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HLA-G 3’UTR 14 bp Insertion Is Associated with a Decreased Risk of Developing Human African Trypanosomiasis in the Côte d’Ivoire Population

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Open Journal of Genetics 2019年第2期9卷 31-41页

作者： Bernardin Ahouty Mathurin Koffi David Courtin Ilboudo Hamidou Didier Sokouri Innocent Abé Laure Gineau Thomas Konan Lingué Kouakou Tidou Abiba Sanogo Enock Matovu bruno Bucheton Vincent Jamonneau Simon-pierre N’Guetta Felix Houphouet Boigny University (UFHB) Cocody Abidjan C&#244 te d’Ivoire Jean Lorougnon Guédé University (UJLoG) Daloa C&#244 te d’Ivoire Institut de Recherche pour le Développement (IRD) Mère et Enfant face aux Infections Tropicales Faculté de Pharmacie Université Paris Descartes Sorbonne Paris Cité France Centre International de Recherche-Développement sur l’Elevage en Zone Subhumide (CIRDES) Bobo-Dioulasso Burkina Faso Programme National d’élimination de la Trypanosomiase Humaine Africaine Abidjan C&#244 te d’Ivoire School of Veterinary Medicine Makerere University Kampala Uganda Institut de Recherche pour le Développement (IRD) IRD-CIRAD 177 Intertryp Université de Montpellier Montpellier France Institut pierre Richet Bouaké C&#244 te d’Ivoire

Human African trypanosomiasis (HAT), or sleeping sickness, caused by Trypanosoma brucei gambiense, is associated with diverse clinical outcomes. Host’s genetic factors involved in immunity are potential factors that can regulate infection. Genetic polymorphisms within HLA-G could influence the level of HLA-G expression and therefore play a critical role in infection outcomes. The goal of our study was to investigate the association of 14 bp Indel HLA-G polymorphism with the susceptibility/resistance to HAT. DNA samples were collected from 119 cases, 221 controls and 43 seropositive individuals living in Ivorian HAT foci. The 14 bp Indel polymorphism was determined by PCR. Homozygous individuals for 14 bp insertion had a lower risk of progressing to active HAT (p = 0.012, OR = 0.27, 95% CI: 0.09 - 0.8). Moreover, the frequency of 14 bp insertion homozygous genotype was higher in the seropositive group (11%) than in the HAT cases group (3%) (p = 0.043, OR = 0.27, 95% CI: 0.07 - 0.99), which suggested a protective effect of 14 bp insertion homozygous genotype. Genetic polymorphisms in HLA-G may be associated with a variable risk to develop HAT. The 14 bp insertion appears to favour the occurrence of long-lasting T. b. gambiense latent infections.

关键词： HLA-G Human African Trypanosomiasis Trypanosoma brucei gambiense Genetic Association Study

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Transient analysis of a fluid bu er driven by a birth and death process

Transient analysis of a fluid bu er driven by a birth and de...

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The 19th International Teletraffic Congress-ITC19

作者： Fabrice Guillemin bruno Sericola Fabrics Guillemin France Telec:om 2 Avenue pierre Marzin 22300 Lannion France bruno Sericola INRIA-IRISA Campus de Beaulieu 35042 Rennes Cedex Prance

＜正＞We analyze the transient behavior of a uid queue when the instantaneous rate of the input process is governed by a general birth and death process. These uid ows models are widely used in the performance analysis of telecommunication systems. The transient analysis of such models has already been considered in earlier works with a nite state space background process. We consider in this paper a in nite state space driving process and we study the uid queue by using results from spectral theory.

关键词： Fluid bu er spectral theory orthogonal polynomials transient analysis

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漂白化学品在脱墨生产线上的最佳应用

漂白化学品在脱墨生产线上的最佳应用

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2001中国造纸学会学术报告会

作者： Gerard Galland Laurence Magnin bruno Carre pierre Larnicol 冯文英法国造纸技术中心（CTP）纤维资源部 CTP CTP脱墨项目部法国Atofina应用中心制浆造纸部

讨论了在含磨木浆脱墨浆（DIP）生产线上漂白化学品的应用情况。在碎浆段使用碱性化学品如过氧化氢是很有效的,因为氢氧化钠有助于油墨分离,过氧化氢能防止返黄并提高白度。比较了各种漂白化学品在脱墨段后对含磨木浆DIP进行漂白的情况...

讨论了在含磨木浆脱墨浆（DIP）生产线上漂白化学品的应用情况。在碎浆段使用碱性化学品如过氧化氢是很有效的,因为氢氧化钠有助于油墨分离,过氧化氢能防止返黄并提高白度。比较了各种漂白化学品在脱墨段后对含磨木浆DIP进行漂白的情况。传统漂白剂如过氧化氢、连二亚硫酸钠和FAS可取得最佳的漂白效果,而二氧化氯、臭氧和氧气可导致返黄,是不适合漂白的。在碱性条件下碎浆后,用还原性漂白剂或过氧化氢均能取得相同的白度增益,但在中性条件下碎浆后使用过氧化氨比还原性漂剂更有效。在漂白含有大量彩色印刷纸（彩色账簿纸和彩色废新闻纸）的含磨木浆的DIP时,仅用单段漂白不能满足标准漂白脱墨浆（ONP／OMG）的光学性能要求。使用过氧化氢和一种还原性漂白剂相结合的流程将是必要的。现代脱墨厂通常由一段热分散系统分开的两个独立的脱墨单元组成。在热分散段使用过氧化氢漂白化学品对油墨分离和漂白都是有效的。

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An Overview of the Synthesis and Gene Transfer Properties of Triblock Copolymers Poly(2-Methyl-2-Oxazoline-b-Tetrahydrofurane-b-2-Methyl-2-Oxazoline)

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Journal of Biomaterials and Nanobiotechnology 2014年第2期5卷 53-65页

作者： Bazoly Rasolonjatovo bruno Pitard Philippe Guégan Hervé Cheradame Institut du Thorax INSERM UMR 915 8 Quai Moncousu Nantes France Laboratory LAMBE University of Evry UMR 8587 Bld Mitterrand 91025 Evry cedex France Polytheragene 4 rue Pierre Fontaine Evry France Université pierre et Marie Curie Laboratoire de Chimie des Polymères 94200 Ivry sur Seine Paris France

The synthesis of poly(2-methyl-2-oxazoline-b-tetrahydrofurane-b-2-methyl-2-oxazoline) triblock copolymer of low molar mass has been carried out. Characterization of the purified polymer by 1H and 13C NMR spectroscopies is described. These block copolymers did not give DNA containing polyplexes. The in vivo transfection properties were investigated by injection of tibialis muscles and intratracheal administration of female Swiss mice. These triblock copolymers with a molar ratio [2-methyl-2-oxazoline units]/[tetrahydrofurane units] in the 3 - 5 range gave a higher transfection efficiency than that of Lutrol or of PE6400 which are the gold standards of this transfection technique. Hydrolysis increased the performances of muscle transfection, showing the beneficial effect of the presence of positive charges, but was clearly detrimental to the transfection efficiency of pulmonary epithelium.

关键词： Triblock Copolymer Cell Transfection Vector Gene Therapy Neutral Amphiphilic Block Copolymers

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儿童气道管理：超声可否实时评价气管插管？

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麻醉与镇痛 2011年第4期7卷 79-83页

作者： bruno Marciniak, MD pierre Fayoux, MD Anne Hebrard MD Renee Krivosic-Horber, MD Thomas Engelhardt, MD, PhD bruno Bissonnette, BSc, MD, FRCPC 何睿林(译) 蒋宗滨(校) Pole d'Anesthesie Reanimation Hopital Jeanne de Flandre CHRU Rue Eugene Avine 59037 Lille Cedex France UPRES JE2490 Predinical research group in perinatal medicine Lille 2 University Lille France U. F. d' ORL pediatrique Pole d' ORL Hopital Claude Huriez. CHRU Lille France Royal Aberdeen Children's Hospital Foresterhill Aberdeen UK Department of Anesthesia Hospital Sick Children Toronto Canada 不详

背景儿童气管插管需要相当的专业知识，对许多麻醉医师而言也是一种挑战。确认气管导管位置的方法有直接目测法或间接测法，例如听诊和二氧化碳波形图。这些方法具有不同的敏感性和特异性，尤其在婴幼儿。超声检查是无创的方法，更容易... 详细信息

背景儿童气管插管需要相当的专业知识，对许多麻醉医师而言也是一种挑战。确认气管导管位置的方法有直接目测法或间接测法，例如听诊和二氧化碳波形图。这些方法具有不同的敏感性和特异性，尤其在婴幼儿。超声检查是无创的方法，更容易被麻醉医师所采用。本研究中，我们探讨了正常小儿气道气管插管期间的特征性实时超声检查所见及这种方法在临床应用的可行性。方法需行气管插管并具有正常气道的30例健康儿童被纳入研究。在使用深度吸入麻醉行气管插管时，应用Sonosite Titan（Sonosite。Bothell，WA）超声仪扫描小儿气道，记录特征性图像。通过听诊和良好的呼气末二氧化碳波形图来进一步确认气管导管放置位置的正确性。结果研究病例的平均年龄（±标准差）为48±37个月，体重19．7±8．6kg，性别比（男／女）为1：2。验证气管插管成功依据下列标准：1）确认气管和气管环；2）确认声带；3）气管导管经过时声门变宽；4）气管导管位于隆突上方，给予肺手动通气后可确认胸腔脏层．壁层胸膜界面的运动（如滑动征）。一例食管插管因见到导管位于左侧气管旁间隙而被识别。结论本研究描述了正常小儿气管插管期间超声气道的特征，提示超声检查可用于儿童气道管理。

关键词：实时超声检查气管插管气道管理健康儿童呼气末二氧化碳波形图实时评价气管导管位置麻醉医师

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Inhibition of elastin and collagen networks degradation in human skin by gingival fibroblast. In vitro, ex vivo and in vivo studies.

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Journal of Cosmetics, Dermatological Sciences and Applications 2011年第1期1卷 4-14页

作者： bruno Gogly Francois Come Ferré Hafida Cherifi Adrien Naveau Benjamin Philippe Fournier Dept. of dentistry A. Chenevier-H. Mondor hospital. AP-HP Centre de recherches des Cordeliers Pierre et Marie Curie University

Skin aging shows an imbalance between synthesis and degradation of the extracellular matrix. The overproduction of degradative enzymes (MMPs) during the chronology- and photo-induced aging leads to a degradation of the elastic and collagen networks. In a model of collagen and elastin destruction, we showed that the gingival fibroblast was able to preserve these macromolecules by inhibiting the overproduction of metalloproteinases by overproduction of TIMP-1 and modulation of the inflammatory cytokines activity. The objective of this study is to evaluate the effect of the gingival fibroblasts on human skin. The results in vitro and ex vivo show that the gingival fibroblast protects the skin collagen and elastic network by the inhibition of MMPs which leads to an overproduction of the TIMP-1. Moreover, the gingival fibroblast modulates the activity of some enzymes responsible for the inflammation;they inhibit the IL-1β and stimulate the production of TGF-β1. In vivo studies with a duration of six months and 50 women with pronounced wrinkles show that the culture supernatant of gingival fibroblasts diluted to 5% leads to a statistically significant decrease in the number and length of wrinkles.

关键词： elastin collagen skin Matrix Metalloproteinases gingival fibroblast

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The Simultaneous Repression Of CCR and CAD, Two Enzymes of the Lignin Biosynthetic Pathway, Results in Sterility and Dwarfism in Arabidopsis thaliana

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Molecular Plant 2011年第1期4卷 70-82页

作者： Johanne Thevenin Brigitte Pollet bruno letarnec Luc Saulnier Lionel Gissot Alessandra Maia-Grondard Catherine Lapierre Lise Jouanin Institut Jean pierre Bourgin (IJPB) INRA-AgroParisTech UMR1318 78026 Versailles Cedex France Unite de Recherche 1268 Biopolymeres Assemblages Interactions (BIA) INRA BP71627 44316 Nantes Cedex 03 France Laboratoire Commun de Cytologie et d'lmagerie Vegetale IJPB INRA-AgroParisTech UMR1318 78026 Versailles France Plateau technique de Chimie du vegetal IJPB INRA-AgroParisTech UMR1318 78026 Versailles France

Cinnamoyl CoA reductase （CCR） and cinnamyl alcohol dehydrogenase （CAD） catalyze the last steps of mono- lignol biosynthesis. In Arabidopsis, one CCR gene （CCR1, Atlg15950） and two CAD genes （CAD C At3g19450 and CAD D At4g34230） are involved in this pathway. A triple cad c cad d ccrl mutant, named ccc, was obtained. This mutant displays a severe dwarf phenotype and male sterility. The lignin content in ccc mature stems is reduced to 50% of the wild-type level. In addition, stem lignin structure is severely affected, as shown by the dramatic enrichment in resistant inter-unit bonds and incorporation into the polymer of monolignol precursors such as coniferaldehyde, sinapaldehyde, and ferulic acid. Male sterility is due to the lack of lignification in the anther endothecium, which causes the failure of anther de- hiscence and of pollen release. The cc~ hypolignified stems accumulate higher amounts of flavonol glycosides, sinapoyl malate and feruloyl malate, which suggests a redirection of the phenolic pathway. Therefore, the absence of CAD and CCR, key enzymes of the monolignol pathway, has more severe consequences on the phenotype than the individual absence of each of them. Induction of another CCR （CCR2, Atlg80820） and another CAD （CAD1, At4g39330） does not compensate the absence of the main CCR and CAD activities. This lack of CCR and CAD activities not only impacts lignification, but also severely affects the development of the plants. These consequences must be carefully considered when trying to reduce the lignin content of plants in order to facilitate the lignocellulose-to-bioethanol conversion process.

关键词： Arabidopsis auxin Cinnamyl Alcohol Dehydrogenase (CAD) Cinnamoyl CoA Reductase (CCR) cell wall dwarfism lignins phenolics sterility.

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High Contribution of Sea Salt Aerosols on Atmospheric Particles Measured at an Urban Tropical Location in Reunion Island

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Journal of Environmental Protection 2013年第8期4卷 828-842页

作者： Chatrapatty Bhugwant Miloud Bessafi Olivier Favez Laura Chiappini bruno Sieja Eva leoz-Garziandia Institut National de l’Environnement Industriel et des Risques (INERIS) Verneuil en Halatte France le2P University of Réunion Island Réunion Island France Observatoire Réunionais de l’Air (ORA) Réunion Island France

PM10 was monitored during 2008-2011 period at LUT and BON, two urban tropical stations close to each other at Saint-pierre city, in Reunion Island (south-western Indian Ocean). During the study period, notable PM10 concentrations are observed at BON close to the coasts. At LUT, a more inland site, the daily PM10 concentration range between 13 and 70 μg/m3. Importantly, the limit value for the protection of the human health is systematically exceeded at BON while it is never exceeded at LUT. Also, the quality objective (QO: 30 μg/m3, on annual average) and the limit value for the human health protection (LV: 40 μg/m3, on annual average) are exceeded at BON each year during 2008-2011, while at LUT no regulatory values are exceeded. Nitrogen dioxide, an atmospheric tracer of anthropogenic activities was also monitored at LUT and BON. The mean diurnal NO2 variation is of the same level and order of magnitude and exhibits a similar pattern at both stations suggesting that distinct sources influence the PM10 at LUT and at BON. Chemical analysis was performed on daily filters sampled in September-November 2011 at the two stations to determine the sea salt contribution on PM10 across Saint-pierre city. It showed that the sea salt contribution to the PM10 is 55% at BON in September 2011. The sea salt particles are therefore the main cause for the exceedances of the regulatory values of PM10 recorded at BON. The results importantly suggest that the notable PM10 concentrations measured at this urban marine site might have some but minor impact on human health.

关键词： PM10 Nitrogen Dioxide Anthropogenic Sea Salt Aerosols Chemical Characterization Regulatory Values Human Health Lung Cancer Urban Tropical

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Correlation between Central and Lateral Neck Dissection in Differentiated Thyroid Carcinoma

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International Journal of Otolaryngology and Head & Neck Surgery 2012年第3期1卷 109-115页

作者： Olivia Mazzaschi Marine lefevre bruno Angelard Nathalie Chabbert-Buffet Jean Lacau St.Guily Sophie Perie Department of Otolaryngology-Head and Neck Surgery Faculty of MedicineUniversity Pierre et Marie Curie Paris VITenon HospitalAssistance Publique-Hopitaux de ParisParisFrance Department of Pathology Faculty of MedicineUniversity Pierre et Marie Curie Paris VITenon HospitalAssistance Publique-Hopitaux de ParisParisFrance Department of Obstetrics Gynaecology and Reproductive Medicine-Endocrinology SectionFaculty of MedicineUniversity Pierre et Marie Curie Paris VITenon HospitalAssistance Publique-Hopitaux de ParisParisFrance

Objective: To determine the histopathological correlation between central and lateral neck metastasis in differentiated thyroid carcinoma, and its potential therapeutic impact. Although the central neck dissection (CND) is recommended in differentiated thyroid carcinoma, the indication for lateral neck dissection (LND) remains controversial. Design: Retrospective study. Methods and Main Outcome Measures: Pathological analysis of systematic ipsilateral central neck dissection (CND) and LND performed with total thyroidectomy in differentiated thyroid carcinoma was retrospectively reviewed according to “side” and to “patient”. Results: A total of 56 sides (46 patients) were suitable for analysis. Analysis by “side” revealed that CND and LND dissection samples were both negative in 15 cases, both positive in 32, CND was positive and LND was negative for 8 cases and CND was negative and LND was positive in 1 case. The combined presence of positive LND and positive CND was therefore observed in 32/40 “sides” and 26/46 “patients”. Analysis by “side” of the impact of the treatment decision to perform ipsilateral LND only in patients with positive CND and vice versa demonstrated a sensitivity, specificity, and accuracy of 97%, 65%, and 84%, respectively. Conclusions: In most cases, the presence of positive LND was associated with positive ipsilateral CND. The very low prevalence of positive LND in patients with negative CND may justify LND as a second step procedure only in patients with positive CND, except in the case of documented lateral neck metastasis.

关键词： Central Neck Dissection Lateral Neck Dissection Differentiated Thyroid Carcinoma Pathological Analysis Thyroid Carcinoma Neck Metastasis

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DTI and Structural MRI Classification in Alzheimer’s Disease

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Advances in Molecular Imaging 2012年第2期2卷 12-20页

作者： Lilia Mesrob Marie Sarazin Valerie Hahn-Barma leonardo Cruz de Souza bruno Dubois Patrick Gallinari Serge Kinkingnéhun LIP6 Université Pierre et Marie Curie Paris France Research and Resource Memory Centre Pitié-Salpêtrière Hospital Paris France Université pierre et Marie Curie Paris France

In this paper, we propose a fully automated method to individually classify patients with Alzheimer’s disease (AD) and elderly control subjects based on diffusion tensor (DTI) and anatomical magnetic resonance imaging (MRI). We propose a new multimodal measure that combines anatomical and diffusivity measures at the voxel level. Our approach relies on whole-brain parcellation into 73 anatomical regions and the extraction of multimodal characteristics in these regions. Discriminative features are identified using different feature selection (FS) methods and used in a Support Vector Machine (SVM) for individual classification. Fifteen AD patients and 16 elderly controls were discriminated using mean diffusivity alone, combination of mean diffusivity and fractional anisotropy, and multimodal measures in the 73 ROIs and the overall accuracy obtained was 65.2%, 68.6% and 72% respectively. Overall accuracy reached 99% in multimodal measures when relevant regions were selected.

关键词： MRI DTI Multimodal Classification Alzheimer’s Disease

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