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Poroelastic solid flow with double point material point method

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Journal of Hydrodynamics 2017年第3期29卷 423-430页

作者： bruno Zuada Coelho Alexander Rohe Kenichi Soga Department of geo-engineering DeltaresDelftrife-Netherlands Department of Engineering University of CambridgeCambridgeUK

This paper presents the numerical modelling of one and two-dimensional poroelastic solid flows,using the material point method with double point *** double point formulation offers the convenience of allowing for transitions in the flow conditions of the liquid,between free surface flow and groundwater *** numerical model is validated by comparing the solid flow velocity with the analytical *** influence of the Young＇s modulus on the solid flow velocity is discussed for both one and two-dimensional analysis *** effect of the shape of the two-dimensional solid is *** is shown that the solid stiffness has an effect on the poroelastic flow velocity,due to swelling and bending for the one and two-dimensional cases,*** shape is found to be an important factor on the flow velocity of the poroelastic solid.

关键词： Material point method geocontainers double point formulation large deformations

The bottlenose dolphin Tursiops truncatus foraging around a fish farm:Effects of prey abundance on dolphins' behavior

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Current Zoology 2009年第4期55卷 243-248页

作者： bruno A■DZ LóPEZ The Bottlenose Dolphin Research Institute BDRI

The extent to which prey abundance influences both bottlenose dolphin foraging behavior and group size in the presence of human activities has not previously been *** primary aim of this study was to identify and quantify how wild bottlenose dolphins respond,individually and as groups,to the relative abundance of prey around a fish *** views of dolphins' behavior were obtained by focal following individual animals whilst simultaneously collecting surface and underwater behavioral data.A total of 2150 dive intervals were analyzed,corresponding to 342 focal samples,lasting over 34 *** dolphins remained submerged for a mean duration of 46.4 seconds and a maximum of 249 *** study provides the first quantified data on bottlenose dolphin diving behavior in a marine fin-fish farm *** study's results indicate that within a fish farm area used intensively by bottlenose dolphins for feeding,dolphins did not modify dive ***,underwater observations confirmed that dolphins find it easier to exploit a concentrated food source and it appears that hunting tactic and not group size plays an important role during feeding ***,bottlenose dolphins appear capable of modifying their hunting tactics according to the abundance of *** top predators display behavioral responses to activities not directed at them,the task of studying all possible effects of human activities can become even more challenging.

关键词： Bottlenose dolphin Tursiops truncatus Diving behavior Foraging behavior Prey abundance Human activities,Hunting tactics Aquaculture

Wave Propagation Across Acoustic/Biot’s Media:A Finite-Difference Method

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Communications in Computational Physics 2013年第4期13卷 985-1012页

作者： Guillaume Chiavassa bruno Lombard Centrale Marseille Laboratoire de Mecanique Modelisation et Procedes PropresUMR 7340 CNRSTechnopole de Chateau-Gombert38 rue Frederic Joliot-Curie13451 MarseilleFrance Laboratoire de Mecanique et d’Acoustique UPR 7051 CNRS31 chemin Joseph Aiguier13402 MarseilleFrance

Numerical methods are developed to simulate the wave propagation in heterogeneous 2D fluid/poroelastic *** propagation is described by the usual acoustics equations(in the fluid medium)and by the low-frequency Biot’s equations(in the porous medium).Interface conditions are introduced to model various hydraulic contacts between the two media:open pores,sealed pores,and imperfect ***-posedness of the initial-boundary value problem is *** grid numerical methods previously developed in porous heterogeneous media are adapted to the present context:a fourth-order ADER scheme with Strang splitting for timemarching;a space-time mesh-refinement to capture the slow compressional wave predicted by Biot’s theory;and an immersed interface method to discretize the interface conditions and to introduce a subcell *** experiments and comparisons with exact solutions are proposed for the three types of interface conditions,demonstrating the accuracy of the approach.

关键词： Biot’s model poroelastic waves jump conditions imperfect hydraulic contact highorder finite differences immersed interface method

Tweaking the acid-sensitivity of transiently thermoresponsive polyacrylamides with cyclic acetal repeating units

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Science China Chemistry 2020年第4期63卷 504-512页

作者： Simon Van Herck bruno G.De Geest Department of Pharmaceutics Ghent UniversityGhentBelgium

Merging the characteristics of thermoresponsive and stimuli-degradable polymers yields so-called transiently thermoresponsive polymers, which can find application for the design of injectable gels, nanoparticles, etc. within a biomedical context. Among these polymers, only a limited number is reported which shows selective degradation under mild acidic conditions. However,extension of the library of transiently thermoresponsive polymers is desired to broadening the biomaterials toolbox to suit specific needs. Three monomers were developed by modification of 2-hydroxyethylacrylamide(HEAm) via tetrahydropyranylation or-furanylation with 3,4-dihydro-2 H-pyran(DHP), 2,3-dihydrofuran(DHF) or 2,3-dihydro-5-methylfuran(MeDHF). The presence of an acetal or ketal bond provided the monomers a pH-dependent hydrolysis behavior ranging from minutes to days. RAFT polymerisation allowed for the construction of homopolymers with temperature responsive behavior and pH-dependent hydrolysis which was strongly influenced by nature of the monomeric repeating units.

关键词： acetals polyacrylamides stimuli-responsive

Capsule endoscopy and panendoscopy:A journey to the future of gastrointestinal endoscopy

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World Journal of Gastroenterology 2024年第10期30卷 1270-1279页

作者： bruno Rosa JoséCotter Department of Gastroenterology Hospital da Senhora da OliveiraGuimarães 4835-044Portugal Life and Health Sciences Research Institute School of MedicineUniversity of MinhoBraga 4710-057Portugal ICVS/3B's PT Government Associate LaboratoryBraga 4710-057Portugal

In 2000,the small bowel capsule revolutionized the management of patients with small bowel ***,the technological development achieved by the new models of double-headed endoscopic capsules,as miniaturized devices to evaluate the small bowel and colon[pan-intestinal capsule endoscopy(PCE)],makes this non-invasive procedure a disruptive concept for the management of patients with digestive *** technology is expected to identify which patients will require conventional invasive endoscopic procedures(colonoscopy or balloon-assisted enteroscopy),based on the lesions detected by the capsule,i.e.,those with an indication for biopsies or endoscopic *** use of PCE in patients with inflammatory bowel diseases,namely Crohn’s disease,as well as in patients with iron deficiency anaemia and/or overt gastrointestinal(GI)bleeding,after a non-diagnostic upper endoscopy(esophagogastroduodenoscopy),enables an effective,safe and comfortable way to identify patients with relevant lesions,who should undergo subsequent invasive endoscopic *** recent development of magnetically controlled capsule endoscopy to evaluate the upper GI tract,is a further step towards the possibility of an entirely non-invasive assessment of all the segments of the digestive tract,from mouth-to-anus,meeting the expectations of the early developers of capsule endoscopy.

关键词： Non-invasive endoscopy Panendoscopy Magnetically controlled capsule endoscopy Crohn’s disease Digestive bleeding

Identifying representative days of solar irradiance and wind speed in Brazil using machine learning techniques

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Energy and AI 2024年第1期15卷 151-170页

作者： Rafaela Ribeiro bruno Fanzeres Industrial Engineering Department Pontifical Catholic University of Rio de Janeiro(PUC-Rio)22451-900Rio de JaneiroRJBrazil

The investment levels in electricity production capacity from variable Renewable Energy Sources have substantially grown in Brazil over the last decades,following the worldwide-seeking-goal of a carbon-neutral economy and the country’s incentives in diversifying its generation *** a long-term perspective,the current non-storable capability of renewable energy sources requires an adequate uncertainty characterization over the *** this context,the main objective of this work is to provide a thorough descriptive analytics of the time-linked hourly-based daily dynamics of wind speed and solar irradiance in the main resourceful regions of *** on unsupervised Machine Learning methods,we focus on identifying similar days over the years,Representative Days,that can depict the fundamental underlying behaviour of each *** analysis is based on a historical dataset of different sites with the highest potential and installed capacity of each source spread over the country:three in the Northeast and one in the South Regions,for wind speed;and three in the Northeast and one in the Southeast Regions,for solar *** use two Partitioning Methods(𝐾-Means and𝐾-Medoids),the Hierarchical Ward’s Method,and a Model-Based Method(Self-Organizing Maps).We identified that wind speed and solar irradiance can be effectively represented,respectively,by only two representative days,and two or three days,depending on the region and method(segments data with respect to the intensity of each source).Analysis with higher Representative Days highlighted important hidden patterns such as different wind speed modulations and solar irradiance peak-hours along the days.

关键词： Partitioning clustering methods Hierarchical clustering methods Model-based clustering methods Representative days Solar irradiance Wind speed

Systemic therapy of hepatocellular carcinoma:Current status and future perspectives

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World Journal of Gastroenterology 2014年第12期20卷 3087-3099页

作者： Domenico Germano bruno Daniele Oncology Unit A.O. "G.Rummo"

The management of hepatocellular carcinoma (HCC) has substantially changed in the past few decades, the introduction of novel therapies (such as sorafenib) have improved patient survival. Nevertheless, HCC remains the third most common cause of cancer-related deaths worldwide. Decision-making largely relies on evidence-based criteria, as showed in the US and European clinical practice guidelines, which endorse five therapeutic recommendations:resection; transplantation; radiofrequency ablation; chemoembolization; and sorafenib. Many molecularly targeted agents that inhibit angiogenesis, epidermal growth factor receptor, and mammalian target of rapamycin are at different stages of clinical development in advanced HCC. Future research should continue to unravel the mechanism of hepatocarcinogenesis and to identify key relevant molecular targets for therapeutic intervention. Identification and validation of potential surrogate and predictive biomarkers hold promise to individualize patient’s treatment to maximize clinical benefit and minimize the toxicity and cost of targeted agents.

关键词： Hepatocellular Carcinoma Molecular agents Targheted therapy Sorafenib

Greasy hair against obesity

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Signal Transduction and Targeted Therapy 2022年第1期7卷 11-12页

作者： Sandra Nickel bruno Christ Department of General Visceral and Vascular SurgeryJena University Hospital07740 JenaGermany Cell Transplantation/Molecular Hepatology Lab Department of VisceralTransplantThoracic and Vascular SurgeryUniversity of Leipzig Medical Center04103 LeipzigGermany

In their article,Choa et *** the perspective to loose fat by in creasing seboge *** a T cell-depe ndent mechanism,they suggest that stimulation of sebum production by thymic stromal lymphopeietin(TSLP)"pulls"lipids out of the adipose tissue.^(1) The World Population Review(***/)ranks obesity rates to one third of the global *** co-morbidities comprise diabetes type 2,ischemic stroke and cardiovascular complications render this epidemic disease the number 1 cause of deaths worldwide(***/).

关键词： obesity al stimulation

Anti-fibrotic and anti-inflammatory effect of mesenchymal stromal cell-derived extracellular vesicles in chronic kidney disease

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BIOCELL 2023年第7期47卷 1499-1508页

作者： GIULIA CHIABOTTO STEFANIA bruno Department of Medical Sciences University of TorinoTorino10126Italy Molecular Biotechnology Center University of TorinoTorino10126Italy

Renal fibrosis and inflammation are common pathological features of chronic kidney disease(CKD).Since currently available treatments can only delay the progression of CKD,the outcome of patients with CKD is still *** therapeutic option for the prevention of CKD-related complications could be the use of mesenchymal stromal cells(MSCs),which have shown beneficial effects in tissue fibrosis and regeneration after ***,safety issues,such as cellular rejection and carcinogenicity,limit their clinical *** the bioactive factors secreted by MSCs,extracellular vesicles(EVs)have shown the same beneficial effect of MSCs,without any notable side *** heterogeneous population of membranous nano-sized particles can deliver genetic material and functional proteins to injured cells,prompting tissue *** we describe the anti-fibrotic and antiinflammatory properties of MSC-derived EVs in CKD preclinical models and summarize the potential molecular mechanisms involved in the regulation of renal fibrosis and inflammation.

关键词： Chronic kidney disease Renal fibrosis Epithelial-to-mesenchymal transition Mesenchymal stromal cell Extracellular vesicles