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Enhancement of Essential Oil Yield from Melaleuca Leucadendra *** by Lignocellulose Degradation Pre-Treatment Using Filamentous Fungi

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Journal of Bioresources and Bioproducts 2021年第4期6卷 379-386页

作者： Tjokorda I.Indira Khairul Hadi burhan Robert Manurung Ana Widiana Department of Bioengineering School of Life Science and TechnologyInstitute of Technology BandungIndonesia Agriculture and Bioproduct Technology Research Group Institute of Technology BandungJl.Raya Jatinangor Km 20.75Sumedang 45363Indonesia Department of Biology Faculty of Sciences and Technology Sunan Gunung Djati UniversityJl.A.H.Nasution No.105Bandung 40614Indonesia

The essential oil from Melaleuca leucadendra *** has been widely used as a perfume and traditional remedy,cosmetics and pharmaceutical products ingredient since many years *** common technology to recover the oil is hydro-distillation and ***,all oil can not be fully extracted from the leaves by this method due to the recalcitrant structure of leaves that hindrance the access of the *** a submerged fermentation as a pretreatment step prior to the extraction process helped to loosen the lignocellulose structure and enhance oil release in the extraction *** this study,the raw materials were collected from the natural forest in Buru Island,Maluku,*** biological agents applied in these processes were Phanerochaete chrysosporium ITBCC136 and Trichoderma viride *** oil extraction process was conducted by method of steam-distillation,the oil was analysed using gas chromatography-mass spectroscopy(GC-MS),and the lignocellulose content in the biomass was measured by the fractionation *** treatment using *** provided the highest increase in yield percentage up to 3.47%as compared with control of 1.45%,with the lowest percentages of the remained cellulose,while the fermentation with the presence of *** did not affect the oil yield even the lignin content was decrease as much as 21%.The percentages of 1,8-cineole in the oil were almost unchanged,which was about 20%of the oil.

关键词： Cajuput oil Cineole Filamentous fungi Lignocellulose biodegradation Phanerochaete chrysosporium Trichoderma viride

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Human cyclosporiosis in Turkey

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World Journal of Gastroenterology 2004年第12期10卷 1844-1847页

作者： Süleyman Yazar Saban Yalcln izzet sahin Department of Parasitology Medical FacultyErciyes University38039Kayseri-Turkey

Six patients infected with Cydospora cayetanensis who sought medical care at three different hospitals in Turkey are herein *** patients were male and the others were female and their ages ranged from 7 to 62 *** first patient was HIV-positive and presented with watery diarrhea with a frequency of up to 18 times a day for more than ten months and diagnosed as cyclosporiosis in Kayseri,1996. The second patient was also HIV positive and diagnosed as cyclosporiosis in Kayseri,*** third patient was an acute myeloblastic leukemia(AML)patient and diagnosed in Istanbul,*** fourth patient was idiopathic hepatic cirrhosis complaining of diarrhea and weakness and diagnosed in Kayseri,*** fifth and sixth patients were immunocompetent patients complaining of diarrhea and diagnosed in Izmir and Kayseri,*** occurring from one to ten times a day conlJnued for 7 to 70 d in the last 5 *** with a trimethoprim/sulfamethoxazole compound was done for all *** symptomatic and parasitologic improvements were quickly *** summary,*** infection is rare in Turkey and most patients infected with this pathogen tend to be immunosuppressive individuals at present.

关键词： Adult Child Cyclospora purification Cyclosporiasis Feces Female Humans Male Middle Aged Turkey

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Impact of Electric Vehicle Aggregator with Communication Time Delay on Stability Regions and Stability Delay Margins in Load Frequency Control System

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Journal of Modern Power Systems and Clean Energy 2021年第3期9卷 595-601页

作者： Ausnain Naveed sahin Sonmez Saffet Ayasun the Department of Electrical and Electronic Engineering Nigde Omer Halisdemir UniversityNigdeTurkey the Department of Electrical and Electronic Engineering Gazi UniversityAnkaraTurkey

This paper investigates the impact of electric vehicle(EV)aggregator with communication time delay on stability regions and stability delay margins of a single-area load frequency control(LFC)***,a graphical method characterizing stability boundary locus is *** a given time delay,the method computes all the stabilizing proportional-integral(PI)controller gains,which constitutes a stability region in the parameter space of PI ***,in order to complement the stability regions,a frequency-domain exact method is used to calculate stability delay margins for various values of PI controller *** qualitative impact of EV aggregator on both stability regions and stability delay margins is thoroughly analyzed and the results are authenticated by time-domain simulations and quasi-polynomial mapping-based root finder(QPmR)algorithm.

关键词： Communication time delay electric vehicle(EV)aggregator frequency regulation proportional-integral(PI)controller design stability delay margin stability region

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Structure instability and high microwave dielectric permittivity of nonstoichiometric(Sr_(0.4)Ce_(0.4))_(1-x)Nd_(x)Ti_(0.8)Mg_(0.2)O_(3)system for wireless communication

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Journal of Materiomics 2021年第1期7卷 25-33页

作者： burhan Ullah Wen Lei Xianwei Wang Bihui Zhang Wen-Zhong Lu School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan430074China Key Lab of Functional Materials for Electronic Information(B) Ministry of EducationWuhan430074China Department of Physics Islamia College University PeshawarPakistan Laboratory of Functional Materials School of PhysicsHenan Normal UniversityXinxiang453007China

(Sr_(0.4)Ce_(0.4))_(1-x)Nd_(x)Ti_(0.8)Mg_(0.2)O_(3)[(SC)NdTMgO3,x=0.1-0.4]non-stoichiometric system were obtained through conventional solid-state synthesis *** perovskite peaks were attributed to either single(x0.3,the(SC)NdTMgO3 compound,exhibits structure instability and(200)/(310)peaks *** peaks splitting indicates cubic(C-phase)to tetrogonal(T-phase)structure phase *** ceramic samples appear nearly dense,presenting a non-uniform grain size *** observed trend of the microwave dielectric properties(er,tf,Q×f)is mainly related to the formation of structure phase transition,packing fraction,relative density and ionic polarizability.A key microwave(MW)dielectric properties of er=53,Q×f=26,700 GHz and tf=+2.8 pmm/℃could be obtained for composition with x=0.4.

关键词： (SC)NdTMgO_(3)system Phase transition Microwave dielectric

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Practical points that gastrointestinal fellows should know in management of COVID-19

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World Journal of Clinical Cases 2022年第16期10卷 5133-5145页

作者： Tevhide sahin Cem Simsek Hatice Yasemin Balaban Department of Gastroenterology Hacettepe UniversityFaculty of MedicineAnkara 06100Turkey

Pandemics obligate providers to transform their clinical *** extensive effort has been put to find out feasible approaches for gastrointestinal diseases and also to manage coronavirus disease 2019(COVID-19)related gastrointestinal ***,hepatitis,and pancreatitis can be seen in the COVID-19 *** procedures increase the risk of contamination for medical staff and patients despite precautions,therefore indications should be tailored to balance risks vs ***,whether the immunosupression in inflammatory bowel diseases,liver transplantation,and autoimmune liver diseases increases COVID-19 related risks and how to modify immunosupression are topics of ongoing *** review aims to provide most up to date practical approaches that a gastrointestinal fellow should be aware on the problems and management of gastrointestinal and hepatobiliary diseases during the COVID-19 pandemic.

关键词： COVID-19 Gastrointestinal diseases Practical points Endoscopy Gastrointestinal fellows

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Combined duplication of the colon and vermiform appendix in an adult patient

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World Journal of Gastroenterology 2008年第4期14卷 641-643页

作者： sahin Kabay Mehmet Yucel Faik Yaylak Alper Hacioglu Mustafa C Algin Esra G Olgun Levent sahin Tayfun Aydin Department of Urology Dumlupinar University HospitalKutahya 43100Turkey Department of General Surgery Dumlupinar University HospitalKutahya 43100Turkey Department of Pathology Dumlupinar University HospitalKutahya 43100Turkey Department of Anesthesiology Dumlupinar University HospitalKutahya 43100Turkey

Combined duplication of the colon and vermiform appendix is one of the rare congenital anomalities of the alimentary tract. Only a few cases have been reported in the adult population. A 28-year-old man presented to the clinic with a mass in the right flank. Imaging showed only a hydronephrotic atrophic kidney. The f inal diagnosis was only available at exploration. Combined duplication of the tubular colon and vermiform appendix was conf irmed histopathologically. The patient was treated with nephrectomy and complete resection of the duplicated colon and vermiform appendix. The patient recovered uneventfully,and has done well for the past year. This is believed to be one of the first reports of combined duplication of the tubular colon and vermiform appendix as a cause of hydronephrotic atrophic kidney in an adult patient.

关键词： Colon duplication Appendix duplication Hydronephrosis Kidney

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The tumor microenvironment of pancreatic adenocarcinoma and immune checkpoint inhibitor resistance: a perplex relationship

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Cancer Drug Resistance 2020年第4期3卷 699-709页

作者： Irem sahin Sevda Turen Pranav Santapuram Ibrahim Halil sahin Baskent University School of Medicine Department of Medicine AnkaraAnkara 06810Turkey TC Istanbul Kültür University Faculty of Health SciencesDepartment of NursingIstanbul 34158Turkey Emory University School of Medicine Department of MedicineAtlantaGA 30322USA Moffitt Cancer Center Department of Gastrointestinal OncologyTampaFL 33612USA

Pancreatic cancer is one of the most aggressive cancers with a high mortality rate even among patients with early-stage *** recent studies with novel therapeutic approaches have led to modest improvement in survival outcomes,limited progress is achieved for the use of immunotherapeutics in this challenging *** checkpoint inhibitors,thus far,single-agent or in combination,have not yielded significant improvement in survival outcomes except in mismatch repair-deficient pancreatic *** tumor microenvironment of pancreatic cancer has been considered as an attractive target for over a decade based on preclinical studies that suggested it may adversely affect drug delivery and antitumor *** this review article,we elaborate on the biology of pancreatic cancer microenvironment,its highly complicated interaction with cancer cells,and the immune *** also discuss plausible explanations that led to the failure of immune checkpoint inhibitors as therapeutic agents and the potential impacts of pancreatic cancer stroma on these negative studies.

关键词： Pancreatic adenocarcinoma durvalumab nivolumab ipilimumab pembrolizumab immune checkpoint inhibitors immunotherapy resistance mismatch repair deficient microsatellite instability high microsatellite stable tumor-associated macrophages myeloid-derived suppressor cells T regs T cells

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Real-time,decentralized and bio-inspired topology control for holonomic autonomous vehicles

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International Journal of Intelligent Computing and Cybernetics 2012年第3期5卷 359-380页

作者： Cem Safak sahin M.Ümit Uyar Advanced Information Technologies BAE SystemsBurlingtonMassachusettsUSA Department of Electrical Engineering The City College of The City University of New YorkNew YorkUSA

Purpose–This paper aims to present an approach for a bio-inspired decentralization topology control mechanism,called force-based genetic algorithm(FGA),where a genetic algorithm(GA)is run by each holonomic autonomous vehicle(HAV)in a mobile ad hoc network(MANET)as software agent to achieve a uniform spread of HAVs and to provide a fully connected network over an unknown geographical *** HAV runs its own FGA to decide its next movement direction and speed based on local neighborhood information,such as obstacles and the number of neighbors,without a centralized control unit or global ***/methodology/approach-The objective function used in FGA is inspired by the equilibrium of the molecules in physics where each molecule tries to be in the balanced position to spend minimum energy to maintain its *** this approach,a virtual force is assumed to be applied by the neighboring HAVs to a given *** equilibrium,the aggregate virtual force applied to an HAV by its neighbors should sum up to *** the aggregate virtual force is not zero,it is used as a fitness value for the *** value of this virtual force depends on the number of neighbors within the communication range of Rcom and the distance among *** chromosome in our GA-based framework is composed of speed and movement *** FGA is independently run by each HAV as a topology control mechanism and only utilizes information from neighbors and local terrain to make movement and speed decisions to converge towards a uniform distribution of *** authors developed an analytical model,simulation software and several testbeds to study the convergence properties of the ***-The paper finds that coverage-centric,bio-inspired,mobile node deployment algorithm ensures effective sensing coverage for each mobile node after initial *** FGA is also an energy-aware self-organization framework since it reduces energy consumption by eliminating unnecessary excessive mo

关键词： Genetic algorithms Spatial node distribution Mobile ad hoc networks Topology control Bio-inspired algorithm Analytical model Mobile networks

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Fruit Yield and Quality, and Irrigation Water Use Efficiency of Summer Squash Drip-Irrigated with Different Irrigation Quantities in a Semi-Arid Agricultural Area

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Journal of Integrative Agriculture 2014年第11期13卷 2518-2526页

作者： Yasemin Kuslu Ustun sahin Fatih M Kiziloglu Selcuk Memis Department of Agricultural Structures and Irrigation Atatürk University

Fruit yield, yield components, fruit mineral content, total phenolic content, antioxidant activity and irrigation water use efifciency （IWUE） of summer squash responses to different irrigation quantities were evaluated with a ifeld study. Irrigations were done when the total evaporated water from a Class A pan was about 30 mm. Different irrigation quantities were adjusted using three different plant-pan coefifcients （Kcp, 100% （Kcp1）, 85% （Kcp2） and 70% （Kcp3））. Results indicated that lower irrigation quantities provided statistically lower yield and yield components. The highest seasonal fruit yield （80.0 t ha-1） was determined in the Kcp1 treatment, which applied the highest volume of irrigation water （452.9 mm）. The highest early fruit yield, average fruit weight and fruit diameter, length and number per plant were also determined in the Kcp1 treatment, with values of 7.25 t ha-1, 264.1 g, 5.49 cm, 19.95 cm and 10.92, respectively. Although the IWUE value was the highest in the Kcp1 treatment （176.6 kg ha-1 mm-1）, it was statistically similar to the value for Kcp3 treatment （157.1 kg ha-1 mm-1）. Total phenolic content and antioxidant activity of fruits was higher in the Kcp1 （44.27 μg gallic acid equivalents （GAE） mg-1 fresh sample） and in the Kcp2 （84.75%） treatments, respectively. Major （Na, N, P, K, Ca, Mg and S） and trace （Fe, Cu, Mn, Zn and B） mineral contents of squash fruits were the highest in the Kcp2 treatment, with the exception of P, Ca and Cu. Mineral contents and total phenolic content were signiifcantly affected by irrigation quantities, but antioxidant activity was not affected. It can be concluded that the Kcp1 treatment was the most suitable for achieving higher yield and IWUE. However, the Kcp2 treatment will be the most suitable due to the high fruit quality and relatively high yield in water shortage conditions.

关键词： summer squash drip irrigation irrigation water use efifciency total phenolic content antioxidant activity fruit mineral content

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COVID-19 pandemic:Its impact on liver disease and liver transplantation

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World Journal of Gastroenterology 2020年第22期26卷 2987-2999页

作者： Tevfik Tolga sahin Sami Akbulut Sezai Yilmaz Deaprtment of Surgery and Liver Transplant Institute Inonu University Faculty of MedicineMalatya 244280Turkey

Severe pulmonary disease caused by the novel coronavirus[severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)],has devastated many countries around the *** has overwhelmed the medical *** priorities of many institutions have changed to manage critically ill corona virus infectious disease-2019(COVID-19)patients,which affected the working style of many *** and transplant surgeons look after a very sensitive patient *** with liver disease need special attention and continuous ***,transplant candidates also need special *** professionals in the field of hepatology face the overwhelming task of taking care of COVID-19 patients with hepatic complications,liver disease or transplant patients who are SARS-CoV-2 positive,and the patients on routine surveillance who do not have *** review will evaluate COVID-19 from the perspective of its effect on the liver and its possible effects on patients with liver ***,the level of care for liver transplant recipients during the pandemic will be discussed.

关键词： SARS-Cov-2 COVID-19 Acute liver injury Chronic liver disease Liver transplantation Risk factors

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