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THE REPRESENTATION OF THE SOLUTION OF STURM-LIOUVILLE EQUATION WITH DISCONTINUITY CONDITIONS

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Acta Mathematica Scientia 2018年第4期38卷 1195-1213页

作者： Ozge akcay Department of Mathematics Mersin University

The aim of this paper is to construct the integral representation of the solution of Sturm-Liouville equation with eigenparameter-dependent discontinuity conditions at an interior point of the finite interval. Moreover, we examine the properties of the kernel function of this integral representation and obtain the partial differential equation provided by this kernel function.

关键词： Sturm-Liouville equation discontinuity conditions integral representation

Host genetic factors affecting hepatitis B infection outcomes:Insights from genome-wide association studies

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World Journal of Gastroenterology 2018年第30期24卷 3347-3360页

作者： Izzet Mehmet akcay Seyma Katrinli Kamil Ozdil Gizem Dinler Doganay Levent Doganay Department of Molecular Biology and Genetics Istanbul Technical University Department of Gastroenterology and Hepatology Umraniye Teaching and Research Hospital

The clinical outcome of hepatitis B virus(HBV) infection depends on the success or failure of the immune responses to HBV,and varies widely among individuals,ranging from asymptomatic self-limited infection,inactive carrier state,chronic hepatitis,cirrhosis,hepatocellular carcinoma,to liver failure,depending on the success or failure of immune response to ***-wide association studies(GWAS) identified key genetic factors influencing the pathogenesis of HBV-related *** this review,we discuss GWAS for persistence of HBV infection,antibody response to hepatitis B vaccine,and HBV-related advanced liver *** persistence is associated with multiple genes with diverse roles in immune *** strongest associations are found within the classical human leukocyte antigen(HLA) genes,highlighting the central role of antigen presentation in the immune response to *** variants affect both epitope binding specificities and expression levels of HLA *** other susceptibility genes regulate the magnitude of adaptive immune responses,determining immunity vs *** persistence and nonresponse to vaccine share the same risk variants,implying overlapping genetic *** the other hand,the risk variants for HBV-related advanced liver diseases are largely different,suggesting different host-virus dynamics in acute vs chronic HBV *** findings of these GWAS are likely to pave the way for developing more effective preventive and therapeutic interventions by personalizing the management of HBV infection.

关键词： Genome-wide association studies Hepatitis B infection Hepatocellular carcinoma Cirrhosis Antigen

Clinical characteristics of intermediate uveitis in adult Turkish patients

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 759-763页

作者： Esra Kardes Betul Ilkay Sezgin akcay Kansu Bozkurt Cihan Unlu Gurkan Erdogan Gulunay Akcali Department of Ophthalmology Umraniye Research and Training Hospital

·AIM: To describe the clinical characteristics of Turkish patients with intermediate uveitis(IU) and to investigate the effect of clinical findings and complications on final visual acuity(VA).·METHODS: We retrospectively analyzed the medical records of patients with IU who had at least 6mo of follow-up and were older than 16 y.· RESULTS: A total of 78 eyes of 45 patients were included in the study and the mean follow-up period was19.4mo. The mean age at the time of presentation was42.9s. Systemic disease associations were found in17.7% of cases; sarcoidosis(8.8%) and multiple sclerosis(6.6%) were the most common diseases. Recurrence rate(odds ratio=45.53; 95%CI: 2.181-950.58), vitritis equals to or more than 3+ cells(odds ratio =57.456; 95%CI: 4.154-794.79) and presenting with VA less than 20/40(odds ratio =43.81; 95% CI: 2.184-878.71) were also found as high risk factors for poor final VA. At the last follow-up examination, 67.9% of eyes had VA of 20/40 or better.·CONCLUSION: IU is frequently seen at the beginning of the fourth decade of life. The disease is most commonly idiopathic in adult Turkish patients. Patients with severe vitritis at presentation and patients with frequent recurrences are at high risk for poor visual outcome.

关键词： intermediate uveitis Turkish adult

Subfoveal choroidal thickness changes after intravitreal bevacizumab therapy for neovascular age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 849-851页

作者： Cihan ünlü Gurkan Erdogan Betul Onal Gunay Betul Ilkay Sezgin akcay Esra Kardes Department of Opthalmology ümraniye Training and Research Hospital

Dear Sir,Iam ***ünlü,from the Department of Opthalmology,ümraniye Training and Research Hospital,Istanbul,Turkey.I write to present our study findings on subfoveal choroidal thickness(SFCT)changes after intravitreal bevacizumab(IVB)therapy for neovascular age-related macular degeneration(AMD).AMD is the leading cause of severe visual loss in adults older than 60y[1].Visual loss in late stages of AMD may be the result of one of the two processes:geographic atrophy(GA)or choroidal neovascularization(CNV).Many types of

关键词： AMD CNV

Effect of refractive error on temperament and character properties

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 72-76页

作者： Emine Kalkan akcay Fatih Canan Huseyin Simavli Derya Dal Hacer Yalniz Nagihan Ugurlu Omer Gecici Nurullah Cagil Department of Ophthalmology Faculty of MedicineYildirim Bayezid University Department of Psychiatry Faculty of MedicineAkdeniz University Department of Ophthalmology Pamukkale University School of Medicine Deparment of Ophthalmology Erzurum Training and Research Hospital Alcoholism and Drug Treatment and Rehab Center Akdeniz University

AIM: To determine the effect of refractive error on temperament and character properties using Cloninger’s psychobiological model of ***: Using the Temperament and Character Inventory(TCI), the temperament and character profiles of 41 participants with refractive errors(17 with myopia,12 with hyperopia, and 12 with myopic astigmatism) were compared to those of 30 healthy control ***, temperament comprised the traits of novelty seeking, harm-avoidance, and reward dependence, while character comprised traits of self-directedness,cooperativeness, and ***: Participants with refractive error showed significantly lower scores on purposefulness,cooperativeness, empathy, helpfulness, and compassion(P <0.05, P <0.01, P <0.05, P <0.05, and P <0.01,respectively).CONCLUSION: Refractive error might have a negative influence on some character traits, and different types of refractive error might have different temperament and character properties. These personality traits may be implicated in the onset and/or perpetuation of refractive errors and may be a productive focus for psychotherapy.

关键词： astigmatism character hyperopia refractive error temperament

Monitoring and Fault Diagnosis by Multivariate Statistical Methods in Chemical Processes

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Monitoring and Fault Diagnosis by Multivariate Statistical M...

Is T1-2 Disc Herniation Rare? A Case Report

7th World Congress on Recovery, Recycling and Re-integration

作者： Ridvan Berber Levent akcay Dept.Chem.Eng. Faculty of Engineering Ankara University Tandogan 06100 Ankara Turkey State Institute of Statistics Bakanliklar 06100 Ankara Turkey

Process monitoring, early fault detection and diagnosis, is important in chemical and manufacturing processes for safety, controlling product quality and minimizing waste The multivariate statistical methods, which systematically reduce the number of related variables and transform the system to a simpler form, are highly developed within the field of chemometrics, but they deserve to be explored and applied to process data in other areas. In this study, Principle Component Analysis by NIPALS algorithm and Partial Least Square by NIPALS and Kernel algorithms are coded in MATLAB 6.0 with a graphical user interface for off-line process monitoring and fault diagnosis in continuous and batch processes. The concept of 'high leverage point plot' was introduced to identify out-of-control variables in continuous processes, and 'dissimilarity index', which is easier to implement than the classical score plots, was introduced to differentiate the 'bad' batches from the good ones in batch operations. Data from the literature (simulated PVC plant data) as well as from real industrial plants (textile glue production plant and bakers' yeast plant) were used to assess the effectiveness of the illustrated methods. Comparative studies revealed that score plots detected out-of-control observations more accurately than the other control plots like SPE, Hotelling T2 and high leverage point plots. Hotelling T2 and SPE graphs predicted almost the same out-of-control observations with the leverage graphs. The results of dissimilarity index were similar to those of score plot for the identification of 'good' or 'bad' batches. This work, thus, provides a thorough analysis of multivariate statistical methods for process monitoring and fault diagnosis in chemical processing industries, and highlights the relative merits of individual techniques.

关键词： multivariate statistical methods, process monitoring, fault diagnosis

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International Journal of Clinical Medicine 2014年第8期5卷 444-446页

作者： Murat Aydin Emrah akcay Alattin Yurt Department of Neurosurgery Bozyaka Educational and Research HospitalIzmirTurkey

Backround: The English literature contains very few reports on disc herniation at upper thoracic levels. This report presents a patient with T1-2 disc herniation who underwent successful surgery. Case Presentation: A 47-year-old female presented that the right T1 root was compressed by foraminal disc herniation at the T1-2 level. Conclusion: The anterior approach is an easy and appropriate method to treat central and foraminal disc herniation of the thoracic spine.

关键词： Disc Herniation Thoracic Spine T1-2 Level Surgery

Association of Body Mass Index and Lipid Profiles in Children

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Open Journal of Pediatrics 2015年第2期5卷 141-146页

作者： Gulsen Meral Aysegul Uslu Ali Unsal Yozgatli Faruk akcay Department of Children Health and Disease Kagithane State HospitalIstanbulTurkey Department of Obstetrics&Gynecology Kagithane State HospitalIstanbulTurkey

We examined the lipid values of obese and normal-weight children, to look if there is an association between Body Mass Index (BMI) and lipid profiles. Our study group included 100 volunteers (50 children with normal BMI and 50 with high BMI) who were admitted to Kagithane State Hospital Pediatrics Clinic for various reasons between July 2010 and May 2011. The inclusion criteria were as follows: age between 2 and 14 years, no chronic disease and no developmental defects. The high BMI group had significantly higher Low Density Lipoprotein (LDL) levels in comparison to the normal BMI group (p?< 0.05). We also found that the high BMI group had higher cholesterol levels close to upper limit than the normal BMI group. We found high triglyceride levels not only in the high BMI group but also in the normal BMI group with a rate of 26% and 24% respectively. The difference of 2% was not significant. We advise that identification and treatment of elevated LDL cholesterol levels is of tremendous significance for obese children or adolescents for future cardiovascular disease risk in adulthood. In the light of these findings, we must not overlook cardiovascular risk in the normal BMI group children. We believe that necessary precautions must be taken for preventing overweight and dyslipidemia in early childhood. Accordingly, it is of paramount importance not only to reduce obesity in children and adolescents but also to monitor dyslipidemia in normal BMI children to avoid the subsequent risk for cardiovascular disease.

关键词： Body Mass Index Children Cholesterol Dyslipidemia

厚植被地区块状硫化物矿床的生物地球化学勘查：土耳其东北部特拉布宗省Kanko

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国外地质勘探技术 1999年第6期 10-18,5页

作者： akcay.,M 胡西顺

1 前言 1986年土耳其矿产法方面的变化标志着外国矿业公司的新纪元。这部新法规鼓励他们在土耳其形成联合投资并勘探新矿床。由此产生了迅速的影响,不久许多公司提出了在这个国家的勘探计划。这项勘探运动被证明是成功的,主要使用的是... 详细信息

1 前言 1986年土耳其矿产法方面的变化标志着外国矿业公司的新纪元。这部新法规鼓励他们在土耳其形成联合投资并勘探新矿床。由此产生了迅速的影响,不久许多公司提出了在这个国家的勘探计划。这项勘探运动被证明是成功的,主要使用的是水系沉积物地球化学和体积采样,由此导致了土耳其西部几个贵金属矿床的发现(akcay等,1996)。

关键词：植被地区硫化物矿床生物地球化学勘探土耳其