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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 1-2页

作者： buring j.e. Lee I.-M 朱国栋

Background: Observations that risk for colorectal cancer is elevated in patien ts with inflammatory bowel disease and that long-term use of anti-inflammatory drugs may reduce colorectal cancer risk have raised the possibility that inflam mation may play a role in the development of colorectal cancer. While a recent p rospective study observed a positive association between C-reactive protein(CRP ), a marker of inflammation, and risk for colon cancer, data testing this hypoth esis are sparse. Objective:To evaluate whether plasma CRP levels predict colorec tal cancer risk in women. Design: Prospective cohort study, with 97%morbidity f ollow-up and 100%mortality follow-up within the past 2 years. Setting:Women’ s Health Study. Participants: 27 913 apparently healthy women age 45 years or ol der who had CRP measured at entry into a trial of low-dose aspirin and vitamin e. Maximum length of intervention and follow-up was 10.8 years. Measurements: S elf-reported incident colorectal adenocarcinoma confirmed by medical record rev iew. Results: 169 women de- veloped colorectal adenocarcinomas during follow-up. Baseline CRP levels were not significantly associated with colorectal cancer risk. The multivariate haza rd ratios according to cutoff points for CRP proposed in clinical guidelines wer e 0.79 (95%CI, 0.53 to 1.17) for the category of 1 to 3 mg/L and 0.66 (CI, 0.43 to 1.03) for the category of greater than 3 mg/L (P for trend = 0.09), as compa red with the category of less than 1 mg/L. High CRP levels were also not associa ted with increased risk in analyses done according to tumor location and stage a t diagnosis,according to alternative cutoff points for CRP, or in any of the sub groups evaluated. Limitations: Despite multivariate analysis, residual confoundi ng might still be present. Although this study was prospective, we cannot comple tely exclude undetected cancer at ***- ements for CRP were available for only 71%of women in the cohort; however, th e

关键词：结肠直肠癌 C-反应蛋白发病风险结肠癌结肠直肠腺癌炎症性肠病炎症反应前瞻性队列研究抗炎药物临床指南

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经不依赖载脂蛋白(a)同工型大小的分析所测定的脂蛋白(a)与最初健康女性未来发生心血管事件风险的关系

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世界核心医学期刊文摘（心脏病学分册） 2007年第3期3卷 5-6页

作者： Danik j.S. Rifai N. buring j.e. Ridker P.M. 郭俊 Dr.Center for Cardiovascular Disease Prevention Brigham and Women's Hospital90 Commonwealth AveBostonMA 02215United States

背景:关于脂蛋白(a)这一与纤溶酶原同源的脂蛋白是否是女性发生心血管事件风险的有临床意义标记物仍存在争议。通过不同分析方法获得的脂蛋白(a)水平之间一致性较差。

关键词：心血管事件同工型非致死性纤溶酶原心血管风险同源的亚组女性健康分析方法总胆固醇

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眼干燥症短期问卷调查的真实性和重复性

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世界核心医学期刊文摘（眼科学分册） 2006年第10期2卷 55-56页

作者： Gulati A. Sullivan R. buring j.e. D.A.Schaumberg 韩治华 Schepens eye Research Institute Harvard Medical SchoolBostonMAUnited States

Purpose:To clinically validate and ascertain the repeatability of a short questionnaire for dry eye syndrome(DeS),consisting of two questions pertaining to symptoms(dryness and irritation)and one question regarding previous history of clinically diagnosed ***:Clinical validation study with repeated ***:A short questionnaire for DeS was administered to participants of two large cohort studies,the Women’s Health Study(WHS)and the Physicians’Health Study(PHS).A supplementary questionnaire comprising 16 questions pertaining to symptoms was mailed to a subset of 450 WHS and 240 PHS participants,selected so that a third of these subjects had DeS based on their response to the short *** of the dryness and irritation symptom questions was ascertained using intraclass correlation coefficient(ICC).Standardized ophthalmologic examination was performed on 53 *** and specificity of the short questionnaire was determined using a combination of clinical tests to define clinical ***:An ICC of 0.75 for dryness and 0.65 for irritation was found between subsequent ***’responses to the dryness and irritation questions were highly correlated(r=0.75)with a score derived from responses to the longer 16-symptom *** short questionnaire for DeS had a sensitivity of 77% and specificity of 83% when cut off point for clinical DeS was Schirmer 1 value ≤ 10 mm or tear breakup timee short questionnaire for DeS is a sensitive and repeatable tool that is easy to administer in large epidemiologic research studies as well as clinical research.

关键词：眼干燥症问卷调查眼刺激泪膜破裂时间群组研究临床病史症状问卷眼科检查内科医生组内相关

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女性整体心血管风险的改良评估方法的确立和验证:Reynolds风险评分

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世界核心医学期刊文摘（心脏病学分册） 2007年第8期3卷 3-4页

作者： Ridker P.M. buring j.e. Rifai N. Cook N.R. 刘少伟 Dr.Center for Cardiovascular Disease Prevention Brigham and Women' s Hospital 900 Commonwealth Ave E Boston MA 02215 United States

背景:虽然对动脉粥样硬化的认识有所深入,但预测女性心血管事件的方法在很大程度上仍依赖于传统的危险因素。目的:基于大量的传统和新型危险因素确立预测女性心血管事件风险的方法并进行验证。设计、机构和参与者:对24558例最初健康且... 详细信息

背景:虽然对动脉粥样硬化的认识有所深入,但预测女性心血管事件的方法在很大程度上仍依赖于传统的危险因素。目的:基于大量的传统和新型危险因素确立预测女性心血管事件风险的方法并进行验证。设计、机构和参与者:对24558例最初健康且年龄≥45岁的美国女性进行中位时间10.2年(至2004年3月)的随访,评估35个因素对新发心血管事件(经判定的心肌梗死、缺血性卒中、冠状动脉血运重建和心血管死亡联合终点)的预测作用。

关键词：心血管风险心血管事件联合终点 Reynolds 缺血性卒中美国女性协变量率更总胆固醇患

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空腹与餐后甘油三酯预测女性心血管事件风险的比较

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世界核心医学期刊文摘（心脏病学分册） 2007年第11期3卷 6-7页

作者： Bansal S. buring j.e. Rifai N. P.M. Ridker 吴超能 Center for Cardiovascular Disease Prevention Brigham and Women's Hospital 900 Commonwealth Ave E Boston MA 02215 United States Dr.

背景:关于甘油三酯(TG)与新发心血管事件的关系尚无定论。尽管通常是检测空腹TG,然而餐后高甘油三酯血症可能是动脉粥样硬化(AS)的重要相关因素。目的:研究TG水平(空腹vs餐后)与未来心血管事件的相关性。设计。

关键词：空腹 TG 餐后心血管甘油三酯事件风险女性

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Are hydrides under high-pressure-high-temperature superconductors?

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National Science Review 2024年第7期11卷 9-12页

作者： j.e.Hirsch Department of Physics University of California

Contrary to the current consensus, I argue that the existing evidence for high-temperature superconductivity in hydrides under high pressure is not compelling. I suggest that the focus of the field should urgently shift to establish unequivocally experimentally whether or not superconductivity in pressurized hydrides exists, instead of continuing to search for new materials that might show elusive signals of unproven superconductivity at ever higher temperatures. The implications of a negative finding for the theoretical understanding of superconductivity are discussed.

关键词： Hydrides

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Annual variation of adult survival of a south-temperate House Wren population in Argentina

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Avian Research 2024年第2期15卷 229-237页

作者： Gustavo j.Fernandez Mariana e.Carro Paulo e.Llambías Grupo de Investigacion en ecofisiología de Fauna Silvestre INIBIOMA-CONICETAsentamiento Universitario San Martín de los Andes(AUSMA)Universidad Nacional Del ComahuePasaje de la Paz 235(8370)San Martín de los AndesNeuquenArgentina Grupo de Investigacion de Biología de Aves IADIZA CCT-MendozaUniversidad Nacional de CuyoAvenida RuizLeal s/n Parque General San Martin5500MendozaArgentina

Identifying factors affecting the survival of individuals is essential for understanding the evolution of life-history traits and population *** numerous studies on this subject in north-temperate environments,there is a lack of equivalent studies at similar latitudes in the ***,we used a 14-year dataset of capture,banding,and resighting to estimate the annual variation in the apparent adult survival probability of a south-temperate population of House Wrens(Troglodytes aedon bonariae).We evaluated temporal variation in sur-vival and the effect of environmental(climatic)and demographic variables(adult abundance,total number of fledglings produced during each breeding season)on survival *** found that the probability of adult survival decreased as the abundance of breeding adults *** density-dependent effect could be related to the resident lifestyle of southern House Wrens,which could determine an intense competition for territories and resources that ultimately would affect their survival.

关键词： Annual variation CjS Density-dependence Survival Troglodytes aedon bonariae

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Insm1:orchestrating cellular mimicry in the thymus medulla

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Cellular & Molecular Immunology 2024年第4期21卷 414-416页

作者： K.D.james j.e.Cowan UCL Institute of Immunity and Transplantation The Pears BuildingRowland Hill StreetLondonNW32PPUK

The thymus is the primary production site for a functional and self-tolerant T-cell *** establishment of immune tolerance is mediated by the generation and presentation of tissue-restricted self-antigens(TRAs)by medullary thymic epithelial cells(mTeCs),which screen T-cell receptors for self-reactivity to eliminate autoreactive T *** studies have extended our understanding of mTeC heterogeneity by examining the mechanisms by which mTeCs mimic the peripheral self[1].

关键词： medullary eliminate restricted

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Unmixing detrital zircon U-Pb ages reveals tectonic and climatic depositional influences on the Carboniferous Ansilta Formation,Calingasta-Uspallata Basin,Western Argentina

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Geoscience Frontiers 2024年第4期15卷 61-77页

作者： j.R.Malone j.e.Malone j.L.Isbell D.H.Malone j.P.Craddock K.N.Pauls Department of Geological Sciences Jackson School of GeosciencesUniversity of Texas at AustinAustinTX 78712USA Iowa Geological Survey University of IowaIowa CityIA 52240USA Department of Geosciences University of Wisconsin-MilwaukeeMilwaukeeWI 53211USA Department of Geography Geology and the EnvironmentIllinois State UniversityNormalIL 61790-4400USA

The Late Paleozoic Ice Age(LPIA)was a principal control of sedimentation across Gondwana from the late Devonian through early *** assess the hypothesis that glacial to interglacial transitions in western Argentina were the primary control influencing sediment routing patterns among the various Carboniferous-Permian basins in western *** Carboniferous Ansilta Formation consists of glaciomarine,nearshore,and fluvial systems deposited during the LPIA along the eastern margin of the Calingasta-Uspallata Basin in *** lower,glacially influenced succession of the Ansilta Formation records at least five glacial advances;the upper succession of consists of progradational shallow marine,deltaic,and fluvial *** combine 1225 new U-Pb zircon ages from six samples of the Carboniferous Ansilta Formation in the Calingasta-Uspallata Basin with 5864 U-Pb ages from 147 pub-lished samples in the detrital Pymix forward mixture model to characterize provenance *** the glacially influenced lower Ansilta Formation,sediment was derived locally from the Protoprecordillera,which was a prominent highland with alpine glaciers flowing west and east into the Calingasta-Uspallata and Paganzo basins,***,there was little or no connection between these two basins during Serpukhovian-Bashkirian *** fluvial/deltaic upper Ansilta had distal sediment sources in the Sierras ***,our results support the collapse of the Protoprecordillera topographic barrier,enabling drainage patterns connecting the Paganzo and Calingasta-Uspallata basins by late Pennsylvanian-early Permian time.

关键词： Late Paleozoic Ice Age Argentina Calingasta-Uspallata Basin Ansilta Formation Detrital zircon provenance

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包括C-反应蛋白的心血管风险预测模型对女性的预测效应

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世界核心医学期刊文摘（心脏病学分册） 2007年第10期3卷 8-页

作者： Cook N.R. buring j.e. Ridker P.M. 罗亮 Division of Preventive Medicine Brigham and Women's Hospital900 Commonwealth Avenue EastBostonMA 02215United States Dr.

背景:当高敏C-反应蛋白(hsCRP)成为心血管风险的独立预测因素,总体风险预测模型便纳入使用。目的:探讨和比较包括与不包括hsCRP的心血管风险预测模型。设计:观察性队列研究。地点:美国女性卫生保健。参与者:参与女性健康研究并平均随访1... 详细信息

背景:当高敏C-反应蛋白(hsCRP)成为心血管风险的独立预测因素,总体风险预测模型便纳入使用。目的:探讨和比较包括与不包括hsCRP的心血管风险预测模型。设计:观察性队列研究。地点:美国女性卫生保健。参与者:参与女性健康研究并平均随访10年。

关键词：风险预测模型心血管反应蛋白女性

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