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Carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct: A case report

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World Journal of Gastroenterology 2008年第29期14卷 4705-4708页

作者： bum-soo kim Sun-Hyung Joo Kwang-Ro Joo Department of Surgery East-West Neo Medical Center University of KyungHee College of Medicine149 Sangil-dong Gangdong-gu Seoul 134-727 Korea Department of Internal Medicine East-West Neo Medical Center University of KyungHee College of Medicine149 Sangil-dong Gangdong-gu Seoul 134-727 Korea

Tubulovillous adenomas are common in the colon and rectum, but are rare in the common bile duct. Biliary adenomas may produce obstructive jaundice, which can be easily confused with a malignant neoplasm or stone. We report a case of a carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct causing obstructive jaundice. A 55-year-old male presented with a 10-d history of pruritus and progressive jaundice. Abdominal sonography and computed tomography showed a mass in the distal common bile duct. Endoscopic retrograde cholangiopancreatography showed luminal narrowing of the bile duct due to a polypoid mass. Positron emission tomography demonstrated no abnormal uptake. It was thought that this mass was a malignant tumor, thus a pylorus-preserving panceaticoduodenectomy was performed. The final pathology showed a tubulovillous adenoma with carcinoma in situ of the distal common bile duct. At follow-up 8 mo later, endoscopy showed multiple polyps in the rectum, colon and stomach. The polyps were removed by endoscopic mucosal resection and shown to be tubular adenomas with high grade dysplasia. Biliary adenomas require careful follow-up for early detection of recurrence and malignant transformation.

关键词： Common bile duct Adenoma Carcinomain situ

Laparoscopic resection of an adrenal pseudocyst mimicking a retroperitoneal mucinous cystic neoplasm

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World Journal of Gastroenterology 2009年第23期15卷 2923-2926页

作者： bum-soo kim Sun-Hyung Joo Sung-Il Choi Jeong-Yoon Song Division of Hepatobiliary Surgery Department of Surgery Kyung Hee University College of Medicine and East-West Neo Medical Center 149 Sangil-dong Gangdong-gu Seoul 134-727 South Korea

Adrenal pseudocysts are rare cystic masses that arise within the adrenal gland and are usually non-functional and asymptomatic. Adrenal pseudocysts consist of a fibrous wall without a cellular lining. We report a patient with a 9 cm, left-sided suprarenal cystic mass who presented with abdominal discomfort of 2 years＇ duration. A 38-year-old woman was referred to our service for evaluation of abdominal discomfort and gastrointestinal symptoms. Routine laboratory tests were within normal limits. An abdominal computed tomography scan showed a 9 cm × 8 cm × 8 cm well-defined cystic lesion displacing the left kidney. Magnetic resonance imaging showed a cystic lesion with low signal intensity on the Tl-weighted image and high signal intensity on the T2-weighted image. A laparoscopic left adrenalectomy was performed to diagnose the lesion. The final pathology showed an adrenal pseudocyst without a cellular lining. The patient had no postoperative complications and she was discharged four days after surgery.

关键词： Adrenal gland Pseudocyst Laparoscopy Adrenalectomy

Laparoscopic cholecystectomy in patients with anesthetic problems

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World Journal of Gastroenterology 2013年第29期19卷 4832-4835页

作者： bum-soo kim Sun-Hyung Joo Jin-Hyun Joh Jae-Woo Yi Department of Surgery School of Medicine Kyung Hee University Seoul 134-727 South Korea Departments of Surgery and Anesthesiology and Pain Medicine School of Medicine Kyung Hee University Seoul 134-727 South Korea

Laparoscopic cholecystectomy is a standard operation for benign gallbladder disease. As experience with laparoscopic cholecystectomy has increased, the procedure has become possible in patients with anesthetic problems. Patients with ankylosing spondylitis or severe kyphosis represent a challenging group to anesthesiologists and laparoscopic surgeons since these diseases are associated with difficult intubation, restrictive ventilatory defects, and cardiac problems. The relatively new approach of awake fiberoptic intubation is considered to be the safest option for patients with anticipated airway difficulties. Laparoscopic cholecystectomy is usually performed under general anesthesia but considerable difficulties in anesthetic management are encountered during laparoscopic surgery; for example, hemodynamic instability may develop in patients with cardiopulmonary dysfunction due to pneumoperitoneum and position changes during the operation. Nonetheless, regional anesthesia can be considered as a valid option for patients with gallbladder disease who are poor candidates for general anesthesia due to cardiopulmonary problems. We report three cases of laparoscopic cholecystectomy successfully performed in patients with anesthetic problems that included cardiopulmonary disease, severe kyphosis, and ankylosing spondylitis.

关键词： Laparoscopic cholecystectomy Kyphosis Ankylosing spondylitis Anesthetic problems

Chylous ascites in laparoscopic renal surgery: Where do we stand?

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World Journal of Clinical Urology 2016年第1期5卷 37-44页

作者： bum soo kim Tae Gyun Kwon Department of Urology Kyungpook National University Hospital Kyungpook National University School of Medicine Department of Urology Chilgok Kyungpook National University Hospital Kyungpook National University School of Medicine

Postoperative chylous ascites, which is caused by the disruption of lymphatic channels and persistent lymphatic leakage, was a rare complication in the urologic field before laparoscopic surgery was introduced. Now that laparoscopic urologic surgery, especially laparoscopic nephrectomy, is widely performed, chylous ascites as a complication of laparoscopic renal surgery has been reported more frequently. With these accumulated experiences and data comes knowledge about the proper diagnosis and management of chylous ascites, although there is still some debate regarding the correct protocol for diagnosis and management. Therefore, we performed a systematic review of the current literature regarding the etiology, incidence, diagnosis, management, and prognosis of chylous ascites after laparoscopic renal surgery, as well as strategies used to prevent it, and discuss current perspectives on overcoming this complication in the laparoscopic age.

关键词： Chylous ascites Kidney Laparoscopy Nephrectomy Postoperative complications

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki kim bum Jun kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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韩国社会福祉联合劝募会的可持续募捐活动

云梦学刊 2020年第6期41卷 41-46页

作者：金范洙赵广范(译) 曾桂林(审校) 韩国平泽大学韩国平泽市450701 不详

一、绪论所有国家都在思考怎样解决在经济发展过程中出现的贫困问题、环境问题等诸多社会问题。这些问题的解决需要大量经费。通过先例我们可以知道,一些先进国家通过慈善基金或者共同募金制度来确保财政,并且把它用于解决地区社会的诸... 详细信息

一、绪论所有国家都在思考怎样解决在经济发展过程中出现的贫困问题、环境问题等诸多社会问题。这些问题的解决需要大量经费。通过先例我们可以知道,一些先进国家通过慈善基金或者共同募金制度来确保财政,并且把它用于解决地区社会的诸多社会问题。

关键词：慈善基金募捐活动韩国社会福祉联合劝募先例

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi soo-Ho Choi Keun-Young kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Classification of Regular Planar Graphs with Diameter Two

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Acta Mathematica Sinica,English Series 2007年第3期23卷 411-416页

作者： Moo Young SOHN Sang bum kim Young soo KWON Rong Quan FENG Mathematics Changwon National University Changwon 641-773 Korea Mathematics Pohang University of Science and Technology Pohang 790-784 Korea LMAM School of Mathematical Sc-iencesPeking University Beijing 100871 P. R. China

In the present paper, the regular planar graphs with diameter two are classified.

关键词： graph regular diameter planar outer planar

Hepatitis B virus mutations related to liver disease progression of Korean patients

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World Journal of Gastroenterology 2014年第2期20卷 460-467页

作者： bum-Joon kim Department of Biomedical Sciences Microbiology and ImmunologyLiver Research Instituteand Cancer Research InstituteCollege of MedicineSeoul National UniversitySeoul 110-799South Korea

Hepatitis B virus(HBV)infection is a global health problem and more than 350 million people worldwide are chronic carriers of the *** the recent dramatic decline in HBV chronic patients through successful programs of hepatitis B surface antigen vaccination,South Korea is still recognized as an endemic area of HBV *** infections in South Korea exhibit several distinct features in epidemiologic and clinical *** this review paper,we summarize the distinct HBV mutation patterns related to clinical severity and the molecular epidemiologic traits in Korean chronic patients based on previous ***,several lines of evidence,including our previous results,have led to the conclusion that a combination of the exclusive predominance of genotype C2,which is prone to mutations,the high prevalence of basal core promoter double mutations,and the presence of distinct immune responses against HBV proteins in the Korean population may generate the distinct HBV variants rarely or not encountered in other areas,which results in distinct clinical manifestations in Korean chronic *** may provide a novel insight into the relationships between clinical severity,HBV genotype distribution,and HBV naturally occurring variants.

关键词： Hepatitis B virus Mutation South Korea Hepatocellular carcinoma Genotype C2