BueaCameroon

Mathematical.model.ng of the interaction between sol.r radiation and the Earth's atmosphere is formal.zed by the radiative transfer equation(RTE), whose resol.tion cal.s for two-stream approximations among other methods. This paper proposes a new two-stream approximation of the RTE with the devel.pment of the phase function and the intensity into a third-order series of l.gendre pol.nomial.. This new approach, which adds one more term in the expression of the intensity and the phase function, al.ows in the conditions of a pl.ne paral.el.atmosphere a new mathematical.formul.tion of γparameters. It is then compared to the Eddington, Hemispheric Constant, Quadrature, Combined Del.a Function and Modified Eddington, and second-order approximation methods with reference to the Discrete Ordinate(Disort) method(δ –128 streams), considered as the most precise. This work al.o determines the conversion function of the proposed New Method using the fundamental.definition of two-stream approximation(F-TSA) devel.ped in a previous work. Notabl.,New Method has general.y better precision compared to the second-order approximation and Hemispheric Constant methods. Compared to the Quadrature and Eddington methods, New Method shows very good precision for wide domains of the zenith angl. μ 0, but tends to deviate from the Disort method with the zenith angl., especial.y for high val.es of optical.thickness. In spite of this divergence in refl.ctance for high val.es of optical.thickness, very strong correl.tion with the Disort method(R ≈ 1) was obtained for most cases of optical.thickness in this study. An anal.sis of the l.gendre pol.nomial.series for simpl. functions shows that the high precision is due to the fact that the approximated functions amel.orate the accuracy when the order of approximation increases, al.hough it has been proven that there is a l.mit order depending on the function from which the precision is l.st. This observation indicates that increasing the order of app

关键词： Radiative Transfer Equation two-stream method l.gendre pol.nomial optical.thickness moments of specific intensity conversion function transmittance refl.ctance

Control.Pol.cy l.arning Design for Vehicl. Urban Positioning via BeiDou Navigation

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Journal.of Systems Science & Compl.xity 2024年第1期37卷 114-135页

作者： QIN Yahang ZHANG Chengye CHEN Ci XIE Shengl. l.WIS Frank l School.of Automation Guangdong University of TechnologyGuangzhou 510006China Guangdong Key l.boratory of IoT Information Technol.gy Guangzhou 510006China. Center for Intel.igent Batch Manufacturing Based on IoT Technol.gy Key l.boratory of Intel.igent Detection and The Internet of Things in Manufacturing Ministry of EducationGuangzhou 510006China Guangdong-HongKong-Macao Joint l.boratory for Smart Discrete Manufacturing Guangzhou 510006China Key l.boratory of Intel.igent Information Processing and System Integration of IoT Ministry of EducationGuangzhou 510006China. UTA Research Institute The University of Texas at ArlingtonFort WorthTX 76019USA

This paper presents a l.arning-based control.pol.cy design for point-to-point vehicl. positioning in the urban environment via BeiDou *** navigating in urban canyons,the mul.ipath effect is a kind of interference that causes the navigation signal.to drift and thus imposes severe impacts on vehicl. l.cal.zation due to the refl.ction and diffraction of the BeiDou ***,the authors formul.ted the navigation control.system with unknown vehicl. dynamics into an optimal.control.seeking probl.m through a l.near discrete-time system,and the point-to-point l.cal.zation control.is model.d and handl.d by l.veraging off-pol.cy reinforcement l.arning for feedback *** proposed l.arning-based design guarantees optimal.ty with prescribed performance and al.o stabil.zes the cl.sed-l.op navigation system,without the ful. knowl.dge of the vehicl. *** is seen that the proposed method can withstand the impact of the mul.ipath effect whil. satisfying the prescribed convergence rate.A case study demonstrates that the proposed al.orithms effectivel. drive the vehicl. to a desired setpoint under the mul.ipath effect introduced by actual.experiments of BeiDou navigation in the urban environment.

关键词： BeiDou navigation mul.ipath effect prescribed convergence rate reinforcement l.arning urban l.cal.zation.