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Management of hypertension in COVId-19

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World Journal of Cardiology 2020年第5期12卷 228-230页

作者： daniel Antwi-Amoabeng bryce d beutler Alastair E Moody Zahara Kanji Nageshwara Gullapalli Christopher J Rowan department of Internal Medicine Reno School of MedicineUniversity of NevadaRenoNV 89052United States department of Anesthesiology University of UtahSalt Lake CityUT 84132United States Renown Institute for Heart and Vascular Health RenoNV 89512United States

The ACE2 receptor plays a central role in severe acute respiratory syndrome coronavirus 2 host cell entry and *** has therefore been postulated that angiotensin converting enzyme inhibitors and angiotensin receptor blockers may upregulate ACE2 expression and thus increase susceptibility to *** suggest that alternative anti-hypertensive agents should be preferred among individuals who may be exposed to this increasingly common and potentially lethal virus.

关键词： Angiotensin converting enzyme inhibitor Angiotensin receptor blocker Carvedilol Coronavirus disease-19 COVId-19 SARS-CoV-2 Verapamil

Cardiac adverse events of immune checkpoint inhibitors in oncology patients:A systematic review and meta-analysis

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World Journal of Cardiology 2020年第11期12卷 584-598页

作者： Nso Nso daniel Antwi-Amoabeng bryce d beutler Mark B Ulanja Jasmine Ghuman Ahmed Hanfy Joyce Nimo-Boampong Sirri Atanga Rajkumar doshi Sostanie Enoru Nageshwara Gullapalli department of Medicine Icahn School of Medicine at Mount SinaiQueensNY 10029United States department of Internal Medicine University of NevadaReno School of MedicineRenoNV 89502United States department of Radiology University of Southern CaliforniaKeck School of MedicineLos AngelesCA 90033United States department of Internal Medicine Warren Alpert Medical School of Brown UniversityProvidenceRI 02903United States department of Medicine United Health Services Wilson Medical CenterJohnson CityNY 13790United States department of Cardiovascular disease SUNY Downstate Health Science UniversityBrooklynNY 11203United States

BACKGROUNd Immune checkpoint inhibitors(ICIs)are novel therapeutic agents used for various types of *** have revolutionized cancer treatment and improved clinical outcomes among cancer ***,immune-related adverse effects of ICI therapy are *** immune-related adverse events(irAEs)are rare but potentially life-threatening *** To estimate the incidence of cardiovascular irAEs among patients undergoing ICI therapy for various *** We conducted this systematic review and meta-analysis by searching PubMed,Cochrane CENTRAL,Web of Science,and SCOPUS databases for relevant interventional trials reporting cardiovascular *** performed a single-arm meta-analysis using OpenMeta[Analyst]software of the following outcomes:Myocarditis,pericardial effusion,heart failure,cardiomyopathy,atrial fibrillation,myocardial infarction,and cardiac *** assessed the heterogeneity using the I2 test and managed to solve it with Cochrane’s leave-one-out *** risk of bias was performed with the Cochrane’s risk of bias *** A total of 26 studies were *** incidence of irAEs follows:Myocarditis:0.5%[95%confidence interval(CI):0.1%-0.9%];Pericardial effusion:0.5%(95%CI:0.1%-1.0%);Heart failure:0.3%(95%CI:0.0%-0.5%);Cardiomyopathy:0.3%(95%CI:-0.1%-0.6%);atrial fibrillation:4.6%(95%CI:1.0%-14.1%);Myocardial infarction:0.4%(95%CI:0.0%-0.7%);and Cardiac arrest:0.4%(95%CI:0.1%-0.8%).CONCLUSION The most common cardiovascular irAEs were atrial fibrillation,myocarditis,and pericardial *** rare,data from post market surveillance will provide estimates of the long-term prevalence and prognosis in patients with ICIassociated cardiovascular complications.

关键词： Atrial fibrillation Cancer Immune checkpoint inhibitors Immunotherapy Cardiovascular adverse events Pericardial effusion

Hepatitis C virus control among persons who inject drugs requires overcoming barriers to care

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World Journal of Gastroenterology 2013年第44期19卷 7846-7851页

作者： Marija Zeremski Jon E Zibbell Anthony d Martinez Steven Kritz bryce d Smith Andrew H Talal division of Gastroenterology and Hepatology Weill Cornell Medical College New YorkNY 10065 United States division of Viral Hepatitis Centers for Disease Control and Prevention Atlanta GA 30333United States division of Gastroenterology Hepatology and Nutrition State University of New York at Buffalo Buffalo NY 14203 United States Addiction Research and Treatment Corporation Brooklyn NY 11201 United States

despite a high prevalence of hepatitis C virus(HCV)infection,the vast majority of persons who inject drugs(PWId)have not engaged in HCV care due to a large number of *** about the infection among both PWId and providers remains an important challenge as does discrimination faced by PWId in conventional health care *** providers also remain hesitant to prescribe antiviral therapy due to concerns about adherence and relapse to drug use resulting in ***,however,as a result of improvements in treatment efficacy combined with professional society and government endorsement of HCV treatment for PWId,a pressing need exists to develop strategies to engage these individuals into HCV *** this article,we propose several strategies that can be pursued in an attempt to engage PWId into HCV *** advocate that multidisciplinary approaches that utilize health care practitioners from a wide range of specialties,as well as co-localization of medical services,are strategies likely to result in increased numbers of PWId entering into HCV *** of HCV therapy after stabilization through drug treatment is an additional strategy likely to increase PWId engagement into HCV *** full impact of direct acting antivirals for HCV will only be realized if innovative approaches are pursued to engage all HCV infected individuals into treatment.

关键词： Treatment of hepatitis C Viral infection Human immunodeficiency virus Hepatitis C virus coinfection Persons who inject drugs Obstacles to treatment

SVEAT score outperforms HEART score in patients admitted to a chest pain observation unit

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World Journal of Cardiology 2022年第8期14卷 454-461页

作者： daniel Antwi-Amoabeng Chanwit Roongsritong Moutaz Taha bryce david beutler Munadel Awad Ahmed Hanfy Jasmine Ghuman Nicholas T Manasewitsch Sahajpreet Singh Claire Quang Nageshwara Gullapalli department of Internal Medicine Reno School of MedicineUniversity of NevadaRenoNV 89502United States Institute for Heart and Vascular Health Renown Regional Medical CenterRenoNV 89502United States

BACKGROUNd Timely and accurate identification of subgroup at risk for major adverse cardiovascular events among patients presenting with acute chest pain remains a *** available risk stratification scores are ***,a new scoring system called the Symptoms,history of Vascular disease,Electrocardiography,Age,and Troponin(SVEAT)score has been shown to outperform the History,Electrocardiography,Age,Risk factors and Troponin(HEART)score,one of the most used risk scores in the United *** To assess the potential usefulness of the SVEAT score as a risk stratification tool by comparing its performance to HEART score in chest pain patients with low suspicion for acute coronary syndrome and admitted for overnight *** We retrospectively reviewed medical records of 330 consecutive patients admitted to our clinical decision unit for acute chest pain between January 1st to April 17th,*** avoid potential biases,investigators assigned to calculate the SVEAT,and HEART scores were blinded to the results of 30-d combined endpoint of death,acute myocardial infarction or confirmed coronary artery disease requiring revascularization or medical therapy[30-d major adverse cardiovascular event(MACE)].An area under receiving-operator characteristic curve(AUC)for each score was then calculated.C-statistic and logistic model were used to compare RESULTS A 30-d MACE was observed in 11 patients(3.33%of the subjects).The AUC of SVEAT score(0.8876,95%CI:0.82-0.96)was significantly higher than the AUC of HEART score(0.7962,95%CI:0.71-0.88),P=*** logistic model,SVEAT score with cut-off of 4 or less significantly predicts 30-d MACE(odd ratio 1.52,95%CI:1.19-1.95,P=0.001)but not the HEART score(odd ratio 1.29,95%CI:0.78-2.14,P=0.32).CONCLUSION The SVEAT score is superior to the HEART score as a risk stratification tool for acute chest pain in low to intermediate risk patients.

关键词： Acute chest pain Risk stratification tool Symptoms,history of Vascular disease,Electrocardiography,Age,and Troponin score History,Electrocardiography,Age,Risk factors and Troponin score

Ovarian autoimmune disease： clinical concepts and anima models

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Cellular & Molecular Immunology 2014年第6期11卷 510-521页

作者： bryce d Warren William K Kinsey Lynda K McGinnis Lane K Christenson Susmita Jasti Anne M Stevens Brian K Petroff Margaret G Petroff department of Anatomy and Cell Biology University of Kansas Medical Center Kansas City KS USA department of Molecular and Integrative Physiology University of Kansas Medical Center Kansas City KS USA Research Center for Immunity and I mmunotherapies Children's Hospital and Regional Medical Center and Division of Rheumatology Department of Pediatrics University of Washington Seattle WA USA department of Internal Medicine University of Kansas Medical Center Kansas City KS USA Present address: department of Pathobiology and diagnostic Investigation Michigan State University College of Veterinary Medicine East Lansing MI USA

The ovary is not an immunologically privileged organ, but a breakdown in tolerogenic mechanisms for ovary-specific antigens has disastrous consequences on fertility in women, and this is replicated in murine models of autoimmune disease. Isolated ovarian autoimmune disease is rare in women, likely due to the severity of the disease and the inability to transmit genetic information conferring the ovarian disease across generations. Nonetheless, autoimmune oophoritis is often observed in association with other autoimmune diseases, particularly autoimmune adrenal disease, and takes a toll on both society and individual health. Studies in mice have revealed at least two mechanisms that protect the ovary from autoimmune attack. These mechanisms include control of autoreactive T cells by thymus-derived regulatory T cells, as well as a role for the autoimmune regulator （AIRE）, a transcriptional regulator that induces expression of tissue-restricted antigens in medullary thymic epithelial cells during development of T cells. Although the latter mechanism is incompletely defined, it is well established that failure of either results in autoimmune-mediated targeting and depletion of ovarian follicles. In this review, we will address the clinical features and consequences of autoimmune-mediated ovarian infertility in women, as well as the possible mechanisms of disease as revealed by animal models.

关键词： Ovarian autoimmune clinical concepts animal models

Single-particle photoluminescence connects thermal processing with heterogeneity in the trap distribution of cesium lead bromide nanocrystals

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Nano Research 2024年第12期17卷 10363-10375页

作者： dong Wang Jie Chen dongyan Zhang dariusz M.Niedzwiedzki Richard A.Loomis bryce Sadtler department of Chemistry Washington UniversitySt.LouisMissouri 63130USA Center for Solar Energy and Energy Storage Washington UniversitySt.LouisMissouri 63130USA department of Energy Environmental&Chemical EngineeringWashington UniversitySt.LouisMissouri 63130USA Institute of Materials Science&Engineering Washington UniversitySt.LouisMissouri 63130USA

Understanding the mechanisms of degradation in lead halide perovskite nanocrystals is critical for their future application in optoelectronic *** report single-particle measurements of the photoluminescence from cesium lead bromide nanocrystals coated with a silica shell(CsPbBr_(3)@SiO_(2)).Through correlative imaging,we quantified changes in the fluorescence intensity trajectories of the same nanocrystals before and after annealing them at different *** observe that nearly equal numbers of CsPbBr_(3)@SiO_(2) nanocrystals exhibit an increase versus decrease in the amount of time they spend in an emissive state after annealing at temperatures of 70 and 100℃.On the other hand,annealing at 120℃ produces a decrease in the on-fraction for most nanocrystals and,correspondingly,a substantial decrease in the photoluminescence intensity for a thin film annealed at this *** attribute the differences in behavior among individual nanocrystals to heterogeneity in the distribution of trap states that are initially present.X-ray photoelectron,time-resolved photoluminescence,and transient absorption spectroscopies performed on thin films of CsPbBr_(3)@SiO_(2) nanocrystals indicate that thermal annealing heals electron traps by passivating surface Pb ions and simultaneously creates hole traps through the formation of Pb and Cs *** relative rates of these parallel processes depend on the annealing temperature,which are important to account for when developing passivation strategies for lead halide perovskite nanocrystals in optoelectronic devices that will operate at elevated temperatures.

关键词： single-particle microscopy photoluminescence nanocrystals cesium lead bromide thermal annealing

Longwave infrared multispectral image sensor system using aluminum-germanium plasmonic filter arrays Noor E

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Nano Research 2023年第7期16卷 10018-10025页

作者： Karishma Shaik bryce Widdicombe dechuan Sun Sam E John dongryeol Ryu Ampalavanapillai Nirmalathas Ranjith R Unnithan department of Electrical and Electronic Engineering University of MelbourneParkvilleVIC 3010Australia department of Biomedical Engineering University of MelbourneParkvilleVIC 3010Australia department of Infrastructure Engineering University of MelbourneParkvilleVIC 3010Australia

A multispectral camera records image data in various wavelengths across the electromagnetic spectrum to acquire additional information that a conventional camera fails to *** the advent of high-resolution image sensors and color filter technologies,multispectral imagers in the visible wavelengths have become popular with increasing commercial viability in the last ***,multispectral imaging in longwave infrared(LWIR,8-14μm)is still an emerging area due to the limited availability of optical materials,filter technologies,and high-resolution *** from LWIR multispectral cameras can capture emission spectra of objects to extract additional information that a human eye fails to capture and thus have important applications in precision agriculture,forestry,medicine,and object *** this work,we experimentally demonstrate an LWIR multispectral image sensor with three wavelength bands using optical elements made of an aluminum(Al)-based plasmonic filter array sandwiched in germanium(Ge).To realize the multispectral sensor,the filter arrays are then integrated into a three-dimensional(3d)printed wheel stacked on a low-resolution monochrome thermal *** prototype device is calibrated using a blackbody and its thermal output has been enhanced with computer vision *** applying a state-of-theart deep learning method,we have also reconstructed multispectral images to a better spatial ***,our work demonstrates a versatile spectral thermography technique for detecting target signatures in the LWIR range and other advanced spectral analyses.

关键词： infrared plasmonics germanium(Ge) aluminum(Al) thermal optics longwave infrared(LWIR)multispectral system

Anti-N-methyl-d-aspartate receptor-associated encephalitis: A review of clinicopathologic hallmarks and multimodal imaging manifestations

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World Journal of Radiology 2024年第1期16卷 1-8页

作者： bryce david beutler Alastair E Moody Jerry Mathew Thomas Benjamin Phillip Sugar Mark B Ulanja daniel Antwi-Amoabeng Lucas Anthony Tsikitas department of Radiology University of Southern CaliforniaKeck School of MedicineLos AngelesCA 90033United States department of Anesthesiology University of UtahSalt Lake CityUT 84132United States department of Internal Medicine Christus Ochsner St.Patrick HospitalLake CharlesLA 70601United States

Anti-N-methyl-d-aspartate receptor-associated encephalitis(NMdARE)is a rare immune-mediated neuroinflammatory condition characterized by the rapid onset of neuropsychiatric symptoms and autonomic *** mechanism of pathogenesis remains incompletely understood,but is thought to be related to antibodies targeting the GluN1 subunit of the NMdA receptor with resultant downstream dysregulation of dopaminergic *** adults are most frequently affected;the median age at diagnosis is 21 *** is a strong female predilection with a female sex predominance of 4:*** often develops as a paraneoplastic process and is most commonly associated with ovarian ***,NMdARE has also been described in patients with small cell lung cancer,clear cell renal carcinoma,and other benign and malignant *** is based on correlation of the clinical presentation,electro-encephalography,laboratory studies,and *** tomography,positron emission tomography,and magnetic resonance imaging are essential to identify an underlying tumor,exclude clinicopathologic mimics,and predict the likelihood of long-term functional *** imaging may be of value for prognostication and to assess the response to *** may involve high-dose corticosteroids,intravenous immunoglobulin,and plasma ***,we review the hallmark clinicopathologic features and imaging findings of this rare but potentially devastating condition and summarize diagnostic criteria,treatment regimens,and proposed pathogenetic mechanisms.

关键词： Anti-N-methyl-d-aspartate receptor-associated encephalitis Autoimmune encephalitis Encephalitis Ovarian teratoma Paraneoplastic syndrome Teratoma

Enhanced photoluminescence of a microporous quantum dot color conversion layer by inkjet printing

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Nano Research 2024年第8期17卷 7717-7725页

作者： Junchi Chen Qihao Jin Yidenekachew.J.donie Orlando.T.Perales dmitry Busko bryce.S.Richards Uli Lemmer Light Technology Institute(LTI) Karlsruhe Institute of Technology(KIT)Engesserstrasse 1376131 KarlsruheGermany department of Chemical Engineering and Materials Science University of Minnesota(UMN)421 Washington Ave.SEMinneapolisMN 55455-0132USA Institute for Microstructure Technology Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

Owing to their high color purity,tunable bandgap,and high efficiency,quantum dots(Qds)have gained significant attention as color conversion materials for high-end display ***,inkjet-printed Qd pixels show great potential for realizing full-color mini/micro-light emitting diode(micro-LEd)-based *** a color conversion layer,the photoluminescence intensity of Qds is limited by the insufficient absorptance of the excitation light due to the lack of *** scatterers,such as titanium dioxide microparticles,have been applied after additional surface engineering for sufficient dispersity to prevent nozzle clogging in inkjet printing *** our work,as an alternative approach,we use inkjet printing for depositing a phase separating polymer ink based on polystyrene(PS)and polyethylene glycol(PEG).Qd/polymer composite pixels with scattering micropores are *** morphology of the micropores can be tailored by the weight ratio between PS and PEG which enables the manipulation of scattering *** the presence of the microporous structure,the photoluminescence intensity of the Qd film is enhanced by 110%in drop-cast films and by 35.3%in inkjet-printed Qd pixel arrays compared to the reference samples.

关键词： porous structure inkjet printing phase separation quantum dots display technology