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Signal Transduction and Targeted Therapy 2021年第8期6卷 2280-2281页

作者： Jehad Charo bruno Gomes hoffmann-la roche ag pharmaceutical research and early development oncologyroche innovation center zurichzurichswitzerland hoffmann-la roche ag pharmaceutical research and early development oncologyroche innovation center baselbaselswitzerland

In a recent article published in Science by Hernandez-Lopez et *** antigen receptor(CAR)expressing T(CAR-T)cells with a two-step recognition system successfully discriminated between target cells expressing high and l... 详细信息

关键词： CAR cancer

Persistent X-ray-activated phosphors:mechanisms and applications

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Light(Science & Applications) 2022年第6期11卷 1008-1010页

作者： Cyrille Richard bruno Viana UniversitéParis Cité CNRSINSERMUTCBSUnitéde Technologies Chimiques et Biologiques pour la SantéFacultéde Pharmacie75006 ParisFrance IRCP CNRS UMR8247PSL UniversityChimie ParisTech11 Rue P&M Curie75005 ParisFrance

Trivalent lanthanides in wide bandgap fluoride or phosphate hosts can present persistent luminescence between 200 nm and 1.7 μm after charging by *** are reviewed and applications envisioned.

关键词： lanthanide fluoride luminescence

Pathology of hepatic iron overload

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World Journal of Gastroenterology 2007年第35期13卷 4755-4760页

作者： Yves Deugnier bruno Turlin Liver Unit and CIC INSERM 0203 Pontchaillou University HospitalRennes 35033France Department of Pathology and INSERM U 522 Pontchaillou University HospitalRennes 35033France

Although progress in imaging and genetics allow for a noninvasive diagnosis of most cases of genetic iron overload, liver pathology remains often useful （1） to assess prognosis by grading fibrosis and seeking for associated lesions and （2） to guide the etiological diagnosis, especially when no molecular marker is available. Then, the type of liver siderosis （parenchymal, mesenchymal or mixed） and its distribution throughout the Iobule and the liver are useful means for suggesting its etiology： HLA-linked hemochromatosis gene （HFE） hemochromatosis or other rare genetic hemochromatosis, nonhemochromatotic genetic iron overload （ferroportin disease, aceruloplasminemia）, or iron overload secondary to excessive iron supply, inflammatory syndrome, noncirrhotic chronic liver diseases including dysmetabolic iron overload syndrome, cirrhosis, and blood disorders.

关键词： Iron Liver Biopsy Hemochromatosis Ferroportin HLA-linked hemochromatosis gene Hepcidin Metabolic syndrome

Pernicious anemia: New insights from a gastroenterological point of view

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World Journal of Gastroenterology 2009年第41期15卷 5121-5128页

作者： Edith Lahner bruno Annibale Department of Digestive and Liver Disease University Sapienza 2nd Medical School Ospedale Sant'Andrea Via di Grottarossa 1035 00189 Roma Italy

Pernicious anemia （PA） is a macrocytic anemia that is caused by vitamin B12 deficiency, as a result of intrinsic factor deficiency. PA is associated with atrophic body gastritis （ABG）, whose diagnosis is based on histological confirmation of gastric body atrophy. Serological markers that suggest oxyntic mucosa damage are increased fasting gastrin and decreased pepsinogen I. Without performing Schilling＇s test, intrinsic factor deficiency may not be proven, and intrinsic factor and parietal cell antibodies are use- ful surrogate markers of PA, with 73% sensitivity and 100% specificity. PA is mainly considered a disease of the elderly, but younger patients represent about 15% of patients. PA patients may seek medical advice due to symptoms related to anemia, such as weak-ness and asthenia. Less commonly, the disease is suspected to be caused by dyspepsia. PA is frequently associated with autoimmune thyroid disease （40%） and other autoimmune disorders, such as diabetes mellitus （10%）, as part of the autoimmune polyen-docrine syndrome. PA is the end-stage of ABG. Long- standing Helicobacter pylori infection probably plays a role in many patients with PA, in whom the active infectious process has been gradually replaced by an autoimmune disease that terminates in a burned-out infection and the irreversible destruction of the gastric body mucosa. Human leucocyte antigen-DR genotypes suggest a role for genetic susceptibility in PA. PA patients should be managed by cobalamin replacement treatment and monitoring for onset of iron deficiency. Moreover, they should be advised about possible gastrointestinal long-term consequences, such as gastric cancer and carcinoids.

关键词： Pernicious anemia Autoimmune diseases Atrophic gastritis Intrinsic factor Autoantibodies Parietal cells Vitamin B12 deficiency Helicobacter pylori

The indeterminable resilience of the fascial system

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Journal of Integrative Medicine 2017年第5期15卷 337-343页

作者： bruno Bordoni Fabiola Marelli bruno Morabito Beatrice Sacconi Department of Cardiology Institute of Hospitalization and Care with Scientific AddressFoundation Don Carlo Gnocchi IRCCSMilan 20100Italy Department of Fascial Osteopathic Research:FORe School of Osteopathic Centre for Research and StudiesCRESOGorla Minore(VA)21055Italy Department of Fascial Osteopathic Research:FORe School of Osteopathic Centre for Research and StudiesCRESOFano(Pesaro Urbino)61032Italy Departmente of Neurology Foundation Polyclinic University A.Gemelli University Cattolica del Sacro CuoreRome 00168Italy Department of Radiological Oncological and Anatomopathological SciencesSapienza University of RomeRome 00185Italy

The most recent information on fascial tissue indicates that there are not fascial layers, but polyhedral microvacuoles of connective tissue, which connect the body systems and, by hosting specialized cells, permit several functions, such as motor, nervous, vascular and visceral. These microvacuoles（a repetition of polyhedral units of connective fibrils） under internal or external tension change shape and can manage the movement variations, regulating different body functions and ensuring the maintenance of efficiency of the body systems. Their plasticity is based on perfect functional chaos： it is not possible to determine the motion vectors of the different fibrils, which differ in behavior and orientation; this strategy confers to the fascial continuum the maximum level of adaptability in response to the changing internal and external conditions of the cell. The present commentary deals with this concept, providing clinical examples of different disease patterns, providing contrary examples in which this adaptability does not occur, and lastly suggesting considerations for the approach to manipulative therapy of the fascial tissue. The fascial continuum is like a flock of birds flying together without a predetermined logic and maintaining their individuality at the same time.

关键词： fascia osteopathic manual therapy fibroblast fascial continuum

Seismic fragility curves for structures using non-parametric representations

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Frontiers of Structural and Civil Engineering 2017年第2期11卷 169-186页

作者： Chu MAI Katerina KONAKLI bruno SUDRET Risk Safety & Uncertainty Quantification Institute of Structural Engineering ETH Ziirich Ziirich CH-8093 Switzerland

Fragility curves are commonly used in civil engineering to assess the vulnerability of structures to earthquakes. The probability of failure associated with a prescribed criterion （e.g., the maximal inter-storey drift of a building exceeding a certain threshold） is represented as a function of the intensity of the earthquake ground motion （e.g., peak ground acceleration or spectral acceleration）. The classical approach relies on assuming a lognormal shape of the fragility curves; it is thus parametric. In this paper, we introduce two non-parametric approaches to establish the fragility curves without employing the above assumption, namely binned Monte Carlo simulation and kernel density estimation. As an illustration, we compute the fragility curves for a three-storey steel frame using a large number of synthetic ground motions. The curves obtained with the non-parametric approaches are compared with respective curves based on the lognormal assumption. A similar comparison is presented for a case when a limited number of recorded ground motions is available. It is found that the accuracy of the lognormal curves depends on the ground motion intensity measure, the failure criterion and most importantly, on the employed method for estimating the parameters of the lognormal shape.

关键词： earthquake engineering fragility curves lognormal assumption non-parametric approach kernel density estimation epistemic uncertainty

Configuration-dependent stretchable all-solid-state supercapacitors and hybrid supercapacitors

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Carbon Energy 2023年第5期5卷 1-47页

作者： Ahmad Amiri Ashley bruno Andreas A.Polycarpou J.Mike Walker’66 Mechanical Engineering Department Texas A&M UniversityCollege StationTexasUSA

Given the rise in the popularity of wearable electronics that are able to deform into desirable configurations while maintaining electrochemical functionality,stretchable and flexible(hybrid)supercapacitors(SCs)have become increasingly of interest as innovative energy storage *** outstanding power density,long lifetime with low capacitance loss,and appropriate energy density,in particular in hybrid cases make them ideal candidates for flexible *** aim of this review paper is to provide an in-depth discussion of these stretchable and flexible SCs ranging from fabrication to electro-mechanical *** review paper begins with a short overview of the fundamentals of charge storage mechanisms and different types of multivalent metal-ion hybrid *** research methods leading up to the current state of these stretchable and flexible SCs are then *** is followed by an in-depth presentation of the challenges associated with the fabrication methods for different *** novel strategies to maximize the elastic and electrochemical properties of stretchable/flexible or quasi-solid-state SCs are classified and the pros and cons associated with each are *** advances in mechanical properties and the expected advancements for the future of these SCs are discussed in the last section.

关键词： 1D fiber-like SCs 2D planar supercapacitors 3D sponge and textile structures flexible/stretchable supercapacitors kirigami/origami-inspired structures

How do stream processes affect hazard exposure on alluvial fans? Insights from an experimental study

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Journal of Mountain Science 2020年第4期17卷 753-772页

作者： bruno MAZZORANA Elisa GHIANDONI Lorenzo PICCO Universidad Austral de Chile Faculty of SciencesInstituto de Ciencias de la Tierra5090000 ValdiviaChile Universidad Austral de Chile RINA–Natural and Anthropogenic Risks Research Center5090000 ValdiviaChile Universidad Austral de Chile Laboratory of HydromorphologyFaculty of Forest Sciences and Natural Resources5090000 ValdiviaChile University of Padova Department of LandEnvironmentAgriculture and Forestry35020 LegnaroItaly

Alluvial fans are among the most privileged settlement areas in many mountain regions. These landforms are particularly dynamic being episodically affected by distributary processes generated by extreme flood events. Addressing risk assessment entails determining hazard exposure and unravelling how it might be related to process loading and to process dynamics once the flow becomes unconfined on the surface of alluvial fans. By following a ‘similarity of process concept’, rather than by attempting to scale a real-world prototype, we performed a set of 72 experimental runs on an alluvial fan model. Thereby, we considered two model layouts, one without a guiding channel and featuring a convex shape and the other one with a guiding channel, a bridge, and inclined but planar overland flow areas as to mirror an anthropic environment. Process magnitude and intensity parameters were systematically varied, and the associated biphasic distributary processes video recorded. For each experiment, the exposure was detected by mapping the exposed area in a GIS, thereby discerning between areas exposed to biphasic flows and the associated depositional phenomena or to the liquid flow phase only. Our results reveal that total event volume, sediment availability and stream power in the feeding channel, as well as depositional effects, avulsion, and channelization on the alluvial fan concur to determine the overall exposure. Stream process loading alone, even when rigorously defined in terms of its characterizing parameters, is not sufficient to exhaustively determine exposure. Hence, further developing reliable biphasic simulation models for hazard assessment on settled alluvial fans is pivotal.

关键词： Alluvial fan Hazard Exposure Flood risk Experimental model Process similarity

Purines:From Diagnostic Biomarkers to Therapeutic Agents in Brain Injury

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Neuroscience Bulletin 2020年第11期36卷 1315-1326页

作者： bruno G.Frenguelli Nicholas Dale School of Life Sciences The University WarwickCoventry CV47ALUK

The purines constitute a family of inter-related compounds that serve a broad range of important intracellular and extracellular biological *** particular,adenosine triphosphate(ATP)and its metabolite and precursor,adenosine,regulate a wide variety of cellular and systems-level physiological processes extending from ATP acting as the cellular energy currency,to the adenosine arising from the depletion of cellular ATP and responding to reduce energy demand and hence to preserve ATP during times of metabolic *** inter-relationship provides opportunities for both the diagnosis of energy depletion during conditions such as stroke,and the replenishment of ATP after such *** this review we address these opportunities and the broad potential of purines as diagnostics and restorative agents.

关键词： Purines Adenosine ATP Biomarker Stroke Cerebral ischemia Traumatic brain injury Adenine D-ribose

A conditioned level-set method with block-division strategy to flame front extraction based on OH-PLIF measurements

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Chinese Physics B 2014年第5期23卷 639-652页

作者：韩乐蔡国飙徐旭 Renou bruno Boukhalfa Abdelkrim School of Astronautics Beijing University of Aeronautics and Astronautics UMR 6614 CORIA INSA de RouenAvenue de l’UniversitéBP 0876801 Saint-Etienne du RouvrayFrance

A novel approach to extract flame fronts, which is called the conditioned level-set method with block division （CLSB）, has been developed. Based on a two-phase level-set formulation, the conditioned initialization and region-lock optimiza-tion appear to be beneficial to improve the efficiency and accuracy of the flame contour identification. The original block- division strategy enables the approach to be unsupervised by calculating local self-adaptive threshold values autonomously before binarization. The CLSB approach has been applied to deal with a large set of experimental data involving swirl- stabilized premixed combustion in diluted regimes operating at atmospheric pressures. The OH-PLIF measurements have been carried out in this framework. The resulting images are, thus, featured by lower signal-to-noise ratios （SNRs） than the ideal image; relatively complex flame structures lead to significant non-uniformity in the OH signal intensity; and, the mag- nitude of the maximum OH gradient observed along the flame front can also vary depending on flow or local stoichiometry. Compared with other conventional edge detection operators, the CLSB method demonstrates a good ability to deal with the OH-PLIF images at low SNR and with the presence of a multiple scales of both OH intensity and OH gradient. The robustness to noise sensitivity and intensity inhomogeneity has been evaluated throughout a range of experimental images of diluted flames, as well as against a circle test as Ground Truth （GT）.

关键词： OH-PLIE flame front extraction level-set optical signal processing