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Applications of Engineering Seismology for Site Characterization

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Journal of China University of Geosciences 2009年第3期20卷 546-554页

作者： Oz Yilmaz Murat eser Mehmet Berilgen Anatolian Geophysical 28 Lalebayiri Kemer Country KemerburgazIstanbul 34077 Turkey Yildiz Technical University Istanbul Turkey

We determined the seismic model of the soil column within a residential project site in Istanbul, Turkey. Specifically, we conducted a refraction seismic survey at 20 locations using a receiver spread with 484.5-Hz vertical geophones at 2-m intervals. We applied nonlinear tomography to first-arrival times to estimate the P-wave velocity-depth profiles and performed Rayleigh-wave inversion to estimate the S-wave velocity-depth profiles down to a depth of 30 m at each of the locations. We then combined the seismic velocities with the geotechnical borehole information regarding the lithology of the soil column and determined the site-specific geotechnical earthquake engineering parameters for the site. Specifically, we computed the maximum soil amplification ratio, maximum surface-bedrock acceleration ratio, depth interval of significant acceleration, maximum soil-rock response ratio, and design spectrum periods TA-TB. We conducted reflection seismic surveys along five line traverses with lengths between 150 and 300 m and delineated landslide failure surfaces within the site. We recorded shot gathers at 2-m intervals along each of the seismic line traverses using a receiver spread with 4 840-Hz vertical geophones at 2-m intervals. We applied nonlinear tomography to first-arrival times to estimate a P-wave velocity-depth model and analyzed the reflected waves to obtain a seismic image of the deep near-surface along each of the line traverses.

关键词： engineering seismology geotechnical engineering earthquake engineering shear-wave velocity.

Serum malondialdehyde level in patients infected with Ascaris lumbricoides

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World Journal of Gastroenterology 2003年第10期9卷 2332-2334页

作者： eser Kilic Süleyman Yazar Recep Saraymen Hatice Ozbilge Department of Biochemistry and Clinical Biochemistry Medical FacultyErciyes UniversityKayseriTurkey Department of Parasitology Medical FacultyErciyes UniversityKayseri-Turkey Department of Microbiology Medical FacultyHarran UniversitySanl 1 urfa-Turkey

AIM:The aim of the study was to investigate the changes of serum malondialdehyde level, I.e; the oxidative stress hypothesis in patients infected with Ascaris ***: Serum malondialdehyde activity was measured in 43 patients who were positive for intestinal parasite of Ascaris lumbricoides. Scores were obtained for the positives and their age-and sex-matched 60 Ascaris lumbricoides negative healthy ***: The difference between malondialdehyde levels of patients infected with Ascaris lumbricoides and control group was statistically significant both for females (P＜0.05)and for males (P＜0.05). In the patient and control groups,no correlation was found between age and malondialdehyde levels (P＞0.05) both in females and in males. In addition,no significant correlation could be found between malondialdehyde levels of both females and males for patients and control groups (P＞0.05).CONCLUSION: Malondialdehyde levels clearly increase in patients infected with Ascaris lumbricoides.

关键词： Ascaris lumbricoides Adolescent Adult Animals Ascariasis Child Female Free Radicals Humans Lipid Peroxidation Male Malondialdehyde

A rare cause of foot drop： Tired bullet

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World Journal of Emergency Medicine 2018年第4期9卷 294-296页

作者： Egemen Kiicuk eser Gumus Veli Emre Tiirkmen Emergency Department Sakarya Universty Educational and Research Hospital Sakarya Turkey Neurosurgey Department Sakarya Yenikent State Hospital Sakarya Turkey

Dear editor,In some communities,the using of firearms during the celebrations have become a traditional *** with free falling bullets that named"tired bullet"are increasing in accordance with the increased uncontrolle... 详细信息

关键词：小学英语课外阅读阅读材料

Proteome-wide alterations in an industrial clavulanic acid producing strain of Streptomyces clavuligerus

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Synthetic and Systems Biotechnology 2017年第1期2卷 39-48页

作者： eserÜnsaldı Aslıhan Kurt-Kızıldogan Birgit Voigt Dorte Becher Gülay Ozcengiz Department of Biological Sciences Middle East Technical University06800AnkaraTurkey Department of Agricultural Biotechnology Ondokuz Mayıs University55139SamsunTurkey Institute of Microbiology Ernst-Moritz-Arndt-University of GreifswaldD-17487GreifswaldGermany

The usefulness of genetic/metabolic engineering for further improvement of industrial strains is subject of discussion because of the general lack of knowledge on genetic alterations introduced by iterative cycles of random mutagenesis in such *** industrial clavulanic acid(CA)-overproducer Streptomyces clavuligerus DEPA was assessed to understand proteome-wide changes that have occurred in a local industrial CA overproducer developed through succesive mutagenesis *** proteins that could be identified corresponded to 33 distinct ORFs for underrepresented ones and 60 ORFs for overrepresented *** CA biosynthetic enzymes were overrepresented in *** DEPA;carboxyethylarginine synthase(Ceas2),clavaldehyde dehydrogenase(Car)and carboxyethyl-arginine betalactam-synthase(Bls2)whereas the enzymes of two other secondary metabolites were underrepresented along with two important global regulators[two-component system(TCS)response regulator(SCLAV_2102)and TetR-family transcriptional regulator(SCLAV_3146)]that might be related with CA production and/or differentiation.g-butyrolactone biosynthetic protein AvaA2 was 2.6 fold underrepresented in *** *** levels of two glycolytic enzymes,2,3-bisphosphoglycerate-dependent phosphoglycerate mutase and phosophoglycerate kinase were found decreased while those of dihydrolipoyl dehydrogenase(E3)and isocitrate dehydrogenase,with two isoforms were found as significantly increased.A decrease of amino acid metabolism,methionine biosynthesis in particular,as well as S-adenosylmethionine synthetase appeared as one of the prominent mechanisms of success of *** DEPA strain as a prolific producer of *** levels of two enzymes of shikimate pathway that leads to the production of aromatic amino acids and aromatic secondary metabolites were also *** of the overrepresented stress proteins in *** DEPA included polynucleotide phosphorylase/polyadenylase(PNPase),ATP

关键词： Clavulanic acid Streptomyces clavuligerus Industrial strain Proteomics 2DE MALDI-TOF/MS

Cardiopulmonary Response to Exercise at High Altitude in Adolescents with Congenital Heart Disease

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Congenital Heart Disease 2021年第6期16卷 597-608页

作者： Lukas Minder Markus Schwerzmann Thomas Radtke Hugo Saner Prisca eser Matthias Wilhelm Jean-Paul Schmid Department of Cardiology Bern University Hospital and University of BernBernSwitzerland Center for Congenital Heart Disease Department of CardiologyBern University Hospital and University of BernBernSwitzerland Epidemiology Biostatistics and Prevention InstituteUniversity of ZurichZurichSwitzerland Department of Cardiology Clinic BarmelweidBarmelweidSwitzerland

Objective:To extend our knowledge on tolerance of acute high-altitude exposure and hemodynamic response to exercise in adolescents with congenital heart disease(AscCHD)without meaningful clinical or functional ***:A symptom limited cardiopulmonary exercise stress test and a non-invasive cardiac output measurement during steady state exercise were performed at 540 m and at 3454 m *** of acute mountain sickness were ***:We recruited 21 healthy controls and 16 AscCHD(59%male,mean age 14.7±1.1 years).Three subjects(2 controls,1 AscCHD)presented light symptoms of acute mountain sickness(dizziness and headache).During the symptom limited exercise test at lowland,control subjects showed a significantly higher power to weight index(3.5±0.6 W/kg vs.3.0±0.7 W/kg,p<0.001),heart rate(188.8±10.41/min vs.179.4±13.11/min,p<0.050)and ventilation(92.8±22.9 l/min vs.75.4±18.6 l/min,<0.050).At altitude,power to weight index only remained significantly higher in the control group(2.8±0.6 W/kg vs.2.6±0.6 W/kg,p<0.001).Pulmonary blood flow(PBF)at lowland showed no difference between the control and the AscCHD group,neither at rest(5.4±0.8 l/min vs.5.1±0.9 l/min,p=0.308),nor during the steady state test(10.6±2.4 l/min vs.10.5±2.0 l/min,p=0.825).At high altitude,PBF increased by 110%and 112%,respectively(12.8±2.32 l/min vs.12.5±3.0 l/min;intergroup difference:p=0.986).Conclusions:High altitude exposure was well tolerated in an unselected group of *** significant difference in the cardio-pulmonary adaptation to a control group was noted during a steady state *** of minor acute mountain sickness did occur,which should however not be misinterpreted as signs of hemodynamic maladaptation.

关键词： Adolescents with congenital heart disease high altitude non-invasive cardiac output measurement exercise

Osteogenic composite nanocoating based on nanohydroxyapatite, strontium ranelate and polycaprolactone for titanium implants

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Transactions of Nonferrous Metals Society of China 2018年第9期28卷 1763-1773页

作者： Murat Taner VURAT Ayse eser ELCIN Yasar Murat ELCIN Tissue Engineering Biomaterials and Nanobiotechnology LaboratoryFaculty of Science and Stem Cell InstituteAnkara UniversityAnkara 06100Turkey Biovalda Health Technologies Inc.Ankara 06830Turkey

Titanium and its alloys are commonly used as dental and bone implant *** coating of titanium surfaces could improve their osteoinductive *** this work,we have developed a novel osteogenic composite nanocoating for titanium surfaces,which provides a natural environment for facilitating adhesion,proliferation,and osteogenic differentiation of bone marrow mesenchymal stem cells(MSCs).Electrospinning was used to produce composite nanofiber coatings based on polycaprolactone(PCL),nano-hydroxyapatite(nHAp)and strontium ranelate(SrRan).Thus,four types of coatings,i.e.,PCL,PCL/nHAp,PCL/SrRan,and PCL/nHAp/SrRan,were applied on titanium *** assess chemical,morphological and biological properties of the developed coatings,EDS,FTIR,XRD,XRF,SEM,AFM,in-vitro cytotoxicity and in-vitro hemocompatibility analyses were *** findings have revealed that the composite nanocoatings were both cytocompatible and hemocompatible;thus PCL/HAp/SrRan composite nanofiber coating led to the highest cell *** culture of MSCs on the nanocoatings led to the osteogenic differentiation of stem cells,confirmed by alkaline phosphatase activity and mineralization *** findings support the notion that the proposed composite nanocoatings have the potential to promote new bone formation and enhance bone-implant integration.

关键词： osteogenic nanocoating composite nanofiber titanium implant nanohydroxyapatite strontium ranelate polycaprolactone electrospinning mesenchymal stem cells

Development of a multicellular 3D-bioprinted microtissue model of human periodontal ligament-alveolar bone biointerface:Towards a pre-clinical model of periodontal diseases and personalized periodontal tissue engineering

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Genes & Diseases 2022年第4期9卷 1008-1023页

作者： Murat Taner Vurat ŞükranŞeker Özge Lalegül-Ülker Mahmut Parmaksiz Ayşe eser Elçin Yaşar Murat Elçin Tissue Engineering Biomaterials and Nanobiotechnology LaboratoryAnkara University Faculty of ScienceAnkara University Stem Cell InstituteAnkara 06100Turkey Biovalda Health Technologies Inc.Ankara 06100Turkey

While periodontal (PD) disease is among principal causes of tooth loss worldwide, regulation of concomitant soft and mineralized PD tissues, and PD pathogenesis have not been completely clarified yet. Besides, relevant pre-clinical models and in vitro platforms have limitations in simulating human physiology. Here, we have harnessed three-dimensional bioprinting (3DBP) technology for developing a multi-cellular microtissue model resembling PD ligament-alveolar bone (PDL-AB) biointerface for the first time. 3DBP parameters were optimized;the physical, chemical, rheological, mechanical, and thermal properties of the constructs were assessed. Constructs containing gelatin methacryloyl (Gel-MA) and hydroxyapatite-magnetic iron oxide nanoparticles showed higher level of compressive strength when compared with that of Gel-MA constructs. Bioprinted self-supporting microtissue was cultured under flow in a microfluidic platform for >10 days without significant loss of shape fidelity. Confocal microscopy analysis indicated that encapsulated cells were homogenously distributed inside the matrix and preserved their viability for >7 days under microfluidic conditions. Immunofluorescence analysis showed the cohesion of stromal cell surface marker-1+ human PDL fibroblasts containing PDL layer with the osteocalcin+ human osteoblasts containing mineralized layer in time, demonstrating some permeability of the printed constructs to cell migration. Preliminary tetracycline interaction study indicated the uptake of model drug by the cells inside the 3D-microtissue. Also, the non-toxic levels of tetracycline were determined for the encapsulated cells. Thus, the effects of tetracyclines on PDL-AB have clinical significance for treating PD diseases. This 3D-bioprinted multi-cellular periodontal/osteoblastic microtissue model has potential as an in vitro platform for studying processes of the human PDL.

关键词： 3D bioprinting Alveolar bone Microtissue model Organ-on-a-chip .Periodontal ligament Periodontal tissue engineering Periodontal-osteoblastic biointer face Periodontium-on-a-chip

A diagnostic approach to abdominal tuberculosis

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World Journal of Gastroenterology 2005年第21期11卷 3328-3328页

作者： eser Vardareli Baybora Kircali Osmangazi University Medical Faculty Department of Gastroenterology Meselik Eskisehir

TO THE EDITORWe read with interest the article by Uzunkoy et al[1]. about diagnosis of abdominal tuberculosis. In this article authors concluded that PCR for mycobacterium tuberculosis complex is a noninvasive method which can provide the diagnosis in most cases. If this tests negative or not feasible, laparotomy should be performed.

关键词： Abdominal tuberculosis

Effect of Exercise-Based Cardiac Rehabilitation on Cardiorespiratory Fitness in Adults with Congenital Heart Disease

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Congenital Heart Disease 2021年第1期16卷 73-84页

作者： Prisca eser Thomas Gruber Thimo Marcin Claudia Boeni Kerstin Wustmann Christina DeLuigi Matthias Greutmann Daniel Tobler Markus Schwerzmann Matthias Wilhelm Department of Cardiology InselspitalBern University HospitalUniversity of BernBernSwitzerland Department for Neuroscience and Movement Science University of FribourgFribourgSwitzerland Center for Congenital Heart Disease Bern University HospitalUniversity of BernBernSwitzerland Department of Cardiology University Hospital ZurichUniversity of ZurichZurichSwitzerland Department of Cardiology University Hospital BaselUniversity of BaselBaselSwitzerland

Background:The purpose of this study was to investigate whether patients with adult congenital heart disease(ACHD)benefit from exercise-based cardiac rehabilitation(CR)short-and long-term with regard to improvement of cardiorespiratory ***:Cardiopulmonary exercise tests(CPET)completed by ACHD patients between January 2000 and October 2019 were analysed *** mixed models were performed for peak oxygen consumption(VO_(2))with patients as random effect and age,sex,disease classification,preceding surgery(≤3 months)and preceding CR(≤4 weeks for short term and>4 weeks for long term)as fixed ***:1056 CPETs of 311 ACHD patients with simple(7),moderate(188)or great(116)complexity heart defects were *** 59 patients who completed a CR(median age 27 yrs,38%females)increased peak VO_(2)from before to after CR by a median of 2.7(IQR–0.6 to 5.5)ml/kg/***,in the multivariate mixed model,peak VO_(2)was non-significantly increased short-term after CR(β0.8,95%CI–0.7 to 2.4),not maintained long-term after CR(β0.0,95%CI–1.7 to 1.6)but significantly reduced after surgery(β–5.1,95%CI–7.1 to–3.1).The 20 CR patients after surgery increased their peak VO_(2)by 6.2(IQR 3.6–9.5)ml/kg/min,while the 39 CR patients without preceding surgery increased it by 0.9(IQR–1.5 to 3.1)ml/kg/***:The increase in peak VO_(2)with CR was mainly due to recovery from surgical *** small independent benefit from CR was not maintained long-term,highlighting the potential to improve current CR concepts in ACHD populations.

关键词： Grown-ups with congenital heart disease exercise training cardiac rehabilitation surgical intervention peak oxygen consumption cardiorespiratory fitness