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Effect of drug therapies on self-reported chemosensory outcomes after COVID-19

World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： Marco A.fornazieri bruno M.Cunha Samuel P.Nicácio Lucas K.Anzolin JoséL.b.da Silva Aristides fernandes Neto Deusdedit brandão Neto Richard L.Voegels fábio D.R.Pinna Department of Surgery Londrina State UniversityLondrinaBrazil Department of Medicine Pontifical Catholic University of ParanáLondrinaBrazil Department of Otorhinolaryngology University of São PauloSao PauloBrazil Department of Otorhinolaryngology:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim of this study was to assess the relative efficacy of medications used following severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection on self-reported alterations in taste and/or smell ***:Seven hundred and fourteen persons with self-reported postcoronavirus disease 2019(post-COVID-19)chemosensory disorders were personally interviewed regarding specific medications they were administered following the acute phase of the *** dependent measure—self-reported total recovery of chemosensory symptoms—was subjected to stepwise logistic *** predictors included demographic and clinical variables,in addition to specific medications used to mitigate disease symptoms(i.e.,systemic corticosteroids,oseltamivir,vitamin C,ibuprofen,hydroxychloroquine,azithromycin,ivermectin,nitazoxanide,anticoagulants,and zinc).Results:The median time between COVID-19 symptom onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjects,249(34.9%)reported total recovery of their chemosensory function;437(61.2%)had at least one treatment since the beginning of the *** and those with more comorbidities had undergone more *** recovery rates of the treated and nontreated groups did not differ ***,respondents who had used nitazoxanide tended to have a higher rate of self-reported taste or smell *** who took oral zinc were less likely to ***:No medication employed during the first months after SARS-CoV-2 infection had a clear positive effect on returning self-reported smell or taste function to normal,although nitrazoxide trended in a positive *** zinc had a negative effect on the reported recovery of these senses.

关键词： chemosensory disorder coronavirus infections COVID-19 drug therapy SARS-CoV-2 smell loss taste loss

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Planar matrices and arrays of feynman diagrams

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Communications in Theoretical Physics 2024年第3期76卷 15-32页

作者： freddy Cachazo Alfredo Guevara bruno Umbert Yong Zhang Perimeter Institute for Theoretical Physics WaterlooON N2L 2Y5Canada Department of Physics and Astronomy University of WaterlooWaterlooON N2L 3G1Canada CECs Valdivia y Departamento de física Universidad de ConcepciónCasilla 160-CConcepciónChile Center for the fundamental Laws of Nature Society of Fellows and Black Hole InitiativeHarvard UniversityCambridgeMA 02138United States of America Department of Applied Mathematics Western UniversityLondonON N6A 5B7Canada CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesNo.19A Yuquan RoadBeijing 100049China

Recently,planar collections of feynman diagrams were proposed by borges and one of the authors as the natural generalization of feynman diagrams for the computation of k=3 biadjoint *** collections are one-dimensional arrays of metric trees satisfying an induced planarity and compatibility *** this work,we introduce planar matrices of feynman diagrams as the objects that compute k=4 biadjoint *** are symmetric matrices of metric trees satisfying compatibility *** introduce two notions of combinatorial bootstrap techniques for finding collections from feynman diagrams and matrices from *** applications of the first,we find all 693,13612 and 346710 collections for(k,n)=(3,7),(3,8)and(3,9),*** applications of the second kind,we find all90608 and 30659424 planar matrices that compute(k,n)=(4,8)and(4,9)biadjoint amplitudes,*** an example of the evaluation of matrices of feynman diagrams,we present the complete form of the(4,8)and(4,9)biadjoint *** also start a study of higher-dimensional arrays of feynman diagrams,including the combinatorial version of the duality between(k,n)and(n-k,n)objects.

关键词： feynman diagrams biadjoint amplitudes tropical Grassmannian

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Immune response to inactivated bacterial vector carrying the recombinant K39 antigen of Leishmania infantum in mice

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Asian Pacific Journal of Tropical biomedicine 2024年第5期14卷 199-206页

作者： Lucelina S.Araújo bruno b.Silva Eduarda N.f.N.Santos Arnaldo S.bezerra Samuel S.frota Assis R.Montenegro Eridan O.P.T.florean Maurício fvan Tilburg Maria Izabel f.Guedes Laboratory of biotechnology and Molecular biology Northeast Biotechnology NetworkState University of CearáFortalezaBrazil faculty of Veterinary Medicine State University of CearáFortalezaBrazil

Objective:To evaluate the immunological response elicited by an inactivated bacterial vector carrying the K39 antigen of Leishmania infantum,and a purified ***:Mice were subjected to the following treatments:(1)Purified recombinant K39(rK39)protein at a 20μg dose with complete freund’s adjuvant;(2)Inactivated Escherichia coli(bL21 DE3)carrying the K39 protein at an equivalent total protein content of 200μg;(3)Inactivated bacteria lacking the K39 protein;(4)Non-immunized control *** monitoring was *** groups were challenged by intraperitoneal injection of 10^(7) Leishmania infantum *** euthanasia,the liver and spleen were collected to analyze the levels of TNf,IfN-γ,IL-12,IL-4,and ***:Mice immunized with purified rK39 or the inactivated bacterial vector carrying the K39 antigen of Leishmania infantum showed a long-lasting immune response with high levels of polyclonal antibodies specifically recognizing the recombinant *** IgG1 subclass was the predominant immunoglobulin;however,the induction of IgG2a and the profile of cytokines produced were indicative of the induction of a mixed-type ***:The inactivated bacterial vector carrying the K39 antigen,as well as the purified antigen can induce a long-lasting immune response in immunized mice,predominantly favouring a Th2 profile response.

关键词： Visceral leishmaniasis K39 Inactivated bacterial vector Vaccine Immune response Th1 Th2 Leishmania infantum

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Passive Heating Systems:A Case Study in a brazilian Mountainous Region

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Journal of Civil Engineering and Architecture 2019年第11期13卷 676-685页

作者： Ana Clara L.Pereira Ana Lúcia T.S.da Motta bruno b.f.da costa Priscilla C.P.f.de Oliveira Thiago V.Miranda Programa de Pós-graduacao em Engenharia Civil Universidade Federal FluminenseRio de Janeiro 22211-200Brazil Departamento de Engenharia Civil da Universidade federal do Rio de Janeiro—Campus Macaé Rio de Janeiro 22211-200Brazil

The study of thermal comfort in the built environment is of great relevance since it stimulates the development of more sustainable buildings suited to the local climate and able to meet the human need for *** objective of this research was to develop,construct and test a passive heating system adaptable to existing buildings,reducing the need for major interventions and increasing thermal comfort in the indoor *** adopted methodological approach was a case study in a single-family residence located in the brazilian city of Petrópolis,a mountainous region with a humid subtropical climate and a rigorous *** proposed passive heating system is totally isolated,thus mitigating air infiltration and promoting increase of temperature in the internal environment through the absorption of solar energy and greenhouse *** kind of solution is especially interesting for residents of this region,since most of the city buildings are not adequately prepared to handle low ***,given local climatic conditions,residents need to spend a lot of money on the acquisition and operation of electric or gas heating *** results indicated that the developed system,in fact,increased the temperature of the studied room when compared to an adjacent room,which did not receive the *** findings of this paper,therefore,provide a valuable reference for experts and practitioners in the selection of heating systems to be used in cold regions,and proved that passive systems can provide thermal comfort at the same time that optimize the interaction of the building with the local ecosystem.

关键词： Passive heating systems thermal comfort bioclimatic architecture sustainable buildings

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Driving factors behind multiple populations

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 172-181页

作者： Ruoyun Huang baitian Tang Chengyuan Li Doug Geisler Mario Mateo Ying-Yi Song Holger baumgardt Julio A.Carballo-bello Yue Wang Jundan Nie bruno Dias JoséG.fernández-Trincado School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China CSST Science Center for the Guangdong-Hong Kong-Macao Greater bay Area Zhuhai 519082China Departamento de Astronomía Universidad de ConcepcionConcepcionChile Instituto de Investigación Multidisciplinario en Ciencia y Tecnología Universidad de La SerenaLa SerenaChile Departamento de Astronomía Facultad de CienciasUniversidad de La SerenaChile Department of Astronomy University of MichiganAnn Arbor 48109USA david A.Dunlap Department of Astronomy&Astrophysics University of TorontoToronto ON M5S 3H4Canada Dunlap Institute for Astronomy&Astrophysics University of TorontoToronto ON M5S 3H4Canada School of Mathematics and Physics The University of QueenslandSt.Lucia QLD 4072Australia Instituto de Alta Investigación Universidad de TarapacáAricaChile CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Instituto de Astrofísica Departamento de Ciencias FísicasFacultad de Ciencias ExactasUniversidad Andres BelloSantiagoChile Instituto de Astronomía Universidad Católica del NorteAntofagastaChile

Star clusters were historically considered simple stellar populations,with all stars sharing the same age and initial chemical ***,the presence of chemical anomalies in globular clusters(GCs),called multiple stellar populations(MPs),has challenged star formation theories in dense *** studies show that mass,metallicity,and age are likely controlling parameters for the manifestation of *** the limit between clusters with/without MPs in physical parameter space is crucial to reveal the driving mechanism behind their *** this study,we look for MP signals in Whiting 1,which is traditionally considered a young *** the Magellan telescope,we obtained low-resolution spectra withinλλ=3850-5500?for eight giants of Whiting *** measured the C and N abundances from the CN and CH spectral indices.C and N abundances have variations comparable with their measurement errors(~0.1 dex),suggesting that MPs are absent from Whiting *** these findings with literature studies,we propose a limit in the metallicity *** compactness index parameter space,which relatively clearly separates star clusters with/without MPs(GCs/open clusters).This limit is physically *** a larger scale,the galactic environment determines cluster compactness and metallicity,leading to metal-rich,diffuse,old clusters formed ex *** proposed limit also impacts our understanding of the formation of the Sagittarius dwarf galaxy:star clusters formed after the first starburst(age≤8-10 Gyr).These clusters are simple stellar populations because the enriched galactic environment is no longer suitable for MP formation.

关键词： stellar galactic galaxy

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Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

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Journal of Sport and Health Science 2024年第3期13卷 409-418页

作者： Jérémy Raffin Yves Rolland Annelise Genoux Guillaume Combes Mikael Croyal bertrand Perret Sophie Guyonnet bruno Vellas Laurent O.Martinez Philipe de Souto barreto for the MAPT/DSA Group Institut du Vieillissement Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France Centre d'Epidémiologie et de Recherche en Santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France LimitAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service de biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'Institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France bioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-forme de spectrométrie de masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

background:Adenosine triphosphatase inhibitory factor 1(If1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains ***,the apolipoprotein A-I(apoA-I),a PA-modulated lipoprotein,could play a role in this relationship because it shares a binding site with If1 on the cell-surface ATP *** examined here the associations between chronic PA and plasma If1 concentrations among older adults,and we investigated whether apoA-I mediated these ***:In the present work,1096 healthy adults(63.8%females)aged 70 years and over who were involved in the Multidomain Alzheimer Prevention Trial study were ***1 plasma concentrations(square root of ng/mL)were measured at the 1-year visit of the Multidomain Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed using questionnaires administered each year from baseline to the 3-year *** linear regressions were performed to investigate the associations between the first-year mean PA levels and If1 *** analyses were conducted to examine whether apoA-I mediated these *** linear regressions were carried out to investigate whether the 1-year visit If1 concentrations predicted subsequent changes in ***:Multiple linear regressions indicated that first-year mean PA levels were positively associated with If1 concentrations(b=0.021;SE=0.010;p=0.043).Mediation analyses revealed that about 37.7%of this relationship was mediated by apoA-I(b_(ab)=0.008;SE=0.004;p=0.023).Longitudinal investigations demonstrated that higher concentrations of If1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(time×If1:b=0.148;SE=0.066;p=0.025).Conclusion:This study demonstrates that regular PA is associated with plasma If1 concentrations,and it suggests that apoA-I partly med

关键词： Aging Apolipoprotein bioenergetics Exerkine Mitochondria

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Distinct physiological mechanisms underpin growth and rehydration of Hymenaea courbaril and Hymenaea stigonocarpa upon short-term exposure to drought stress

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Journal of forestry Research 2023年第1期34卷 113-123页

作者： Luana M.Luz Ediane C.Alves Nariane Q.Vilhena Tamires b.Oliveira Zara G.b.Silva Joze M.N.freitas Candido f.O.Neto Roberto C.L.costa Lucas C.costa Universidade federal Rural da AmazOia CapanemaPA 68700-665Brazil Universidade federal Rural da AmazEia BelémPA 66077-830Brazil

Plants hold biochemical and physiological mechanisms to withstand drought ***,depending on water deficit interval,plant rehydration relies on how it can retain growth or a positive water balance—or rarely *** this study,two species of Hymenaea,one from the Amazon and the other from the brazilian Cerrado,were investigated for their physiological mechanism associated with growth rehydration upon short-term exposure to drought *** findings demonstrate that Hymenaea courbaril tends to invest in nitrogen to the detriment of carbon compounds,-as it is limited by lower net photosynthesis-and adjust root growth to attenuate drought stress *** contrast,Hymenaea stigonocarpa takes advantage of higher water potential and a basal rate of lower net photosynthesis to support aboveground growth under such ***,it is postulated that there are distinct ways of controlling water status and growth between *** and ***,which are determined either by the ability of the species to keep net photosynthesis at low levels of water content or by favoring the accumulation of nitrogen *** mechanisms were effective with regards to water use efficiency and thus it is reasonable to suggest that strategies are not exclusive and may work under adverse conditions,as observed in Amazon and brazilian Cerrado ***.

关键词： Hymenaea courbaril Hymenaea stigonocarpa Growth Photosynthesis Water deficit

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Journal of Energy Chemistry 2022年第10期31卷 88-113,I0003页

作者： Magno b.costa Moisés A.de Araújo Marcos V.de Lima Tinoco Juliana f.de brito Lucia H.Mascaro Departamento de Química Universidade Federal de São CarlosRodovia Washington Luizkm 235São CarlosSão Paulo 13565-905Brazil Instituto de Química de São Carlos Universidade de São PauloAvenida Trabalhador Sancarlense400São CarlosSão Paulo 13566-590Brazil Instituto de Química Universidade Estadual PaulistaRua Professor Francisco Degnis/nAraraquaraSão Paulo 14800-900Brazil

This review shows the importance of WO_(3)photoanode as a potentially low-cost,efficient,stable,and photoactive material for light-driven water *** such,this manuscript aims to review the most recent publications regarding the strategies to improve the phoelectroactivity of WO_(3)films for water *** addition,this review aims to graphically highlight and discuss the general trendings of the photocurrent density response and stability test of the recent outstanding studies in the literature for photoelectrochemical water splitting *** strategies covered in this review will not only concern the WO_(3)morphology and crystal plane growth,but also the many arrangements possibilities to improve the WO_(3)efficiency for water photoelectrooxidation,such as defect engineering based on oxygen vacancies,doping,decorations,and homo and *** these strategies are compared by the photocurrent density results and by the stability of these *** best results in this sense were observed in cases where the use of heterojunction was applied together with a desired morphology and crystal plane of the WO_(3)***,the modifications that caused a decrease in the photocurrent density reaching values that are even lower than the pure WO_(3)were also *** this way,this review intends to improve the knowledge about the synthesis and design of WO_(3)photoanodes to further obtain an efficient photocatalyst to minimize the recombination losses or losses across the interfaces and improve the photoelectroactivity for water splitting in the large-scale application.

关键词： Solar energy H_(2)production N-type semiconductor Photoelectrode design Oxygen evolution reaction

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EurbeST——商业养蜂条件下的抗螨蜂种选育

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中国蜂业 2024年第2期75卷 22-23页

作者： R.buechler A.Uzunov C.costa M.Meixner Y Le Conte f.Mondet M.Kovacic S.Andonov N.L.Carreck L.Dimitrov b.basso M.bienkowska R.dall’Olio f.Hatjina U.Wirtz 陈超(文\图) 单金琼(文\图) 不详

上期我们讲了抗螨蜜蜂的选育以及取得的成效,本期我们继续讨论选育抗螨蜜蜂过程中遇到的问题及建议。一、种蜂王的用户调查对目前蜂王市场的调查显示,客户的期望值很高,但满意度一般。欧洲养蜂人希望买到高品质的蜂王,其中最重要的是抗... 详细信息

上期我们讲了抗螨蜜蜂的选育以及取得的成效,本期我们继续讨论选育抗螨蜜蜂过程中遇到的问题及建议。一、种蜂王的用户调查对目前蜂王市场的调查显示,客户的期望值很高,但满意度一般。欧洲养蜂人希望买到高品质的蜂王,其中最重要的是抗病和高产。但是,他们对抗病性的满意度最低(图1)。近50%的用户认为选择育种是实现免用药养蜂的重要甚至唯一的手段。具有悠久育种传统的国家的用户对选择育种的认可率更高。

关键词：选择育种用户调查蜂王问题及建议抗螨养蜂人蜜蜂商业养蜂

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NiTi laser textured implants with improved in vivo osseointegration:An experimental study in rats

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Journal of Materials Science & Technology 2022年第19期114卷 120-130页

作者： M.M.costa A.Miranda f.bartolomeu O.Carvalho S.Matos G.Miranda f.S.Silva Center for MicroElectroMechanical Systems(CMEMS-UMinho) University of MinhoCampus de AzurémGuimarães 4800-058Portugal Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de GualtarBraga 4710-057Portugal ICVS/3b’s-PT Government Associate Laboratory Braga/GuimarãesPortugal Center for Innovation and Research in Oral Sciences(CIROS) Faculty of MedicineUniversity of CoimbraFMUCPortugal CICECO Aveiro Institute of MaterialsDepartment of Materials and Ceramic EngineeringUniversity of AveiroAveiro 3810-193Portugal

Laser surface texturing is a versatile approach for manufacturing implants with suitable surfaces for *** work explores the use of laser to fabricate NiTi textured implants,testing two dif-ferent groove-based *** performance was evaluated in vivo through implantation in Sprague dawley rats’femur,being then analyzed after 4 and 12 weeks of ***-out experiments and histological characterization allowed to assess bone-implant bond and osseointegration and to compare the laser textured solutions with non-textured *** showed that,at 4 weeks of implantation,mainly immature woven bone was present whilst at 12 weeks a more mature bone had ***-sidering the largest implantation time(12 weeks),results showed extraction forces considerably higher for textured implants(G2 and G3).Moreover,when comparing G2 and G3,it was found that G2(having the highest textured surface area)displayed the maximum extraction force among all groups,with an increase of 212%when compared to non-textured implants(G1).These results prove that the design and manufacturing technology are effective to promote an im-proved bone-implant bond,aiming the development of orthopedic implants.

关键词： NiTi Laser surface texturing In vivo studies Osseointegration Implants

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