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Topiramate as a neuroprotective agent in a rat model of spinal cord injury

Neural Regeneration Research 2017年第12期12卷 2071-2076页

作者： Firat Narin Sahin Hanalioglu Huseyin Ustun Kamer Kilinc burcak bilginer Department of Neurosurgery Hacettepe University Faculty of Medicine Ankara Turkey Department of Pathology Ankara Training and Research Hospital Ankara Turkey Department of Biochemistry TOBB University of Economics and Technology Faculty of Medicine Ankara Turkey

Topiramate（TPM） is a widely used antiepileptic and antimigraine agent which has been shown to exert neuroprotective effects in various experimental traumatic brain injury and stroke models. However, its utility in spinal cord injury has not been studied extensively. Thus, we evaluated effects of TPM on secondary cellular injury mechanisms in an experimental rat model of traumatic spinal cord injury（SCI）. After rat models of thoracic contusive SCI were established by free weight-drop method, TPM（40 mg/kg） was given at 12-hour intervals for four times orally. Post TPM treatment, malondialdehyde and protein carbonyl levels were significantly reduced and reduced glutathione levels were increased, while immunoreactivity for endothelial nitric oxide synthase, inducible nitric oxide synthase, and apoptotic peptidase activating factor 1 was diminished in SCI rats. In addition, TPM treatment improved the functional recovery of SCI rats. This study suggests that administration of TPM exerts neuroprotective effects on SCI.

关键词： nerve regeneration spinal cord injury topiramate neuroprotection oxidative damage nitricoxide motor function neural regeneration

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Early rehabilitation improves neurofunctional outcome after surgery in children with spinal tumors

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Neural Regeneration Research 2014年第2期9卷 129-134页

作者： Nezire Kose Ozge Muezzinoglu Sevil Bilgin Sevilay Karahan Ilkay Is kay burcak bilginer Department of Physiotherapy and Rehabilitation Faculty of Health SciencesHacettepe University Department of Biostatistics Faculty of Health SciencesHacettepe University Department of Neurosurgery Faculty of MedicineHacettepe University

To investigate the effect of early rehabilitation on neurofunctional outcome after surgery in chil- dren with spinal tumors, this study reviewed the medical charts and radiographic records of 70 pediatric patients （1-17 years old） who received spinal tumor surgical removal. The peddiatric patients received rahabilitation treatment at 4 （range, 2-7） days after surgery for 10 （range, 7-23） days. Results from the Modified McCormick Scale, Functional Independence Measure for Chil- dren, American Spinal Injury Association Impairment Scale and Karnofsky Performance Status Scale demonstrated that the sensory function, motor function and activity of daily living of pedi- atric children who received early rehabilitation were significantly improved. Results also showed that tumor setting and level localization as well as patients＇s clinical symptoms have no influences on neurofunctional outcomes.

关键词： nerve regeneration spinal cord injury spinal cord tumor children rehabilitation func-tion sense motor retrospective analysis neural regeneration

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Lyme Borreliosis with Opthalmologic Presentation

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Open Journal of Rheumatology and Autoimmune Diseases 2012年第4期2卷 85-87页

作者： Ayse Gultekingil Keser Rezan Topaloglu Mehmet Orhan Yelda bilginer Esra Baskin Yonca Akova Department of Opthalmology Baskent University Faculty of Medicine Ankara Turkey. Department of Opthalmology Hacettepe University Faculty of Medicine Ankara Turkey Department of Pediatric Nephrology and Rheumatology Baskent University Faculty of Medicine Ankara Turkey Department of Pediatric Nephrology and Rheumatology Hacettepe University Faculty of Medicine Ankara Turkey Department of Pediatrics Hacettepe University Faculty of Medicine Ankara Turkey

Lyme disease is a tick-borne multisystemic disease with multiple clinical presentations including rheumatological conditions. We present a 12 year old girl complaining of fever, arthralgia and redness in her eyes which was found to be the result of panuveitis. Borrelia antibodies were positive and she received 21-day treatment regimen with Ceftriaxon with resolution of all complaints at the end of treatment. Lyme disease classically occurs in three stages starting with erythema migrans, however atypical presentations skipping this stage and presenting with opthalmologic involvement in form of uveitis can be seen.

关键词： Lyme Borreliosis Uveitis

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