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Fluid Dynamics & Materials Processing 2022年第5期18卷 1529-1537页

作者： Yazid Statra Sara Fawaz Hocine Menana bruno Douine Universitéde Lorraine GREENNancyF-54000France

The electromagnetic properties of high temperature superconductors(HTS)are characterized with the explicit intent to improve their integration in electric power systems.A tape and a coil made of Bismuth Strontium Calcium Copper Oxide(BSCCO)are considered in the presence of electromagnetically active materials in order to mimic properly the electromagnetic environment typical of electrical *** characterization consists of the determining the critical current and the AC losses at different values of the frequency and the transport *** effects induced by the proximity of the active materials are studied and some related experimental issues are analyzedc.

关键词： AC losses HTS coils experimental characterization proximity of electromagnetically active materials

Clinical applications of hepatocyte transplantation

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World Journal of Gastroenterology 2009年第17期15卷 2074-2077页

作者： Giada Pietrosi Giovanni Battista Vizzini Salvatore Gruttadauria bruno Gridelli Department of Gastroenterology and Hepatology Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IsMeTT) University of Pittsburgh Medical Center Palermo 90127 Italy Department of Surgery Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IsMeTT) University of Pittsburgh Medical Center Palermo 90127 Italy

The shortage of organ donors is a problem worldwide, with approximately 15% of adult patients with lifethreatening liver diseases dying while on the waiting list. The use of cell transplantation for liver disease is an attempt to correct metabolic defects, or to support liver function as a bridge to liver transplantation and, as such, has raised a number of expectations. Most of the available studies briefly reported here focus on adult hepatocyte transplantation (HT), and the results are neither reproducible nor comparable, because the means of infusion, amount of injected cells and clinical variability differ among the studies. To better understand the specif ic role of HT in the management of end-stage liver disease, it is important that controlled studies, designed on the principles of evidence-based medicine, be done in order to guarantee the reproducibility of results.

关键词： Hepatocyte transplantation Metabolic dis-eases Chronic liver disease Liver failure Stem cells

Effect of biochar fertilizers on amino acid variability of Secale cereale and Lupinus angustifolius

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Biochar 2019年第2期1卷 187-201页

作者： Katja Wiedner Corinna Schimpf Steven Polifka bruno Glaser Soil Biogeochemistry Institute of Agronomy and Nutritional SciencesMartin Luther University Halle-WittenbergVon-Seckendorff-Platz 306120 Halle(Saale)Germany

Little is known on the effects of biochar on N uptake and amino acid variability in crops such as winter rye and narrow-leafed lupine despite the fact that amino acids are important indicators,for food quality and plant stress.N uptake of both crops showed contrasting results when treated with different biochar *** amino acid contents referred to total nitro-gen generally tend to decrease in rye grains in the presence of biochar;whereas lupine seeds were more or less unaffected by biochar combined with mineral fertilizer or *** lupine seeds,total amino acid contents significantly increased when biochar was mixed with digestate but decreased when mixed with fermented ***,one of the most limiting amino acids in cereals,reached the recommended value of 4 g kg^(−1) in rye grain for most biochar *** lupine seeds,lysine decreased when biochar had been applied but were still in the recommended range when used as animal ***,an indicator for plant stress,significantly decreased(−49%)in rye when 2 Mg biochar ha^(−1) was added in combination with mineral *** contrast,proline increased when biochar was added to organic(digestate and compost)fertilizers(up to 43%).Further biochar research should focus much more on food quality,which is a key challenge for global food production.

关键词： Food quality Protein Lupine Winter rye Yield

Evaluating rehabilitation interventionsin Parkinson's disease with functional MRI:a promising neuroprotective strategy

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Neural Regeneration Research 2015年第5期10卷 702-703页

作者： Carlo Augusto Mallio bruno Beomonte Zobel Carlo Cosimo Quattrocchi Departmental Faculty of Medicine and Surgery Unit of Diagnostic ImagingUniversità Campus Bio-Medico di Roma

Parkinson＇s disease （PD） is a progressive neurodegenerative disorder affecting approximately 10 million people world- wide （Planetta et al., 2014; Zigmond and Smeyne, 2014）. The principal clinical features of PD are bradykinesia, rigidity, tremor at rest and postural instability （Planetta et al., 2014）. It is known that both PD itself and the use of anti-parkinson drugs are associated with several non-motor symptoms such as cognitive impairment, neuropsychiatric disturbances and sleep, autonomic, and sensory disorders （Park and Stacy, 2009; Foster et al., 2014）. The histopathological hallmark of PD is the reduction of dopaminergic cells in the substantia nigra pars compacta, causing dopamine deficiency in spe- cific nuclei of the basal ganglia such as the dorsal striatum （Fearnley and Lees, 1991; Planetta et al., 2014）. The disrup- tion of the dopaminergic system has long been regarded as the major cause of PD; however, it has been shown that a widespread involvement of several non-dopaminergic path- ways also contribute to the clinical manifestations of PD （Park et al., 2014）.

关键词： MRI Evaluating rehabilitation interventionsin Parkinson’s disease with functional MRI

Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia

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World Journal of Gastroenterology 2019年第30期25卷 4261-4277页

作者： Johanna Waidhauser Anne Bornemann Martin Trepel bruno Markl Institute of Pathology and Molecular Diagnostics University Medical Center AugsburgAugsburg 86156Germany Department of Hematology and Clinical Oncology University Medical Center AugsburgAugsburg 86156Germany

BACKGROUND In recent years,increasing evidence of second neoplasms associated with gastrointestinal stromal tumors(GIST)has been *** case reports,mostly retrospective studies and a few reviews,have been *** our knowledge,however,no systematic review or meta-analysis of the existing data has been performed so *** To prepare a compilation,as complete as possible,of all reported second tumor entities that have been described in association with GIST and to systematically analyze the published studies with regard to frequency,localization,and types of GIST-associated *** The MEDLINE and EBSCO databases were searched for a combination of the keywords GIST/secondary,synchronous,coincident/tumor,neoplasm,and relevant publications were selected by two independent *** Initially,3042 publications were *** deletion of duplicates,1631 remained,and 130 papers were selected;22 of these were original studies with a minimum of 20 patients,and 108 were case *** the 22 selected studies,comprising a total number of 12050 patients,an overall rate of GIST-associated neoplasias of 20%could be *** second neoplasias were found in the gastrointestinal tract(32%)and in the male and female urogenital tract(30%).The specific risk scores of GISTs associated with other tumors were significantly lower than those without associated *** In this first systematic review,we could confirm previously reported findings of a more than coincidental association between GIST and other *** question whether there is an underlying causal association will need further *** data suggest that even GIST with a very low risk of disease progression should prompt screening for second neoplasia and subsequent frequent controls or extended staging.

关键词： Gastrointestinal stromal tumor Associated Secondary Neoplasia Tumor

Bone marrow mononuclear cells for joint therapy: The role of macrophages in inflammation resolution and tissue repair

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World Journal of Stem Cells 2021年第7期13卷 825-840页

作者： bruno C Menarim James N MacLeod Linda A Dahlgren Gluck Equine Research Center Department of Veterinary ScienceCollege of AgricultureFood and EnvironmentUniversity of KentuckyLexingtonKY 40546United States Department of Large Animal Clinical Sciences Virginia-Maryland College of Veterinary MedicineVirginia TechBlacksburgVA 24060United States

Osteoarthritis(OA)is the most prevalent joint disease causing major disability and medical *** is a central feature of OA and is primarily driven by *** macrophages not only drive inflammation but also its resolution,through a coordinated,simultaneous expression of pro-and anti-inflammatory mechanisms that are essential to counteract damage and recover *** OA therapies are largely based on anti-inflammatory principles and therefore block pro-inflammatory mechanisms such as prostaglandin E2 and Nuclear factor-kappa B signaling ***,such mechanisms are also innately required for mounting a pro-resolving response,and their blockage often results in chronic low-grade *** minor injury,macrophages shield the damaged area and drive tissue *** the damage is more extensive,macrophages incite inflammation recruiting more macrophages from the bone marrow to maximize tissue repair and ultimately resolve ***,sustained damage and inflammation often overwhelms pro-resolving mechanisms of synovial macrophages leading to the chronic inflammation and related tissue degeneration observed in ***,experimental and clinical studies have shown that joint injection with autologous bone marrow mononuclear cells replenishes inflamed joints with macrophage and hematopoietic progenitors,enhancing mechanisms of inflammation resolution,providing remarkable and long-lasting *** creating an ideal environment for resolution with high concentrations of interleukin-10 and anabolic growth factors,macrophage progenitors also have a direct role in tissue *** constitute a large part of the early granulation tissue,and further transdifferentiate from myeloid into a mesenchymal *** cells,characterized as fibrocytes,are essential for repairing osteochondral ***“omics”studies focused on identifying key drivers of macrophagemediated resolution of j

关键词： Osteoarthritis Arthropathy Synovitis Hematopoietic progenitor Homeostasis Cell therapy

Exact solitary wave solutions of a nonlinear Schrdinger equation model with saturable-like nonlinearities governing modulated waves in a discrete electrical lattice

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Chinese Physics B 2018年第12期27卷 420-430页

作者： Serge bruno Yamgoue Guy Roger Deffo Eric Tala-Tebue Francois Beceau Pelap Department of Physics Higher Teacher Training College BambiliThe University ofBamendaP.O.Box 39Bamenda Cameroon Unite de Recherche de Mecanique et de Modelisation des Systemes Physiques (UR-2MSP) Faculte des SciencesUniversite de DschangBP 69DschangCameroun Department of Telecommunication and Network Engineering Fotso Victor University Institute of TechnologyThe University of DschangP.O.Box 134BandjounCameroon

In this paper, we introduce and propose exact and explicit analytical solutions to a novel model of the nonlinear Schr¨odinger(NLS) equation. This model is derived as the equation governing the dynamics of modulated cutoff waves in a discrete nonlinear electrical lattice. It is characterized by the addition of two terms that involve time derivatives to the classical equation. Through those terms, our model is also tantamount to a generalized NLS equation with saturable;which suggests that the discrete electrical transmission lines can potentially be used to experimentally investigate wave propagation in media that are modeled by such type of nonlinearity. We demonstrate that the new terms can enlarge considerably the forms of the solutions as compared to similar NLS-type equations. Sine–Gordon expansion-method is used to derive numerous kink, antikink, dark, and bright soliton solutions.

关键词： nonlinear Schrdinger equation nonlinear time derivative terms saturable nonlinearity exact solitary solutions

Single ventricle:amphibians and human beings

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World Journal of Pediatrics 2022年第10期18卷 643-646页

作者： Paolo Angelini bruno Marino Antonio F.Corno Texas Heart Medical Group Texas Heart InstituteBaylor CollegeHoustonTX77030USA Department of Pediatrics Obstetrics and GynecologyUniversity La Sapienza00161RomeItaly Children’s Heart Institute McGovern Medical SchoolMemorial Hermann Children’s HospitalUniversity of Texas Health Science Center in Houston6410 Fannin StreetMSB 6.274HoustonTX77030USA

Survival to adult life in patients born with“functionally”single ventricle,without any surgical treatment,as natural history,is extremely rarely reported[1,2,3,4,5,6,7].In general,these group of patients with“functionally”single ventricle are symptomatic from the first weeks of life,and require two to three staged operations to obtain that the single ventricle pumps the oxygenated blood to the systemic circulation,while the less oxygenated blood is deviated by gravity from the superior and inferior vena cava directly to the lungs[1,8,9].The result of this artificial“Fontan circulation”is high systemic venous pressure,and the chronic elevation of the systemic venous pressure may results in liver failure,renal failure.

关键词： ventricle Survival operations

Snow gliding and loading under two different forest stands: a case study in the north-western Italian Alps

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Journal of Forestry Research 2013年第4期24卷 633-642页

作者： Davide Viglietti Margherita Maggioni Enrico bruno Ermanno Zanini Michele Freppaz University of Torino-Dipartimento di Scienze Agrarie Forestalie Alimentari and NatRisk-LNSA Via L.

The presence of a thick snowpack could interfere with forest stability, especially on steep slopes with potential damages for young and old stands. The study of snow gliding in forests is rather complex be- cause this phenomenon could be influenced not only by forest features, but also by snow/soil interface characteristics, site morphology, meteoro- logical conditions and snow physical properties. Our starting hypothesis is that different forest stands have an influence on the snowpack evolu- tion and on the temperature and moisture at the snow/soil interface, which subsequently could affect snow gliding processes and snow forces. The aim of this work is therefore to analyse the snowpack evolution and snow gliding movements under different forest covers, in order to deter- mine the snow forces acting on single trees.

关键词： snow/soil interface temperature water content snow forces trees

m^(6)A Profile Dynamics Indicates Regulation of Oyster Development by m^(6)A-RNA Epitranscriptomes

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Genomics, Proteomics & Bioinformatics 2023年第4期21卷 742-755页

作者： Lorane Le Franc bruno Petton Pascal Favrel Guillaume Rivière Laboratoire de Biologie des Organismes et des Ecosyste`mes Aquatiques(BOREA) Muséum d’Histoire NaturelleSorbonne UniversitéUniversitéde Caen NormandieUniversitédes AntillesCNRS UMR 8067IRD14032 CaenFrance Ifremer Laboratoire des Sciences de l’Environnement MarinUMR 6539 CNRS/UBO/IRD/IfremerCentre Bretagne29280 PlouzanéFrance

The N6-methylation of RNA adenosines(N6-methyladenosine,m^(6)A)is an important regulator of gene expression with critical implications in vertebrate and insect ***,the developmental significance of epitranscriptomes in lophotrochozoan organisms remains *** methylated RNA immunoprecipitation sequencing(MeRIP-seq),we generated transcriptome-wide m^(6)A-RNA methylomes covering the entire development of the oyster from oocytes to *** RNA classes display specific m^(6)A signatures,with messenger RNAs(mRNAs)and long non-coding RNAs(lncRNAs)exhibiting distinct profiles and being highly methylated compared to transposable element(TE)*** are dynamic and correspond to the chronological steps of development(cleavage,gastrulation,organogenesis,and metamorphosis),with minimal mRNA and lncRNA methylation at the morula stage followed by a global *** m^(6)A levels are correlated with transcript levels,and shifts in methylation profiles correspond to expression *** methylated transcripts cluster according to embryo-larval stages and bear the corresponding developmental functions(cell division,signal transduction,morphogenesis,and cell differentiation).The m^(6)A level of TE transcripts is also regulated and peaks during the *** demonstrate that m^(6)A-RNA methylomes are dynamic and associated with gene expression regulation during oyster *** putative epitranscriptome implication in the cleavage,maternal-to-zygotic transition,and cell differentiation in a lophotrochozoan model brings new insights into the control and evolution of developmental processes.

关键词： RNA methylation Transcription Embryo Metamorphosis Evo-devo