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Diagnosis Delay and Assessment of the Quality of Life of Patients with Endometriosis Using the Endometriosis Health Profile 5 Questionnaire in a Sub-Saharan Population

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Open Journal of Obstetrics and Gynecology 2023年第5期13卷 907-917页

作者： Monzango Sibo Mboloko Esimo Mputu Lobota Itewa Monka Kitenge Kia Kayembe Tambola Grace Samba Kevine Maesheka Patrick Ntanga Kabuya Amba Naomie Maxime Fastrez buka ikoko Ndjukendi Ally Sangana Georges Barhayiga Berthe Mbanzulu Pita Longo Mbenza Clément Ferrier Emile Darai Department of Gynecology and Obstetrics University Clinics of Kinshasa Faculty of Medicine Kisangani Democratic Republic of the Congo Department of Gynecology Service of Laparoscopic Surgery Onyx Medical Center Kisangani Democratic Republic of the Con-go 3Department of Gynecology and Obstetrics Erasme Endometriosis Clinic Free University of Brussels Brussels Kingdom of Belgium Department of Psychiatry Neuro-Psychopathological Center of Kinshasa Faculty of Medicine Kinshasa Democratic Republic of the Congo Department of Surgery Department of Laparoscopic Visceral Surgery HJ Hospital Kinshasa Democratic Republic of the Congo Department of Anesthesia and Resuscitation University Clinics of Kinshasa Faculty of Medicine Kinshasa Democratic Republic of the Congo Department of Internal Medicine University Clinics of Kinshasa Faculty of Medicine Kinshasa Democratic Republic of the Congo Department of Gynecology and Obstetrics Tenon Hospital Sorbonne University Paris France

Context: Endometriosis is a pathology that directly affects the daily lives of women with frequent impairment of their quality of life. In our environment, medical, socio-cultural, financial factors and factors related to the organization of the health care system greatly delay its diagnosis. The objectives of the present study were to determine the diagnosis delay and to assess the quality of life before surgery of women with endometriosis using the specific Endometriosis Health Profile 5 (EHP-5) questionnaire. Methods: We carried out a descriptive, observational, retrospective study in 8 medical centers in the City of Kinshasa, from January 2019 to October 2022. A total of 80 women with endometriosis confirmed by laparoscopy (16 diagnostic and 64 operative laparoscopies) and histopathology were interviewed. We used the revised American Society for Reproductive Medicine (rASMR) classification, the Endometriosis Fertility Index (EFI) score was calculated for infertile women and the EHP-5 questionnaire to assess quality of life. Our data was entered and analyzed using Statistical Analysis Software 16.1 (STATA 16.1). Results: Diagnosis delay of endometriosis was on average 12 ± 4.3 years. The overall mean EHP-5 score of all patients showed a severe deterioration in quality of life (604 ± 235). A negative relationship was observed between the age of the patient, the diagnostic delay, and the alteration of the quality of life in patients over 36 years old and those with about 11 years of diagnostic delay presenting the slight alteration. Patients with a high social level had very severe quality impairment. Women on hormonal treatment, those with a history of pregnancy, childbirth, miscarriage and abortion had a slight and significant deterioration in quality of life (p 0.05). Conclusion: Despite some limitations, our preliminary study highlights that in sub-Saharan Africa, the diagnosis of endometriosis is delayed and associated with a severe alteration in quality of li

关键词： Diagnosis Delay EHP-5 Endometriosis Quality of Life Sub-Saharan

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Regulation of B-1a cells: another novel function of the basic helix-loop-helix transcriptional regulator BHLHE41

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Cellular & Molecular Immunology 2017年第10期14卷 802-804页

作者： buka Samten The Department of Pulmonary Immunology the University of Texas Health Science CenterTylerTX 75708USA

The basic helix-loop-helix transcription factors e40(BHLHE40)and e41(BHLHE41)were originally discovered as regulators of the proliferation and differentiation of chondrocytes and nerve cells.1–3 Later studies showed that these transcriptional regulators participate in a variety of physiological processes for the maintenance of homeostasis,such as the regulation of endothelial cells,4 adipocytes,5 circadian rhythms,6 and tumor development.7 Interest in the significance of these transcriptional regulators in the immune response was spurred by the finding that the deletion of BHLHE40 leads to abnormal activation of T cells and B cells with resistance to activation induced cell death and accumulation of autoreactive T and B cells resulting in autoimmune diseases in aged animals.

关键词： homeostasis helix diseases

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CD52 as both a marker and an effector molecule of T cells with regulatory action： Identification of novel regulatory T cells

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Cellular & Molecular Immunology 2013年第6期10卷 456-458页

作者： buka Samten Center for Pulmonary and Infectious DiseaseControl Department of Microbiology and Immu-nology University of Texas Health ScienceCenter Tyler TX USA

Regulation of immune responses is central to an effective clearance of pathogens. An effective immune response is also necessary for preventing the development of cancer and auto- immune diseases and for maintaining homeostasis. Although the thymus is the central lymphoid organ that regulates immune responses for self-tol- erance during the maturation of T cells, regulatory immune cells are still required for the proper functioning of mature immune cells in the periphery. Regulatory cells are a subpopulation of immune cells that suppress proliferation and cytokine production by other immune cells in res- ponse to antigenic stimulation.

关键词：免疫系统疾病内环境稳定认同(心理学) 社会控制正式胸腺胰岛素肿瘤

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抗人膀胱癌免疫毫微球的制备及活性检测

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中华微生物学和免疫学杂志 1996年第1期16卷 54-57页

作者：布卡盛洁谢蜀生魏树礼北京医科大学免疫学系 100083 药学院药剂教研室

人膀胱癌单克隆抗体ＢＤＩ－１通过异型双功能交联剂ＳＰＤＰ与载阿霉素人血清白蛋白毫微球偶联，制备了免疫毫微球ＤＢＩ－１－ＨＳＡ（ＡＤＲ）－ＮＳ。此免疫毫微球在体外对人膀胱场细胞ＢＩＵ－８７及Ｅ－Ｊ有特异杀伤效应，而对人... 详细信息

人膀胱癌单克隆抗体ＢＤＩ－１通过异型双功能交联剂ＳＰＤＰ与载阿霉素人血清白蛋白毫微球偶联，制备了免疫毫微球ＤＢＩ－１－ＨＳＡ（ＡＤＲ）－ＮＳ。此免疫毫微球在体外对人膀胱场细胞ＢＩＵ－８７及Ｅ－Ｊ有特异杀伤效应，而对人直肠癌细胞Ｌｏｖｏ无杀伤；荷瘤裸鼠体内实验表明，此免疫毫微球可明显抑制人膀胱癌细胞的生长。

关键词：免疫毫微球单克隆抗体膀胱癌阿霉素

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变态反应和免疫学

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美国医学会杂志（中文版） 1990年第5期9卷 273-274页

作者： buka.,SC 吴安然

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Prenatal metal mixture exposure and birth weight: A two-stage analysis in two prospective cohort studies

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Eco-Environment & Health 2022年第3期1卷 165-171页

作者： Jie Hu George D.Papandonatos Tongzhang Zheng Joseph M.Braun Bin Zhang Wenyu Liu Chuansha Wu Aifen Zhou Simin Liu Stephen L.buka Kunchong Shi Wei Xia Shunqing Xu Yuanyuan Li Key Laboratory of Environment and Health(HUST) Ministry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environmental Health(Incubation)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Epidemiology Brown University School of Public HealthProvidenceRI 02903USA Division of Women’s Health Department of MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonMA 02115USA Department of Biostatistics Brown University School of Public HealthProvidenceRI 02903USA Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital) Wuhan 430019China Division of Endocrinology Department of MedicineWarren Alpert Medical School of Brown UniversityProvidenceRI 02903USA

The understanding of the impact of prenatal exposure to metal mixtures on birth weight is *** aimed to identify metal mixture components associated with birth weight and to determine additional pairwise interactions between metals showing such *** of 18 metals were measured using inductively coupled plasma mass spectrometry in urine samples collected in the 3rd trimester from a prenatal cohort(discovery;n=1849)and the Healthy Baby Cohort(replication;n=7255)in Wuhan,*** the discovery set,we used two penalized regression models,i.e.,elastic net regression for main effects and a lasso for hierarchical interactions,to identify important mixture components associated with birth weight,which were then *** observed that 8 of the 18 measured metals were retained by elastic net regression,with five metals(vanadium,manganese,iron,cesium,and barium)showing negative associations with Z-scores for birth weight and three metals(cobalt,zinc,and strontium)showing positive *** replication set,associations remained significant for vanadium(β=-0.035;95%confidence interval[CI],-0.059 to0.010),cobalt(β=-0.073;95%CI,0.049 to 0.097),and zinc(β=-0.040;95%CI,0.016 to 0.065)after Bonferroni *** additionally identified and replicated a single pairwise interaction between iron and copper exposure on birth weight(P<0.001).Using a two-stage analysis,we identified and replicated individual metals and additional pairwise interactions-associated birth *** approach could be used in other studies estimating the effect of complex mixtures on human health.

关键词： Prenatal exposure Metal mixture Birth cohort Two-stage analysis

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伤寒性肾小球肾炎

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西安交通大学学报(医学版) 1982年第4期 1023-1024页

作者： buka I ,K M Coovadia ,吴修斌 ,孙新民

伤寒、链球菌感染后肾炎在南非下层社会中常见。本文报导了15例伤寒性肾小球肾炎,并与链球菌感染后肾炎作对比。病人与方法:患者年龄为2—13岁,10名为女孩,为住院病人,与同医院的PSGN作对照。肾炎诊断:根据眼睑及末梢浮肿、尿少、高血... 详细信息

伤寒、链球菌感染后肾炎在南非下层社会中常见。本文报导了15例伤寒性肾小球肾炎,并与链球菌感染后肾炎作对比。病人与方法:患者年龄为2—13岁,10名为女孩,为住院病人,与同医院的PSGN作对照。肾炎诊断:根据眼睑及末梢浮肿、尿少、高血压、管型尿、镜检发现白细胞、抗“O”试验(ASOT)效价>200,白蛋白<2g/L,即可诊断。

关键词：肾炎肾疾病伤寒沙门氏杆菌病肾小球肾单位

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用免疫磁性微球从骨髓中分离癌细胞

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药学学报 1998年第1期33卷 52-56页

作者：康继超沙木屯布卡谢蜀生魏树礼北京医科大学药剂教研室

用物理吸附结合化学键共价结合的方法，将抗人膀胱癌单克隆抗体连接到预先制备的聚苯乙烯磁性微球表面，构建了能特异地与靶细胞结合并赋予其以磁响应性的免疫磁性微球（ｉｍｍｕｎｏｍａｇｎｅｔｉｃｍｉｃｒｏｓｐｈｅｒｅｓ，ＩＭＭ... 详细信息

用物理吸附结合化学键共价结合的方法，将抗人膀胱癌单克隆抗体连接到预先制备的聚苯乙烯磁性微球表面，构建了能特异地与靶细胞结合并赋予其以磁响应性的免疫磁性微球（ｉｍｍｕｎｏｍａｇｎｅｔｉｃｍｉｃｒｏｓｐｈｅｒｅｓ，ＩＭＭＳ）。间接免疫荧光检测和ＩＭＭＳ与细胞的结合实验证明，所构建的ＩＭＭＳ可有效地和靶细胞结合。研究了聚苯乙烯磁性微球和抗体反应的质量比、ＩＭＭＳ与靶细胞比例对ＩＭＭＳ与细胞结合效果的影响。用ＩＭＭＳ从动物骨髓中分离癌细胞的初步实验表明，ＩＭＭＳ可有效清除癌细胞，而骨髓细胞仅有很少量的损失。

关键词：免疫磁性微球骨髓净化人膀胱癌骨髓转移瘤

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美国青少年和年轻成人女性抑郁症可作为暴露于亲密伴侣暴力的预测因子

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世界核心医学期刊文摘（儿科学分册） 2006年第9期2卷 13-14页

作者： Lehrer J.A. buka S. Gortmaker S. Shrier L.A. 李开 4601 25th St 7San FranciscoCA 94114United States Dr.

Objective: To examine whether depressive symptomatology is predictive of subsequent intimate partner violence victimization among a national prospective sample of female adolescents and young adults. Design: Home interview data from 2 waves of the school-based National Longitudinal Study of Adolescent Health were used to examine whether baseline depressive symptomatology was associated with increased risk of pastyear exposure to physical abuse by a current partner at 5-year follow-up,controlling for age,race/ethnicity,parental education,retrospective childhood physical and sexual abuse,and baseline dating violence and forced sex. Setting: A stratified random sample of 80 US high schools and 52 middle schools. Participants: All young women (n = 1659) were in a current opposite-sex relationship at follow-up. Main Exposure: Baseline past-week depressive symptomatology,measured as both a dichotomous and continuous variable. Main Outcome Measures: Past-year exposure to mild and moderate to severe physical abuse by a current intimate partner. Results: In adjusted models with dichotomous depressive symptoms,high baseline symptom levels were associated with 1.86 times the odds of subsequent exposure to moderate to severe partner violence (95% confidence interval,1.05-3.29). In adjusted models with continuous depressive symptoms,an increase of 1 SD in baseline symptom levels was associated with a 24% increase in odds of exposure to mild partner violence and a 24% increase in the odds of exposure to moderate to severe partner violence. Conclusions: The findings of this study suggest that depressive symptomatology among girls during adolescence is associated with increased risk of subsequent exposure to physical partner violence. Prevention,identification,and treatment of depressive symptomatology among adolescent girls may help to reduce the like-lihood of subsequent victimization.

关键词：女性抑郁症美国青少年强迫性躯体虐待家庭访问纵向研究连续变量二分类变量随机样本身体虐

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苹果杂种后代抗寒性遗传规律分析

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新疆农业科学 2024年第7期61卷 1689-1695页

作者：宋梅布卡·欧尔娜李国萍凌益章新疆生产建设兵团第七师农业科学研究所新疆奎屯833200

【目的】研究新疆北疆苹果杂种后代抗寒性的遗传规律,筛选出抗寒性强的苹果新品种,为新疆苹果抗寒选育奠定基础。【方法】以苹果品种花红×元帅、国光×花红、冬立蒙×花红等3个组合的杂种一代(F_(1)代),以及赤阳×新红(花红×元帅)、... 详细信息

【目的】研究新疆北疆苹果杂种后代抗寒性的遗传规律,筛选出抗寒性强的苹果新品种,为新疆苹果抗寒选育奠定基础。【方法】以苹果品种花红×元帅、国光×花红、冬立蒙×花红等3个组合的杂种一代(F_(1)代),以及赤阳×新红(花红×元帅)、金冠×新光(国光×花红)、金冠×新冬(冬立蒙×花红)等3个组合的杂种二代(F_(2)代)为材料,分析苹果杂种F_(1)代、F_(2)代抗寒力性状和F_(1)代与大苹果重交的后代抗寒力遗传倾向,以及抗寒小苹果与大苹果正反交杂种组合的抗寒力。【结果】抗寒力杂种苗F_(1)代为26.45%,而F_(2)代仅1.35%,F_(2)代较F_(1)代降低了25.1%。F_(2)代均比F_(1)代变异率高,其中以金冠×新光(国光×花红)组合变异率最高。各级次出现株数顺序为4级>2级>3级>1级>0级。【结论】抗寒小苹果与不抗寒大苹果杂交,杂种后代在抗寒力受小苹果影响很大,小苹果有很强的遗传能力,以抗寒力强的F_(1)代作亲本与大苹果杂交,F_(2)代抗寒力显著降低;用不抗寒大苹果和抗寒小苹果互为父母本杂交时,以抗寒小苹果为母本显著优于其作父本者。

关键词：苹果杂种后代抗寒性遗传规律

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