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Investigation of role of cartilage surface polymer brush border in lubrication of biological joints

Friction 2022年第1期10卷 110-127页

作者： JinJing LIAO David W.sMITH saeed MIRAMINI bruce.s.gardiner Lihai ZHANG Department of Infrastructure Engineering.The University of Melbourne.Victoria 3010 Australia Faculty of Engineering and Mathematical sciences The University of Western AustraliaWA 6009Australia College of science Health.Engineering and Education.Murdoch UniversityWA 6150Australia

Although experimental evidence has suggested that the polymer brush border(PBB)on the cartilage surface is important in regulating fluid permeability in the contact gap,the current theoretical understanding of joint lubrication is still *** address this research gap,a multiscale cartilage contact model that includes PBB,in particular its effect on the fluid permeability of the contact gap,is developed in this *** modeling is employed to estimate the permeability of the contact *** permeability is classified into two categories:For a gap size>1μm,the flow resistance is assumed to be dominated by the cartilage roughness;for gap sizesistance is assumed to be dominated by the surface polymers extending beyond the collagen network of the articular *** gap sizes of less than 1μm,the gap permeability decreases exponentially with increasing aggrecan concentration,whereas the aggrecan concentration varies inversely with the gap ***,the gap permeability is employed in a macroscale cartilage contact model,in which both the contact gap space and articular cartilage are modeled as two interacting poroelastic *** fluid exchange between these two media is achieved by imposing pressure and normal flux continuity boundary *** model results suggest that PBB can substantially enhance cartilage lubrication by increasing the gap fluid load support(e.g.,by 26 times after a 20-min indentation compared with the test model without a PBB).Additionally,the fluid flow resistance of PBB sustains the cartilage interstitial fluid pressure for a relatively long period,and hence reduces the vertical deformation of the ***,it can be inferred that a reduction in the PBB thickness impairs cartilage lubrication ability.

关键词： assumed polymer hence

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The Effect of Frat-1, Idax and Axam toward the Wnt signaling Pathway

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Journal of Life sciences 2011年第6期5卷 421-427页

作者： Nur Farahiyah Motiammad Reena Peter bruce gardiner school of Mechatronic Universiti Malaysia Perlis Perlis Arau 02600 Malaysia Melbourne school of Engineering The University of Melbourne Melbourne Victoria 3010 Australia

This paper describes the effect of Frat-1, Idax and Axam toward the Wnt signaling pathway. The Wnt pathway is an important intracellular signaling pathway that plays a crucial role in the cell cycle process at several levels of development. Understanding this pathway thoroughly will enable identification of new drug targets and thereby open avenues to more effective therapies for a range of Wnt pathway related diseases such as cancer, osteoporosis, and mesothelioma. Dishevelled (Dsh) is one of the multi-module proteins working in the Wnt pathway. The function of Dsh depends on the regulators which bind to it, components it interacts with and most importantly the Wnt signal. It is important to note that positive regulators are those factors that induce gene transcription. Conversely, the negative regulators induce β-Catenin degradation. The positive regulator such as Frat-1 would promote the Wnt signaling pathway and downstream gene transcription. Meanwhile the negative regulator such as Idax and Axam would inhibit the signaling pathway and promotes β-Catenin degradation which will thereby prevent aberrant gene transcription.

关键词： Wnt信号通路基因转录信号转导通路监管机构骨质疏松症负调控因子细胞周期药物靶点

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