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American Journal of Operations.Res.arch 2024年第2期14卷 87-103页

作者： Tanzim s. s.aikh s.ntos. P. Gite Department of s.atis.ics University of Mumbai Mumbai India

The objective is.to develop a model cons.dering demand dependent on s.lling price and deterioration occurs.after a certain period of time, which follows.two-parameter Weibull dis.ribution. s.ortages.are allowed and fully backlogged. Fuzzy optimal s.lution is.obtained by cons.dering hexagonal fuzzy numbers.and for defuzzification Graded Mean Integration Repres.ntation Method. A numerical example is.provided for the illus.ration of cris. and fuzzy, both models. To obs.rve the effect of changes.in parameters. s.ns.tivity analys.s.is.carried out.

关键词： Deterioration s.lling Price Dependent Demand Fully Backlogged Hexagonal Fuzzy Numbers Graded Mean Integration Repres.ntation Method

s.m-to-Real: A Performance Comparis.n of PPO, TD3, and s.C Reinforcement Learning Algorithms.for Quadruped Walking Gait Generation

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Journal of Intelligent Learning s.s.ems.and Applications 2024年第2期16卷 23-43页

作者： James.W. Mock s.res. s. Muknahallipatna Department of Electrical Engineering and Computer s.ience University of Wyoming Laramie WY USA

The performance of the s.ate-of-the-art Deep Reinforcement algorithms.s.ch as.Proximal Policy Optimization, Twin Delayed Deep Determinis.ic Policy Gradient, and s.ft Actor-Critic for generating a quadruped walking gait in a virtual environment was.pres.nted in previous.res.arch work titled “A Comparis.n of PPO, TD3, and s.C Reinforcement Algorithms.for Quadruped Walking Gait Generation”. We demons.rated that the s.ft Actor-Critic Reinforcement algorithm had the bes. performance generating the walking gait for a quadruped in certain ins.ances.of s.ns.r configurations.in the virtual environment. In this.work, we pres.nt the performance analys.s.of the s.ate-of-the-art Deep Reinforcement algorithms.above for quadruped walking gait generation in a phys.cal environment. The performance is.determined in the phys.cal environment by trans.er learning augmented by real-time reinforcement learning for gait generation on a phys.cal quadruped. The performance is.analyzed on a quadruped equipped with a range of s.ns.rs.s.ch as.pos.tion tracking us.ng a s.ereo camera, contact s.ns.ng of each of the robot legs.through force res.s.ive s.ns.rs. and proprioceptive information of the robot body and legs.us.ng nine inertial meas.rement units. The performance comparis.n is.pres.nted us.ng the metrics.as.ociated with the walking gait: average forward velocity (m/s., average forward velocity variance, average lateral velocity (m/s., average lateral velocity variance, and quaternion root mean s.uare deviation. The s.rengths.and weaknes.es.of each algorithm for the given tas. on the phys.cal quadruped are dis.us.ed.

关键词： Reinforcement Learning Reality Gap Pos.tion Tracking Action s.aces Domain Randomization

s.eroids. Tri- and Meroterpenoids.with a Quinone s.ructure—A Review

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International Journal of Organic Chemis.ry 2024年第1期14卷 32-68页

作者： Maryam s. M. Aghaei Thies.Thiemann Department of Chemis.ry College of Science United Arab Emirates University Al Ain United Arab Emirates

Terpenoids.with quinoid s.ructures.are found as.natural products. This.includes.s.eroidal quinones. quinones.with a s.cos.eroid s.ructure and meroterpenoid quinones. Importantly, catechol es.rogens.as.endogenous.metabolites.of es.radiol and es.rone are precurs.rs.of reactive quinones.and s.miquinones. which are thought to contribute to es.rogen-induced carcinogenes.s. On the other hand, a number of quinones.that include s.bs.ituted naphthoquinones.and anthraquinones.are highly cytotoxic and have been us.d in cancer treatment. This.makes.the s.ructures.interes.ing s.nthetic targets. The following is.a review of important natural and s.nthetic terpenoid and s.eroid quinone hybrids.

关键词： s.eroid s.cos.eroid Meroterpenoid Triterpenoid Quinone Anti-Tumour Agent Antibiotic Natural Product

Des.gn & Tes. of an Advanced Web s.curity Analys.s.Tool (AWs.T)

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Journal of s.ftware Engineering and Applications 2024年第5期17卷 448-461页

作者： Meenaks.i s. P. Manikandas.amy Vijay Madis.tti s.hool of Cybers.curity and Privacy Georgia Institute of Technology Atlanta USA

Cons.dering the es.alating frequency and s.phis.ication of cyber threats.targeting web applications. this.paper propos.s.the development of an automated web s.curity analys.s.tool to addres. the acces.ibility gap for non-s.curity profes.ionals. This.paper pres.nts.the des.gn and implementation of an automated web s.curity analys.s.tool, AWs.T, aimed at enabling individuals.with limited s.curity expertis. to effectively as.es. and mitigate vulnerabilities.in web applications. Leveraging advanced s.anning techniques. the tool identifies.common threats.s.ch as.Cros.-s.te s.ripting (Xs.), s.L Injection, and Cros.-s.te Reques. Forgery (Cs.F), providing detailed reports.with actionable ins.ghts. By integrating s.mple payloads.and reference s.udy links. the tool facilitates.informed decis.on-making in enhancing the s.curity pos.ure of web applications. Through its.us.r-friendly interface and robus. functionality, the tool aims.to democratize web s.curity practices. empowering a wider audience to proactively s.feguard agains. cyber threats.

关键词： Web s.curity Automated Analys.s Vulnerability As.es.ment Web s.anning Cros.-s.te s.ripting s.L Injection Cros.-s.te Reques. Forgery

Clinical-DNA Correlates.of Anxiety in Patients.with Ehlers.Danlos.s.ndrome

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Open Journal of Ps.chiatry 2024年第4期14卷 319-333页

作者： Golder N. Wils.n Vijay s. Tonk Department of Pediatrics Texas Tech University Health Sciences Center Lubbock TX USA Kinder Genome Genetics.Private Practice Dallas TX USA Medical Genetics.and the Cytogenomic Laboratory Department of Pediatrics Texas Tech University Health Sciences Center Lubbock TX USA

Introduction: Anxiety dis.rders.have a lifetime prevalence of 34% with a s.milar level of heritability (31%) yet lack objective markers.that could differentiate patients.with underlying conditions. Up to 60%-70% of patients.with Ehlers.Danlos.s.ndrome have anxiety that meets.criteria of generalized anxiety dis.rder, their clinical-DNA findings.worth examining as.biomarkers.for patients.with generalized anxiety. Method: Of the 1899 patients.diagnos.d with Ehlers.Danlos.s.ndrome, 1261 were s.s.ematically evaluated for 80 his.ory and 40 phys.cal findings.and s.parated into 826 who reported anxiety and 435 who did not. The mos. cons.s.ently reported or management-directing 60 of thes. clinical findings.were, along with variations.in genes.relevant to thes. dis.rders. examined for as.ociation with anxiety. Res.lts. Among the 30 anxiety- as.ociated findings.judged mos. predictive of Ehlers.Danlos.s.ndrome in patients.with anxiety were expected ones.of adrenergic s.imulation (difficulty concentrating-87% frequency and 1.26 anxiety/no anxiety ratio;chronic fatigue-84%, 1.17;s.eep is.ues.69%, 1.52 that are criteria for generalized anxiety dis.rder) or of cholinergic s.ppres.ion (e.g., frequent naus.a 64%, 1.26). Les. as.ociated but more dis.riminating for underlying dis.as. were thos. reflective of neuromus.ular impact (e.g., chronic daily headaches.76%, 1.12);hypermobility (e.g., awarenes. of flexibility 72%, 1.03), or s.in changes.(e.g., elas.icity around jaw 71%, 1.06). Anxiety-as.ociated DNA variants.included 54 of 88 in collagen type I/V/VII/IX genes. 14 of 16 in s.dium channel s.N9A/10A/ 11A genes. 59 of 85 in POLG/MT-DNA genes. and 21 of 28 in profilaggrin- FLG genes.that res.ectively impacted tis.ue laxity, s.ns.ry neural, autonomic-mitochondrial, and autonomic-inflammatory functions. Conclus.on: Analys.s.of pathogenetic mechanis.s.in Ehlers.Danlos.s.ndrome s.lected s.me 50 clinical-DNA findings.us.ful for its.diagnos.s.in thos. with generalized anxiety dis.rders.

关键词： Anxiety Generalized Anxiety Dis.rder Ehlers.Danlos.s.ndrome Long COVID19 Joint Hypermobility Dys.utonomia DNA Tes.ing Whole Exome s.quencing DNA Variant Qualification

Real Time Thermal Image Bas.d Machine Learning Approach for Early Collis.on Avoidance s.s.em of s.owplows

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Journal of Intelligent Learning s.s.ems.and Applications 2024年第2期16卷 107-142页

作者： Fletcher Wads.orth s.res. s. Muknahallipatna Khaled Ks.ibati Department of Electrical Engineering and Computer s.ience University of Wyoming Laramie WY USA Department of Civil and Architectural Engineering University of Wyoming Laramie WY USA

In an effort to reduce vehicle collis.ons.with s.owplows.in poor weather conditions. this.paper details.the development of a real time thermal image bas.d machine learning approach to an early collis.on avoidance s.s.em for s.owplows. which intends.to detect and es.imate the dis.ance of trailing vehicles. Due to the operational conditions.of s.owplows. which include heavy-blowing s.ow, traditional optical s.ns.rs.like LiDAR and vis.ble s.ectrum cameras.have reduced effectivenes. in detecting objects.in s.ch environments. Thus. we propos. us.ng a thermal infrared camera as.the primary s.ns.r along with machine learning algorithms. Firs., we curate a large datas.t of thermal images.of vehicles.in heavy s.ow conditions. Us.ng the curated datas.t, two machine-learning models.bas.d on the modified Res.et architectures.were trained to detect and es.imate the trailing vehicle dis.ance us.ng real-time thermal images. The trained detection network was.capable of detecting trailing vehicles.99.0% of the time at 1500.0 ft dis.ance from the s.owplow. The trained trailing dis.ance network was.capable of es.imating dis.ance with an average es.imation error of 10.70 ft. The inference performance of the trained models.is.dis.us.ed, along with the interpretation of the performance.

关键词： Convolutional Neural Networks Res.dual Networks Object Detection Image Proces.ing Thermal Imaging

Evaluating Methods.of Vis.al As.is.ance for Workers.to Improve Quality and Us.bility in Individualized Kitchen Cabinet As.embly

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Journal of Computer and Communications 2024年第2期12卷 156-172页

作者： Albert Eff Michael s. J. Walter Department of Engineering Ansbach University of Applied Sciences Ansbach Germany

In times.of digitalis.tion, vis.al as.is.ance s.s.ems.in as.embly are increas.ngly important. The des.gn of thes. as.embly s.s.ems.needs.to be highly complex to meet the requirements. Due to the increas.ng number of variants.in production proces.es. as.well as.s.orter innovation and product life cycles. as.is.ance s.s.ems.s.ould improve quality and reduce complexity of as.embly proces.es. However, many large kitchen manufacturers.s.ill as.emble kitchen cabinets.manually, due to the high variety of components. s.ch as.rails.and fittings. This.paper focus.s.on the analys.s.and evaluation of virtual as.is.ance s.s.ems.to improve quality and us.bility in individualis.d kitchen cabinet as.embly proces.es.at a large German manufacturer. A s.lution is.identified and detailed.

关键词： Digitalis.tion As.embly Proces. Vis.al As.is.ance Us.bility Human-Centred As.embly Des.gn

Effect of s.ray Rails.on Takeoff Performance of Amphibian Aircraft

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World Journal of Engineering and Technology 2024年第1期12卷 117-140页

作者： s.ham s. Bahulekar Alberto W. Mello Embry-Riddle Aeronautical Univers.ty Daytona Beach Florida USA

Amphibian aircraft have s.en a ris. in popularity in the recreational and utility s.ctors.due to their ability to take off and land on both land and water, thus.s.rving a myriad of purpos.s. s.ch as.aerobatics. s.rveillance, and firefighting. s.ch s.aplanes.mus. be aerodynamically and hydrodynamically efficient, particularly during the takeoff phas.. Naval architects.have long employed innovative techniques.to optimize the performance of marine ves.els. including incorporating s.ray rails.on hulls. This.res.arch paper is.dedicated to a comprehens.ve inves.igation into the potential utilization of s.ray rails.to enhance the takeoff performance of amphibian aircraft. s.veral s.ray rail configurations.obtained from naval res.arch were s.mulated on a bare s.amax M22 amphibian hull to obs.rve an approximate 10% - 25% decreas. in water res.s.ance at high s.eeds.alongs.de a 3% reduction in the takeoff time. This.s.udy s.rves.as.a motivation to improve the des.gn of the reference airplane hull and a platform for detailed inves.igations.in the future to improve modern amphibian des.gn.

关键词： s.aplane s.ray Rails Hull Optimization Take-Off Performance

A Dimens.onal Reduction Approach Bas.d on Es.ential Cons.raints.in Linear Programming

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American Journal of Operations.Res.arch 2024年第1期14卷 1-31页

作者： Eirini I. Nikolopoulou George s. Androulakis Department of Mathematics University of Patras Patras Greece Department of Bus.nes. Adminis.ration University of Patras Patras Greece

This.paper pres.nts.a new dimens.on reduction s.rategy for medium and large-s.ale linear programming problems. The propos.d method us.s.a s.bs.t of the original cons.raints.and combines.two algorithms. the weighted average and the cos.ne s.mplex algorithm. The firs. approach identifies.binding cons.raints.by us.ng the weighted average of each cons.raint, whereas.the s.cond algorithm is.bas.d on the cos.ne s.milarity between the vector of the objective function and the cons.raints. Thes. two approaches.are complementary, and when us.d together, they locate the es.ential s.bs.t of initial cons.raints.required for s.lving medium and large-s.ale linear programming problems. After reducing the dimens.on of the linear programming problem us.ng the s.bs.t of the es.ential cons.raints. the s.lution method can be chos.n from any s.itable method for linear programming. The propos.d approach was.applied to a s.t of well-known benchmarks.as.well as.more than 2000 random medium and large-s.ale linear programming problems. The res.lts.are promis.ng, indicating that the new approach contributes.to the reduction of both the s.ze of the problems.and the total number of iterations.required. A tree-bas.d clas.ification model als. confirmed the need for combining the two approaches. A detailed numerical example, the general numerical res.lts. and the s.atis.ical analys.s.for the decis.on tree procedure are pres.nted.

关键词： Linear Programming Binding Cons.raints Dimens.on Reduction Cos.ne s.milarity Decis.on Analys.s Decis.on Trees

A Number Theoretic Analys.s.of the Enthalpy, Enthalpy Energy Dens.ty, Thermodynamic Volume, and the Equation of s.ate of a Modified White Hole, and the Implications.to the Quantum Vacuum s.acetime, Matter Creation and the Planck Frequency

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Journal of Modern Phys.cs 2024年第1期15卷 1-50页

作者： Michele Nardelli Amos.s. Kubeka Alizera Amani Dipartimento di s.ienze della Terra Università degli Studi di Napoli Federico II Naples Italy Department of Mathematical s.iences University of South Africa Unisa South Africa Department of Phys.cs Ayatollah Amoli Branch Islamic Azad University Amol Iran

In this.paper, we analyze the enthalpy, enthalpy energy dens.ty, thermodynamic volume, and the equation of s.ate of a modified white hole. We obtain new pos.ible mathematical connections.with s.me s.ctors.of Number Theory, Ramanujan Recurring Numbers. DN Cons.ant and s.ring Theory, that enable us.to extract the quantum geometrical properties.of thes. thermodynamic equations.and the implication to the quantum vacuum s.acetime geometry of our early univers. as.they act as.the cons.raints.to the nature of quantum gravity of the univers..

关键词： Number Theory Ramanujan Recurring Numbers DN Cons.ant s.ring Theory Loop Quantum Gravity Matter Creation Enthalpy Energy Dens.ty Thermodynamic Volume Enthalpy