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Homocysteine as a Biomarker for Predicting Disease-Free Survival in Breast Cancer

Advances in Breast Cancer Research 2013年第2期2卷 24-31页

作者： Daniela Filippini Ierardi Luis Gustavo Raimundo Gimena Aguiar Patrícia Bandeira Rueda Germano Luiz Henrique Gebrim Nelson Carvas bruno frederico aguilar calegare Vania D’Almeida Catarina Segreti Porto Miriam Galvonas Jasiulionis Mariangela Correa Departamento de Farmacologia Universidade Federal de Sao Paulo Sao Paulo Brazil Instituto do Cancer do Estado de Sao Paulo Sao Paulo Brazil Disciplina de Imunologia Universidade Federal de Sao Paulo Sao Paulo Brazil Centro de Referência da Saúde da Mulher Hospital Pérola Byington Sao Paulo Brazil Disciplina de Mastologia Universidade Federal de Sao Paulo Sao Paulo Brazil Departamento de Psicobiologia Universidade Federal de Sao Paulo Sao Paulo Brazil Instituto de Educacao e Ciência Hospital Alemao Oswaldo Cruz Sao Paulo Brazil

Introduction: Breast cancer is the leading cause of cancer mortality among women. Some biomarkers and clinical features are used for the diagnosis and prognosis of this tumor, but no prognostic or predictive marker is routinely available specifically for hormone receptor positive tumors. Homocysteine is well known as a risk factor in atherosclerotic vascular diseases, but its participation in cancer biology is still unclear. The aim of this study was to evaluate serum Homocysteine and Cysteine as biomarkers of disease progression in breast tumor. As a secondary objective, the effect of a short course (one month) of hormonal treatment on Homocysteine, Cysteine and DNA methylation levels was also evaluated. Methods: Blood samples, tumor samples and normal adjacent tissue were collected during the initial biopsy (pre-treatment) and after one month of hormonal therapy (post-treatment). Serum Homocysteine and Cysteine were analyzed by HPLC and tissue global DNA methylation was determined by the Methylation-Sensitive Restriction Enzyme (MSRE) technique. Results: Variations in Homocysteine levels were significantly correlated with Disease-Free Survival. Cox proportional risk model demonstrated that nodal status and Homocysteine levels were independent prognostic factors for disease-free survival (DFS). A significant difference was observed between pre-and post-treatment levels of Homocysteine and Cysteine in advanced tumors, suggesting a prognostic role in patients with poor clinical characteristics. Conclusion: Although more studies are needed to confirm these results, our research suggests that Hcy might be used as a prognostic biomarker for breast cancer.

关键词： Homocysteine Cysteine Breast Cancer Estrogen Receptor Prognostic and Predictive Biomarker Tamoxifen Anastrozol

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Endoscopic management and prevention of migrated esophageal stents

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World Journal of Gastrointestinal Endoscopy 2014年第2期6卷 49-54页

作者： bruno da Costa Martins Felipe Alves Retes bruno frederico Medrado Marcelo Simas de Lima Caterina Maria Pia Simione Pennacchi Fabio Shiguehissa Kawaguti Adriana Vaz Safatle-Ribeiro Ricardo Sato Uemura Fauze Maluf-Filho Department of Gastroenterology Endoscopy DivisionCancer Institute of the University of So Paulo

The use of self-expandable metallic stents has increased recently to palliate inoperable esophageal neoplasia and also in the management of benign strictures. Migration is one of the most common complications after stent placement and the endoscopist should be able to recognize and manage this situation. Several techniques for managing migrated stents have been described, as well as new techniques for preventing stent migration. Most stents have a "lasso" at the upper flange which facilitates stent repositioning or removal. An overtube, endoloop and large polypectomy snare may be useful for the retrieval of stents migrated into the stomach. External fixation of the stent with Shim's technique is efficient in preventing stent migration. Suturing the stent to the esophageal wall, new stent designs with larger flanges and double-layered stents are promising techniques to prevent stent migration but they warrant validation in a larger cohort of patients.

关键词： Endoscopy Stents Esophageal cancer Benign strictures Complications

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A Laurentian affinity for the Embu Terrane,Ribeira Belt(SE Brazil),revealed by zircon provenance statistical analysis

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Geoscience Frontiers 2023年第1期14卷 149-161页

作者： bruno V.Ribeiro frederico M.Faleiros Ginaldo A.C.Campanha Peter A.Cawood Christopher L.Kirkland Milo Barham Erin L.Martin Marina Seraine Dina I.G.Cabrita Maria T.A.G.Yogi VidyãV.Almeida Anny J.A.Forero-Ortega Elton L.Dantas Timescales of Mineral Systems Group School of Earth and Planetary SciencesCurtin UniversityPerthWA 6102Australia Isotopia Laboratory School of EarthAtmosphere and EnvironmentMonash UniversityClaytonVictoria 3800Australia Department of Mineralogy and Geotectonics University of São PauloRua do Logo 56205508-900 São PauloBrazil Department of Geological Science and Geological Engineering of Queen's University KingstonOntarioCanada Department of Earth Sciences Carleton UniversityOttawaOntarioCanada Geodynamics Division Geological Survey of Brazil(CPRM)Rua Costa 5501304-010 São PauloSPBrazil Institute for Geophysics Pontificia Universidad JaverianaBogotáColombia Institute of Geoscience University of BrasiliaCampus Universitário Darcy RibeiroAna Norte70919-900 BrasiliaDFBrazil

New and compiled detrital zircon U-Pb ages from the southern Neoproterozoic-Cambrian Ribeira Belt,SE Brazil,demonstrate Laurentian affinity of the Embu Terrane which is statistically distinct from the adjoining Apiaíand São Roque terranes with cratonic affinity(e.g.,São Francisco Craton).Zircon provenance results indicate that the type-area of the Embu Terrane is dominated by detrital zircon age modes at ca.1200 Ma,1400 Ma,and 1800 Ma,with maximum depositional age of ca.1000 *** contrast,the Apiaíand São Roque terranes are dominated by Paleoproterozoic detrital zircon ages(ca.2200-2000 Ma age dominant component),with maximum depositional ages of ca.1400 Ma and 1750 Ma,*** scaling(MDS)analysis of non-parametric similarity measurements on zircon age populations indicates for the first time that the Embu Terrane encompass two statistically distinct detrital zircon age spectra,which is also reflected in the metamorphic zircon age *** statistical characterization of the Embu Terrane through populational metrics allow a quantitative comparison with surrounding tectonic domains and rock samples classified such as *** results clearly highlight the distinction between the statistically differentiated Embu Terrane from the Apiaíand São Roque terranes,supporting an allochthonous *** addition,we demonstrate that rocks samples previously classified as Embu-type are significantly dissimilar to the definition of Embu Terrane,failing to support alternative tectonic models(e.g.,intracontinental evolution).Detrital zircon age spectra reveal that the Apiaíand São Roque terranes have similar zircon provenance to domains sourced from the São Francisco Craton,whereas detrital zircon populations from the Embu Terrane have greater affinity with SW Laurentia basins(and their inferred sediment sources),consistent with previous ***,we interpret the Embu Terrane as a Rodinia descendant developed along the active margin o

关键词： Ribeira belt Embu terrane Detrital zircon Multidimensional scaling Rodinia and gondwana Paleogeography

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Effects of Mirror Therapy on the Lower Limb Functionality Hemiparesis after Stroke

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Health 2016年第14期8卷 1442-1452页

作者： bruno Vieira Cortez Constância Karyne da Silva Coêlho Danylo Rafhael Costa Silva Maria da Conceição Barros Oliveira Giselle Borges Vieira Pires de Oliveira Francisco Mayron de Sousa e Silva Éric Heleno Freire Ferreira frederico Danúbia da Cunha de Sá-Caputo Mario Bernardo-Filho Janaína de Moraes Silva Departamento de Fisioterapia Faculdade Maurício de Nassau Teresina Brasil Pós-graduaç ã o da Rede Nordeste de Biotecnologia da Universidade Federal do Piauí Universidade Federal do Piauí Teresina Brasil Departamento de Fisioterapia Universidade Estadual do Piauí Teresina Brasil Laboratório de Vibracoes Mecanicas e Práticas Integrativas e Complementares Universidade do Estado do Rio de Janeiro Rio de Janeiro Brasil

Introduction: Mental exercise using the mirror therapy (MT) improves the retention of newly acquired skills and the performance of sequential motor skills in subjects with post-stroke hemiparesis. Objectives: The study aimed to analyze the mirror therapy effect on the range of motion and the lower limb functionality in post-stroke hemiparesis subjects. Materials and Methods: Eleven participants with hemiparesis in the lower limb were subjected to the 10 sessions of a MT protocol. The interventions were three times per week per 30 minutes each day. Evaluation of active and passive ankle goniometry (dorsiflexion and eversion movements);Ascent and Descent Ladder Rate (ADLR);Time Up and Go test (TUG test);EFEI scale;and FAAM scale were performed. The data were collected before and after the intervention using MT, and then statistically compared. Results: The MT improved significantly (p < 0.01) the range of motion of the paretic lower limb both evaluated by active and passive ankle goniometry. An increase in the speed of gait and other functional tasks related to the paretic lower limbs were found through the TUG and ADLR tests. It also demonstrated a positive influence on the functionality of the paretic lower limb motor control through the analysis of the scores in the FAAM and EFEI scales. Conclusion: It is concluded that the MT therapy can help the patients with post-stroke hemiparesis in the improvement of several functions. Probably, the mirror therapy would aid in the repair of the injuries in the cortical areas.

关键词： Mirror Therapy Stroke Hemiparesis Visual Feedback Functionality

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Ornamental Rock Waste Application for Soil Remineralization

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Journal of Earth Science and Engineering 2021年第1期9卷 7-12页

作者： bruno Bender Daubermann Julia Thais Decker frederico Sporket Regina Célia Espinosa Modolo Pedro Roque Giehl Joséde Souza Fundaçāo Liberato-DPPI-Rua Inconfidentes 395Bairro PrimaveraNovo HamburgoRio Grande do SulBrazil UNISINOS Engenharia MecânicaBrazil

This study consists in the investigation of the application of ornamental rock tailings applied in remineralization in the Brazilian soil through the rocking *** to the Brazilian dependence on the importation of agricultural inputs,the use of the method aims beyond improving the physical and chemical properties of the soil,supplying the demand for such data,and in return to give an adequate end to pollutant *** tailings have chemical characteristics that are of great importance for soil *** methodology employed was divided into three stages,the first one was the physicochemical characterization of the rock dust,followed by the characterization of the soil experimented and the cultivation of the plant species Phaseolus *** results obtained so far showed favorable results since the characteristics obtained through the physicochemical analyses were compatible with those suitable for the soil,after the application of the powder,which had its high pH and which proved that the tailings corrected the soil acidity of the sample in question,placing it at an ideal level for the cultivation of new species.

关键词： Ornamental rocks agriculture soil remineralization

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