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含有咪唑烷基脲的皮质激素霜剂能否安全用于甲醛过敏患者?

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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 43-44页

作者： Isaksson m. Gruvberger B. Goon A.T.-J. bruze m. 罗素菊 Departm.nt of Occupational and Environm.ntal Derm.tology University Hospital S-205 02 Sweden Dr.

A topical corticosteroid preparation on the Swedish m.rket, Flutivate cream. contains a fairly high concentration of form.ldehyde (FA). In this study, we have investigated the clinical relevance of contact allergy to FA when treating an allergic eczem. with Flutivate cream. containing an FA-releasing preservative. In a random.zed, double-blind study, 7 patients hypersensitive to both FA and nickel repeatedly applied Flutivate  cream.containing FA or Betnovate cream.not containing FA to areas of experim.ntally induced nickel derm.titis. 17 controls allergic to nickel, but not FA, went through the sam. procedure. In 29 per cent of the FA-allergic individuals, the experim.ntal derm.titis healed when treated with Flutivate cream.com.ared with 71 per cent of the controls (P = 0.04). The conclusion to draw from.this study is that an individual hypersensitive to FA should not use the corticosteroid preparation Flutivate cream.on derm.titis skin.

关键词：过敏患者霜剂皮质激素接触性变态反应治疗程序双盲研究

瑞典南部酮洛芬引发的光变态反应性接触性皮炎

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世界核心医学期刊文摘（皮肤病学分册） 2006年第6期2卷 48-48页

作者： Hindsén m. Zim.rson E. bruze m. 潘敏 Departm.nt of Occupational and Environm.ntal Derm.tology University Hospital SE-205 02 Sweden

The non-steroidal anti-inflam.atory drug ketoprofen is widely used for topical treatm.nt. In Sweden, ketoprofen has been available for topical application since 1995. Photoallergic contact derm.titis from.ketoprofen-containing topical preparations usually includes severe eczem.tous reactions. Ketoprofen is derived from.propionic acid, and it is also a substituted benzophenone and therefore structurally sim.lar to fenofibrate and sunscreen agents based on benzophenones. During the last 2 years, 35 patients have been refereed to our departm.nt with suspected photoallergic or allergic reactions after having used ketoprofen-containing gels. Photopatch testing with the photopatch standard series, the ketoprofen-containing gels and their ingredients, fenofibrate, benzophenone-3, benzophenone-10 and benzophenone-4, was perform.d. Photoallergic reactions to ketoprofen were noted in 35 patients and a sim.ltaneous contact allergy to ketoprofen in 2 patients. Sim.ltaneous photoallergy to fentichlor, tetrachlorosalicylanilide and fenofibrate was registered in 74%, 40%and 73%of the patients, respectively.

关键词：变态反应性接触性皮炎酮洛芬瑞典局部治疗非甾体抗炎药非诺贝特苯甲酮变应性反应水杨酰苯胺斑贴试验

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腋臭剂:异丁子香酚的实验性激发研究

世界核心医学期刊文摘（皮肤病学分册） 2005年第9期1卷 41-41页

作者： bruze m. Johansen J.D. Andersen K.E. 潘敏 Departm.nt of Occupational and Environm.ntal Derm.tology University Hospital S205 02 Malm Sweden

Axillary derm.titis is com.on and overrepresented in people with contact allergy to fragrances. m.ny people suspect their deodorants to be the incrim.nating products. In order to investigate the significance of isoeugenol in deodorants for the developm.nt of axillary derm.titis when used by people with and without contact allergy to isoeugenol, patch tests with deodorants and ethanol solutions with isoeugenol, as well as repeated open application tests (ROAT) with roll-on deodorants with and without isoeugenol at various concentrations, were perform.d in 35 derm.titis patients, 10 without and 25 with contact allergy to isoeugenol. A positive ROAT was observed only in patients hypersensitive to isoeugenol (P m.s daily on healthy skin can thus elicit axillary derm.titis within a few weeks in people with contact allergy to isoeugenol.

关键词：异丁子香酚接触性变态反应腋部斑贴试验接触性过敏反应致病物质走珠酒精溶液

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经皮吸收的硫代硫酸金钠在斑贴试验中的应用

世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 57-57页

作者： m.ller H. Schütz A. Bjrkner B. bruze m. 罗素菊冯义国 Departm.nt of Derm.tology Malm University Hospital S-20502 Malm Sweden

Contact allergy to gold has been shown to be correlated to wearing of golden jewellery as well as to the presence of dental gold. The prerequisite for sensitization and elicitation of an allergic contact derm.titis to gold is ionization and percutaneous absorption of the allergen. The present study was undertaken with the aim.to dem.nstrate gold in blood after an occlusive patch testing with gold sodium.thiosulfate (GSTS). Patients were patch tested with GSTS 0.5, 2.0 and 5.0%in petrolatum. Venous blood was sam.led before testing as well as on day 3 (D3) or day 7 (D7). Blood gold levels were analysed by inductively coupled plasm. m.ss spectrom.try. In all 66 patients, the blood level of gold was significantly higher in the 2nd blood sam.le than in the 1st (m.dian 0.34 versus 0.03 μg/l). The increase was sim.lar in patients allergic and not allergic to gold. There was no difference between gold levels on D3 and on D7 after epicutaneous application. Presum.bly, other allergens m.y also be taken up in blood during patch testing.

关键词：硫代硫酸金钠斑贴试验经皮吸收过敏性皮炎血标本分光光度计测定后血离子化

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经全身应用镍证实镍与钯之间存在交叉反应

世界核心医学期刊文摘（皮肤病学分册） 2005年第10期1卷 47-47页

作者： Hindsén m.Spirén A bruze m.潘敏 Departm.nt of Occupational and E nvironm.ntal Derm.tology MalmUniversity Hospital SE-205 02 Malm Sweden

Concom.tant patch test reactions to nickel and palladium.have frequently been reported in patients undergoing investigation because of suspected allergic contact derm.titis. Theoretically,these reactions can be explained by m.ltiple, concom.tant, sim.ltaneous sensitization as well as cross-sensitization. We studied whether concom.tant reactions to nickel and palladium.could represent cross- sensitization in fem.les hypersensitive to com.inations of nickel, palladium.and cobalt. Fem.les were patch tested with serial dilutions of nickel sulfate, cobalt chloride and palladium.chloride on the upper back. 1 m.nth later,when the patch test reactions were gone, the patients were random.zed into 2 groups that were challenged orally with either nickel or placebo. 1 day later, the areas of previous positive patch test reactionswere read in a blind way looking for flare-up reactions. Nickel provocation but not placebo yielded flare-up reactions on sites previously tested with nickel (P = 0.012) and palladium.(P = 0.006), but were also observed on sites previously tested with cobalt, even though this was not statistically significant. Flare-up reactions of previous patch test reactions to nickel and palladium.after oral challenge with nickel speak in favour of a cross-reactivity m.chanism.

关键词：交叉反应斑贴试验交叉过敏上背部系列稀释激发试验硫酸镍安慰剂氯化钴盲法

三氯化金和硫代硫酸金钠是金接触过敏的标记物

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世界核心医学期刊文摘（皮肤病学分册） 2005年第10期1卷 51-51页

作者： m.ller H Ahnlide I Gruvberger B bruze m.李政霄 Departm.nt of Derm.tology m.lm. University Hospital S-20502 Malm Sweden Prof

The usefulness of a trivalent gold salt, gold trichloride (GTC), was evaluated as a m.rker of contact allergy to gold. Patients patch test-positive or patch test-negative to gold sodium.thiosulfate (GSTS), 13 subjects of each, were patch tested with dilution series of GTC and equim.lar concentrations of GSTS. In order to avoid false-positive and false-negative test reactions, the salts were buffered and placed on polypropene cham.ers. Allergic reactions were registered in 9/13 gold-allergic patients with GSTS and in 2/13 with GTC. The sum.of positive reactions was 18 with GSTS and 5 with GTC. Irritant reactions were none with GSTS and 2 with GTC in the gold-allergic patients. It is concluded that GTC can elicit positive patch test reactions in patients with gold allergy but to a lesser degree when com.ared with GSTS. Thus, GTC cannot be recom.ended in patch testing, and GSTS is still the test agent of choice.

关键词：硫代硫酸金钠三氯化金斑贴试验三价金过敏患者刺激反应试验试剂假阴性阳性反应假阳性