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Efficacy of the subthreshold micropulse yellow wavelength laser photostimulation in the treatment of chronic central serous chorioretinopathy

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1404-1410页

作者： Mehmed Ugur Isιk Mehmet Fatih Kagan Degirmenci ayhan Saglιk Department of Ophthalmology Kastamonu University Faculty of MedicineKastamonu 37100Turkey Department of Ophthalmology CanklrlState HospitalCankin 18800Turkey Department of Ophthalmology Harran University Faculty of MedicineSanllurfa 63000Turkey

AIM:To evaluate the efficacy and safety of subthreshold micropulse yellow laser(SMYL)in the treatment of chronic central serous chorioretinopathy(CCSC).METHODS:The medical records of 58 eyes of 58 patients with CCSC were reviewed.A 577-nm SMYL system was used for the *** fluorescein angiography was used as the primary method of identifying CCSC,and resolution of subretinal fluid(SRF)evaluated by optical coherence tomography(OCT)and fundus *** macular thickness(CMT),central macular volume(CMV),total macular volume(TMV),subfoveal choroidal thickness(SFCT),subretinal fluid height(SRFH),and subfoveal fluid basement diameter values were measured by spectral domain-OCT(SD-OCT)for all ***:The mean age of the patients was 42.4±9.9(range:20-72)*** mean follow-up was 11.4±8.5(range:6-37)*** BCVA at at the final follow up after treatment was statistically significant from the *** SRF resolution was 12.1%of the eyes in the 1^st month,67.2%of the eyes in the 3rd month and 67.2%of the eyes in the last follow *** initial median CMT,CMV,TMV,and SFCT values before treatment was significantly higher than 3^rd month visit values(P<0.001).In the multivariate analysis performed,age and disease duration were found to be a risk factor for persistent SRF(P=0.017,P=0.016,respectively).CONCLUSION:SMYL treatment provides a significant anatomical and functional improvement and is effective in eliminating SRF in eyes with CCSC.

关键词： central serous chorioretinopathy subthreshold micropulse laser optical coherence tomography

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Development of a functional chocolate using gamma-amino butyric acid producer Lacticaseibacillus rhamnosus NRRL B-442

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Food Bioscience 2022年第3期47卷 700-706页

作者： Merve Ozer burcu Ozturk Ali Adnan Hayaloglu Sebnem Tellioglu Harsa İzmir Institute of Technology Faculty of EngineeringDepartment of Food EngineeringGulbahçe Campus35430UrlaİzmirTurkey İnönü University Faculty of EngineeringDepartment of Food Engineering44280MalatyaTurkey

The human microbiota is influenced by the immune and nervous systems of the ***-aminobutyric acid (GABA) is known as bioactive compound and it has important physiological functions,such as anti-hypertensive and antidepressant *** acid bacteria (LAB),especially Lactobacillus species are known as the most important GABA producers because of the food-grade *** purpose of this study is to develop a functional chocolate using microencapsulated GABA producer Lacticaseibacillus rhamnosus NRRL B-442 strain for patients having an anxiety ***-in-oil emulsion technique was conducted for microencapsulation using whey-pullulan *** and free *** cell counts were 6.75 and 7.20 log CFU/g in chocolates,respectively,at the end of 60 *** simulated in vitro digestion analysis,survival rate of microencapsulated bacteria in chocolate samples was found at higher percentage (87%) than free bacteria (75%).Furthermore,microencapsulated *** did not affect the physical,chemical,and sensory properties of ***,*** with the highest GABA producing capability may provide insight for an anxiety disorder patient,since this strain has been thought as having a therapeutic effect.A new functional food model was developed for “GutBrain Axis” phenomena since the chocolate could be accepted as a good carrier for GABA producer bacteria.

关键词： Microencapsulation Anxiety disorder Functional food Simulated digestion

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Effects of storage media,supplements and cryopreservation methods on quality of stem cells

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World Journal of Stem Cells 2021年第9期13卷 1197-1214页

作者： Ozgur Dogus Erol burcu Pervin Mehmet Emin Seker Fatima Aerts-Kaya Department of Stem Cell Sciences Hacettepe University Graduate School of Health SciencesAnkara 06100Turkey Center for Stem Cell Research and Development Hacettepe UniversityAnkara 06100Turkey

Despite a vast amount of different methods, protocols and cryoprotective agents(CPA), stem cells are often frozen using standard protocols that have beenoptimized for use with cell lines, rather than with stem cells. Relatively fewcomparative studies have been performed to assess the effects of cryopreservationmethods on these stem cells. Dimethyl sulfoxide (DMSO) has been a key agent forthe development of cryobiology and has been used universally for ***, the use of DMSO has been associated with in vitro and in vivotoxicity and has been shown to affect many cellular processes due to changes inDNA methylation and dysregulation of gene expression. Despite studies showingthat DMSO may affect cell characteristics, DMSO remains the CPA of choice, bothin a research setting and in the clinics. However, numerous alternatives to DMSOhave been shown to hold promise for use as a CPA and include albumin,trehalose, sucrose, ethylene glycol, polyethylene glycol and many more. Here, wewill discuss the use, advantages and disadvantages of these CPAs for cryopreservationof different types of stem cells, including hematopoietic stem cells,mesenchymal stromal/stem cells and induced pluripotent stem cells.

关键词： Cryoprotective agents Dimethyl sulfoxide Hematopoietic stem cells Mesenchymal stromal/stem cells Induced pluripotent stem cells

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Electrochemical,spectroscopic,and molecular docking studies of the interaction between the anti-retroviral drug indinavir and dsDNA

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Journal of Pharmaceutical Analysis 2020年第5期10卷 473-481页

作者： Fariba Mollarasouli burcu Dogan-Topal Mehmet Gokhan Caglayan Tugba Taskin-Tok Sibel A.Ozkan Ankara University Department of Analytical Chemistry06560AnkaraTurkey Department of Chemistry Yasouj UniversityYasouj75918-74831Iran Department of Chemistry Gaziantep University27310GaziantepTurkey Institute of Health Sciences Department of Bioinformatics and Computational BiologyGaziantep University27310GaziantepTurkey

In this study,an electrochemical DNA biosensor was developed using a straightforward methodology to investigate the interaction of indinavir with calf thymus double-stranded deoxyribonucleic acid(ctdsDNA)for the first *** decrease in the oxidation signals of deoxyguanosine(dGuo)and deoxyadenosine(dAdo),measured by differential pulse voltammetry,upon incubation with different concentrations of indinavir can be attributed to the binding mode of indinavir to *** currents of the dGuo and dAdo peaks decreased linearly with the concentration of indinavir in the range of 1.0 e10.0 mg/*** limit of detection and limit of quantification for indinavir were 0.29 and 0.98 mg/mL,respectively,based on the dGuo signal,and 0.23 and 0.78 mg/mL,respectively,based on the dAdo *** gain further insights into the interaction mechanism between indinavir and ct-dsDNA,spectroscopic measurements and molecular docking simulations were *** binding constant(Kb)between indinavir and ct-dsDNA was calculated to be 1.64108 M1,based on spectrofluorometric *** obtained results can offer insights into the inhibitory activity of indinavir,which could help to broaden its *** is,indinavir can be used to inhibit other mechanisms and/or hallmarks of viral diseases.

关键词： Glassy carbon electrode Calf thymus double-stranded deoxyribonucleic acid(ct-dsDNA) Biosensor Fluorescence Molecular docking

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Prediction of the undrained shear strength of remolded soil with non-linear regression,fuzzy logic,and artificial neural network

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Journal of Mountain Science 2024年第9期21卷 3108-3122页

作者： YÜNKÜL Kaan KARAÇOR Fatih GÜRBÜZ ayhan BUDAK TahsinÖmür Department of Civil Engineering Faculty of Engineering and ArchitectureTokat Gaziosmanpaşa UniversityTokat 60100Türkiye Department of Civil Engineering Faculty of Engineering and ArchitectureKafkas UniversityKars 36000Türkiye Department of Civil Engineering Faculty of EngineeringGazi UniversityAnkara 06570Türkiye Ministry of Youth and Sports Ankara 06090Türkiye

This study aims to predict the undrained shear strength of remolded soil samples using non-linear regression analyses,fuzzy logic,and artificial neural network modeling.A total of 1306 undrained shear strength results from 230 different remolded soil test settings reported in 21 publications were collected,utilizing six different measurement *** water content,plastic limit,and liquid limit were used as input parameters for fuzzy logic and artificial neural network modeling,liquidity index or water content ratio was considered as an input parameter for non-linear regression *** non-linear regression analyses,12 different regression equations were derived for the prediction of undrained shear strength of remolded ***-Forward backpropagation and the TANSIG transfer function were used for artificial neural network modeling,while the Mamdani inference system was preferred with trapezoidal and triangular membership functions for fuzzy logic *** experimental results of 914 tests were used for training of the artificial neural network models,196 for validation and 196 for *** was observed that the accuracy of the artificial neural network and fuzzy logic modeling was higher than that of the non-linear regression ***,a simple and reliable regression equation was proposed for assessments of undrained shear strength values with higher coefficients of determination.

关键词： Undrained shear strength Liquidity index Water content ratio Non-linear regression Artificial neural networks Fuzzy logic

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Composition of Pancarli Magmatic Ni-Cu±(PGE) Sulfide Deposit in the Cadomian-Avalonian Belt, Eastern Turkey

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Journal of Earth Science 2020年第3期31卷 536-550页

作者： Esra Yildirim Nail Yildirim Cahit Donmez Kurtulus Gunay Taner Korkmaz Mustafa Akyildiz burcu Goren Firat University Department of Geology EngineeringElazig 23119Turkey General Directorate of Mineral Research and Exploration of Turkey Department of Mineral Research and ExplorationAnkara 06520Turkey Cukurova University Department of Geology EngineeringAdanaTurkey

Pancarli Ni-Cu±(PGE)sulfide deposit occurs in the Neoproterozoic basement complex of the Bitlis massif,which is one of the Andean-type active continental margin fragments with arc-type assemblages represented by the Cadomian orogenic *** sulfides are associated with quartzo-feldspathic gneisses(country rock)and mafic intrusions(host rock).Composed of only semi-massive ore,the Ni-Cu±(PGE)sulfide deposit is a small-scale deposit,and it does not contain net-textured and disseminated *** mineral assemblage comprises pyrrhotite,pentlandite,and *** semi-massive ore samples contain 2.2 wt.%-2.9 wt.%Ni,0.8 wt.%-2.2 wt.%Cu(Cu/(Cu+Ni)=0.2-0.5)and 0.13 wt.%-0.17 wt.%*** Cu/Ni ratios(average 0.57)are consistent with the segregation of sulfides from a basaltic *** Pt+Pd100%S values of 0.08 ppm-0.89 ppm,relatively low Pt/Pd ratios of 0.2-1.4,and Pd/Ir ratios of 4.5-39 have also been *** values demonstrate that the magma reached S saturation before its emplacement and the mineralization with high Cu/Pd ratios formed by sulfides segregated from a PGE-depleted magma.δ^34S isotope values(average-3.1‰)of Pancarli sulfides are lower than mantle ***δ^34S value indicates contamination from surrounding *** the composition,remobilization style and magma type,the Pancarli Ni-Cu±(PGE)sulfide deposit is similar to the deposits associated with Andean-type magmatic arcs located in the convergent plate margin settings.

关键词： Ni-Cu±(PGE)sulfide deposit δ^34S isotopes Neoproterozoic Andean type eastern Turkey

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Levels of serologic markers of celiac disease in patients with reflux esophagitis

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World Journal of Gastroenterology 2006年第41期12卷 6707-6710页

作者： Sait Bagcl C Nuri Ercin Zeki Yesilova ayhan Ozcan Bulent Degertekin Kemal Dagalp Department of Gastroenterology Gulhane School of MedicineAnkaraTurkey Department of Pathology Gulhane School of Me-dicineAnkaraTurkey

AIM： TO investigate the prevalence of celiac disease serologic markers （antigliadin IgA, IgG, and antiendomysial IgA） in patients with reflux esophagitis and to detect the relationship between reflux esophagitis and celiac disease （CD）. METHODS： This study was performed prospectively between January 2003 and January 2004. Sixty-eight adult reflux esophagitis patients and 40 people as control group for symptoms related with gastrointestinal system were enrolled in this study. The diagnostic work-up induded an accurate medical history with gastrointestinal symptoms, routine laboratory measurements, the detection of antibodies against gliadin （IgA and IgG） and endomysium （IgA）, and an upper endoscopy with postbulbar biopsy. RESULTS： IgA-AGA and IgG-AGA were positive at 8.8% and 10.3% in patients with reflux esophagitis. In control group, it was found that 10% people had positive IgA-AGA, and 7.5% people had positive IgG-AGA. There was no significant relationship between patients and control group regarding positive IgA-AGA and IgG- AGA. The patients and persons in control group had no positive IgA-EMA. On postbulbar biopsies, no finding was detected concerning celiac disease. There were no symptoms and signs for gluten enteropathy in patients and control group. CONCLUSION： This review supports that an association does not exist between celiac disease and reflux esophagitis. We think these diseases exist independently from each other.

关键词： Celiac disease Reflux Esophagitis

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Adsorption and desorption behavior of silver ions onto valonia tannin resin

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Transactions of Nonferrous Metals Society of China 2012年第11期22卷 2846-2854页

作者： Meral YURTSEVER .ayhan SENGL Department of Environmental Engineering Engineering Faculty Sakarya University

Valonia tannin （VT） was gelated through polymerization with formaldehyde to prepare an adsorbent, which was found effective to remove Ag＋ from aqueous solution. The adsorption-desorption behaviors of valonia tannin resin （VTR） were investigated under various initial Ag＋ concentrations, solution temperatures, pH values etc. The applicability of empirical kinetic models was also studied. The pseudo-second-order model studies revealed the Ag＋ sorption was very rapid. VT and VTR were characterized using FTIR and SEM before and after adsorption. The Ag＋ biosorption on VTR increased with a rise in initial concentration of Ag＋ and with a decrease in temperature. Desorption experiments were conducted at low pH values and the solutions of H2SO4, HNO3 and HCl were used for desorption. The VTR shows high adsorption capacity to Ag＋ in a wide pH range of 2.0-7.0, and a maximum adsorption capacity of 97.08 mg/g was obtained at pH 5.0 and 296 K when the initial concentration of Ag＋ was 100.0 mg/L. Ag＋ ion desorption could reach 99.6% using 1 mol/L HCl＋1% thiourea （NH2CSNH2） solution. By utilizing such characteristics of VTR, it is expected that it can be applied to recovering Ag＋ efficiently and simply with low cost.

关键词： biosorption desorption kinetics silver Ag+ ions absorbent valonia tannin resin

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Improvement in renal functions with transcatheter aortic valve implantation

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Journal of Geriatric Cardiology 2013年第4期10卷 317-322页

作者： Telat Keleş Huseyin ayhan Durmaz Sarı Aslan AN Erdoğan KE Kasapkara Bilen Bayram Akçay Bozkurt Department of Cardiology Yıldırım Beyazıt University Bilkent 06800 Ankara Turkey Department of Cardiology Ankara Ataturk Education and Research Hospital Bilkent 06800 Ankara Turkey Department of Cardiovascular Surgery Ankara Ataturk Education and Research Hospital Bilkent 06800 Ankara Turkey.

BACKGROUND & OBJECTIVES:In recent years, emerging transcatheter aortic valve implantation (TAVI) has become an alternative for surgery。 However, with advanced age, several co-morbid factors together with contrast agent usage can cause deterioration in renal function and increase in the risk of acute kidney injury (AKI) with poor prognosis in patients with AKI。 Therefore, many patients cannot benefit from this treatment。 In this study, we aim to examine the effects of TAVI on renal functions。 METHODS AND RESULTS: Seventy patients, mean age of 77.6 years, underwent TAVI between July 2011 and December 2012。 Estimated glomerular filtration rate (eGFR) was calculated by using the Cockcroft and Gault Formula。 Patients were monitored for 48 h for urine output。 Stage 1 AKI, according to the VARC-2 AKIN system, developed in only five (7.1%) of the patients after the procedure。 There was a statistically significant increase between the mean 1(st) month eGFRs before (68。2 vs。 61.0, P < 0.01) and after (68。2 vs。 63.6, P < 0.05) the TAVI in the cohort。 After TAVI (48。5 mL/min, P < 0.01) and the 1(st) month (52.1 mL/min, P < 0.01), the eGFR of the 36 (51.4%) patients diagnosed with chronic kidney disease before the procedure showed a statistically significant increase in renal functions。 The hospital mortality rate was higher in the group which developed AKI (P < 0.01)。 First month eGFR showed a more statistically significant increase than pre-TAVI eGFR (62.8 and 69.8, P < 0.05, respectively) in AKI developing patients and this difference - though statistically not significant - continued into the sixth month。 CONCLUSIONS: In this study, we showed that the treatment of aortic stenosis through TAVI allows improvement of renal functions, and that AKI rates will be lower with careful patient selection, proper pre-procedural hydration, and careful use of contrast agent。

关键词： Transcatheter aortic valve implantation Kidney injury Improvement

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Is increased red cell distribution width an indicating marker of nonalcoholic steatohepatitis and fibrotic stage?

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World Journal of Gastroenterology 2013年第42期19卷 7412-7418页

作者： Mustafa Cengiz burcu Aslan Candir Güldal Yilmaz Gülen Akyol Seren Ozenirler Department of Gastroenterology Gazi University Faculty of Medicine06500 AnkaraTurkey Department of Internal Medicine Gazi University Faculty of Medicine06500 AnkaraTurkey Department of Pathology Gazi University Faculty of Medicine06500 AnkaraTurkey

AIM:To evaluate the red cell distribution width(RDW)as an indicator of the presence of non-alcoholic steatohepatitis(NASH)and its association with fibrotic ***:A retrospective study was carried out that included sixty-two biopsy proven NASH,32 simple steatosis patients and 30 healthy *** correlation between the clinical and histopathological features of NASH patients and RDW values was *** fibrosis scores were measured using a 0 to 4 point scale and were divided in to two groups;fibrosis scores0-1 were termed mild and fibrosis scores 2-4 were termed advanced *** values were compared between NASH,simple steatosis and healthy *** and multivariate analyses were performed to evaluate the independent predicting factors for the presence of liver fibrosis caused by ***:Patients with NASH had higher RDW values compared with simple steatosis and healthy control groups[14.28%±0.25%vs 13.37%±0.12%,12.96%±0.14%(P<0.01),respectively].Patients with advanced fibrosis had higher RDW values than the mild fibrosis group(15.86%±0.4%vs 13.63%±0.67%,P<0.01,respectively).RDW also correlated with fibrotic scores(r=0.579 andP<0.01).The variables that were significant in the univariate analysis were evaluated in multivariate logistic regression analysis,and RDW was an independent predicting factor of NASH(OR=1.75,95%CI:1.129-2.711,P<0.05).CONCLUSION:RDW a new non-invasive marker that can be used to demonstrate the presence of NASH and indicate advanced fibrotic scores.

关键词： Non-alcoholic steatohepatitis Liver fibrosis Red cell distribution width Simple steatosis Noninvasive marker Liver biopsy

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