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Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

Journal of Sport and Health Science 2024年第3期13卷 409-418页

作者： Jérémy Raffin Yves Rolland Annelise Genoux Guillaume Combes Mikael Croyal Bertrand Perret Sophie Guyonnet bruno vellas Laurent O.Martinez Philipe de Souto Barreto For the MAPT/DSA Group Institut du Vieillissement Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France Centre d'Epidémiologie et de Recherche en Santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France LimitAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service de Biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'Institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-forme de spectrométrie de masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background:Adenosine triphosphatase inhibitory factor 1(IF1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains ***,the apolipoprotein A-I(apoA-I),a PA-modulated lipoprotein,could play a role in this relationship because it shares a binding site with IF1 on the cell-surface ATP *** examined here the associations between chronic PA and plasma IF1 concentrations among older adults,and we investigated whether apoA-I mediated these ***:In the present work,1096 healthy adults(63.8%females)aged 70 years and over who were involved in the Multidomain Alzheimer Prevention Trial study were ***1 plasma concentrations(square root of ng/mL)were measured at the 1-year visit of the Multidomain Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed using questionnaires administered each year from baseline to the 3-year *** linear regressions were performed to investigate the associations between the first-year mean PA levels and IF1 *** analyses were conducted to examine whether apoA-I mediated these *** linear regressions were carried out to investigate whether the 1-year visit IF1 concentrations predicted subsequent changes in ***:Multiple linear regressions indicated that first-year mean PA levels were positively associated with IF1 concentrations(B=0.021;SE=0.010;p=0.043).Mediation analyses revealed that about 37.7%of this relationship was mediated by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).Longitudinal investigations demonstrated that higher concentrations of IF1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(time×IF1:B=0.148;SE=0.066;p=0.025).Conclusion:This study demonstrates that regular PA is associated with plasma IF1 concentrations,and it suggests that apoA-I partly med

关键词： Aging Apolipoprotein Bioenergetics Exerkine Mitochondria

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阿尔茨海默病的药物回顾和展望

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Science Bulletin 2024年第10期69卷 1369-1374页

作者： Davide Angioni Julien Delrieu Nicola Coley Pierre-Jean Ousset Jiong Shi bruno vellas Institut Hospitalo Universitaire HealthAge Alzheimer’s Disease Research and Clinical CenterToulouse University HospitalToulouse 31000France Center for Epidemiology and Research in Population Health(CERPOP) University of ToulouseINSERM UMR1295UPSToulouse 31000France Department of Epidemiology and Public Health Toulouse University HospitalToulouse 31000France Department of Neurology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China

With population aging,the number of people with dementia is expected to increase over the coming ***’s disease(AD),the leading cause of dementia worldwide,is characterized by a progressive loss of autonomy leading to dramatic consequences for patients and their caregivers,as well as an increase in health and social care *** main physiopathological features of AD include deposition of amyloid plaques and neurofibrillary tau tangles.

关键词：阿尔茨海默病 Alzheimer tau

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Cross-sectional associations between cortical thiclmess and physical activity in older adults with spontaneous memory complaints:The MAPT Study

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Journal of Sport and Health Science 2023年第3期12卷 324-332页

作者： Jérémy Raffin Yves Rolland Clara Fischer Jean-Francois Mangin Audrey Gabelle bruno vellas Philipe de Souto Barreto the MAPT/DSA Group Gérontopôle de Toulouse Institut du VieillissementCentre Hospitalo-Universitaire de ToulouseToulouse 31000France UniversitéPaul-Sabatier/Institut National de la Santéet de la Recherche Médicale UnitéMixte de Recherche 1027 Facultéde médecineUniversity of Toulouse ⅢToulouse 31000France Centre pour l'Acquisition et le Traitement des Images Multicenter Neuroimaging Platform NeurospinUniversitéParis-SaclayGif sur Yvette 91191France Memory Resources and Research Center Montpellier University HospitalMontpellier 34295France Institut National de la Santéet de la Recherche Médicale Unité1061 i-site Montpellier Universitéd'Excellence University of MontpellierMontpellier 34090France 不详

Background:Age-related changes in brain structure may constitute the starting point for cerebral function *** activity(PA)demonstrated favorable associations with total brain volume,but its relationship with cortical thickness(CT)remains *** investigated the cross-sectional associations between PA level and CT in community-dwelling people aged 70 years and ***:A total of 403 older adults aged 74.8±4.0 years(mean±SD)who underwent a baseline magnetic resonance imaging examination and who had data on PA and confounders were *** was assessed with a *** were categorized according to PA *** linear regressions were used to compare the brain CT(mm)of the inactive group(no PA at all)with 6 active groups(growing PA levels)in 34 regions of ***:Compared with inactive persons,people who achieved PA at a level of 1500-1999 metabolic equivalent task-min/week(i.e.,about6-7 h of brisk walking for exercise) and those who achieved it at 2000-2999 metabolic equivalent task-min/week(i.e.,8-11 h of brisk walking for exercise)had higher CT in the fusiform gyrus and the temporal ***,dose-response associations between PA and CT were found in the fusiform gyrus(B=0.011,SE=0.004,adj.p=0.035),the temporal pole(B=0.026,SE=0.009,adj.p=0.048),and the caudal middle frontal gyrus,the entorhinal,medial orbitofrontal,lateral occipital,and insular ***:This study demonstrates a positive association between PA level and CT in temporal areas such as the fusiform gyrus,a brain region often associated to Alzheimer’s disease in people aged 70 years and *** investigations focusing on PA type may help to fulfil remaining knowledge gaps in this field.

关键词： Alzheimer's disease Brain aging Cortical thickness Physical activity

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阿尔茨海默病治疗:未来干预措施的策略

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英国医学杂志中文版 2021年第1期24卷 4-7页

作者：施炯 Marwan N.Sabbagh bruno vellas 美国克利夫兰诊所法国图卢兹大学医院中心

施炯及其同事探讨有关阿尔茨海默病临床试验的最新证据以及新的治疗策略。神经退行性疾病是影响大脑神经元存活和功能的多种疾病总称。由于神经元丢失通常会导致认知功能下降并发展为痴呆症,所以痴呆症是神经退行性疾病的共同特征。根... 详细信息

施炯及其同事探讨有关阿尔茨海默病临床试验的最新证据以及新的治疗策略。神经退行性疾病是影响大脑神经元存活和功能的多种疾病总称。由于神经元丢失通常会导致认知功能下降并发展为痴呆症,所以痴呆症是神经退行性疾病的共同特征。根据世界卫生组织(WHO)的数据,2015年全世界痴呆症患者估计为4747万人。随着人口的老龄化,这一数字将在2030年达到7563万,到2050年将达到1.346亿。

关键词：阿尔茨海默病神经退行性疾病神经元存活神经元丢失临床试验痴呆症治疗策略干预措施

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