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deep subwavelength nanometric image reconstruction using Fourier domain optical normalization

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Light(Science & Applications) 2016年第1期5卷 632-640页

作者： Jing Qin Richard M Silver bryan M Barnes Hui Zhou Ronald G dixson Mark-Alexander Henn Engineering Physics division Physical Measurement LaboratoryNational Institute of Standards and Technology100 Bureau Dr MS 8212GaithersburgMD 20899-8212USA

Quantitative optical measurements of deep subwavelength,three-dimensional(3d),nanometric structures with sensitivity to sub-nanometer details address a ubiquitous measurement challenge.A Fourier domain normalization approach is used in the Fourier optical imaging code to simulate the full 3d scattered light field of nominally 15 nm-sized structures,accurately replicating the light field as a function of the focus *** the full 3d light field,nanometer scale details such as a 2 nm thin conformal oxide and nanometer topography are rigorously fitted for features less than one-thirtieth of the wavelength in *** densely packed structures are positioned nearly an order of magnitude closer than the conventional Rayleigh resolution limit and can be measured with sub-nanometer parametric *** approach enables a practical measurement sensitivity to size variations of only a few atoms in size using a high-throughput optical configuration with broad application in measuring nanometric structures and nanoelectronic devices.

关键词： computational microscopy light scattering metrology quantitative nanoscale microscopy sub-nanometer uncertainties

dual pH and microbial-sensitive galactosylated polymeric nanocargoes for multi-level targeting to combat ulcerative colitis

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Asian Journal of Pharmaceutical Sciences 2023年第4期18卷 124-141页

作者： Mahira Zeeshan Qurat Ul Ain Benno Weigmann darren Story bryan R.Smith Hussain Ali department of Pharmacy Faculty of Biological SciencesQuaid-i-Azam UniversityIslamabad 45320Pakistan department of Medicine 1 University of Erlangen-NurembergKussmaul Campus for Medical ResearchErlangen 91052Germany Biomedical Engineering department Michigan State UniversityEast Lansing 48824USA Institute for Quantitative Health Science and Engineering Michigan State UniversityEast Lansing 48824USA Faculty of Pharmacy Capital University of Science and TechnologyIslamabad 44000Pakistan

Ulcerative colitis(UC)is a type of inflammatory bowel disease characterized by inflammation,ulcers and irritation of the mucosal *** drug delivery in UC encounters challenges because of multifaceted ***-loaded galactosylated-PLGA/Eudragit S100/pullulan nanocargoes(dexa-GP/ES/Pu NCs)have been developed with a dual stimuli-sensitive coating responsive to both colonic pH and microbiota,and an underneath galactosylated-PLGA core(GP).The galactose ligand of the GP preferentially binds to the macrophage galactose type-lectin-C(MGL-2)surface ***,both stimuli and ligand-mediated targeting facilitate nanocargoes to deliver dexa specifically to the colon with enhanced macrophage *** emulsion method coupled with a solvent evaporation coating technique was employed to prepare dexa-GP/ES/Pu *** nanocargoes were tested using in vitro,ex vivo techniques and dextran sodium sulfate(dSS)induced UC *** nanocargoes had desired physicochemical properties,drug release,cell uptake and cellular *** using a dSS-colitis model showed high localization and mitigation of colitis with downregulation of NF-ĸB and COX-2,and restoration of clinical,histopathological,biochemical indices,antioxidant balance,microbial alterations,FTIR spectra,and epithelial junctions’***,dexa-GP/ES/Pu NCs found to be biocompatible nanocargoes capable of delivering drugs to the inflamed colon with unique targeting properties for prolonged duration.

关键词： Galactosylated nanocargoes pH-sensitive drug delivery Pullulan Microbial sensitive Ulcerative colitis Macrophage galactose type-lectin C

Exercise and children's cognition:The role of exercise characteristics and a place for metacognition

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Journal of Sport and Health Science 2015年第1期4卷 47-55页

作者： Phillip d.Tomporowski bryan Mc Cullick daniel M.Pendleton Caterina Pesce department of Kinesiology University of Georgia department of Human Motion and Sport Science Italian University Sport and Movement

definitive conclusions concerning the impact of exercise interventions on children＇s mental functioning are difficult to ascertain because of procedural differences among studies. A narrative review of studies was conducted to evaluate the role of two types of exercise interventions on children＇s cognition. Acute and chronic exercise interventions were classified as quantitative or qualitative on the basis of manipulations of task complexity and, by inference, mental engagement. Both types of interventions enhance aspects of children＇s cognition; however, their effects on metacognitive processes are unknown. The role of metacognitive processes and their regulation of children＇s behavior and academic performance are highlighted.

关键词： Academic achievement Child development Executive function Intelligence Memory Mental engagement

Association between hereditary hemochromatosis and hepatocellular carcinoma: a comprehensive review

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Hepatoma Research 2020年第3期6卷 1-14页

作者： Aparna Jayachandran Ritu Shrestha Kim R.Bridle darrell H.G.crawford The University of Queensland Faculty of MedicineBrisbaneQLD 4006Australia Gallipoli Medical Research Institute Greenslopes Private HospitalBrisbaneQLD 4120Australia

Hepatocellular carcinoma(HCC)is a significant global health problem with high morbidity and *** incidence is increasing exponentially worldwide with a close overlap between annual incidence and death *** though significant advances have been made in HCC treatment,fewer than 20%of patients with HCC are suitable for potentially curative *** hemochromatosis(HH)is an important genetic risk factor for *** is an autosomal recessive disorder of iron metabolism,characterised by elevated iron deposition in most organs including the liver,leading to progressive organ *** is a complication of HH,nearly always occurring in patients with cirrhosis and contributes to increased mortality *** the susceptibility of development of HCC in HH patients has gained much *** review summarises the current knowledge with regard to the association of HH and HCC in order to encourage further *** this review,we focus particularly on HFE gene-related ***,we highlight and discuss emerging clinical research which addresses the prevalence of HCC in HH patients and the coincidence of HH with other risk factors for HCC *** also focus on the therapeutic tools in the management of HCC associated with HH.

关键词： Hepatocellular carcinoma hereditary hemochromatosis HFE gene C282Y mutation H63d mutation liver cirrhosis

Sulfidation and selenidation of nickel nanoparticles

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Carbon Energy 2021年第4期3卷 582-589页

作者： Brian B.Lynch Andrew P.Kelliher bryan d.Anderson Alexander Japit Michael A.Spencer Mehedi H.Rizvi Mehmet F.Sarac Veronica Augustyn Joseph B.Tracy department of Materials Science and Engineering North Carolina State UniversityRaleighNorth CarolinaUSA

NPs using elemental sulfur,1-hexadecanthiol,thiourea,trioctylphosphine sulfide,elemental selenium,and *** maintaining mole ratios of 2 mmol sulfur/selenium precursor:mmol Ni,products with phases of Ni_(3)S_(2),Ni_(9)S_(8),NiS,NiSO_(4)·6H_(2)O,Ni_(3)S_(4),Ni_(3)Se_(2),and NiSe have been *** products have voids that form through the Kirkendall effect during *** relating the chemical properties of the precursors to the phases of the products have been *** some precursors contained phosphorus,there was no significant incorporation of phosphorus in any of the *** increase of the NP size during sulfidation and selenidation is consistent with *** application of Ni sulfide and selenide NPs as electrocatalysts for the hydrogen evolution reaction is also demonstrated.

关键词： conversion chemistry electrocatalysis nanoparticles nickel selenide sulfide

The Biodegradation of dispersed Oil does Not Induce Toxicity at Environmentally-Relevant Concentrations

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Open Journal of Marine Science 2019年第3期9卷 113-120页

作者： Roger C. Prince bryan M. Hedgpeth Aaron d. Redman Josh d. Butler ExxonMobil Biomedical Sciences Inc. Annandale NJ USA

Applying dispersants to spilled crude oil results in an oil in water dispersion of microscopic oil droplets that soon dilutes to levels below 1 ppm oil. These levels are substantially below those known to induce acute toxicity in 96-hour tests. We show here that oil hydrocarbons are biodegraded very rapidly in such situations (50% loss in 4 days in this experiment), and that no increase in acute toxicity to mysids (Americamysis bahia) is seen during this biodegradation, or over the following 20 days as the oil is further degraded (78% loss of detectable hydrocarbons in this experiment).

关键词： Oil Spills dispersants Biodegradation Acute Toxicity Hopane Americamysis bahia

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美国燃烧工程公司核容器的生产概况

锅炉技术 1985年第2期 27-34页

作者： J.d.crawford

燃烧工程(CE)公司的核容器制造厂位于田纳西州的恰塔努卡市(Chattanooga),占地面积约40万平方英尺,可生产直径达30英尺,重量达1000吨的核容器。该厂具有20多年的设计和制造经验,已交货或订货的核容器超过200台。

关键词：核容器成形压力壳蒸发器浓缩器爆炸胀管管板焊接封头北美洲美国美利坚合众国

Occult Hemothorax after Transcatheter Aortic Valve Implantation (TAVI)

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Open Journal of Anesthesiology 2013年第5期3卷 272-274页

作者： Kenneth d. Eichenbaum bryan Noorda Walter Bethune dennis E. Feierman department of Anesthesiology Maimonides Medical Center New York USA.

We present a case of occult hemothorax, a rare but dangerous complication resulting from cannulation of the internal jugular vein. To date we are not aware of any case reports of bleeding sequelae resulting from direct parenchymal lung injury. The insidious nature of this complication, in which the clinical presentation occurred several hours after central venous cannulation, provides an important reminder for clinicians to follow up central line placement with imaging studies. In this case, the latent period prior to the appearance of clinical manifestations of hemorrhage along with the patient’s subsequent acute decompensation raises questions as to the nature of the underlying injury and mechanisms of both detection and prevention. The patient underwent two right video-assisted thoracoscopic surgical explorations, the first revealed ongoing venous bleeding from within the parenchyma of the right upper lobe which was controlled by a wedge resection. She was ultimately discharged home and, as of the time of this writing, appears to have recovered completely, suffering no long-term sequelae as a result of this complication.

关键词： Central Line Complication Hemothorax TAVI

内蒙锡林浩特晚石炭世辉长质岩体的成因：陆内伸展背景下富水地幔源区熔融的产物

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岩石学报 2018年第10期34卷 2956-2972页

作者：庞崇进王选策温淑女 Krapez bryan 王炎阳廖闻桂林理工大学地球科学学院、广西有色金属隐伏矿床勘查及材料开发协同创新中心、广西隐伏金属矿产勘查重点实验室桂林541004 澳大利亚科廷大学地球与行星科学学院、地球科学研究所珀斯WA6845 长安大学地球与资源学院西安710054 北京大学造山带与地壳演化教育部重点实验室、北京大学地球与空间科学学院北京100871

内蒙中部晚石炭世岩浆活动的成因及动力学背景对于揭示古亚洲洋俯冲和兴蒙造山带演化的具有重要意义。本文选取锡林浩特南部晚石炭世辉长质侵入体为研究对象,开展高精度SIMS锆石U-Pb定年、全岩主微量和Sr-Nd-Hf同位素分析,旨在讨论其岩... 详细信息

内蒙中部晚石炭世岩浆活动的成因及动力学背景对于揭示古亚洲洋俯冲和兴蒙造山带演化的具有重要意义。本文选取锡林浩特南部晚石炭世辉长质侵入体为研究对象,开展高精度SIMS锆石U-Pb定年、全岩主微量和Sr-Nd-Hf同位素分析,旨在讨论其岩石成因,为制约兴蒙造山带的演化和理解深部流体循环过程提供更多信息。辉长质岩体样品的锆石CL图像呈弱环状结构、条带状或岩浆生长带(Th/U=0. 3～2. 5)。SIMS锆石U-Pb定年结果表明,锡林浩特辉长质岩体的侵位年龄为316. 9±2. 2Ma,为兴蒙造山带晚石炭世区域性岩浆活动的产物。该岩体经历了橄榄石和单斜辉石的分离结晶作用,但受堆晶作用和地壳物质混染作用的影响较小;同时具有较低的87Sr/86Sr初始比值(0. 7034～0. 7041),但相对高的εNd(t)(+5. 58～+6. 88)和εHf(t)值(+12. 07～+13. 44),并显示Rb、Sr、U和Pb等流体活动性元素相对富集,但Nb和Ta等非流体活动性元素相对亏损的特征,暗示其起源于遭受含水流体交代富集的地幔源区。流体交代富集作用很可能发生在源区部分熔融过程中或者在部分熔融之前较短的时间内,即反映较为年轻的交代事件。锡林浩特辉长闪长岩具有相对较高的Si O_2(51. 7%～53. 2%)、Cr (138. 4×10^(-6)～757. 2×10^(-6))和Ni (50. 4×10-6～141. 1×10^(-6))含量以及Zn/Fe比值(10. 8～11. 5),但相对较低的Al2O3(13. 1%～16. 8%)含量,暗示源区可能富含斜方辉石,由橄榄岩+辉石岩脉组成。通过对比总结兴蒙造山带晚石炭世岩浆岩岩石组合的地球化学特征以及其他地质资料,本文认为古亚洲洋在晚石炭世之前已经闭合,而锡林浩特辉长质岩体形成于陆内伸展的构造背景。结合同期玄武岩母岩浆的高含水量特征(高达4. 41%),本文认为锡林浩特及其邻区晚石炭世岩浆活动是遭受地幔转换带滞留俯冲板块析出富水流体交代的地幔源区部分熔融的产物,从而建立了深部流体循环过程与造山后伸展背景下岩浆活动的成因联系。

关键词：晚石炭世侵入岩流体活动性元素辉长岩深部流体循环兴蒙造山带