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Seasonal variation and host sex affect bat–bat fly interaction networks in the Amazonian savannahs

Integrative Zoology 2024年第3期19卷 400-416页

作者： Paulo mEJIA Gustavo Lima URBIETA bruna da Silva XAVIER IsaíJorge de CASTRO JoséJúlio DE TOLEDO Gustavo GRACIOLLI Lucio AndréVIANA DIAS William Douglas CARVALHO Programa de Pós-Graduação em Biodiversidade Tropical Universidade Federal do Amapá(UNIFAP)MacapáAPBrazil Programa de Pós-Graduação em Ecologia Instituto de BiologiaCentro de Ciências da SaúdeUniversidade Federal do Rio de Janeiro(UFRJ)Rio de JaneiroRJBrazil Laboratório de mamíferos Instituto de Pesquisas Científicas e Tecnológicas do Estado do Amapá(IEPA)MacapáAPBrazil Programa de Pós-Graduação em Biologia Animal Laboratório de SistemáticaEcologia e Evolução(LSEE)Instituto de BiociênciasUniversidade Federal de Mato Grosso do Sul(UFMS)Campo GrandeMTBrazil Terrestrial Ecology Group(TEG-UAm) Departamento de EcologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAm) Universidad Autónoma de MadridMadridSpain

Bats are the second-most diverse group of mammals in the world,and bat flies are their main ***,significant knowledge gaps remain regarding these antagonistic interactions,especially since diverse factors such as seasonality and host sex can affect their network ***,we explore the influence of such factors by comparing species richness and composition of bat flies on host bats,as well as specialization and modularity of bat–bat fly interaction networks between seasons and adult host *** captured bats and collected their ectoparasitic flies at 10 sampling sites in the savannahs of AmapáState,northeastern region of the Brazilian *** female bats being more parasitized and recording greater bat fly species richness in the wet season,neither relationship was statistically *** pooled network could be divided into 15 compartments with 54 links,and all subnetworks comprised>12 *** total number of links ranged from 27 to 48(for the dry and wet seasons,respectively),and female and male subnetworks had 44 and 41 links,*** values were very low for the pooled network and for all *** results revealed higher bat fly species richness and abundance in the wet season,whereas specialization and modularity were higher in the dry ***,the subnetwork for female bats displayed higher specialization and modularity than the male ***,both seasonality and host sex contribute in different ways to bat–bat fly network *** studies should consider these factors when evaluating bat–bat fly interaction networks.

关键词： Amapá Amazon biome bat flies bats interaction networks

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Hydroelectrolytic and Energetic Replenisher in Horses Undergoing marcha Training

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Open Journal of Veterinary medicine 2024年第8期14卷 203-216页

作者： José D. ribeiro Filho bruna.m. ribeiro micheline O. Silva Samuel R. Alves Anaïs C. Benitez Waleska m. F. Dantas marcel F. B. Avanza Raffaella B. C. Teixeira Pedro Ancelmo N. Ermita Laice A. Silva Rinaldo B. Viana Hélio C. manso Filho Department of Veterinary Federal University of Viosa Viosa Brazil Institute of Studies of the Wet Tropic Federal University of Southern and Southeastern Par Xinguara Brazil Department of Veterinary Clinic and Surgery Federal University of Minas Gerais Belo Horizonte Brazil Institute of Animal Health and Production Federal Rural University of Amazonia Belm Brazil Zootecnics Department Federal Rural University of Pernambuco Recife Brazil

The study aimed to assess the clinical, laboratory, and blood gas analysis of horses undergoing marcha training and the effects of voluntary ingestion of hydroelectrolytic and energy replenishers after exercise. Eight horses of both genders aged between 5 and 10 years, were included in the study. The exercise consisted of a 10-min warm-up followed by 45 min uninterrupted marcha on a flat dirt track in the morning. After exercise, the horses received one of the following treatments: Drinking water (control group);Hydroelectrolytic and energy replenisher containing sodium chloride, potassium chloride, calcium acetate, magnesium chloride, sodium citrate, dextrose, maltodextrin, and sucrose in three different concentrations (Replenishers A, B, and C). The horses were distributed across the four treatments in a 4 × 4 Latin Squares design using a Split-plot system with 48-hr intervals. Clinical and laboratory evaluations were conducted at four time points: T0 - 5 min before exercise;T1 - up to 5 min after exercise;T2 - 2 hr after starting treatment;and T4 - 4 hr after beginning treatment. Concentrations of urea, creatinine, lactate, phosphorus, and ionized calcium significantly changed after exercise. An increase in blood pH and a decrease in chloride concentrations were observed when replenishers B and C were offered after exercise. The replacements were ingested spontaneously by the animals in a volume greater than that of the control group (water). Replacement B was the most ingested by the animals, demonstrating its greatest potential.

关键词： Dehydration Electrolyte Replacement Exercise Rehydration Voluntary Intake

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促进慢性阻塞性肺疾病哮喘患者自我监控空气质量的护理干预措施: 整合性综述

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International Journal of Nursing Sciences 2024年第1期11卷 46-56页

作者： bruna F.Sebastiao Raquel m.Hortelao Sara S.Granadas Jose m.Faria Joana R.Pinto Helga Rafael Henriques Nursing School of Lisbon LisbonPortugal Hospital Center of Central Lisbon Portugal CUF Tejo Hospital LisbonPortugal University Hospital Center of Northern Lisbon LisbonPortugal Nursing Research Innovation and Development Centre of Lisbon(CIDNUR)LisbonPortugal

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronie obst ructive pulmonary disease overlap,A-CO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通... 详细信息

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronie obst ructive pulmonary disease overlap,A-CO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过系统性综述,寻找证据,以指导制订护理干预措施,促进ACO患者对空气质量的自我管理。方法2023年3月 ,系统检索CINAHL、medline、Academie Search Complete .Scopus、WebofScience、Cochrane图书馆、乔安娜布里格斯研究所(JoannaBriggsInstitute,JBI)循证实践数据库,以及GoogleScholar。对纳人研究进行数据提取和综合,并对护理干预措施进行分类。采用JBI研究质量评估工具进行方法学质量评估。结果共纳入5篇来自不同国家的研究。促进ACO患者自我监控空气质量的干预措施包括:警觉性干预措施(医务人员定期巡诊、进行症状评估),监测干预措施(监测室内外诱发因素) ,教育干预措施(空气质量警报、避免接触过敏原),以及相关政策的影响,如无烟政策和改善空气质量的综合战略。尽管这些研究报告了不同的干预措施,方法质量也存在差异,但这些干预措施显示了预防患者病情恶化、尽量减少急诊就诊和住院治疗的潜力。这些关键点可作为护理干预措施的关键组成部分。结论有必要采取全面措施,让护士参与促进患者自我监控空气质量的多学科团队.提高认识、制订和实施护理干预,从而使ACO患者受益。同时,需要进--步开展研究,以扩大证据基础并完善这些干预措施。

关键词：空气质量哮喘哮喘-慢阻肺重叠慢性病慢性阻塞性肺疾病护理自我管理

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Social determinants of gastrointestinal malformation mortality in Brazil:a national study

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World Journal of Pediatric Surgery 2024年第2期7卷 134-141页

作者： Ayla Gerk Amanda Rosendo Luiza Telles Aricia Gomes miranda madeleine Carroll bruna Oliveira Trindade Sarah Bueno motter Esther Freire Gabriella Hyman Julia Ferreira Fabio Botelho Roseanne Ferreira David P mooney Joaquim Bustorff-Silva Program in Global Surgery and Social Change Harvard Medical SchoolBostonMassachusettsUSA Faculty of medicine and Health Sciences McGill UniversityMontrealQuebecCanada Harvey E.Beardmore Division of Pediatric Surgery The Montreal Children's HospitalMcGill University Health CentreMontrealQuebecCanada Department of Surgery Universidade Estadual de Campinas(UNICAMP)CampinasBrazil Instituto de Educação médica(IDOmED/Estácio Campus Vista Carioca)Rio de JaneiroBrazil Faculty of medicine Universidade Federal do Delta do ParnaibaParnaibaPiauiBrazil Universidade Federal de Ciencias da Saude de Porto Alegre Porto AlegreBrazil Universidade Federal da Bahia SalvadorBrazil Department of Health Research methods McMaster UniversityHamiltonSouthern OntarioCanada Department of Pediatric Surgery Boston Children's HospitalBostonMassachusettsUSA

Introduction In Brazil,approximately 5%are born with a congenital disorder,potentially fatal without *** study aims to evaluate the relationship between gastrointestinal congenital malformation(GICm)mortality,health indicators,and socioeconomic factors in *** GICm admissions(Q39-Q45)between 2012 and 2019 were collected using national *** demographics,socioeconomic factors,clinical management,outcomes,and the healthcare workforce density were also accounted *** Surgical Workforce density and the number of neonatal intensive care units in a region were extracted from national datasets and combined to create a clinical index termed'NeoSurg'.Socioeconomic variables were combined to create a socioeconomic index termed SocEcon'.Simple linear regression was used to investigate if the temporal changes of both indexes were *** correlation between mortality and the different indicators in Brazil was evaluated using Pearson's correlation *** Over 8 years,Brazil recorded 12804 GICm *** Southeast led with 6147 cases,followed by the Northeast(2660),South(1727),North(1427),and midwest(843).The North and Northeast reported the highest mortality,lowest NeoSurg,and SocEcon Index ***,mortality rates declined across regions from 7.7%(2012)to 3.9%(2019),a 51.7%*** North and midwest experienced the most substantial reductions,at 63%and 75%,*** significantly correlated with the indexes in nearly all regions(pminants of health and GICm mortality in Brazil,using two novel indexes in the pediatric *** findings provide an opportunity to rethink and discuss new indicators that could enhance our understanding of our country and could lead to the development of necessary solutions to tackle existing challenges in Brazil and globally.

关键词： Northeast Brazil globally

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促进慢性阻塞性肺疾病哮喘患者自我监控空气质量的护理干预措施:整合性综述（英文）

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International Journal of Nursing Sciences 2024年第1期 46-56页

作者： bruna F.Sebasti?o Raquel m.Hortel?o Sara S.Granadas José m.Faria Joana R.Pinto Helga Rafael Henriques Nursing School of Lisbon Hospital Center of Central Lisbon CUF Tejo Hospital University Hospital Center of Northern Lisbon Nursing Research Innovation and Development Centre of Lisbon (CIDNUR)

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronic obstructive pulmonary disease overlap,ACO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过... 详细信息

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronic obstructive pulmonary disease overlap,ACO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过系统性综述,寻找证据,以指导制订护理干预措施,促进ACO患者对空气质量的自我管理。方法 2023年3月,系统检索CINAHL、medline、Academic Search Complete、Scopus、Web of Science、Cochrane图书馆、乔安娜布里格斯研究所(Joanna Briggs Institute,JBI)循证实践数据库,以及Google Scholar。对纳入研究进行数据提取和综合,并对护理干预措施进行分类。采用JBI研究质量评估工具进行方法学质量评估。结果共纳入5篇来自不同国家的研究。促进ACO患者自我监控空气质量的干预措施包括:警觉性干预措施(医务人员定期巡诊、进行症状评估),监测干预措施(监测室内外诱发因素),教育干预措施(空气质量警报、避免接触过敏原),以及相关政策的影响,如无烟政策和改善空气质量的综合战略。尽管这些研究报告了不同的干预措施,方法质量也存在差异,但这些干预措施显示了预防患者病情恶化、尽量减少急诊就诊和住院治疗的潜力。这些关键点可作为护理干预措施的关键组成部分。结论有必要采取全面措施,让护士参与促进患者自我监控空气质量的多学科团队、提高认识、制订和实施护理干预,从而使ACO患者受益。同时,需要进一步开展研究,以扩大证据基础并完善这些干预措施。

关键词：空气质量哮喘哮喘-慢阻肺重叠慢性病慢性阻塞性肺疾病护理自我管理

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The Use of Secondary Grape Biomass in Beef Cattle Nutrition on Carcass Characteristics, Quality and Shelf Life of meat

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Food and Nutrition Sciences 2024年第6期15卷 447-469页

作者： Vitor L. molosse Guilherme L. Deolindo Rafael V. P. Lago bruna Klein Claiton A. Zotti marcelo Vedovato marcylene V. da Silveira Priscila m. Copetti maria R. C. Schetinger Juscivete F. Favero Eliana L. Fiorentin Aleksandro S. da Silva Universidade do Estado de Santa Catarina (UDESC) Chapec Brazil Department of Animal Science UDESC Chapec Brazil Department of Animal Science Universidade do Oeste de Santa Catarina Xanxere Brazil Dean Lee Research and Extension Center Louisiana State University Alexandria LA USA Department of Biochemistry Universidade Federal de Santa Maria Santa Maria Brazil Department of medicina Veterinria UNOCHAPEC Chapec Brasil

We determined whether the inclusion of 100 g/kg dry matter of grape pomace silage (GPS) and grape pomace bran (GPB) as substitutes for other traditional fiber sources in the diet of steers (Charolais x Nellore) would improve carcass characteristics, meat quality and composition, and shelf life. Twenty-four animals (248 ± 19.32 kg of initial body weight) were fed a high concentrate diet for 121 days. Carcass characteristics were measured, and the longissimus dorsi muscle was analyzed for fatty acid (FA) profile and composition. The meat was sliced and stored in air-permeable packages for 10 days. On each sampling day (d 1, 3, 7, and 10), oxidative stability, bacterial load, lipid and protein oxidation, and staining were analyzed. The experimental diets influenced the pH of cold carcasses only. The GPS group had a higher pH than the control. The GPS and GPB groups showed improved oxidant status (i.e., lower lipid peroxidation and concentrations of reactive oxygen species were in the meat of both groups than in control). On the first day of storage, the antioxidant enzyme glutathione S-transferase activity was more significant in the meat of the GPS and GPB groups than in the control. The bacterial loads in the meat were attenuated by GPS inclusion;there were lower total coliform counts and a trend toward lower counts for enterobacteria in the control group. The diets altered the FA profile of the meat;i.e., the GPB diet allowed for a more significant amount of the n-6 omegas in the meat, while the GPS diet showed a tendency for a more significant amount of n-6 and 9 omegas. Both diets (GPS and GPB) increased the amounts of long-chain FAs. The GPS diet decreased saturated FA levels. We conclude that the dietary treatments GPS and GPB are a promising alternative to maintain meat quality standards throughout in real-world retail conditions. These treatments gave rise to an improvement in the nutritional value of the meat due to the more significant amounts of FAs that im

关键词： Animal Nutrition Antioxidant Biomass Grape meat Quality microbiology Residue

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Xanthophyll β-cryptoxanthin treatment inhibits hepatic steatosis without altering vitamin A status inβ-carotene 9',10'-oxygenase knockout mice

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 188-198页

作者： Chun Liu bruna Paola m.Rafacho Xiang-Dong Wang Nutrition and Cancer Biology Laboratory JM USDA Human Nutrition Research Center on Aging at Tufts UniversityBostonMAUSA

Background:β-cryptoxanthin(BCX),one of the major carotenoids detected in human circulation,can protect against the development of fatty liver *** can be metabolized throughβ-carotene-15,15'-oxygenase(BCO1)andβ-carotene-9',10'-oxygenase(BCO2)cleavage pathways to produce both vitamin A and apo-carotenoids,respectively,which are considered important signaling molecules in a variety of biological ***,we have demonstrated that BCX treatment reduced hepatic steatosis severity and hepatic total cholesterol levels in both wide type and BCO1^(-/-)/BCO2^(-/-)double knock out(KO)*** the protective effect of BCX is seen in single BCO2^(-/-)KO mice is ***:In the present study,male BCO2^(-/-)KO mice at 1 and 5 months of age were assigned to two groups by age and weight-matching as follows:(I)-BCX control diet alone(AIN-93 purified diets);(II)+BCX 10 mg(supplemented with 10 mg of BCX/kg of diet)for 3 *** 4 and 8 months of age,hepatic steatosis and inflammatory foci were evaluated by *** and BCX concentrations in liver tissue were analyzed by high-performance liquid chromatography(HPLC).Hepatic protein expressions of SIRT1,acetylated and total FoxO1,PGC1α,and PPARαwere determined by the Western blot ***-time PCR for gene expressions(mCAD,SCD1,FAS,TNFα,and IL-1βgene expression relative toβ-actin)was conducted in the ***:Steatosis was detected at 8 months but not at 4 months of ***,BCX supplementation significantly reduced the severity of steatosis in the livers of BCO2KO mice,which was associated with changes in hepatic SIRT1 acetylation of FOXO1,PGC1αprotein expression and PPARαprotein expression in BCO2^(-/-)KO *** analysis showed that hepatic BCX was detected in BCX supplemented groups,but there were no differences in the hepatic levels of retinol and retinyl palmitate(RP)among all ***:The present study provided experimental evidence that BCX intervention can r

关键词： β-cryptoxanthin(BCX) oxygenases fatty liver

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Fluid dynamics performance of phase change material particles in a Wurster spout–fluid bed

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Particuology 2019年第1期17卷 163-175页

作者： Rui Correia bruna Barbon Paulob Ana Silvia Pratab Almerindo D. Ferreira ADAI-LAETA Department of Mechanical EngineeringUniversity of Coimbra3030-78& CoimbraPortugal Department of Food Engineering School of Food EngineeringStare University of Campinas80 Monteiro Lobato Street13083-862CampinasBrazil

Spout–fluid-bed coating of solid–lipid materials, including some Phase Change materials (PCms), is a rarely used approach because of the probability of a phase change during the process. However, if mastered, this process could enable the commercialization of high-load PCm particles to develop new materials. An understanding of the thermal and fluid dynamics profiles inside a reactor can be used to establish optimized coating conditions, to avoid premature PCm melting and to maximize the drying rate. This research studies, through computational simulation, the behavior of particles and the experimental thermal profile inside a Wurster spout–fluid bed. A simplified model approach of momentum was simulated using OpenFOAm and carnauba wax particles as a PCm material. The simulation showed that appropriate flow conditions inside the Wurster tube must vary between 200 and 300 m3/h to ensure a better particle coating. The measured experimental thermal profile was uniform in the reactor and it was 5–10 °C lower than the set temperature. Thus, a maximum airflow at 70 °C that was used in the equipment is considered suitable for the further coating of PCm particles. The methodology proved useful for the preliminary identification of flow and temperature conditions in the spout–fluid process.

关键词： Computational fluid dynamics OpenFOAm Simulation Carnauba wax

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NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2^(V617F)-positive myeloproliferative neoplasm cells

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2440-2449页

作者： bruna Alves Fenerich Jaqueline Cristina Fernandes Ana Paula Nunes Rodrigues Alves Juan Luiz Coelho-Silva Renata Scopim-ribeiro Priscila Santos Scheucher Christopher A.Eide Cristina E.Tognon Brian J.Druker Eduardo magalhães Rego João Agostinho machado-Neto Fabiola Traina Department of medical Images Hematologyand Clinical OncologyUniversity of Sao Paulo at Ribeirao Preto Medical SchoolRibeirao PretoSao PauloBrazil Center for Cell-Based Therapy Sao Paulo Research FoundationRibeirao PretoSao PauloBrazil Knight Cancer Institute Oregon Health&Science UniversityPortlandORUSA Howard Hughes medical Institute PortlandORUSA Department of Internal medicine University of Sao Paulo Medical SchoolSao PauloBrazil Department of Pharmacology Institute of Biomedical Sciences of the University of Sao PauloSao PauloBrazil

Recent data indicate that IGF1R/IRS signaling is a potential therapeutic target in BCR-ABL1-negative myeloproliferative neoplasms(mPN);in this pathway,IRS2 is involved in the malignant transformation induced by JAK2^(V617F),and upregulation of IGF1R signaling induces the mPN ***157,a synthetic compound designed as an IGF1R-IRS1/2 inhibitor,has been shown to induce antineoplastic effects in solid ***,we aimed to characterize the molecular and cellular effects of NT157 in JAK2^(V617F)positive mPN cell lines(HEL and SET2)and primary patient hematopoietic *** JAK2^(V617F)cell lines,NT157 decreased cell viability,clonogenicity,and cell proliferation,resulting in increases in apoptosis and cell cycle arrest in the G2/m phase(pment inhibited IRS1/2,JAK2/STAT,and NFκB signaling,and it activated the AP-1 complex,downregulated four oncogenes(CCND1,mYB,WT1,and NFKB1),and upregulated three apoptotic-related genes(CDKN1A,FOS,and JUN)(pmation in cells from polycythemia vera patients(pmechanism of NT157 action in a mPN context and suggest that targeting IRS1/2 proteins may represent a promising therapeutic strategy for mPN.

关键词： JAK2 IGF1R neoplasms STAT3

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melt Extrusion of Environmentally Friendly Poly(L-lactic acid)/Sodium metabisulfite Films for Antimicrobial Packaging Applications

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Journal of Renewable materials 2021年第2期9卷 337-349页

作者： Norma m.P.machado Gustavo C.melo matheus F.Camargo Giulianna G.Feijó bruna.m.S.Putton Clarice Steffens Rogerio L.Cansian Luiz A.Pessan Francys K.V.moreira Department of materials Engineering Federal University of São CarlosSão CarlosBrazil Department of Food Engineering Regional Integrated University of High Uruguay and Missions(URI)ErechimBrazil

Food packaging materials compounded with antimicrobial additives can substantially diminish the incidence of foodborne ***,poly(L-lactic acid)(PLA)films containing sodium metabisulfite(Nam)were produced by melt extrusion as an attempt to develop a new biodegradable material with antimicrobial properties for *** cycle assessment(LCA)simulations revealed that the environmental footprints of the PLA film did not change upon Nam addition,and that Nam is more eco-friendly than silver *** PLA/Nam films with Nam content varying from 0.5 to 5.0 wt.%were characterized by differential scanning calorimetry(DSC),thermogravimetric analysis(TGA),and optical and mechanical properties *** optical properties were sustained after the addition of Nam,but high Nam contents degraded the light transparence of the PLA matrix at some *** thermal stability and tensile properties of the PLA film decreased proportionally to the Nam content,while no changes were observed on Tg,Tm and Xc,as determined by *** diffusion tests revealed that the PLA/Nam films had no antimicrobial activity on Saccharomyces cerevisiae at 35°C,which was related to the limited migration of Nam from the glassy PLA *** biodegradable PLA films compounded with Nam through melt extrusion display adequate optical,thermal,and mechanical properties to cover most food packaging applications,representing an essential step toward the development of eco-friendly packaging materials that can potentially exhibit an antimicrobially active surface.

关键词： Biobased packaging antimicrobial activity life cycle assessment

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