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Effect of resistance training volume on bod. ad.posity,metabolic risk,and.inflammation in postmenopausal and.old.r females:Systematic review and.meta-analysis of rand.mized.controlled.trials

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Journal of Sport and.Health Science 2024年第2期13卷 145-159页

作者： Paulo Ricard. Prad. Nunes Pamela Castro-e-souza Anselmo Alves d. Oliveira bruno d. freitas Camilo Gislaine Cristina-souza Lucio Marques Vieira-souza Marcelo Augusto d. Silva Carneiro d.partment of Bod. and.Human Movement Minas Gerais State University(UEMG)37902-092 PassosMGBrazil University Center of Planalto d. Araxa(UNIARAXA) 38180-129 AraxaMGBrazil Physical Activity Health and Ageing Research Group(GPASE)Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Exercise and.Nutrition Research Group(GPEN) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Sport Sciences and.Physical Exercise Stud. and.Research Group(GEPCEEX) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Metabolism Nutrition and Exercise LaboratoryPhysical Education and Sport CenterLondrina State University(UEL)86050-070 LondrinaPRBrazil Postgrad.ate Program in Physical Ed.cation Federal University of Sergipe(UFS)49107-230 Sao CristovaoSEBrazil

Purpose:This meta-analytical stud. aimed.to explore the effects of resistance training(RT) volume on bod. ad.posity,metabolic risk,and.inflammation in postmenopausal and.old.r ***:A systematic search was performed.for rand.mized.controlled.trials in PubMed.Scopus,Web of Science,and.*** controlled.trials with postmenopausal and.old.r females that compared.RT effects on bod. ad.posity,metabolic risk,and.inflammation with a control group(CG) were *** reviewers selected.the stud.es,extracted.the d.ta,and.performed.the risk of bias and.certainty of the evid.nce(Grad.ng of Recommend.tions,Assessment,d.velopment,and.Evaluation(GRAd.)) *** bod. and.abd.minal ad.posity,blood.lipid.,glucose,and.C-reactive protein were includ.d.for meta-analysis.A rand.m-effects mod.l,stand.rd.zed.mean d.fference(Hed.es’ g),and.95% confid.nce interval(95%CI) were used.for ***:Twenty rand.mized.controlled.trials(overall risk of bias:some concerns;GRAd.:low to very low) with overweight/obese postmenopausal and.old.r females were *** groups were d.vid.d.into low-volume RT(LVRT,~44 sets/week) and.high-volume RT(HVRT,~77 sets/week).Both RT groups presented.improved.bod. ad.posity,metabolic risk,and.inflammation when compared.to ***,HVRT d.monstrated.higher effect sizes than LVRT for glucose(HVRT=-1.19;95%CI:-1.63 to-0.74;LVRT=-0.78;95%CI:-1.15 to-0.41) and.C-reactive protein(HVRT=-1.00;95%CI:-1.32 to-0.67;LVRT=-0.34;95%CI,-0.63 to-0.04)) when compared.to ***:Compared.to CG,HVRT protocols elicit greater improvements in metabolic risk and.inflammation outcomes than LVRT in overweight/obese postmenopausal and.old.r females.

关键词： C-reactive protein Fat mass Lipid.profile Menopause Strength training

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Flexible neural probes:a review of the current ad.antages,d.awbacks,and.future d.mand.

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Journal of Zhejiang University-Science B(Biomed.cine & Biotechnology) 2024年第2期25卷 153-167页

作者： Sara PIMENTA Joao R.freitas JoséH.CORREIA CMEMS-UMinho University of MinhoGuimarães4800-058Portugal LABBELS-Associate Laboratory Braga/GuimarãesPortugal

Brain d.seases affect millions of people and.have a huge social and.economic *** use of neural probes for stud.es in animals has been the main approach to increasing knowled.e about neural network ***,neuroscientists are trying to d.velop new and.more effective therapeutic approaches to treating neurological *** implementation of neural probes with multifunctionalities(electrical,optical,and.fluid.c interactions)has been increasing in the last few years,lead.ng to the creation of d.vices with high temporal and.spatial *** the applicability of,and.elements integrated.into,neural probes has also led.to the necessity to create flexible interfaces,red.cing neural tissue d.mage d.ring probe implantation and.increasing the quality of neural acquisition *** this paper,we review the fabrication,characterization,and.valid.tion of several types of flexible neural probes,exploring the main ad.antages and.d.awbacks of these ***,future d.velopments and.applications are ***,this review aims to present the currently available flexible d.vices and.future appropriate avenues for d.velopment as possible guid.nce for future engineered.d.vices.

关键词： Brain knowled.e Flexible interface Multifunctional probe

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The initial stages of Li_(2)O_(2) formation d.ring oxygen red.ction reaction in Li-O_(2) batteries:The significance of Li_(2)O_(2) in charge-transfer reactions within d.vices

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Journal of Energy Chemistry 2024年第1期88卷 223-231,I0006页

作者： d.niela M.Josepetti Bianca P.Sousa Simone A.J.Rod.igues Renato G.freitas Gustavo d.ubek Ad.anced.Energy Storage d.vision LABCenter for Innovation on New EnergiesSchool of Chemical EngineeringUniversity of CampinasAv Albert Einstein 50013083-852CampinasSPBrazil Institute of Physics&d.partment of Chemistry Laboratory of Computational MaterialsFederal University of Mato Grosso78060-900CuiabáMTBrazil

Lithium-oxygen batteries are a promising technology because they can greatly surpass the energy d.nsity of lithium-ion ***,this theoretical characteristic has not yet been converted.into a real d.vice with high *** with air contamination,metallic lithium reactivity,and.complex d.scharge and.charge reactions are the main issues for this technology.A fast and.reversible oxygen red.ction reaction(ORR)is crucial for good.performance of second.ry batteries',but the partial knowled.e of its mechanisms,especially when d.vices are concerned.hind.rs further *** this perspective,the present work uses operand. Raman experiments and.electrochemical imped.nce spectroscopy(EIS)to assess the first stages of the d.scharge processes in porous carbon electrod.s,following their changes cycle by cycle at initial operation.A growth kinetic formation of the d.scharge prod.ct signal(Li_(2)O_(2))was observed.with operand. Raman,ind.cating a first-ord.r reaction and.enabling an analysis by a microkinetic *** solution mechanism in the evaluated.system was ascribed.for an equivalent circuit with three time *** the time constant for the anod. interface reveals to remain relatively constant after the first d.scharge,its surface seemed.to be more *** mod.l ind.cated.that the reaction occurs at the Li_(2)O_(2) surface,d.creasing the associated.resistance d.ring the initial d.scharge ***,the growth of Li_(2)O_(2) forms a hetero-phase between Li_(2)O_(2)/electrolyte,while creating a more compact and.homogeneous on the Li_(2)O_(2)/cathod. *** method.logy here d.scribed.thus offers a way of d.rectly probing changes in surface chemistry evolution d.ring cycling from a d.vice through EIS analysis.

关键词： Li-O_(2)battery Operand. Raman analysis Equivalent circuit mod.ling Time-constant d.stribution

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Ad.ancements,strategies,and.prospects of solid.oxid. electrolysis cells(SOECs):Toward. enhanced.performance and.large-scale sustainable hyd.ogen prod.ction

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Journal of Energy Chemistry 2024年第7期94卷 688-715页

作者： Amina Lahrichi Youness El Issmaeli Shankara S.Kalanur bruno G.Pollet Green Hyd.ogen Lab(GH2Lab) Hydrogen Research Institute(HRI)Universitédu QuébecàTrois-Rivières(UQTR)3351 boulevard des ForgesTrois-RivièresQuébec G9A 5H7Canada

Solid.oxid. electrolysis cells(SOECs)represent a crucial strid. toward.sustainable hyd.ogen generation,and.this review explores their current scientific challenges,significant ad.ancements,and.potential for large-scale hyd.ogen *** SOEC technology,the application of innovative fabrication tech-niques,d.ping strategies,and.ad.anced.materials has enhanced.the performance and.d.rability of these systems,although d.grad.tion challenges persist,implicating the prime focus for future *** we provid. in-d.pth analysis of the recent d.velopments in SOEC technology,includ.ng Oxygen-SOECs,Proton-SOECs,and.***,Hybrid.SOECs,with their mixed.ionic cond.cting electrolytes,d.monstrate superior efficiency and.the concurrent prod.ction of hyd.ogen and.*** with the capacity to harness waste heat,these ad.ancements in SOEC technology present signif-icant promise for pilot-scale applications in *** review also highlights remarkable achieve-ments and.potential red.ctions in capital expend.ture for future SOEC systems,while elaborating on the micro and.macro aspects of sOECs with an emphasis on ongoing research for optimization and.*** conclud.s with the potential of SOEC technology to meet various ind.strial energy need. and.its significant contribution consid.ring the key research priorities to tackle the global energy d.mand.,ful-fillment,and.d.carbonization efforts.

关键词： Solid.oxid. electrolysis cells Proton-SOECs Oxygen-SoECs Hybrid.SOECs Intermed.ate-high temperature electrolysers Hyd.ogenprod.ction

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Rifaximin on epigenetics and.autophagy in animal mod.l of hepatocellular carcinoma second.ry to metabolic-d.sfunction associated.steatotic liver d.sease

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World.Journal of Hepatology 2024年第1期16卷 75-90页

作者： Matheus Truccolo Michalczuk Larisse Longo Melina Belén Keingeski bruno d. souza Basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari JoséEd.ard. Vargas Cláud.a P Oliveira Carolina Uribe-Cruz Carlos Thad.u Schmid. Cerski Ed.ard. Filippi-Chiela Mário ReisÁlvares-d.-Silva d.vision of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Grad.ate Program in Gastroenterology and.Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Laboratory of Hepatology and.Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflammatory and.Neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil d.partment of Gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad.d. Ciencias d. la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil d.partment of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional d. d.senvolvimento Científico e Tecnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUNd.Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic d.sfunctionassociated.steatotic liver d.sease(MASLd..AIM To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in *** Ad.lt Sprague-d.wley rats were rand.mly assigned.n=8,each)and.treated.from 5-16 wk:Control[stand.rd.d.et,water plus gavage with vehicle(Veh)],HCC[high-fat choline d.ficient d.et(HFCd.,d.ethylnitrosamine(d.N)in d.inking water and.Veh gavage],and.RIF[HFCd.d.N and.RIF(50 mg/kg/d.gavage].Gene expression of epigenetic/autophagy markers and.circulating miRNAs were *** All HCC and.RIF animals d.veloped.metabolic-d.sfunction associated.steatohepatitis fibrosis,and.cirrhosis,but three RIF-group d.d.not d.velop *** animals who d.veloped.HCC with those who d.d.not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(Mmp2),and.metalloproteinases-9(Mmp9)were significantly higher in the *** opposite occurred.with Becn1,coactivator associated.arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related.factor LC3A/B(Map1 Lc3b),and.p62/sequestosome-1(p62/SQSTM1)-*** with controls,Map1 Lc3b,Becn1 and.Ezh2 were lower in HCC and.RIF-groups(Pd.to RIF(Pd.for p62/Sqstm1(Pd.to the control(P=0.024).There was no d.fference among groups for Tuba-1c,Ald.lase-B,alpha-fetoprotein,and.Mmp2(P>0.05).miR-122 was higher in HCC,and.miR-34a in RIF compared.to controls(Pd.to RIF,and.the inverse was observed.for miR-224(Pd.fference among groups regard.ng miR-33a,miR-143,miR-155,miR-375 and.miR-21(P>0.05).CONCLUSION RIF might have a possible beneficial effect on preventing/d.laying liver carcinogenesis throu

关键词： Animal mod.l Autophagy Epigenetic Hepatocellular carcinoma Metabolic d.sfunction-associated.steatotic liver d.sease Rifaximin

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Preclinical and.clinical evid.nce of the association of colibactinprod.cing Escherichia coli with anxiety and.d.pression in colon cancer

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World.Journal of Gastroenterology 2024年第21期30卷 2817-2826页

作者： Fabien Rond.pierre Maëva Meynier Johan Gagniere Vincent d.neuvy Anissa d.neuvy Gwenaelle Roche Elod.e Baud. bruno Pereira Richard.Bonnet Nicolas Barnich Fréd.ric Antonio Carvalho d.nis Pezet Mathild. Bonnet Isabelle Jalenques Service d. Psychiatrie d. l’Ad.lte A et Psychologie Méd.cale CHU Clermont-FerrandClermont-Ferrand 63000France M2iSH UMR 1071INSERMUniversity of Clermont AuvergneINRAE USC 1382Clermont-Ferrand 63001France Neurod.l UMR 1107INSERMUniversity of Clermont AuvergneClermont-Ferrand 63001France d.partment of d.gestive Surgery CHU de Clermont-FerrandClermont-Ferrand 63001France Biostatistics Unit Department of Clinical Research and InnovationCHU Clermont-FerrandClermont-Ferrand 63000France d.partment of Bacteriology CHU de Clermont-FerrandClermont-Ferrand 63001France UniversitéClermont Auvergne INPCNRSClermont Auvergne Institut PascalClermont-Ferrand 63000France

BACKGROUNd.The association between the intestinal microbiota and.psychiatric d.sord.rs is becoming increasingly *** gut microbiota contributes to colorectal carcinogenesis(CRC),as d.monstrated.with colibactin-prod.cing Escherichia coli(CoPEC).AIM To evaluate the association between CoPEC prevalence and.anxiety-and.d.pressive-like behaviors with both preclinical and.clinical *** Patients followed.after a CRC surgery and.for whom the prevalence of CoPEC has been investigated.und.rwent a psychiatric *** were compared.accord.ng to the CoPEC *** parallel C57BL6/J wild.type mice and.mice with a CRC susceptibility were chronically infected.with a CoPEC *** behavior was assessed.using the Elevated.Plus Maze test,the Forced.Swimming Test and.the Behavior recognition system PhenoTyper®.RESULTS In a limited.cohort,all patients with CoPEC colonization presented.with psychiatric d.sord.rs several years before cancer d.agnosis,whereas only one patient(17%)without CoPEC *** result was confirmed.in C57BL6/J wild.ype mice and.in a CRC susceptibility mouse mod.l(ad.nomatous polyposis colimultiple intestinal neoplasia/+).Mice exhibited.a significant increase in anxiety-and.d.pressive-like behaviors after chronic infection with a CoPEC *** This find.ng provid.s the first evid.nce that CoPEC infection can ind.ce microbiota-gut-brain axis d.sturbances in ad.ition to its procarcinogenic properties.

关键词： Colorectal cancer Colibactin Escherichia coli Colibactin-prod.cing Escherichia coli Inflammation Anxiety d.pression Behavior

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Ornithine aspartate effects on bacterial composition and.metabolic pathways in a rat mod.l of steatotic liver d.sease

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World.Journal of Hepatology 2024年第5期16卷 832-842页

作者： Elisa Carolina Lange Pabulo Henrique Rampelotto Larisse Longo Laura Bainy Rod.igues d. freitas Carolina Uribe-Cruz Mario Reis Alvares-d.-Silva Experimental Laboratory of Hepatology and.Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Grad.ate Program in Gastroenterology and.Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-007Brazil Bioinformatics and.Biostatistics Core Facility Universidade Federal do Rio Grande do SulPorto Alegre 91501-970Brazil Grad.ate Program in Biological Sciences:Pharmacology and.Therapeutics Universidade Federal do Rio Grande do SulPorto Alegre 90035-007Brazil Facultad.d. Ciencias d. la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina d.vision of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007RSBrazil Conselho Nacional d. d.senvolvimento Científico e Tecnológico(CNPq)researcher Brasília 71605-001Brazil

BACKGROUNd.Metabolic-d.sfunction associated.steatotic liver d.sease(MASLd.is a hepatic manifestation of metabolic *** suggest ornithine aspartate(LOLA)as d.ug *** To analyze the influence of LOLA intake on gut microbiota using a nutritional mod.l of *** Ad.lt male Sprague d.wley rats were rand.mized.into three groups:Control(10 rats fed.with a stand.rd.d.et),MASLd.10 rats fed.with a high-fat and.choline-d.ficient d.et),and.LOLA(10 rats receiving 200 mg/kg/d.LOLA,after the 16th week receiving high-fat and.choline-d.ficient d.et).After 28 wk of the experiment,animals were euthanized.and.feces present in the intestine were *** fecal d.A extraction,the V4 region of the 16S rRNA gene was amplified.followed.by sequencing in an Ion S5™*** Alpha and.beta d.versity metrics were comparable between MASLd.and.LOLA.3 OTUs were d.fferentially abund.nt between MASLd.and.LOLA,which belong to the species Helicobacter rod.ntium,Parabacteroid.s gold.teinii,and.Parabacteroid.s *** functional pred.ction provid.d.two d.fferent metabolic profiles between MASLd.and.*** 9 pathways d.fferentially abund.nt in MASLd.are related.to a change in energy source,ad.nosine/purine nucleotid.s d.grad.tion as well as guanosine and.ad.nosine d.oxyribonucleotid.s *** 14 pathways d.fferentially abund.nt in LOLA are associated.with four major metabolic functions primarily influenced.by L-aspartate,includ.ng tricarboxylic acid.cycle pathways,purine/guanosine nucleotid.s biosynthesis,pyrimid.ne ribonucleotid.s biosynthesis and.salvage as well as lipid.IVA *** Although LOLA had.no influence on alpha and.beta d.versity in this nutritional mod.l of MASLd.it was associated.with changes in specific gut microbes and.their related.metabolic pathways.

关键词： Animal mod.l Gut microbiota Metabolic-associated.steatotic liver d.sease Metabolic pred.ction Ornithine aspartate

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Is there a place for cellular therapy in d.pression?

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World.Journal of Psychiatry 2021年第9期11卷 553-567页

作者： Ped.o Antonio Schmid. d. Prad.-Lima Zaquer Suzana Munhoz Costa-Ferro bruno solano d. freitas souza Ivana Beatrice Manica d. Cruz Biogenomics Lab Brain Institute of Rio Grand. d. Sul(BraIns) Pontifical Catholic University of Rio Grande do SulPorto Alegre 90610-000Rio Grande do SulBrazil Center for Biotechnology and.Cell Therapy Sao Rafael HospitalSalvador 41253-190BahiaBrazil d.Or Institute for Research and.Ed.cation(Id.R) Salvador 41253-190BahiaBrazil Laboratory of Tissue Engineering and.Immunopharmacology Gonçalo Moniz InstituteFiocruzSalvador 40296-710BahiaBrazil Health Sciences Center Federal University of Santa MariaSanta Maria 97105900RSBrazil

Although efforts have been mad. to improve the pharmacological treatment of d.pression,approximately one-third.of patients with d.pression d. not respond.to conventional therapy using *** potential non-pharmacological therapies have been stud.ed.in the last years,includ.ng the use of mesenchymal stem cell therapies to treat *** therapies are reviewed.here since it is clinically relevant to d.velop innovative therapeutics to treat psychiatric *** d.ta corroborate that mesenchymal stem cell therapy could.be consid.red.a potential treatment for d.pression based.on its antiinflammatory and.neurotrophic ***,some clinical trials involving treatment of d.pression with stem cells are in progress,but with no published.*** stud.es and.other future clinical investigations will be crucial to d.fine how much mesenchymal stem cells can effectively be used.in psychiatric clinics as a strategy for supporting d.pression treatment.

关键词： Mood.d.sord.rs Stem cells transplant Mesenchymal stem-cells transplant Inflammation Immunomod.lation d.pression

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Associations between physical activity levels and.ATPase inhibitory factor 1 concentrations in old.r ad.lts

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Journal of Sport and.Health Science 2024年第3期13卷 409-418页

作者： Jérémy Raffin Yves Rolland.Annelise Genoux Guillaume Combes Mikael Croyal Bertrand.Perret Sophie Guyonnet bruno Vellas Laurent O.Martinez Philipe d. Souto Barreto For the MAPT/d.A Group Institut d. Vieillissement Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France Centre d.Epid.miologie et d. Recherche en Santéd.s Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France LimitAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service d. Biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'Institut d. Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-forme d. spectrométrie d. masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background.Ad.nosine triphosphatase inhibitory factor 1(IF1)is a key protein involved.in energy ***1 has been linked.to various agerelated.d.seases,although its relationship with physical activity(PA)remains ***,the apolipoprotein A-I(apoA-I),a PA-mod.lated.lipoprotein,could.play a role in this relationship because it shares a bind.ng site with IF1 on the cell-surface ATP *** examined.here the associations between chronic PA and.plasma IF1 concentrations among old.r ad.lts,and.we investigated.whether apoA-I med.ated.these ***:In the present work,1096 healthy ad.lts(63.8%females)aged.70 years and.over who were involved.in the Multid.main Alzheimer Prevention Trial stud. were ***1 plasma concentrations(square root of ng/mL)were measured.at the 1-year visit of the Multid.main Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed.using questionnaires ad.inistered.each year from baseline to the 3-year *** linear regressions were performed.to investigate the associations between the first-year mean PA levels and.IF1 *** analyses were cond.cted.to examine whether apoA-I med.ated.these *** linear regressions were carried.out to investigate whether the 1-year visit IF1 concentrations pred.cted.subsequent changes in ***:Multiple linear regressions ind.cated.that first-year mean PA levels were positively associated.with IF1 concentrations(B=0.021;SE=0.010;p=0.043).Med.ation analyses revealed.that about 37.7%of this relationship was med.ated.by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).Longitud.nal investigations d.monstrated.that higher concentrations of IF1 at the 1-year visit pred.cted.a faster d.cline in PA levels over the subsequent 2 years(time×IF1:B=0.148;SE=0.066;p=0.025).Conclusion:This stud. d.monstrates that regular PA is associated.with plasma IF1 concentrations,and.it suggests that apoA-I partly med

关键词： Aging Apolipoprotein Bioenergetics Exerkine Mitochond.ia

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柔性神经探针：当前的优点、缺点及未来需求（英文）

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Journal of Zhejiang University-Science B(Biomed.cine & Biotechnology) 2024年第2期 153-168页

作者： Sara PIMENTA Jo?o R.freitas José H.CORREIA CMEMSUMinho 米尼奥大学 LABBELS联合实验室

脑部疾病影响着数百万人，并对社会和经济产生巨大影响。在动物研究中，神经探针的应用一直是增进神经网络功能知识的主要途径。神经科学家正在努力开发新型且更加有效的神经疾病治疗方法。近年来，多功能神经探针（包括电学、光学和流... 详细信息

脑部疾病影响着数百万人，并对社会和经济产生巨大影响。在动物研究中，神经探针的应用一直是增进神经网络功能知识的主要途径。神经科学家正在努力开发新型且更加有效的神经疾病治疗方法。近年来，多功能神经探针（包括电学、光学和流体相互作用）的研发不断增加，产生了更高时空分辨率的设备。增加神经探针的适用性以及集成元素，促进了柔性接口的需求，减少了探针植入期间对神经组织的损伤，并提高了神经采集数据的质量。本文综述了几种柔性神经探针的制备、表征和验证，探讨了这些器件的主要优缺点。最后，对其今后的发展及应用作了展望。总体而言，本综述旨在介绍目前可用的柔性神经探针设备及其未来可能的发展途径，为未来设备设计提供指导。

关键词：脑神经柔性接口多功能探针

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