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FTY720,a sphingosine analog,altered placentome histoarchitecture in ewes

journal of Animal Science and Biotechnology 2020年第2期11卷 380-392页

作者： Kathrin A.Dunlap bryan G.White David W.Erikson M.Carey Satterfield Christiane Pfarrer Guoyao Wu Fuller W.Bazer Robert C.Burghardt Kayla j.Bayless Greg A.johnson Department of Animal Science Texas A&M UniversityCollege StationTX 77843USA Okanagan College Salmon Arm Campus Salmon ArmBritish ColumbiaCanada Endocrine Technologies Core Oregon National Primate Research CenterOregon Health&Science UniversityBeavertonORUSA Department of Anatomy University of Veterinary Medicine HannoverBischofsholer Damm 1530173 HannoverGermany Department of Veterinary Integrative Biosciences College of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843USA Department of Molecular and Cellular Medicine Texas A&M Health Science CenterCollege StationTX 77843USA

Background:The lysosphingolipid,sphingosine-1-phosphate,is a well-described and potent pro-angiogenic ***,as well as the sphingosine phosphorylating enzyme sphingosine kinase 1,are expressed in the placentomes of sheep and the decidua of rodents;however,a function for this signaling pathway during pregnancy has not been *** objective of this study was to investigate whether sphingosine-1-phosphate promoted angiogenesis within the placentomes of pregnant *** were given daily jugular injections of FTY720(2-amino-2[2-(−4-octylphenyl)ethyl]propate-1,3-diol hydrochloride),an S1P ***:FTY720 infusion from days 30 to 60 of pregnancy did not alter maternal organ weights nor total number or mass of placentomes,but did alter placentome *** of caruncular crypts and cotyledonary villi was decreased,as was the relative area of cotyledonary tissue within ***,the percentage of area occupied by cotyledonary villi per unit of placentome was increased,while the thickness of the caruncular capsule was decreased in ewes treated with ***,FTY720 infusion decreased the number and density of blood vessels within caruncular tissue near the placentome capsule where the crypts emerge from the ***,FTY720 infusion decreased asparagine and glutamine in amniotic fluid and methionine in allantoic fluid,and decreased the crown rump length of day 60 ***:While members of the sphingosine-1-phosphate signaling pathway have been characterized within the uteri and placentae of sheep and mice,the present study uses FTY720 to address the influence of S1P signaling on placental *** present evidence that modulation of the S1P signaling pathway results in the alteration of caruncular vasculature,placentome architecture,abundance of amino acids in allantoic and amniotic fluids,and fetal growth during pregnancy in *** marked morphological changes in placentome histoarchitec

关键词： Placentome Pregnancy Sheep Sphingosine1 phosphate(S1P)

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THE BEAT OF BEIjING j-Fever on Collaborating with Soulspeak and the Sound of the Capital

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城市漫步（GBA版） 2019年第7期 36-37页

作者： bryan Grogan 不详

How do you capture the sound of a city?So many have tried and so few have truly succeeded in achieving anything more than a subjective interpretation of their chosen metropolis,The air of chaos that pervades China’s capital city,Reijing,has fascinated many bands and musicians,with punks,noise artists,industrial folk and straight-up avant garde musicians attempting to replicate the intensity of one of the largest and most storied cities in the world.

关键词： straight chaos truly

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THE BEAT OF BEIjING j-Fever on Collaborating with Soulspeak and the Sound of the Capital

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城市漫步（上海版、英文） 2019年第7期 30-31页

作者： bryan Grogan 不详

How do you capture the sound of a city?So many have tried and so few have truly succeeded in achieving anything more than a subjective interpretation of their chosen *** air of chaos that pervades China's capital city,Beijing,has fascinated many bands and musicians,with punks,noise artists,industrial folk and straight-up avant garde musicians attempting to replicate the intensity of one of the largest and most storied cities in the world.

关键词： straight chaos truly

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A private SUSY 4HDM with FCNC in the up-sector

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Chinese Physics C 2021年第2期45卷 330-344页

作者： M.A.Arroyo-Ure?a j.Lorenzo Díaz-Cruz bryan O.Larios-López M.A.Pérez de León Facultad de Estudios Superiores Cuautitlan-UNAM Cuautitlan Mesoamerican Center for Theoretical Physics UNACH CIFFU and Facultad de Ciencias Físico-Matemáticas Benemérita Universidad Autónoma de Puebla Apdo.Postal 1364 Departamento de Gravitación y Altas Energías Facultad de Ciencias Universidad Nacional Autónoma de Honduras Ciudad Universitaria

We present a SUSY model with four Higgs doublets of the "private type," in which all fermion types（up, down, and charged leptons） obtain their masses from a different Higgs doublet H_f （f = u1, d, e）. The conditions for anomaly cancellation imply that the remaining Higgs doublet of the model (Hu2) must have the same hypercharge as Hu1, and thus, can only couple to up-type quarks, which opens the possibility to have FCNCs only in this sector. We study the Lagrangian of the model, and in particular, the Higgs potential, to identify the Higgs mass-eigenstates and their interactions; for the Yukawa matrices, we consider the four-texture case. We obtain constraints on the model parameters by using LHC measurements on the properties of the 125 GeV Higgs boson（h）, and identify viable regions of the parameter space. Subsequently, these constraints are used to evaluate the prospects for detecting the FCNC decay mode t → ch at the future high-luminosity（HL） option for the LHC, which are compared with current limits from LHC-run2. Moreover, we evaluate the FCNC decay of the next heavier Higgs boson H2→ tc, which can typically reach BR（H2→ tc） ≈ O(10-4-10-5). The search for the signal at HL-LHC is also studied, and it is found that it may be detectable for specific regions of the model parameter space.

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水平钻井在俄克拉荷马州的应用情况及其范围

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国外钻井技术 1993年第1期8卷 1-9页

作者： bryan.,j 翟应虎

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Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis

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World journal of Orthopedics 2022年第7期13卷 631-643页

作者： Ian S Hong Allison j Rao Tyler L CarlLee joshua D Meade Daniel j Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor james E Fleischli bryan Michael Saltzman Department of Orthopedic Surgery Atrium Health Musculoskeletal InstituteCharlotteNC 28207United States Department of Sports Medicine Orthocarolina Research InstituteCharlotteNC 28207United States Department of Orthopedic Surgery Columbia University Irving Medical CenterNew York CityNY 10032United States Department of Orthopaedic Surgery Carolinas Medical CenterCharlotteNC 28207United States Department of Orthopedic Surgery OrthoCarolina Sports Medicine CenterCharlotteNC 28207United States

BACKGROUND Rotator cuff pathology is a very common source of shoulder ***,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar *** management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of *** To evaluate if a relationship exists between outcomes of RCR in the setting of *** This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between *** were stratified based on rotator cuff tear size and glenohumeral osteoarthritis *** were paired 1:1 with patients without glenohumeral *** included had a minimum two year *** of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were *** A total of 142 patients were *** number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without *** rotator cuff repair,both groups showed favorable patientreported *** Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis.

关键词： Rotator cuff repair Rotator cuff tear Glenohumeral osteoarthritis Shoulder Arthroscopic Outcomes

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Evaluation of Size Structure in Freshwater Cyanobacterial Populations: Methods to Quantify Risk Associated with Changes in Biomass and Microcystin Concentrations

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journal of Water Resource and Protection 2019年第6期11卷 810-829页

作者： Nancy j. Leland james F. Haney Kristin Conte Karen Malkus-Benjamin bryan Horsely Lim-Tex North Andover MA USA Department of Zoology University of New Hampshire Durham NH USA Manchester Water Works Manchester NH USA Town of Barnstable Barnstable MA USA Association to Preserve Cape Cod Dennis MA USA

Cyanobacterial populations in surface waters, including drinking water supplies and recreational waters, represent an ever present challenge for resource managers. As communities continuously respond to external and internal processes, dynamic profiles of composition, dominance, growth and toxigenicity emerge. In this study measures of size structure and biomass, quantified using light microscopy and fluorometry, were used to estimate microcystin concentrations through linear regression analysis. Toxigenic profiles using cyanobacterial biomass were developed for lakes dominated by Microcystis spp. and Dolichospermum spp., influenced by both genus-specific pigment concentrations as well as microcystin concentrations. Community composition (Log %MIC) and biomass were used to describe microcystin concentrations in mixed assemblages, where composition was the first input variable. The accessory photopigment phycocyanin was used to describe the linear relationship between the daily growth and net microcystin production rates in the bloom-forming Microcystis spp. samples, suggesting that this size-fractionated sample may provide indications of potential toxigenicity in the whole lake water sample. Future investigations using fluorometric evaluation of cyanobacterial populations could provide additional applications and metrics for use by resource managers to quantify risk association with elevated cyanotoxin concentrations.

关键词： Microcystis Dolichospermum Phycocyanin Microcystins Growth Rates

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Occupational Eye Lens Radiation Dose While Performing Interventional Procedures over 18 Months Using a Face-Shield Equipped Suspended Radiation Protection System

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Open journal of Radiology 2020年第2期10卷 101-114页

作者： Thomas j. Kwarcinski Andrew Lichliter joseph Oros Niraj KC bryan Yoder Chet R. Rees Department of Radiology Baylor University Medical Center Dallas TX USA

Background: Numerous studies have demonstrated increasing evidence for cataractogenesis at lower levels of ionizing radiation than previously believed, with some suggesting possible absence of a threshold. Genetic differences between individuals also result in increased susceptibility in some operators, who might not be aware. European occupational exposure limits have been reduced and operators are seeking protective measures. Objective: To evaluate the protective effect of a face-shield equipped suspended protection system (Zero-Gravity®, TIDI Products, Neenah, WI) along with adherence to safety practices against radiation dose to the eye lens for an interventional radiologist performing a wide variety of procedures. Materials and Methods: In this institutional review board-approved single-institution study, one interventional radiologist wore a highly sensitive personnel monitoring dosimeter badge on the cap near the left eye while performing 299 procedures (3690 fluoroscopy minutes) over 18 consecutive months while utilizing the suspended protection system along with adherence to other generally recommended safety practices and movement away from the field during angiographic power injections. Dosimetry reports and procedural information were retrospectively reviewed. Results: Total lens dose equivalent to the left eye over 18 months was 0.11 mSv (annualized dose = 0.073 mSv, or 7.3 mRem). The patient-dose-area product standardized dose of 0.00576 μSv/Gy⋅cm2 is well below reports of conventional lead aprons, shields, and protective eyewear. Conclusion: Eye exposur

关键词： Lens Dose Reduction Radiation Safety Radiation-Induced Cataractogenesis Suspended Protection System

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A simple scoring system to estimate perioperative mortality following liver resection for primary liver malignancy-the Hepatectomy Risk Score(HeRS)

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 315-324,I0001,I0002页

作者： Dimitrios Moris Brian I.Shaw Cecilia Ong Ashton Connor Mariya L.Samoylova Samuel j.Kesseli Nader Abraham jared Gloria Robin Schmitz Zachary W.Fitch bryan M.Clary Andrew S.Barbas Department of Surgery Duke University Medical CenterDurhamNCUSA

Background:Selection of the optimal treatment modality for primary liver cancers remains complex,balancing patient condition,liver function,and extent of *** individuals with preserved liver function,liver resection remains the primary approach for treatment with curative intent but may be associated with significant *** purpose of this study was to establish a simple scoring system based on Model for End-stage Liver Disease(MELD)and extent of resection to guide risk assessment for liver ***:The 2005-2015 NSQIP database was queried for patients undergoing liver resection for primary liver *** first developed a model that incorporated the extent of resection(1 point for major hepatectomy)and a MELD-Na score category of low(MELD-Na=6,1 point),medium(MELD-Na=7-10,2 points)or high(MELD-Na>10,3 points)with a score range of 1-4,called the Hepatic Resection Risk Score(HeRS).We tested the predictive value of this model on the dataset using logistic *** next developed an optimal multivariable model using backwards sequential selection of variables under logistic *** performed K-fold cross validation on both *** operating characteristics were plotted and the optimal sensitivity and specificity for each model were calculated to obtain positive and negative predictive ***:A total of 4,510 patients were *** was associated with increased odds of 30-day mortality[HeRS=2:OR=3.23(1.16-8.99),P=0.025;HeRS=3:OR=6.54(2.39-17.90),P<0.001;HeRS=4:OR=13.69(4.90-38.22),P<0.001].The AUC for this model was *** AUC for the optimal multivariable model was higher at *** K-fold cross validation,the positive predictive value(PPV)and negative predictive value(NPV)of these two models were similar at PPV=6.4%and NPV=97.7%for the HeRS only model and PPV=8.4%and NPV=98.1%for the optimal multivariable ***:The HeRS offers a simple heuristic for estimating 30-day mortality after resectio

关键词： Hepatocellular carcinoma(HCC) cholangiocarcinoma liver resection Model for End-stage Liver Disease(MELD) outcomes

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大气CO_2逐渐增加引起的半球间气候变化的不对称性

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地球科学进展 1990年第5期5卷 82-86页

作者： R.j.Stouffer S.Manabe K.bryan 张欣利美

对应于大气中CO_2增加的海气耦合模式的瞬时响应一直是若干研究项目的主题。这些研究项目中使用的模式考虑了海流热运移的影响,与汉森等使用的模式不同。这里我们运用美国国家海洋大气局(NOAA)地球物理流体力学实验室最新提出的耦合模... 详细信息

对应于大气中CO_2增加的海气耦合模式的瞬时响应一直是若干研究项目的主题。这些研究项目中使用的模式考虑了海流热运移的影响,与汉森等使用的模式不同。这里我们运用美国国家海洋大气局(NOAA)地球物理流体力学实验室最新提出的耦合模式评估了大气CO_2的增加对气候的影响。该响应模式显示出一个明显的和预想不到的半球间气候变化的不对称性。南半球的环极海洋是一深铅直混合区,表面气温增加很慢,在模式中北半球地面空气热得较快且随纬度增加而增加。但北大西洋北部则例外,那里表面空气增温较慢,因为温盐环流减弱了这种趋势。

关键词：气候不对称性北半球南半球 CO2

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