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Sirolimus,bevacizumab,5-Fluorouracil and irinotecan for advanced colorectal cancer:A pilot study

World Journal of Gastroenterology 2009年第34期15卷 4278-4283页

作者： Francois Ghiringhelli Boris Guiu bruno chauffert Sylvain Ladoire Department of Medical Oncology Georges-Francois Leclerc Cancer Center Department of Radiology Georges-Francois Leclerc Cancer Center

AIM： To evaluate the efficacy and the safety of combined 5-Fluorouracil, irinotecan, bevacizumab and sirolimus in refractory advanced colorectal carcinoma. METHODS： We initiated a regimen with at day 1 an injection （iv） of bevacizumab at 5 mg/kg, followed by 180 mg/m^2 irinotecan, followed by Leucovorin 400 mg/m^2, followed by a 5-Fluorouracil bolus 400 mg/m^2 and a 46-h infusion 2400 mg/m^2. Sirolimus was given orally as continuous administration of 2 mg twice a day every days. This treatment was repeated every 14 d. RESULTS： A total of 12 patients were enrolled. All patients presented with metastatic disease that had failed at least three lines of chemotherapy that contained oxaliplatin, irinotecan and bevacizumab. Cetuximab failure was also observed in all K-Ras wildtype patients. The median number of cycles was 8.5 （range 2-20） and clinical benefit was observed in eight patients. The median time to progression was 5 mo and the median survival was 8 too. Grade 3 neutropenia developed in four patients, and grade 3 diarrhea and stomatitis in ***： The combination regimen of 5-Fluorouracil,irinotecan, bevacizumab and sirolimus in advanced colorectal carcinoma after failure of dassical *** is feasible and promising. Further evaluation of this combination is required.

关键词： Colorectal cancer Bevacizumab 5-Fluorouracil Irinotecan Sirolimus Antineoplastic combinedchemotherapy protocols Angiogenesis

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Impact of homogeneous pathologic response to preoperative chemotherapy in patients with multiple colorectal liver metastases

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World Journal of Gastroenterology 2017年第45期23卷 8027-8034页

作者： Charles Sabbagh Denis Chatelain Christophe Attencourt Jean-Paul Joly bruno chauffert Cyril Cosse Jean-Marc Regimbeau Depart-ment of Digestive and Oncologic Surgery Amiens University Medical Center INSERM U1088 Jules Verne University of Picardie University of Picardie Department of Anatomic Pathology Amiens University Medical Center Department of Hepatogastroenterology Amiens University Medical Center Department of Medical Oncology Amiens University Medical Center EA4294 Jules Verne University of Picardie

AIM To analyze the homogeneity of pathologic response to preoperative chemotherapy(PRPC) after chemotherapy in patients with multiple liver metastases(LM).METHODS From September 2011 to August 2014,patients with at least two LM undergoing preoperative chemotherapy prior to resection were included in this retrospective,single-center study. The endpoints were PRPC homogeneity(according to both the Rubbia-Brandt and MD Anderson classifications),the impact of PRPC on the MDT decision,factors associated with homogeneous PRPC and overall survival of patients with vs. without homogeneous *** seventy-three patients with a total of 88 liver resections(including 15 two-stage procedures) were included in the study. The homogeneous PRPC rate was 55% according to the Rubbia-Brandt classification and 53% according to the MD Anderson classification. The MDT decision was modified by the PRPC in only 2.7% of patients(n = 2). CONCLUSION The PRPC was homogeneous in only one half of patients and had very little influence on the MDT decision.

关键词： Liver metastases Pathological response Homogeneity Preoperative chemotherapy Colorectal cancer

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Tourism and heritage in the enhancement of Tianjin

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Built Heritage 2020年第2期4卷 1-20页

作者： bruno chauffert-Yvart Françoise Ged Yue Lu Christine Mengin Émilie Rousseau 不详 International Research Center for Architectural Heritage Conservation Shanghai Jiao Tong UniversityShanghaiChina Equipe Interdisciplinaire de Recherches sur le Tourisme UniversitéParis 1 Panthéon-Sorbonne21 rue Broca75005 ParisFrance Full list of author information is available at the end of the article

This article examines what is being promoted about Tianjin’s rich heritage through its tourism and heritage *** industrial city traditionally known for its crafts and gastronomy,Tianjin has gradually begun to promote its Chinese heritage and,since the 2000s,its city centre,which is noteworthy for its former foreign concessions and 19th-and 20th-century architectural *** long neglect,the city centre has become a major component in the promotion of the *** on the analysis of tourism materials and studies conducted since the mid-2000s,this article first discusses the development of tourism in Tianjin and the chronology and interweaving of the services involved in heritage ***,it focuses on the reception of the city’s tourism offerings and on urban development operations in two sectors,Wudadao(or‘Five avenues’),located in the former British Concession,and the‘I-Style Town’in the former Italian Concession.

关键词： Tianjin Foreign concessions Tourism Built heritage Heritage policies Wudadao I-style town

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Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer

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World Journal of Gastroenterology 2010年第9期16卷 1150-1154页

作者： Boris Guiu Julie Vincent Séverine Guiu Sylvain Ladoire Pablo Ortega-Deballon Jean-Pierre Cercueil bruno chauffert Franois Ghiringhelli Department of Radiology INSERM U866University of BurgundyUniversity Hospital Department of Hepatology INSERM U866University of BurgundyUniversity Hospital Department of Oncology INSERM U866AVENIR TeamUniversity of Burgundy Department of Digestive Surgery INSERM U866University of BurgundyUniversity Hospital

Hepatic arterial infusion (HAI) of chemotherapy can be performed in cases of liver-confined metastatic disease,resulting in increased local drug *** we report the case of a 61-year-old man who presented with an isolated large unresectable liver metastasis of colon cancer after failure of surgery and multiple administration of systemic *** patient was treated with a combination of gemcitabine and oxaliplatin using *** tolerance was excellent and a radiological complete response was obtained after 8 cycles of *** rationale for the use of gemcitabine and oxaliplatin as well as that for the combination of the 2 drugs is discussed in this *** of gemcitabine-oxaliplatin should be evaluated in further clinical trials.

关键词： Hepatic artery Chemotherapy Colon cancer Liver metastasis Gemcitabine Oxaliplatin Contrast media Computed tomography

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