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Neurocognitive sequelae of cerebral malaria in adults: A pilot study in Benguela Central Hospital, Angola

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Asian Pacific Journal of Tropical Biomedicine 2013年第7期3卷 532-535页

作者： bruno Peixoto Isabel Kalei Sciences Department of the Instituto Superior de Ciências da Saúde-Norte (CESPU) Research Unit on Psychology and HealthGandra Portugal Central Hospital of Benguela Benguela Angola

Objective:To characterize the neurocognitive sequelae of cerebral malaria(CM)in an adultsample of the city of Benguela,***:A neuropsychological assessment was carriedout in 22 subjects with prior history of CM ranging from 6 to 12 months after the *** results were compared to a control group with no previous history of cerebral *** study was conducted in Benguela Central Hospital,Angola in ***:CM groupobtained lower results on the two last trials of a verbal learning task and on an abstract ***:CM is associated to a slower verbal learning rate and to difficulties in theability to discriminate and perceive relations between new elements.

关键词： Cognition Neuropsychological assessment Verbal learning Abstract reasoning Plasmodium falciparum Angola

Gregarious pupation act as a defensive mechanism against cannibalism and intraguild predation

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Insect Science 2016年第4期23卷 612-620页

作者： Claudia Roberge bruno Frechette Genevieve Labrie Francois Dumont Eric Lucas Universite du Quebec a Montreal Departement des Sciences Biologiques CP 8888 Succ. Centre Ville Montreal Centre de recherche sur les grains Inc (CEROM) 740 chemin Trudeau St-Mathieu-de-Beloeil Quebec J3G OE2 Canada

Coccinellid pupae use an array of defensive strategies against their natural enemies. This study aims to assess the efficiency of gregarious pupation as a defensive mechanism against intraguild predators and cannibals in coccinellid. The study was designed specifically （i） to determine the natural occurrence of gregarious pupation in the field for different coccinellid species, and （ii） to evaluate the adaptive value of gregarious pupation as a defensive mechanism against 2 types of predators （i.e., cannibals and intraguild predators）. In the field, gregarious pupation consisted of a group of 2-5 pupae. The proportion of gregarious pupation observed varied according to species, the highest rate being observed with Harmonia axyridis Pallas （Coccinellidae; 14.17%）. Gregarious pupation had no impact on the probability that intraguild predators and cannibals locate pupae. Intraguild predation occurred more often in site with gregarious pupation, while cannibalism occurred as often in site with gregarious pupation as in site with isolated pupa. However, for a specific pupa, the mortality rate was higher for isolated pupae than for pupae located in a gregarious pupation site both in the presence of intraguild predators and in the presence of cannibals. The spatial location of pupae within the group had no impact on mortality rate. Since it reduces the risk of predation, it is proposed that gregarious pupation act as a defensive mechanism for 11. axyridis pupae.

关键词： attack abatement Coccinellidae dilution effect encounter effect grouping behavior Pentatomidae Selfish herd

Initial failures of anti-tau antibodies in Alzheimer’s disease are reminiscent of the amyloid-βstory

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Neural Regeneration Research 2023年第1期18卷 117-118页

作者： bruno P.Imbimbo Claudia Balducci Stefania Ippati Mark Watling Department of Research&Development Chiesi FarmaceuticiParmaItaly Department of Neuroscience Istituto di Ricerche Farmacologiche“Mario Negri”IRCCSMilanItaly San Raffaele Scientific Institute San Raffaele HospitalMilanItaly CNS&Pain Department TranScrip Ltd.ReadingUK

Tau is an important protein of the central nervous system formed by 352-441 amino acids and encoded by the MAPT(microtubule-associated protein tau)gene on chromosome 17 which generates 6 *** is located in axons,dendrites,nucleus,cell membrane,and synapses of *** protein is also expressed to a lesser extent in astrocytes and oligodendrocytes,although its role in these cells has been little *** protein is also present in the interstitial fluid and can cross into the cerebrospinal fluid(CSF)and reach the systemic circulation.

关键词： tau Alzheimer cerebrospinal

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New insights into the systematics of Entomobryoidea(Collembola: Entomobryomorpha): first instar chaetotaxy, homology and classification

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Zoological Systematics 2019年第4期44卷 249-278页

作者： Feng Zhang bruno CBellini Felipe NSoto-Adames Department of Entomology College of Plant ProtectionNanjing Agricultural UniversityNanjing 210095China Department of Botany and Zoology Biosciences CenterFederal University of Rio Grande do NorteNatalBrazil Division of Plant Industry Florida Department of Agriculture and Consumer ServicesGainesvilleFL 32608USA

The largest superfamily Entomobryoidea is one of the key groups in ***,incorrect recognition of chaetotaxic homology within Entomobryoidea severely impedes the accurate species comparison of adults and phylogenetic *** classification of the superfamily at suprageneric level is disputable in the light of recent *** homology of tergal chaetotaxy was traced and revised based on 38 species of first instar and partial early *** phylogenetic reconstructions were reconstructed mainly relying on first instar characters using both parsimony and likelihoodbased *** selection and several rogue taxa impacted on resolution and support of otherwise well-supported *** published molecular phylogeny,a revised classification of three families and nine subfamilies was presented:Orchesellidae,Entomobryidae and *** includes all basal taxa having a short fourth abdominal *** and Microfalculidae taxa were sunk into *** Paronellidae was divided into two subfamilies:Paronellinae(Paronellini+Cyphoderini+Bromacanthini)and Salininae(Cremastocephalini+Callyntrurini).Microfalculidae(Microfalcula)was closer to Salina and Akabosia and thus transferred into *** study erected a new classification framework for Entomobryoidea based upon comprehensive *** homologization across a wide range provided a standardized,comparable,powerful tool for taxonomy.

关键词： Phylogeny chaetotaxic homologization Orchesellidae Entomobryidae Paronellidae.

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Diagnostic and therapeutic management of hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第42期21卷 12003-12021页

作者： Francesco Bellissimo Marilia Rita Pinzone bruno Cacopardo Giuseppe Nunnari Department of Clinical and Experimental Medicine Division of Infectious Diseases University of Catania

Hepatocellular carcinoma(HCC) is an increasing health problem, representing the second cause of cancerrelated mortality worldwide. The major risk factorfor HCC is cirrhosis. In developing countries, viral hepatitis represent the major risk factor, whereas in developed countries, the epidemic of obesity, diabetes and nonalcoholic steatohepatitis contribute to the observed increase in HCC incidence. Cirrhotic patients are recommended to undergo HCC surveillance by abdominal ultrasounds at 6-mo intervals. The current diagnostic algorithms for HCC rely on typical radiological hallmarks in dynamic contrast-enhanced imaging, while the use of α-fetoprotein as an independent tool for HCC surveillance is not recommended by current guidelines due to its low sensitivity and specificity. Early diagnosis is crucial for curative treatments. Surgical resection, radiofrequency ablation and liver transplantation are considered the cornerstones of curative therapy, while for patients with more advanced HCC recommended options include sorafenib and trans-arterial chemoembolization. A multidisciplinary team, consisting of hepatologists, surgeons, radiologists, oncologists and pathologists, is fundamental for a correct management. In this paper, we review the diagnostic and therapeutic management of HCC, with a focus on the most recent evidences and recommendations from guidelines.

关键词： Cancer Chronic hepatitis Cirrhosis Hepatitis B vir

Intestinal metaplasia surveillance:Searching for the roadmap

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World Journal of Gastroenterology 2013年第10期19卷 1523-1526页

作者： Angelo Zullo Cesare Hassan Alessandro Repici bruno Annibale Gastroenterology and Digestive Endoscopy Unit Nuovo Regina Margherita Hospital00153 RomeItaly Department of Gastroenterology IRCCS Istituto Clinico Humanitas20089 MilanItaly Department of Digestive and Liver Disease Sant'Andrea HospitalII School of Medicine University Sapienza of Rome00153 RomeItaly

Atrophic gastritis and intestinal metaplasia(IM) of the stomach are common and are associated with an increased risk for gastric *** the absence of guidelines,a pragmatic management has been performed in Western countries in patients with these premalignant ***,formal European guidelines have been delivered on this ***,it has been recommended that patients with extensive atrophic gastritis(AG) and/or extensive IM should be offered endoscopic surveillance every 3 *** the contrary,no scheduled endoscopic/histological control has been advised for those patients with precancerous conditions confined to the *** this commentary,we highlighted some potential weaknesses in the management formally recommended by the new *** detail,we discussed that AG and IM patients do not share the same gastric cancer risk,at least in Western countries,deserving a different *** factors significantly associated with gastric cancer risk,such as IM type,first-degree family history of gastric cancer,and smoking habit have not been considered in tailoring the endoscopic ***,some data would suggest that a 3-year follow-up in patients with extensive gastric precancerous conditions could result in an inadequate secondary prevention.

关键词： Intestinal metaplasia Guidelines Atrophic gastritis Gastric cancer Follow-up

A methodological approach for estimating turbidity in a river

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International Journal of Sediment Research 2011年第1期26卷 112-119页

作者： Annamaria De VINCENZO bruno MOLINO Rosa VIPARELLI Pompilio CARAMUSCIO Department of Environmental Physics and Engineering University of Basilicata85100 PotenzaItaly SAVA Department University of Molise86100 CompobassoItaly 3. ENEL R&D Department72020 Tutorano(Br)Italy

During the operations of purging and disposal of sediments of a reservoir it is necessary to know the values of turbidity in the river downstream in natural condition,in the absence of dams or river training *** paper shows that under these conditions the ratio of the average values of sediment discharge to the annual maximum value of water discharge is a function of the average annual *** can be considered as representative synthetic index of the climatic conditions,the lithological features and the land cover of the basin,and the geometric characteristics of the river *** proposed relationship of sediment discharge as a function of water discharge were validated on the basis of data collected from different Italian regions that have very different morphological,geo-lithological and rainfall features and that are characterised by a basin area changing between a few dozen and thousands of square *** results can be considered satisfying.

关键词： Soil erosion Reservoir siltation Flushing Turbidity Sediment transportation

Incidence and mortality of acute and chronic pancreatitis in the Netherlands:A nationwide record-linked cohort study for the years 1995-2005

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World Journal of Gastroenterology 2013年第20期19卷 3018-3026页

作者： BW Marcel Spanier Marco J bruno Marcel GW Dijkgraaf Department of Gastroenterology and Hepatology Rijnstate Hospital6800 TA ArnhemThe Netherlands Department of Gastroenterology and Hepatology Erasmus Medical Center3015 CE RotterdamThe Netherlands Clinical Research Unit Academic Medical Center1105 AZ AmsterdamThe Netherlands

AIM:To analyze trends in incidence and mortality of acute pancreatitis(AP) and chronic pancreatitis(CP) in the Netherlands and for international standard ***:A nationwide cohort is identified through record linkage of hospital data for AP and CP,accumulated from three nationwide Dutch registries:the hospital discharge register,the population register,and the death certificate ***-and age-group specific incidence rates of AP and CP are defined for the period 2000-2005 and mortality rates of AP and CP for the period ***,incidence and mortality rates over time are reported for Dutch and international(European and World Health Organization) standard ***:Incidence of AP per 100000 persons per year increased between 2000 and 2005 from 13.2(95%CI:12.6-13.8) to 14.7(95%CI:14.1-15.3).Incidence of AP for males increased from 13.8(95%CI:12.9-14.7) to 15.2(95%CI:14.3-16.1),for females from 12.7(95%CI:11.9-13.5) to 14.2(95%CI:13.4-15.1).Irregular patterns over time emerged for *** mean incidence per 100000 persons per year was 1.77,for males 2.16,and for females *** for AP fluctuated during 1995-2005 between 6.9 and 11.7 per million persons per year and was almost similar for males and *** CP,mortality for males fluctuated between 1.1(95%CI:0.6-2.3) and 4.0(95%CI:2.8-5.8),for females between 0.7(95%CI:0.3-1.6) and 2.0(95%CI:1.2-3.2).Incidence and mortality of AP and CP increased markedly with *** rates were lowest for World Health Organization standard ***:Incidence of AP steadily increased while incidence of CP *** for both AP and CP remained fairly *** burden and health care costs probably will increase because of an ageing Dutch population.

关键词： Acute pancreatitis Chronic pancreatitis Epidemiology Incidence Mortality

A SEM-based method to determine the mineralogical composition and the particle size distribution of suspended sediment

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International Journal of Sediment Research 2019年第2期34卷 85-94页

作者： Sylvain Pinet bruno Lartiges Jean-Michel Martinez Sylvain Ouillonc University of Toulouse (Paul Sabatier) Geosciences Environment ToulouseCNRS(Centre National de la Recherche Scientifique)IRD(Institut de Recherche pour le Développement) Instituto de Geosciencias Universidade de BrasiliaCampus Universitario Darcy RibeiroICC Centro University of Toulouse LEGOS(Laboratoire d'Etudes en Géophysique et Océanographie Spatiales)

A robust method for characterizing the mineralogy of suspended sediment in continental rivers is *** encompasses 3 steps:the filtration of a few milliliters of water,measurements of X-ray energy dispersive spectra using Scanning Electron Microscopy(SEM),and robust machine learning tools of *** method is applied to suspended particles collected from various Amazonian rivers.A total of more than 204,000 particles were analyzed by SEM-EDXS(Energy Dispersive X-ray Spectroscopy),*** 15,700 particles per sampling station,which lead to the identification of 15 distinct groups of mineralogical *** size distribution of particles collected on the filters was derived from the SEM micrographs taken in the backscattered electron imaging mode and analyzed with ImageJ *** determination of the main mineralogical groups composing the bulk sediment associated with physical parameters such as particle size distribution or aspect ratio allows a precise characterization of the load of the terrigenous particles in rivers or *** the case of the Amazonian rivers investigated,the results show that the identified mineralogies are consistent with previous studies as well as between the different samples *** method enabled the evolution of grain size distribution from fine to coarse material to be described in the water *** about hydrodynamic sorting of mineral particles in the water column are also briefly *** proposed method appears well suited for intensive routine monitoring of suspended sediment in river systems.

关键词： Mineralogy Scanning Electron Microscopy Suspended sediment Machine learning Particle size distribution