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成功治疗银屑病可改善银屑病患者的特异心理因素,但对患者的一般心理因素无显著改善

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世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 16-16页

作者： Fortune D.G. Richards H.L. Kirby B. et al. C.E.M. griffiths 牛新武 Dermatology Centr e Univ. of Manchester Sch. of Medicine Hope Hospital Salford Manchester M6 8 HD UnitedKingdom

Background:Psoriasis has a detrimental effect on patients’quality of life. H owever, there is a relative dearth of information on which aspects of a patient ’s well-being are affected by successful treatment. Objectives:To investigate whether, and to what extent, improvement in the clinical severity of psoriasis induced by photochemotherapy with psoralen plus ultraviolet A (PUVA) translates into meaningful changes in beliefs about psoriasis, coping, stress, distress or disability. Methods:In a prospective study, 72 patients were assessed before PU VA therapy and again when they had achieved clearance of their psoriasis. Result s:Patients demonstrated significant reductions in psoriasis-related disability , psoriasis-related stress or daily hassles and in the frequency of psoriasis- related symptoms. By comparison, there were no significant differences in levels of anxiety, depression or worrying. similarly, patients’perceptions about cure , potential chronicity, causes, consequences and coping also remained unchanged. Conclusions:These results suggest that while clearance of psoriasis produces a significant reduction in factors specific to psoriasis (disability and stress), it does not impact upon psychological distress, on patients’beliefs about psor iasis or on coping. This observation highlights the complex features of patients ’psychological experience of psoriasis and may provide further impetus for inte gration of psychological interventions into standard care protocols.

关键词：银屑病心理因素心理适应劳动能力丧失皮损消退补骨脂素临床改善长波紫外线生活质量无显著性差异

有关白介素-6基因变异与早产儿认知发育障碍相关性的初步研究

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世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 52-53页

作者： Harding D. Brull D. Humphries s.E. 高蕊 Department of Child Health St. Michael's Hospital Bristol BS82JZ United Kingdom

The pro-inflammatory cytokine IL-6 may be neurocytopathogenic, and elevated levels are associated with impaired neurological outcome among children born pre maturely. However, the precise mechanisms underlying this association remain unc lear. The rare C (rather than G) variant at position -572 in the IL-6 gene is associated with an increased IL-6 synthetic response. If IL-6 mediates cerebra l injury, we would anticipate the -572 C allele to be associated with impaired childhood development. We have examined this hypothesis, studying 113 Caucasian children born at ≤32 wk gestation. Cognitive and motor functions were assessed using the griffiths Developmental scales at 2 y and British Ability scales (2nd Ed.) and the ABC Movement score at 51/2 y. Performance (median, interquartile ra nge) in all three scales was worse in the 10 carriers of the C allele than for t hose with GG genotype: griffiths Developmental Quotient: C allele, 92.4 (89.9-9 6.6) versus CG 100.9 (96.7-104.8), p = 0.002; General Cognitive Ability: C alle le, 88.0 (80.3-102.8) versus GG 103.0 (92.0-112.0), p = 0.037; Movement ABC sc ore: C allele 8.3 (6.6-20.3) versus GG 4.0 (1.0-9.5), p = 0.081. The presence of the rare (≥1) IL-6 -572 Callele (CC+GC genotypes) is associated with impa ired cognitive development among children born before 32 wk gestation. These dat a support a role for IL-6 in the genesis of neurologic impairment in such child ren.

关键词：发育障碍神经系统发育评分量表发育量表细胞病变大脑损伤发育商促炎性细胞因子四分位距生

评估大气细颗粒物暴露所致全球疾病负担的一个综合风险函数

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环境与职业医学 2014年第7期31卷 554-554页

作者： Richard T.Burnett C.Arden Pope Ⅲ Majid Ezzati Casey Olives stephen s.Lim sumi Mehta Hwashin H.shin Gitanjali singh bryan Hubbell Michael Brauer H.Ross erson Kirk R.smith John R.Balmes Nigel G.Bruce Haidong Kan Francine Laden Annette Prüss-Ustün Michelle C.Turner susan M.Gapstur W.Ryan Diver Aaron Cohen

[背景]评估归因于环境空气中细颗粒物（PM2.5）长期暴露所致的疾病负担，需要具备相对风险（RR）函数形状和幅度两方面的知识。然而，在世界上很多观察到高PM2.5环境浓度的地方，都缺乏足够的直接证据确定死亡率RR函数的形状。

关键词：大气细颗粒物疾病负担相对风险函数评估 PM2 5 长期暴露环境空气

患缺血缺氧性脑病足月新生儿整幅脑电图上的睡眠觉醒周期

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世界核心医学期刊文摘（儿科学分册） 2006年第6期2卷 60-61页

作者： Osredkar D. Toet M.C. Van Rooij L.G.M. L.s. De Vries 高蕊 Department of Neonatology Wilhelmina Children's HospitalUniversity Medical Cente rUtrecht3508 AB Utrecht Netherlands Dr.

Objective. The objective of this amplitude-integrated electroencephalography (aEEG) study was to evaluate the influence of perinatal hypoxia-ischemia on sleep-wake cycling (sWC) in term newborns and assess whether characteristics of sWC are of predictive value for neurodevelopmental outcome. Methods. From a consecutive series of newborns born during a 10-year period, the aEEG tracings of 171 term newborns with hypoxic-ischemic encephalopathy were assessed for the presence, time of onset, and quality of sWC. sWC patterns were categorized with regard to the background pattern on which they presented, as normal or abnormal sWC. Results. sWC was seen in 95.4%of the surviving newborns and in 8.1%of those who died. The median time intervals from birth to onset of sWC were significantly different in newborns with hypoxicischemic encephalopathy grades I, II, and III (7, 33, and 62 hours, respectively). Newborns with seizure discharges developed sWC with a delay of 30.5 hours. Good outcome was associated with earlier onset of sWC and normal sWC pattern. The difference in the median griffiths’developmental quotients in newborns who started sWC before after 36 hours was 8.5 points. The goodpoor neurodevelopmental outcome was predicted correctly by the onset of sWC beforeafter 36 hours in 82%of newborns. Conclusions. The presence, time of onset, and quality of sWC reflected the severity of the hypoxicischemic insult to which newborns were exposed. The time of onset of sWC has a predictive value for neurodevelopmental outcome.

关键词：足月新生儿睡眠觉醒周期缺血缺氯性脑病脑电图缺血缺氧性脑病出现时间 aEEG 开始时间神经系统不同程度

强化与标准血压控制对痴呆的影响:随机临床试验

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中华高血压杂志 2019年第4期27卷 367-367页

作者：刘青叶鹏 Williamson JD Pajewski NM Auchus AP bryan RN Chelune G Cheung AK Cleveland ML Coker LH Crowe MG Cushman WC Cutler JA Davatzikos C Desiderio L Erus G Fine LJ Gaussoin sA Harris D Hsieh MK Johnson KC Kimmel PL Tamura MK Launer LJ Lerner AJ Lewis CE Martindale-Adams J Moy Cs Nasrallah IM Nichols LO Oparil s Ogrocki PK Rahman M Rapp sR Reboussin DM Rocco MV sachs BC sink KM still CH supiano MA snyder JK Wadley VG Walker J Weiner DE Whelton PK Wilson VM Woolard N Wright JT Jr Wright CB sPRINT MIND investigators for thesPRINT research group

目前还没有有效的治疗方法来降低轻度认知障碍和痴呆的风险。该文旨在探讨强化血压控制对老年痴呆风险的影响。研究人员在美国和波多黎各102个地点对年龄≥50岁有高血压但无糖尿病或脑卒中史的成人进行随机临床试验。于2010年11月8日开... 详细信息

目前还没有有效的治疗方法来降低轻度认知障碍和痴呆的风险。该文旨在探讨强化血压控制对老年痴呆风险的影响。研究人员在美国和波多黎各102个地点对年龄≥50岁有高血压但无糖尿病或脑卒中史的成人进行随机临床试验。于2010年11月8日开始,于2015年8月20日提前停止,获得其主要观察指标(复合心血管事件)和全因死亡率的数据。认知观察指标随访的最后日期为2018年7月22日。

关键词：随机临床试验老年痴呆血压控制轻度认知障碍标准心血管事件治疗方法研究人员

心血管造影和介入学会／血管内科学会（sCAI／sVM）颈动脉支架置入术培训及资格认证专家共识声明

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国际脑血管病杂志 2017年第5期25卷 385-395页

作者： Herbert D. Aronow Tyrone J. Collins William A. Gray Michael R. Jaff bryan W. Kluck Rajah A. G. Patel Kenneth A. Rosenfield Robert D. safian Piotr s. sobieszczyk siddharth A. Wayangankar Christopher J. White 胡挺段振晖马敏敏 From the Cardiovascular Institute of RI Alpert Medical school of Brown University Providence Rhode Island Ochsner Medical Center New Orleans Los Angeles Columbia University Medical Center New York New York Massachusetts General Hospital Boston Massachusetts Lehigh Valley Hospital Allentown Penniosylvania Beaumont Health Royal Oak Michigan Brigham and Women's Hospital Boston Massachusetts Cleveland Clinic Cleveland Ohio 南京大学医学院附属金陵医院(南京军区南京总医院)神经内科 210002

颈动脉支架置入术（carotid artery stcnting，CAs）已成为心血管内科项目针对卒中预防提供的治疗方案中不可或缺的一部分。该专家共识声明的目的在于为这些项目提供医师培训和资格认证方面的指导，从而促进CAs安全有效地融入临床实践... 详细信息

颈动脉支架置入术（carotid artery stcnting，CAs）已成为心血管内科项目针对卒中预防提供的治疗方案中不可或缺的一部分。该专家共识声明的目的在于为这些项目提供医师培训和资格认证方面的指导，从而促进CAs安全有效地融入临床实践。自从2005年《颈动脉支架置入术临床能力声明》发表以来，介入器械出现了大量创新，众多临床试验和观察性研究发表，积累了丰富的真实世界临床经验，而且有健全的国家质量改进计划的广泛参与。总的来说，这些进展已导致在患者合理选择以及安全有效实施CAs所需的认知、技术和临床技能方面发生了实质性变化。因此，我们总结出版了这份指南，旨在介绍培训路径，概述能力要素，提供转归随访策略，明确设施、设备和人员要求，并提出维持CAs能力的标准。

关键词：颈动脉狭窄颈动脉支架专家共识文件卒中

同方期刊数据库

围生期窒息24h内的振幅整合脑电图背景图形的恢复

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世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 25-26页

作者： Van Rooij L.G.M. Toet M.C. Osredkar D. L.s. De Vries 郭战宏 Department o f Neonatology Wilhelmina Children's H. PO Box 85090 3508 AB Utrecht Netherl ands Dr.

Objective: To assess the time course of recovery of severely abnormal initial amplitude integrated electroencephalographic (aEEG) patterns (flat trace (FT), c ontinuous low voltage (CLV), or burst suppression (Bs)) in full term asphyxiated neonates, in relation to other neurophysiological and neuroimaging findings and neurodevelopmental outcome. Methods: A total of 190 aEEGs of full term infants were reviewed. The neonates were admitted within 6 hours of birth to the neonata l intensive care unit because of perinatal asphyxia, and aEEG recording was star ted immediately. In all, 160 infants were included; 65 of these had an initial F T or CLV pattern and 25 an initial Bs pattern. Neurodevelopmental outcome was as sessed using a full neurological examination and the griffiths’mental developme ntal scale. Results: In the FT/CLV group, the background pattern recovered to co ntinuous normal voltage within 24 hours in six of the 65 infants (9%). All six infants survived the neonatal period; one had a severe disability, and five were normal at follow up. In the Bs group, the background pattern improved to normal voltage in 12 of the 25 infants (48%) within 24 hours. Of these infants, one d ied, five survived withmoderate to severe disability, two with mild disability, and four were normal. The patients who did not recover within 24 hours either di ed in the neonatal period or survived with a severe disability. Conclusion: In t his study there was a small group of infants who presented with a severely abnor mal aEEG background pattern within six hours of birth, but who achieved recovery to a continuous normal background pattern within the first 24 hours. sixty one percent of these infants survived without, or with a mild, disability.

关键词：围生期窒息图形的出生后发育量表神经发育神经学影像学结果神经生理学程及性抑制

对有营养不良的牙买加儿童的初期护理中引入早期刺激方法的可行性:聚类随机对照试验

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世界核心医学期刊文摘（儿科学分册） 2005年第1期1卷 1-1页

作者： Powell C. Baker-Henningham H. Walker s. 刘健 Epidemiology Research Unit University of the West Indies MonaKingstonJamaica

目的:本文对早期将社会心理学刺激引入到营养不良儿童初期护理中的可行性进行评估,确定其对儿童发育情况和母亲育儿知识与实际育儿能力的影响。设计: 采用聚类随机对照试验。机构:在3个牙买加教区的18 个诊所进行。受试者为年龄在9-30月... 详细信息

目的:本文对早期将社会心理学刺激引入到营养不良儿童初期护理中的可行性进行评估,确定其对儿童发育情况和母亲育儿知识与实际育儿能力的影响。设计: 采用聚类随机对照试验。机构:在3个牙买加教区的18 个诊所进行。受试者为年龄在9-30月的139名营养不良儿童和他们的母亲,分别被随机分到干预试验组诊所和对照组诊所。在干预试验组,社区保健人员除了日常的工作外,要对受试者进行每周家访,为期1年。

关键词：刺激方法干预试验育儿知识社区保健儿童发育受试组周家心理刺激发育量表运动方面

小孕周极早产儿神经系统发育欠佳与胎盘功能不良时胎心代偿有关

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世界核心医学期刊文摘（妇产科学分册） 2005年第12期1卷 7-7页

作者： Kaukola T. Rsnen J. Herva R. 高雪莲 Department of Obstetrics and Gynecology University of Oulu Kajaanintie 50 FIN- 90220 Oulu Finland Dr

Objective: The purpose of this study was to determine the relationship between fetal cardiovascular hemodynamics and neurodevelopmental outcome in infants born before 32 gestational weeks with placental insufficiency. study design: seventeen fetuses that underwent Doppler ultrasonography within 24 hours before delivery were included in this prospective cross-sectional study. Placental histology was examined. Multiple inflammatory markers and vascular endothelial growth factor (VEGF) and its receptor were analyzed from umbilical cord serum. Neurodevelopmental outcome was assessed by griffiths scales at 1 year of corrected age. Results: Infants with suboptimal outcome (n = 7) had higher umbilical artery, ductus venosus, and inferior vena cava pulsatility index values (P s (P s with normal outcome (n = 10). Placental histology and serum revealed no inflammation. VEGF values were similar among all infants. Conclusion: In placental insufficiency with delivery before 32 gestational weeks, suboptimal neurodevelopment was related to decreased fetal weight-indexed cardiac output and increased systemic venous pressure.

关键词：神经系统发育胎盘功能脐动脉孕妇分娩周前胎盘组织婴儿发育组织学检查胎盘娩出多普勒超声检查