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Racial Disparities in Survival Outcomes of Prostate Cancer Patients after Surgery for Bone Metastases

Journal of Cancer Therapy 2013年第4期4卷 27-36页

作者： Robert L. Satcher Oluwatosin Bamidele Patrick Lin Sue-Hwa Lin bryan Moon Mike Hernandez Valerae Lewis Janice Chilton Department of Health Disparities Research The University of Texas MD Anderson Cancer Center Houston USA Department of Orthopedic Oncology The University of Texas MD Anderson Cancer Center Houston USA Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston USA School of Public Health University of Texas Health Science Center Houston USA

Introduction: This study reviewed patients’ demographic, clinical and treatment characteristics to identify prognostic factors associated with survival of prostate cancer after developing bone metastases. We explored the racial disparities in these factors and how they relate with survival. Methods: We conducted a retrospective study on 79 men diagnosed with bone metastasis secondary to prostate cancer who underwent surgery at a single institution?from november 1977 to June 2011. Descriptive statistics were used to summarize patients’ characteristics. The Kaplan-Meier method was used to estimate characteristics of the survival distribution using two origination points—diagnosis and surgery. Cox hazard regression explored the relationship between prognostic factors and overall survival. Results: The majority of men were White (n = 63;80%) followed by Black (n = 7;9%), Hispanic (n = 7;9%), and Asian (n = 2;2%). Multivariate factors associated with poorer survival after bone metastasis surgery included race (Black), Gleason score > 8, and radiation treatment. Patients not receiving radiation had a longer survival experience relative to patients who received radiation before or after surgery (10.3 vs 6.5 months;P = 0.030). There was an association of PSA level at the time of bone metastasis diagnosis with survival following diagnosis but prior to surgery. The median time interval (Tm in months) between prostate cancer diagnosis and bone metastasis diagnosis was 39.1 (White), 31.2 (Hispanic), 15 (Blacks) and 43 (Asians). Patients with Tm m > 35 months (HR = 3.22;P Conclusion: The median survival and time interval from prostate cancer diagnosis to bone metastasis diagnosis was shorter in Blacks with respect to other races. The more aggressive nature of the disease in Blacks is likely due to the biology of the disease rather than access to treatment.

关键词： Metastasis Bone Prostate Cancer Racial Gleason Score

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棉酚引起雌鼠实验性子宫内膜异位症的快速消退

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现代妇产科进展 1994年第1期3卷 15-18页

作者：李继俊牛海荣 Bertero MC Vernon mw 山东医科大学山东省立医院美国肯塔基大学生殖医学中心

为研究棉酚对子宫内膜异位症的治疗作用及其机理，２４只经自体子宫内膜移植引起的实验性子宫内膜异位症雌鼠随机分成对照组和棉酚治疗组。对照组予以０．５％Ｔｗｅｅｎ８０皮下注射，棉酚组予以０．５％Ｔｗｅｅｎ８０溶释的棉酚混悬... 详细信息

为研究棉酚对子宫内膜异位症的治疗作用及其机理，２４只经自体子宫内膜移植引起的实验性子宫内膜异位症雌鼠随机分成对照组和棉酚治疗组。对照组予以０．５％Ｔｗｅｅｎ８０皮下注射，棉酚组予以０．５％Ｔｗｅｅｎ８０溶释的棉酚混悬液以５ｍｇ／（ｋｇ·ｄ）皮下注射２～３周。结果表明，与对照组比较，经２～３周棉酚治疗的实验性子宫内膜异位症雌鼠卵巢重量和血浆雌二醇明显降低（Ｐ＜０．０１）；而子宫重量和子宫内膜移植病灶也明显减少（Ｐ＜０．０５），棉酚引起移植子宫内膜异位病灶消退率为６６．６％，研究证实：棉酚可有效地阻遏实验性子宫内膜异位病灶的生长发育并可使其快速消退，其作用部位在卵巢和子宫水平而非在下丘脑－垂体水平，实验进一步证实棉酚对子宫内膜异位症的治疗作用并可望开发成为新一代治疗药物。

关键词：棉酚子宫内膜异位动物模型药理

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骨形态发生蛋白信号去除后Sonic hedgehog对小脑颗粒细胞发育的影响

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中国组织工程研究与临床康复 2007年第49期11卷 9851-9854页

作者：秦丽华栾丽菊 E.bryan Crenshaw Ⅲ 雷季良周长满郑亚杰王天昱王玺北京大学医学部解剖学与组织胚胎学系北京市100083 费城儿童医院耳鼻喉科儿童感染中心神经遗传学组

目的:骨形态发生蛋白信号在神经细胞的生长、分化、增殖、凋亡等方面发挥作用,而Sonic hedgehog能调节小脑颗粒细胞的增殖,故实验设计了去除骨形态发生蛋白信号后Sonic hedgehog信号在小脑颗粒细胞发育中作用的观察。方法:实验于2004-11... 详细信息

目的:骨形态发生蛋白信号在神经细胞的生长、分化、增殖、凋亡等方面发挥作用,而Sonic hedgehog能调节小脑颗粒细胞的增殖,故实验设计了去除骨形态发生蛋白信号后Sonic hedgehog信号在小脑颗粒细胞发育中作用的观察。方法:实验于2004-11/2005-10在美国费城儿童医院Crenshaw实验室和北京大学医学部解剖学神经研究实验室完成。①实验材料:C57Bl/6J小鼠40只;Bmpr1b敲除鼠系来源于Karen Lyons博士。②实验过程:通过敲除骨形态发生蛋白Ⅰ型受体的Bmpr1a和Bmpr1b两个亚型基因,去除骨形态发生蛋白信号在小脑内的传导。③实验评估:使用原位杂交和免疫组织化学方法检测了新生幼鼠小脑中Sonic hedgehog信号的表达情况。结果:①在胚胎11.5d,磷酸化SMAD免疫阳性的细胞被观察到在正常鼠神经管背侧的菱形唇附近,受体基因双敲除的小鼠背侧神经管中未发现免疫阳性细胞,此结果提示通过骨形态发生蛋白Ⅰ型受体传导的骨形态发生蛋白信号已消失。当小鼠出生后,磷酸化SMAD免疫阳性细胞主要位于正常小鼠的内颗粒层,在基因敲除鼠只有一小部分区域有磷酸化SMAD蛋白的表达。②Sonic hedgehog表达在正常新生鼠小脑的颗粒细胞层和蒲肯野氏细胞层;基因敲除鼠Sonic hedgehog信号只表达在小脑一小部分区域的颗粒细胞层和蒲肯野氏细胞层,而大部分区域则缺少它的表达。PTCH和n-myc在小脑中的表达与Sonic hedgehog表达部位类似。这提示Sonic hedgehog信号及其PTCH和n-myc都参与了小脑颗粒细胞的发育。结论:实验阐明了骨形态发生蛋白信号去除后,Sonic hedgehog信号对小脑颗粒细胞发育所起到的重要作用。

关键词：骨形态发生蛋白质类蒲肯野细胞小脑组织构建

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Generation of passively Q-switched fiber laser at 1 μm by using MoSSe as a saturable absorber

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Chinese Optics Letters 2017年第2期15卷 15-19页

作者： H. Ahmad S. A. Reduan S. n. Aidit Z. C. Tiu Photonics Research Centre University of Malaya Kuala Lumpur 50603 Malaysia

Passively Q-switched ytterbium-doped fiber lasers （YDFLs） incorporating a molybdenum sulfide selenide （MoSSe）-based saturable absorber （SA） are demonstrated. The modulation depth and saturation intensity of the MoSSe-based SA are measured to be approximately 25.0% and 0.002 mw/cm^2, respectively, using the twin detector technique. The YDFL＇s output has a center wavelength of 1038.5 nm with a top pulse width and energy of 1.2 μs and 18.9 nJ, respectively, at a pump power of 333 mw. The MoSSe-based SA has a good linear optical response, providing significant opportunity for use in applications over an ultra-broadband spectrum, particularly spectroscopy and biomedical diagnostics.

关键词： Mo Generation of passively Q-switched fiber laser at 1 m by using Mo SSe as a saturable absorber SA

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马铃薯种质的组织培养、快速繁殖、保存和出口

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中国马铃薯 1988年第2期 113-116页

作者： n.Espinoza R.Estrada P.Tovar J.bryan J.H.Dodds 夏肖仇国际马铃薯中心国际马铃薯中心秘鲁利马

可用组织培养的方法来繁殖、保存和交换马铃薯的种质。组织培养可以在短期内快速地无性繁殖大量的小植株,同时能在节省用地和劳力的情况下,保持马铃薯的种质。由于离体培养物是无病的,并在可控条件下能保持马铃薯的种质,因此极有利于马... 详细信息

可用组织培养的方法来繁殖、保存和交换马铃薯的种质。组织培养可以在短期内快速地无性繁殖大量的小植株,同时能在节省用地和劳力的情况下,保持马铃薯的种质。由于离体培养物是无病的,并在可控条件下能保持马铃薯的种质,因此极有利于马铃薯种质国际交换。

关键词：快速繁殖马铃薯土豆茄属种质出口

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Quantitative Determination of Density of Ground State Atomic Oxygen from Both TALIF and Emission Spectroscopy in Hot Air Plasma Generated by Microwave Resonant Cavity

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Plasma Science and Technology 2016年第3期18卷 259-265页

作者： F.MARCHAL M.YOUSFI n.MERBAHI G.WATTIEAUX A.PIQUEMAL University of Toulouse UPSLAPLACE CNRS UMR 5213 CEA DAMDIF

Two experimental techniques have been used to quantify the atomic oxygen density in the case of hot air plasma generated by a microwave （mw） resonant cavity. The latter operates at a frequency of 2.45 GHz inside a cell of gas conditioning at a pressure of 600 mbar, an injected air flow of 12 L/min and an input mw power of 1 kW. The first technique is based on the standard two photon absorption laser induced fluorescence （TALIF） using xenon for calibration but applied for the first time in the present post discharge hot air plasma column having a temperature of about 4500 K near the axis of the nozzle. The second diagnostic technique is an actinometry method based on optical emission spectroscopy （OES）. In this case, we compared the spectra intensities of a specific atomic oxygen line （844 nm） and the closest wavelength xenon line （823 nm）. The two lines need to be collected under absolutely the same spectroscopic parameters. The xenon emission is due to the addition of a small proportion of xenon （1% Xe） of this chemically inert gas inside the air while a further small quantity of H2 （2~） is also added in the mixture in order to collect OH（A- X） and nH（A-X） spectra without noise. The latter molecular spectra are required to estimate gas and excitation temperatures. Optical emission spectroscopy measurements, at for instance the position z=12 mm on the axis plasma column that leads to a gas measured temperature equal to 3500 K, an excitation temperature of about 9500 K and an atomic oxygen density 2.09× 1017＋ 0.2×1017 cm-3. This is in very good agreement with the TALIF measurement, which is equal to 2.0×101T cm-3.

关键词： TALIF microwave air plasma atomic oxygen concentration actinometry,optical emission spectroscopy

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覆膜支架在经颈静脉门腔分流术中的应用

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中华放射学杂志 2008年第8期42卷 830-834页

作者：赵剑波李彦豪 Kenneth J.Kolbeck Frederick S.Keller John A.Kaufman Robert E.Barton bryan D.Petersen 南方医科大学南方医院介入放射科广州510515 美国俄勒冈州健康生命科技大学Dotter介入放射学研究所

目的评价经颈静脉肝内门腔分流术（TIPS）专用覆膜支架（Viatorr支架）在TIPS中的应用价值。方法回顾性分析37例在美国俄勒冈州健康生命科技大学Dotter介入放射学研究所采用Viatorr支架行’nPs治疗的患者资料，随访时间为（15．2±9．... 详细信息

目的评价经颈静脉肝内门腔分流术（TIPS）专用覆膜支架（Viatorr支架）在TIPS中的应用价值。方法回顾性分析37例在美国俄勒冈州健康生命科技大学Dotter介入放射学研究所采用Viatorr支架行’nPs治疗的患者资料，随访时间为（15．2±9．3）个月（3～42个月）。TIPS指征包括门静脉高压相关性的急慢性消化道出血，经药物及内镜治疗无效者17例；顽固性肝源性胸、腹水18例，***综合征2例。采用配对t检验比较手术前后门腔静脉压力差（PSG）的变化，以Kaplan-Meier曲线分析支架开通率。结果37例共置入41枚Viatorr支架，其中3枚直径为8mm，38枚为10mm，支架带膜长度为4～8cm，无相关手术并发症。PSG由术前的（22．4±8．4）mmHg（1mmHg=0．133kPa）降为（8．1±3．2）mmHg，差异有统计学意义（t=12．754，P〈0．01）。17例出血患者术后出血均停止，1例于术后17个月复发。18例严重顽固性腹水及肝性胸水患者中，4例术后腹水不消退，其余14例随访期间有2例腹水复发。2例（5．4％）发生分流道阻塞，Kaplan-Meier曲线分析结果显示1年的开通率为97．0％。术后1个月内无病死患者，2例分别于术后3个月及15个月死于多器官功能衰竭，晚期病死率为5．4％，死亡前1周内复查支架均通畅。肝移植患者5例（13．5％）。结论Viatorr支架能明显提高TIPS术后开通率，选择合适的支架，采用正确的释放技术能进一步提高疗效，但长期效果评价尚需验证。

关键词：高血压,门静脉支架放射学,介入性

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Highly Efficient L-Band Fibre -DFB Lasers

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光学学报 2003年第S1期23卷 379-380页

作者： Morten Ibsen David J. Richardson David n. Payne ORC - University of Southampton Southampton SO17 1BJ United Kingdom. Also with Southampton Photonics Ltd. Southampton SO16 4NS United Kingdom.ORC - University of Southampton Southampton SO17 1BJ United Kingdom. Also with Southampton Photonics Ltd. Southampton SO16 4NS United Kingdom.ORC - University of Southampton Southampton SO17 1BJ United Kingdom. Also with Southampton Photonics Ltd. Southampton SO16 4NS United Kingdom.

A more than 12 mw highly efficient fibre-DFB laser operating at 1618.3 nm is fabricated and characterised. Its high-power, low-noise and single-polarisation characteristics make it very suitable WDM-source for L-band ... 详细信息

关键词： DFB Lasers high in for Highly Efficient L-Band Fibre WDM RIn

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Comparison of lipid extraction methods for the microalgae Acutodesmus obliquus

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International Journal of Agricultural and Biological Engineering 2018年第5期11卷 211-217页

作者： Diana Ximena Hurtado Claudia Lorena Garzón-Castro Jhon Cortés-Romero Edisson Tello Camacho Bioprospecting and CAPSAB Research Groups Faculty of EngineeringUniversidad de La SabanaCundinamarca 53753Colombia Biosciences Doctoral Program Faculty of EngineeringUniversidad de La SabanaCundinamarca 53753Colombia Department of Electrical and Electronic Engineering Universidad Nacional de ColombiaBogotá53753Colombia

Microalgae are widely used in the pharmaceutical and energy industries,therefore the conditions for their cultivation and extraction methods play an important role in the profiling and acquisition of *** efficiency of lipid extraction from microalgae has attracted great interest from industry because of the wide variety of lipids and amounts that can be *** obliquus(Scenedesmus obliquus UTEX 393)was used in this *** was cultivated in Bold 3n medium modified with 75%nitrogen at 25℃,pH 6.8,125 r/min and a photoperiod of 18/6 h and illuminated with white light provided by a Light-Emitting Diode Surface Mount Device extensions(LED SMD)with an intensity of 1200μE/(m^(2)·s).The cells were stained with the Red nile(Rn)technique to indicate lipid *** extraction methods were compared,classical,microwave(mw),Soxhlet,and ultrasound(US),using the same solvent proportions(hexane:chloroform:methanol=1:2:3).All samples were analyzed with Fourier Transform Infrared Spectroscopy(FTIR)and Gas Chromatography coupled to Mass Spectrometry(GC-MS).The results showed:1)lipid production detected by Rn was consistent with microalgal growth;2)the mw technique was the best extraction method,according to the statistical analysis through Randomized Complete Block(RCB)design and performance of 4.6%;and 3)the presence of saturated and unsaturated acids was indicated by FTIR ***-MS was able to identify palmitic and linoleic acids as the likely major constituents of the sample.

关键词： Acutodesmus obliquus lipid extraction trans-esterification Red nile(Rn)

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Transition Metal Dichalcogenides(WS2 and MoS2)Saturable Absorbers for Mode-Locked Erbium-Doped Fiber Lasers

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Chinese Physics Letters 2017年第1期34卷 48-51页

作者： n.A.A.Kadir E.I.Ismail A.A.Latiff H.Ahmad H.Arof S.W.Harun Department of Electrical Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur 50603Malaysia Photonics Research Center University of MalayaKuala Lumpur 50603Malaysia

We demonstrate an ultrafast fiber laser based on transition metal dichalcogenide materials which are tungsten disulfide (WS2) and molybdenum disulfide (MoS2) as saturable absorber (SA). These materials are fabricated via a simple drop-casting method. By employing WS2, we obtain a stable harmonic mode-locking at the threshold pump power of 184 mw, and the generated soliton pulse has 3.48 MHz of repetition rate. At the maximum pump power of 250 mw, we also obtain a small value of pulse duration, 2.43 ps with signal-to-noise ratio (SnR) of 57 dB. For MoS2 SA, the pulse is generated at 105 mw pump power with repetition rate of 1.16 MHz. However, the pulse duration cannot be detected by the autocorrelator device as the pulse duration recorded is 468 ns, with the SnR value of 35 dB.

关键词： WS2 and MoS2 SA Transition Metal Dichalcogenides Saturable Absorbers for Mode-Locked Erbium-Doped Fiber Lasers

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