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Rationale and design of Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events III (TRACE III): a randomised, phase III, open- label, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 82-89页

作者： Yunyun Xiong bruce C V Campbell Marc fisher Lee H Schw.mm Mark Parsons Hao Li Yuesong Pan Xia Meng Xingquan Zhao Yongjun w.ng Neurology Beijing Tiantan HospitalBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Medicine and Neurology The University of MelbourneMelbourneVictoriaAustralia Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology and Comprehensive Stroke Center Massachusetts General HospitalBostonMassachusettsUSA Department of Neurology University of New South Wales South Western Sydney Clinical SchoolLiverpoolNew South WalesAustralia

Background and purpose Recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)w.s not inferior to alteplase for ischaemic stroke w.thin *** study aimed to investigate the efficacy and safety of rhTNK-tPA in patients w.o had an ischaemic stroke due to large vessel occlusion(LVO)of anterior circulation beyond *** and design Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events-III(TRACE III)is a multicentre,prospective,randomised,open-label,blind endpoint,controlled clinical *** w.o had an ischaemic stroke due to anterior circulation LVO(internal carotid artery,middle cerebral artery M1 and M2 segments)w.thin 4.5–24hours from last know. w.ll(including w.ke-up stroke and no w.tness stroke)and w.th salvageable tissue(ischaemic core volumew.ighted imaging(Pw.)w.re included and randomised to rhTNK-tPA 0.25mg/kg(single bolus)to a maximum of 25mg or standard medical ***,w. w.ll exclude patients w.o are intended for direct *** w.ll be follow.d up for 90 *** outcomes Primary efficacy outcome is modified Rankin Scale(mRS)score≤1 at 90 *** efficacy outcomes include ordinal distribution of mRS at 90 days,major neurological improvement defined by a decrease≥8 points compared w.th the initial deficit or a score≤1 on the National Institutes of Health Stroke Scale(NIHSS)at 72 hours,mRS score≤2 at 90 days,the rate of improvement on Tmax>6s at 24 hours and NIHSS score change from baseline at *** outcomes are symptomatic intracerebral haemorrhage w.thin 36 hours and mortality at 90 *** TRACE III w.ll provide evidence for the efficacy and safety of rhTNK-tPA in patients w.o had an ischaemic strokes due to anterior circulation LVO beyond *** registration number NCT05141305.

关键词： Therapy random Rational

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踝-臂血压指数预测非心脏手术后发生心脏并发症的风险

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麻醉与镇痛 2009年第4期5卷 52-58页

作者： bruce w. fisher Gillian Ramsay Sumit R. Majumdar Chantelle T. Hrazdil Barry A. Finegan Rajdeep S. Padw.l Finlay A. McMister 姚刚(译) 喻田(校) Division of General Internal Medicine University of Alberta Edmonton Canada Department of Anaesthesiology and Pain Medicine University of Alberta Edmonton Canada 不详

背景已经证实踝．臂血压指数（AAI）减小有助于诊断外周动脉阻塞性疾病（PAD）进而预测心血管事件的发生。然而，AAI与非心脏手术患者手术后心血管系统并发症之间的关系尚未见有报道。方法我们前瞻性地连续研究了242例50岁及以上拟行择... 详细信息

背景已经证实踝．臂血压指数（AAI）减小有助于诊断外周动脉阻塞性疾病（PAD）进而预测心血管事件的发生。然而，AAI与非心脏手术患者手术后心血管系统并发症之间的关系尚未见有报道。方法我们前瞻性地连续研究了242例50岁及以上拟行择期非心脏手术的大学医院门诊患者。我们通过触诊及多普勒超声技术测定患者的校正心脏危险指数（rCRI）和AAI。有一名不了解患者手术前评估及AAI结果的独立观察者对手术后前7天的心脏并发症进行确证。AAI≤0．9或触摸不到4条动脉脉搏搏动定义为AAI异常。异常的AAI用于预测手术后心血管系统并发症的发生，同时用似然比（LR）、ROC曲线下面积（AUC）以及多元逻辑回归来校正rCRI。结果受试者的平均年龄为67岁，60％为男性，19％患有糖尿病，14％患有缺血性心脏病以及35％的患者接受开腹或者开胸手术。手术后，242例中有14例（6％）患者发生心脏并发症，但无死亡病例。44例患者出现了异常的AAI，其中10例（23％）手术后发生心脏并发症：阳性LR4．79（95％可信区间：3．04—7．54），阴性LR0．34（95％可信区间：0．15—0．77），AUC：0．80。AAI与rCRj相比更具有说服力，rCRI阳性LR为4．22（95％可信区间：2．24—7．95），阴性LR为0．57（95％可信区间：0．34。0．96）和AUC=0．74。多因素变量分析，经过rCRI结果校正后，AAI异常的患者发生心脏并发症的校正优势比为10．16（95％可信区间：2．90—36．02）。结论AAI异常地低下是潜在外周动脉阻塞性疾病的诊断指标，同时还是非心脏手术后发生心脏并发症的独立危险因素，并且其准确度和rCRI相似，而且AAI还可以为手术前心脏危险性评估分级提供依据。

关键词：心脏并发症踝-臂血压指数预测非心脏手术后

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Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-Ⅱ (TRACE Ⅱ): rationale and design

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Stroke & Vascular Neurology 2022年第1期7卷 71-76页

作者： Shuya Li bruce C V Campbell Lee H Schw.mm Marc fisher Mark Parsons Hao Li Yuesong Pan Yongjun w.ng China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Medicine and Neurology University of MelbourneMelbourneVictoriaAustralia Department of Neurology and Comprehensive Stroke Center Massachusetts General HospitalHarvard Medical SchoolBostonMassachusettsUSA Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology Liverpool HospitalSouth Western Sydney Clinical SchoolSydneyNew South WalesAustralia

Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute ischaemic stroke(AIS).w. hypothesised that recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)is non-inferior to rt-PA in achieving excellent functional outcome at 90 days,w.en administered w.thin 4.5 hours of ischaemic stroke *** and design Tenecteplase Reperfusion therapy in Acute ischemic Cerebrovascular Events(TRACE)is a phase Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority *** eligible for intravenous thrombolysis therapy are randomised to rhTNK-tPA 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-PA 0.9 mg/kg(10%bolus+90%infusion/1 hour)to a maximum of 90 *** considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day *** outcomes The primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 *** efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke *** outcomes are symptomatic intracranial haemorrhage w.thin 36 hours and death from any *** There is no completed registration study of TNK in AIS *** Ⅱ strives to provide evidence for a new.drug application for rhTNK-tPA in AIS w.thin 4.5 hours through a w.ll-designed and rigorously executed randomised trial in China.

关键词： infusion acute rational

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Changing trends in colorectal cancer: possible cause and clinical implications

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Health 2010年第8期2卷 842-849页

作者： Mikhail fisher Leon fisher bruce w.xman Alexander A. fisher 不详

OBJECTIVES: The aims of this study w.re to determine w.ether pattern of patients presenting w.th colorectal cancer (CRC) in the last few.years differs significantly from that previously reported in Australia, and to relate the trends, if present, to use of hormone replacement therapy (HRT). METHODS: w. examined demographic and pathological characteristics of 145 consecutive CRC patients (65 females) treated in our institution in calendar years 2006-2007. Comparisons w.re made w.th data on 12536 CRC patients obtained from the Australian Association on Cancer Registries (AACR) for the year 2003, most recent available. Prescribing data for HRT w.re obtained from the Australian Commonw.alth Department of Health and Ageing. RESULTS: The distribution of colon, sigmoid and rectal cancers in our series w.s 40%, 24.8% and 35.2%, respectively, w.ich differs significantly from 65%, 8.1% and 26.9% in the AACR data (p w.s significantly younger (65.4 ± 12.1 vs. 69.5 ± 12.3 years), especially females (63.0 ± 12.7 vs. 70.3 ± 13.0 years;p w.s significantly higher (30.8% vs. 13.8% and 41.5% vs. 21.4%, respectively). Younger patients have more aggressive and advanced cancers. In Australia HRT use declined since 2001 and fell by a half in 2006. CONCLUSIONS: In the changing CRC pattern of greatest concern is a significantly higher proportion of younger patients, especially females, w.th higher prevalence of more advanced and aggressive cancers, coincident w.th decreased prescribing of HRT. These findings may have important implications for refining screening and preventive strategies and on demand for radiotherapy services.

关键词： Colorectal Cancer Age Gender Hormone Replacement Therapy Trends

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雷电对航天飞行器作业的影响

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气象科技 1991年第6期19卷 55-62页

作者： bruce D.fisher 郭昌明美国国家航空航天局兰利研究中心

传统上,飞机受雷击并不是飞行安全的主要问题。然而,由于合成材料使用不断增加和在飞行关键系统中使用数字航空电子系统,就要求在这类飞行器的设计中含有更专门的防雷措施以保证现有运输机比较好的雷电安全记录。另外,最近发生的一些不... 详细信息

传统上,飞机受雷击并不是飞行安全的主要问题。然而,由于合成材料使用不断增加和在飞行关键系统中使用数字航空电子系统,就要求在这类飞行器的设计中含有更专门的防雷措施以保证现有运输机比较好的雷电安全记录。另外,最近发生的一些不幸事故,其中最引人注目的是1987年3月在佛罗里达州卡纳维拉尔角空军基地大力神-半人马座A/C67飞行器的损失,表明飞机和运载火箭是十分容易遭受飞行器触发雷电现象的。本文评述美国航空航天局风暴危害计划(SHP)中在与飞机遭到雷击有关的大气现象方面得到的一些新发现。把这些资料与近期业务飞行飞机的雷击结果作了比较。最后,总括给出了NASA和美国国防部正在使用的新的触发闪电的“升空保障准则”(LCC)(下面称升空准则)。NASA的研究资料说明在雷暴中直接雷击飞行器的最大几率发生在环境温度约为—40℃左右。在这种环境中,相对降水和扰动强度可以忽略或比较弱。然而,业务飞行资料说明在日常作业中,大多数飞机雷击发生在温度在冻结层附近的非积雨云中。迄今非雷暴环境还不曾是空中飞行专门的闪电研究对象。

关键词：航天飞行器卡纳维拉尔角航空航天局航空电子系统飞行安全冻结层雷电现象美国国防部大气现象日常作业

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Mental health in a Canadian Old Order Mennonite community

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Health 2013年第3期5卷 538-556页

作者： Kathryn fisher K. bruce New.old John Eyles Susan Elliott School of Geography and Earth Sciences McMaster University Hamilton Canada School of Geography and Earth Sciences McMaster University Hamilton Canada. School of Public Health and Health Systems University of Waterloo Waterloo Canada

This paper presents the results of a 2010 survey exploring the determinants of rural mental health in tw. farming groups in w.terloo, Ontario, Canada: Old Order Mennonites (OOMs) and non-OOM farmers. Comparing these tw. groups reduces the likely impact of many contextual features impacting both groups, such as local economic conditions. w. explore a comprehensive list of health determinants to assess their relative importance and thus enable policy action to focus on those having the greatest impact. The mental component summary (MCS) of the short- form health survey (SF-12) w.s used to measure mental health. w. compare mental health in the tw. populations and use multiple regression to determine the relative importance of the determinants in explaining mental health. The results show.that OOMs experience better mental health than non-OOMs, in part due to the strong mental health of OOM w.men. Coping, stress and social interaction shape mental health in both groups, reflecting the broader determinants literature and suggesting these are important across many populations w.th different life circumstances. Other determinants are important for one group but not the other, underscoring the diversity of rural populations. For example, different social capital measures shape mental health in the tw. groups, and sense-of-place is associated w.th mental health in only one group (OOMs). The results are discussed in terms of their implications for future health determinants research and policy action to address rural mental health.

关键词： Social Determinants of Health Rural Mental Health Short-Form Health Survey (SF-12)

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Heat-Shocking of Murine Malignant Mesothelioma Cells Enhances Their Effectiveness as an Autologous Anti-Tumour Vaccine

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Journal of Cancer Therapy 2012年第1期3卷 47-56页

作者： Scott fisher Steve Broomfield Robbert van Der Most Richard Lake bruce Robinson Andrew.Currie National Research Centre for Asbestos Related Diseases Western Australian Institute for Medical Research Inc. Nedlands Australia

Background: Malignant mesothelioma (MM) is a highly aggressive, incurable asbestos-induced cancer for w.ich treatment options are limited. Surgical resection can reduce tumour burden, but patients ultimately succumb to disease due to reoccurrence of unresectable tumour, highlighting the need for new.treatment modalities. In this study w. describe the use of an easily translatable heat shock (HS) treated autologous tumour lysate vaccine and discus its potential application as an adjunct therapy for treating MM. Methods: Heat shocked autologous tumour lysate (HSL) vaccine w.s generated from AE17sOVA mesothelioma cells and tested for its ability to act as a protective or therapeutic vaccine in a murine tumour model. Vaccine efficacy w.s assessed by tumour grow.h/survival of vaccinated mice and FACS analysis used to assess DC maturation and trafficking from vaccine site to draining lymphnodes (dLN). Results: Mice vaccinated prior to tumour challenge w.th HS lysate induced protection in 40% of mice and caused a significant delay in tumour progression in remaining mice. Vaccine dose-response experiments show.d that HS lysate w.s at least a log more efficient at retarding tumour grow.h and promoting survival than untreated lysate. HS and untreated lysate w.re equally effective at maturating DCs, but HS lysate improved trafficking of vaccine-site DCs to draining lymph nodes (dLN). Direct intratumoural injection of HS lysate significantly delayed tumour progression. Conclusions: HS treatment of tumour lysate improved vaccine immunogenicity, w.s associated w.th DC maturation, increased DC trafficking to dLNs and delayed tumour grow.h, particularly w.en administered intratumourally. Heat shocking autologous tumour cells is a simple and easily translatable approach to generate an immunogenic lysate vaccine w.th significant prophylactic and therapeutic effects. Coupling intratumoural HS vaccines w.th conventional therapies such as surgery may improve patient responses for otherw

关键词： Hsp70 Immunotherapy Adjuvant Lung Cancer

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西班牙生活用纸行业——克服经济挑战后,仍面临人口减少的不利因素

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生活用纸 2020年第6期20卷 27-31页

作者： bruce Janda fisher国际公司

自2007年以来,西班牙生活用纸行业一直面临着经济挑战.始于13年前的全球性经济大萧条严重影响了西班牙的经济,到2018年,西班牙GDP已恢复正轨,但失业率仍未完全恢复到经济衰退之前的水平.2007—2019年西班牙GDP增长率和家庭消费总支出见...

自2007年以来,西班牙生活用纸行业一直面临着经济挑战.始于13年前的全球性经济大萧条严重影响了西班牙的经济,到2018年,西班牙GDP已恢复正轨,但失业率仍未完全恢复到经济衰退之前的水平.2007—2019年西班牙GDP增长率和家庭消费总支出见图1,橙色柱表示GDP的实际增长率,作为对照,蓝色柱表示家庭消费总支出.需要注意的是,这包含了消费者可用于生活用纸的支出.图中所示,2018年西班牙的家庭消费总支出几乎已恢复到2007年的水平.

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A Study of w.rm Dark Matter, the Missing Satellites Problem, and the UV Luminosity Cut-Off

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International Journal of Astronomy and Astrophysics 2023年第1期13卷 25-38页

作者： bruce Hoeneisen Universidad San Francisco de Quito Quito Ecuador

In the w.rm dark matter scenario, the Press-Schechter formalism is valid only for galaxy masses greater than the “velocity dispersion cut-off”. In this w.rk w. extend the predictions to masses below.the velocity dispersion cut-off, and thereby address the “Missing Satellites Problem” of the cold dark matter ΛCDM scenario, and the rest-frame ultra-violet luminosity cut-off required to not exceed the measured reionization optical depth. For w.rm dark matter w. find agreement betw.en predictions and observations of these tw. phenomena. As a by-product, w. obtain the empirical Tully-fisher relation from first principles.

关键词： Cosmology: Dark Matter Galaxies: Statistics

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分手后，成为更好的自己

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作者： (美)布鲁斯·费希尔(bruce fisher)，(美)罗伯特·艾伯蒂(Robert Alberti)

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