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中国化学会第二届全国光功能材料青年学者研讨会

作者： Yi-Wen Zheng Stefano Crespi Bin Chen burkhard k?nig Chen-Ho Tung Li-Zhu Wu Technical Institute of Physics and Chemistry Chinese Academy of Sciences University of Regensburg

In comparison to the well-established approaches, a straightforward and high atom economic methodology for N-aryl amides synthesis with liberation of H2 without preactivation and the use of any directing group has been challenging. Herein, a hydrogen evolution cross-coupling photocatalytic system consisting of a quinolinum ion photocatalyst and a cobaloxime catalyst is utilized for inter/intramolecular amidation of arene C-H with amide N-H bonds with concomitant evolution of H2. This dual catalytic system could be applied for quinazolinones synthesis via a regioselective amidation of simple benzamides. Although photocatalytic hydrogen evolution cross-coupling has been applied in a broad range of transformations, the mechanistic studies lag far ***, mechanism for this dual catalytic system were also thoroughly investigated and discussed here by experimental and computational studies.

关键词： C-H functionalization dehydrogenation amidation photocatalysis

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烷烃C-H键氨基化：铜基光催化C(sp3)-H/N-H偶联

烷烃C-H键氨基化：铜基光催化C(sp3)-H/N-H偶联

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中国化学会第十六届全国光化学学术讨论会（2019）

作者：郑艺文 burkhard k?nig 雷根斯堡大学

含氮化合物普遍存在于天然产物、医药以及功能材料中,因此在有机合成中C-N键的高效构筑备受关注。目前已经有许多关于C(sp)-H键氨基化的报道。同理应该可以用类似的方法对未活化或惰性C(sp)-H键进行氨基化,但是由于C(sp)-H键本身固有的... 详细信息

含氮化合物普遍存在于天然产物、医药以及功能材料中,因此在有机合成中C-N键的高效构筑备受关注。目前已经有许多关于C(sp)-H键氨基化的报道。同理应该可以用类似的方法对未活化或惰性C(sp)-H键进行氨基化,但是由于C(sp)-H键本身固有的性质,使其氨基化更具挑战性。光催化由于反应条件温和而被广泛应用于各种各样的化学转化中。但是到目前为止,仅有个别通过C-H键与N-H键直接偶联实现惰性C(sp)-H键氨基化的报道,且这些报道中所用的氮源主要为磺酰胺类化合物。在此我们利用铜催化在光照条件下实现C(sp)-H键与各种氮源的N-H键的偶联,利用该策略可以实现对多种药物N-H键的烷基化。

关键词：光催化铜催化 C(sp3)-H键活化氨基化

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粒-巨噬细胞集落刺激因子在肺泡蛋白沉积症患者中的表达

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中华结核和呼吸杂志 2001年第7期24卷 417-429页

作者：王选锭罗发满刘富光 burkhard Bewig 浙江大学医学院附属二院呼吸科杭州310009 德国基尔大学附属医院内科

目的　研究粒巨噬细胞集落刺激因子 (GM CSF)蛋白及mRNA在 4例肺泡蛋白沉积症(PAP)患者中的表达 ,探索PAP的发病机制。方法　采用ELISA法测定GM CSF蛋白 ,采用RT PCR检测外周血单个核细胞及肺泡巨噬细胞中GM CSFmRNA表达水平。GM CSFc... 详细信息

目的　研究粒巨噬细胞集落刺激因子 (GM CSF)蛋白及mRNA在 4例肺泡蛋白沉积症(PAP)患者中的表达 ,探索PAP的发病机制。方法　采用ELISA法测定GM CSF蛋白 ,采用RT PCR检测外周血单个核细胞及肺泡巨噬细胞中GM CSFmRNA表达水平。GM CSFcDNA测序采用双脱氧链终止反应法。结果　 4例PAP中 3例外周血单个核细胞和肺泡巨噬细胞均检测不到GM CSF释放 ,但mRNA表达水平均正常。cDNA测序发现 1例PAP患者GM CSFcDNA第 3 82位碱基发生点突变 (T→C) ,致 117位氨基酸序列发生改变 (异亮氨酸→苏氨酸 )。结论　GM CSF蛋白表达异常与PAP发病可能有关 ,GM CSFcDNA点突变可能是导致GM

关键词：肺泡蛋白沉积症粒-巨噬细胞集落刺激因子基因表达基因突变

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On the Role of Intestinal Microbiota in Patients with Cognitive Decline

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Journal of Pharmacy and Pharmacology 2017年第9期5卷 648-653页

作者： Friedrich Leblhuber Barbara Strassert kostja Steiner Johanna Gostner burkhard Schuetz Dietmar Fuchs Department of Gerontology Neuromed Campus Kepler University Clinic Linz 4020 Austria Division of Medical Biochemistry Biocenter Innsbruck Medical University Innsbruck 6020 Austria Biovis Diagnostik MVZ GmbH Limburg 65549 Germany Division of Biological Chemistry Biocenter Innsbruck Medical University Innsbruck 6020 Austria

Objective： The association between gut microbiota composition and biomarkers of immune activation and inflammation was assessed in the elderly. Patients： Serum inflammation markers of fifty-five outpatients （29 females, 26 males, aged 78 ＋ 8.5 years） were analyzed. Stool specimens and thus data on gut microbiota were available from a subgroup of 23 individuals （9 females and 14 males）. Results： Global cerebral atrophy was found in all magnet resonance tomography scans. Mean mini-mental-score examination in Alzheimer＇s disease patients was 18.8 ± 7.1, in patients with mild cognitive impairment 27.8 ± 1.5. Serum neopterin concentrations correlated with concentrations of fecal S100A12 （p 〈 0.001） and cq-antitrypsin （p 〈 0.05）. Faecalibacterium prausnitzii correlated with MMSE （p 〈 0.05）, with Akkermansia muciniphila （p 〈 0.01） and with serum neopterin （p 〈 0.05）. Fecal zonulin correlated inversely with Clostridium cluster I （p 〈 0.02）. Conclusions： Our results underline earlier in vitro and animal studies that cognitive decline associates with age-related changes in the intestinal microbiota and neuroinflammation. However, only correlational evidence can be reported, and a causative relationship still has to be demonstrated.

关键词： Microbiota brain-gut axis prevention cognitive decline.

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Application of Ground Source Heat Pump to a Supermarket in Portugal

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Journal of Civil Engineering and Architecture 2011年第3期5卷 241-247页

作者： Joao Garcia Luis Coelho Rita Cerdeira burkhard Sanner Philippe Lentz Nicolas Frechin Polithecnic Institute of Set（tbal Escola Superior de Tecnologia de Setubal Campus de IPS 1 Setuba12910-76 Portugal European Geothermal Energy Council （EGEC） Brussels Belgium SAUNIer ＆ ASSOCIES Paris France

The objective of the present paper is to describe a technical and economical visibility study of the application of ground source heat pumps （GSHP） in a supermarket in Portugal. The study was developed under the European project ＂Integration of Geothermal Energy Into Industrial Application - IGEIA＂, project number EIE 06/001, supported by the Intelligent Energy for Europe, IEE, of EACI, European Commission. In general for supermarkets installed in single buildings, the building envelope has higher rates of envelope areas per indoor air volume. In Portugal this fact produces high need of heating during the winter season and high cooling needs during the summer season. Inside the building there are strong internal heat loads produced by high densities of lights and equipments. However these internal loads are not distributed uniformly. There are some areas with high production of heat but there are others with production of cooling. Therefore the acclimatization of this kind of buildings is not so easy and the balance of heating and cooling needs is depending of different parameters which should be well evaluated. The energy consummation of the cold display cases and deep freezers in market area and storage is also very high. The different energy needs could be studied in an integrated way and could be partially satisfied by geothermal energy using ground source heat pumps. At the same time the boreholes could be used as an energy reservoir increasing the efficiency of whole system. Four different climatic zones in Portugal were selected, （north coast, interior north, south coast and interior south） using the same system. The results of the study show that the all energy needs can by partially satisfied by geothermal energy but they need to be integrated to increase the global efficiency. The paper shows that the geothermal energy can be an attractive application for the supermarkets in Portugal if the energy solution is studied in an integrated way and if it is also

关键词： Geothermal energy ground source heat pump high efficiency

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