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Orbital angular momentum based intra- and interparticle entangled states generated via a quantum dot source

先进光子学(英文) 2023年第4期5卷 74-84页

作者： Alessia Suprano Danilo Zia Mathias Pont Taira Giordani Giovanni Rodari Mauro Valeri bruno piccirillo Gonzalo Carvacho Nicolo Spagnolo Pascale Senellart Lorenzo Marrucci Fabio Sciarrino Sapienza Universitàdi Roma Dipartimento di FisicaRomaItaly Universite Paris-Saclay UMR 9001Centre for Nanosciences and NanotechnologyCNRSPalaiseauFrance Universitàdi Napoli Federico II Complesso Universitario di Monte Sant’AngeloDipartimento di Fisica“Ettore Pancini”NapoliItaly INFN-Sezione di Napoli NapoliItaly

Engineering single-photon states endowed with orbital angular momentum (OAM) is a powerful toolfor quantum information photonic implementations. Indeed, due to its unbounded nature, OAM is suitable forencoding qudits, allowing a single carrier to transport a large amount of information. Most of the experimentalplatforms employ spontaneous parametric down-conversion processes to generate single photons, evenif this approach is intrinsically probabilistic, leading to scalability issues for an increasing number of qudits.Semiconductor quantum dots (QDs) have been used to get over these limitations by producing on-demand pure and indistinguishable single-photon states, although only recently they have been exploitedto create OAM modes. Our work employs a bright QD single-photon source to generate a complete set ofquantum states for information processing with OAM-endowed photons. We first study hybrid intraparticleentanglement between OAM and polarization degrees of freedom of a single photon whose preparationwas certified by means of Hong–Ou–Mandel visibility. Then, we investigate hybrid interparticle OAM-based entanglement by exploiting a probabilistic entangling gate. The performance of our approach isassessed by performing quantum state tomography and violating Bell inequalities. Our results pave theway for the use of deterministic sources for the on-demand generation of photonic high-dimensionalquantum states.

关键词： orbital angular momentum quantum dot intraparticle entanglement interparticle entanglement Bell violation

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Is human hepatocellular carcinoma a hormone-responsive tumor?

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World Journal of Gastroenterology 2008年第11期14卷 1682-1689页

作者： Massimo Di Maio bruno Daniele Sandro Pignata Ciro Gallo Ermelinda De Maio Alessandro Morabito Maria Carmela piccirillo Francesco Perrone Medical Oncology "N.Giannettasio"Hospital Rossano 87068Italy Medical Oncology "G.Rummo"Hospital Benevento 82100Italy Medical Oncology B National Cancer Institute Napoli 80131Italy Department of Medicine and Public Health Second University of NapoliNapoli 80138Italy Clinical Trials Unit National Cancer InstituteNapoli 80131Italy Clinical Trials Unit National Cancer InstituteVia M.SemmolaNapoli 80131 Italy

Before the positive results recently obtained with multitarget tyrosine kinase inhibitor sorafenib,there was no standard systemic treatment for patients with advanced hepatocellular carcinoma(HCC).Sex hormones receptors are expressed in a significant proportion of HCC samples.Following preclinical and epidemiological studies supporting a relationship between sex hormones and HCC tumorigenesis,several randomized controlled trials (RCTs)tested the efficacy of the anti-estrogen tamoxifen as systemic treatment.Largest among these trials showed no survival advantage from the administration of tamoxifen,and the recent Cochrane systematic review produced a completely negative result.This questions the relevance of estrogen receptor-mediated pathways in HCC.However,a possible explanation for these disappointing results is the lack of proper patients selection according to sex hormones receptors expression,but unfortunately the interaction between this expression and efficacy of tamoxifen has not been studied adequately.It has been also proposed that negative results might be explained if tamoxifen acts in HCC via an estrogen receptor-independent pathway,that requires higher doses than those usually administered, but an Asian RCT conducted to assess dose-response effect was completely negative.Interesting,preliminaryresults have been obtained when hormonal treatment (tamoxifen or megestrol)has been selected according to the presence of wild-type or variant estrogen receptors respectively,but no large RCTs are available to support this strategy.Negative results have been obtained also with anti-androgen therapy.In conclusion,there is no robust evidence to consider HCC a hormone-responsive tumor.Hormonal treatments should not be part of the current management of HCC.

关键词：肝细胞癌性激素荷尔蒙三苯氧胺

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