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Alcoholic hepatitis 2010:A clinician's guide to diagnosis and therapy

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world Journal of Gastroenterology 2010年第39期16卷 4905-4912页

作者： Maziyar Amini bruce A Runyon Department of Gastroenterology and Hepatology Loma Linda University Medical Center

Alcoholic hepatitis(AH)remains a common and life threatening cause of liver failure,especially when it is *** the adjective"acute"is frequently used to describe this form of liver injury,it is usually subacute and has been developing for weeks to months before it becomes clinically *** with this form of alcoholic liver disease usually have a history of drinking heavily for many *** certain aspects of therapy,mainly nutritional support and abstinence are well established,significant debate has surrounded the pharmacologic treatment of AH,and many institutions practice widely varying treatment protocols. In recent years a significant amount of literature has helped focus on the details of treatment,and more data have accumulated regarding risks and benefits of pharmacologic *** particular,the efficacy of pentoxifylline has become increasingly apparent,and when compared with the risks associated with prednisolone,has brought this drug to the forefront of therapy for severe *** review will focus on the clinical and laboratory diagnosis and pharmacologic therapies that should be applied during hospitalization and continued into outpatient *** conclude that the routine use of glucocorticoids for severe AH poses significant risk with equivocal benefit,and that pentoxifylline is a better,safer and cheaper *** the full details of nutritional support lie beyond the scope of this article,nutrition is a cornerstone of therapy and must be addressed in every patient diagnosed with AH. Finally,while traditional psychosocial techniques play a major role in post-hospitalization care of alcoholics, we hope to make the medical clinician realize his or her role in reducing recidivism rates with early and frequent outpatient visits and with the use of baclofen to reduce alcohol craving.

关键词： Alcoholic hepatitis Alcoholic liver disease Pentoxifylline Baclofen

In memory of Perry L. McCarty, seminal founder of Environmental Biotechnology

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Frontiers of Environmental Science & Engineering 2023年第10期17卷 171-173页

作者： bruce E.Rittmann Biodesign Swette Center for Environmental Biotechnology Arizona State UniversityTempeAZ 85287-5701USA

Perry *** passed away on June 4,at the age of *** was a revered leader in Environmental Engineering and *** *** passed away peacefully and with his family on June 4,*** was a world leader in Environmental Engineering,with special emphasis on Environmental Biotechnology,in which we form partnerships with microbial communities that provide services to make human society more sustainable.I was one of Perry’s ***,and we worked together on research,service,and publishing throughout my career.I have deep and personal knowledge of how Perry and his students developed the fundamental principles that have allowed Environmental Biotechnology to flourish and advance humans’sustainability.

关键词： peace allowed passed

One-Dimensional Nonlinear Laplacians under a 3-Point Boundary Condition

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Acta Mathematica Sinica,English Series 2010年第9期26卷 1641-1652页

作者： bruce D.CALVERT Department of Mathematics University of Auckland

we consider a three-point boundary value problem for operators such as the one-dimensional p-Laplacian, and show when they have solutions or not, and how many. The inverse operators are given by various formulas involving zeros of a real-valued function. They are shown to be orderpreserving, for some parameter values, and non-singleton valued for others. The operators are shown to be m-dissipative in the space of continuous functions.

关键词： Boundary value problems nonlinear o.d.e.s p-Laplacian three-point boundary value problem m-dissipative

SUSTAINABLE SITE DEVELOPMENT

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Journal of Green Building 2006年第1期1卷 9-20页

作者： bruce A.Hendee BHA Design Inc.

INTRODUCTION Two weeks ago I went for a trail run at Coyote *** about five miles south of Fort Collins,the Coyote Ridge trail is about a seven mile round trip and takes runners up a geological hogback and then down into a pristine *** I was in a system perfectly balanced but not static;one in which all systems were in a state of dynamic interaction but always shifting in a way that ensured *** was moving in a balanced *** was enough food,water,and shelter produced,but there was no *** I,standing in the valley,had an opportunity to add to the balance.

关键词： trail valley shifting

A new alternative approach for investigating acidization dissolution front propagation in fluid-saturated carbonate rocks

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Science China(Technological Sciences) 2017年第8期60卷 1197-1210页

作者： ZHAO ChongBin HOBBS bruce ORD Alison Computational Geosciences Research Centre Central South University School of Earth and Environment The University of Western Australia

The natural phenomenon associated with the chemical dissolution of dissolvable minerals of rocks can be employed to develop innovative technology in mining and oil extracting engineering. This paper presents a new alternative approach for theoretically dealing with chemical dissolution front （CDF） propagation in fluid-saturated carbonate rocks. Note that the CDF is represented by the porosity front in this study. In this new approach, the porosity, pore-fluid velocity and acid concentration are directly used as independent variables. To illustrate how to use the present new approach, an aeidization dissolution system （ADS） consisting of carbonate rocks, which belongs to one of the many general chemical dissolution systems （CDSs）, is taken as an application example. when the acid dissolution capacity （ADC） number （that is defined as the ratio of the volume of the carbonate rock dissolved by an acid to that of the acid） approaches zero, the present new approach can be used to obtain analytical solutions for the stable ADS. However, if the ADC number is a nonzero finite number, then numerical solutions can be only obtained for the ADS, especially when the ADS is in an unstable state. The related theoretical results have demonstrated that：（1） when the ADS is in a stable state and in the case of the ADC number approaching zero, the present new approach is mathematically equivalent to the previous approach, in which the porosity, pore-fluid pressure and acid concentration are used as independent variables. However, when the ADS is in an unstable state, the use of the present new approach leads to a free parameter that needs to be determined by some other ways. （2） The existence of a non-step-type dissolution front within a transient region should at least satisfy that none of the ADC number, injected acid velocity and reciprocal of the dissolution reaction rate is equal to zero in the stable ADS.

关键词： acidization dissolution front propagation critical length alternative approach critical time carbonate rocks

A unified theory for sharp dissolution front propagation inchemical dissolution of fluid-saturated porous rocks

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Science China(Technological Sciences) 2019年第1期62卷 163-174页

作者： ZHAO ChongBin HOBBS bruce ORD Alison Computational Geosciences Research Centre Central South University School of Earth and Environment The University of Western Australia

This paper presents a unified theory to deal with when, why and how a sharp acidization dissolution front(ADF), which is represented by the porosity distribution curve, can take place in an acidization dissolution system composed of fluid-saturated porous rocks. The theory contains the following main points:(1) A reaction rate of infinity alone can lead to a sharp ADF of the Stefan-type in the acidization dissolution system. This sharp front is unstable when permeability in the downstream region is smaller than that in the upstream region.(2) For a finite reaction rate, when the acid dissolution capacity number approaches zero,the ADF can have a sharp profile of the Stefan-type either on a much smaller time scale or on a much larger time scale than the dissolution time scale. In the former case, the ADF may become unstable on a much larger time scale than the transport time scale, while in the latter case, it may become unstable if the growth rate of a small perturbation is greater than zero.(3) On the dissolution time scale, even if both the reaction rate is finite and the acid dissolution capacity number approaches zero, the profile of an ADF may not be sharp because it is in a transient state. In this case, not only can an ADF change its profile with time, but also its morphology can grow if the growth rate of a small perturbation is greater than zero. Due to the involvement of both the change rate and the growth rate of the ADF profile, it is necessary to conduct a transient linear stability analysis for determining whether or not a time-dependent ADF is stable in the acidization dissolution system.

关键词： sharp dissolution front stationary/steady state transient state acid dissolution capacity acidization dissolution porous rocks

Effects of porosity heterogeneity on chemical dissolution-front instability in fluid-saturated rocks

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Journal of Central South University 2017年第3期24卷 720-725页

作者： ZHAO Chong-bin Peter SCHAUBS bruce HOBBS Computational Geosciences Research Centre Central South University Changsha 410083 China CSIRO Mineral Resource National Research Flagship R O. Box 1130 Bentley WA 6102 Australia School of Earth and Environment The University of Western Australia Crawley WA 6009 Australia

Homogeneity and heterogeneity are two totally different concepts in *** the particle length scale,rocks exhibit strong heterogeneity in their constituents and *** the heterogeneity of porosity obeys the random uniform distribution,both the mean value and the variance of porosities in the heterogeneous porosity field can be used to reflect the overall heterogeneous characteristics of the porosity *** main purpose of this work is to investigate the effects of porosity heterogeneity on chemical dissolution front instability in fluid-saturated rocks by the computational simulation *** related computational simulation results have demonstrated that:1) since the propagation speed of a chemical dissolution front is inversely proportional to the difference between the final porosity and the mean value of porosities in the initial porosity field,an increase in the extent of the porosity heterogeneity can cause an increase in the mean value of porosities in the initial porosity field and an increase in the propagation speed of the chemical dissolution front.2) An increase in the variance of porosities in the initial porosity field can cause an increase in the instability probability of the chemical dissolution front in the fluid-saturated rock.3) The greater the mean value of porosities in the initial porosity field,the quicker the irregular morphology of the chemical dissolution front changes in the supercritical chemical dissolution *** means that the irregular morphology of a chemical dissolution front grows quicker in a porosity field of heterogeneity than it does in that of homogeneity when the chemical dissolution system is at a supercritical stage.

关键词： porosity heterogeneity chemical dissolution front instability computational simulation porous rocks

Neuroendocrine tumors of the gastrointestinal tract: Case reports and literature review

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world Journal of Gastrointestinal Oncology 2014年第8期6卷 301-310页

作者： william J Salyers Kenneth J Vega Juan Carlos Munoz bruce w Trotman Silvio S Tanev Division of Gastroenterology University of Florida College of Medicine/Jacksonville Jacksonville FL 32207 United States Division of Digestive Diseases and Nutrition University of Oklahoma Health Sciences Center Oklahoma City OK 73104 United States Department of Medicine University of Maryland School of Medicine Baltimore MD 21201 United States Department of Pathology Manatee Memorial Hospital Bradenton FL 34208 United States

Neuroendocrine tumors(NET)previously called carcinoid tumors are neoplasms of enterochromaffin/neuroendocrine cell origin which display neurosecretory capacity that may result in the carcinoid *** annual incidence of patients with NET is 8.4 per 100000;yet many NET remain asymptomatic and clinically undetected.A majority of NET follows a benign course;however,some will display malignant *** most commonly occur in the gastrointestinal tract(67%)and bronchopulmonary system(25%).Gastrointestinal NET occur within the stomach,small intestine,liver,and *** report a retrospective study of 11 subjects:Eight with benign carcinoid tumors:duodenal bulb(n=2),terminal ileum(n=1),sigmoid colon(n=2),and rectum(n=3);three with malignant carcinoid:liver(n=1)and intra-abdominal site(n=2).The diagnosis,endoscopic images,outcome,treatment and review of the literature are presented.

关键词： Neuroendocrine Carcinoid Gastrointestinal Tumors

Using on-site liver 3-D reconstruction and volumetric calculations in split liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2016年第6期15卷 587-592页

作者： Trevor w Reichman Brittany Fiorello Ian Carmody Humberto Bohorquez Ari Cohen John Seal David bruce George E Loss Ochsner Multi-Organ Transplant Institute Ochsner Medical Center

BACKGROUND： Split liver transplantation increases the number of grafts available for transplantation. Pre-recovery assessment of liver graft volume is essential for selecting suitable recipients. The purpose of this study was to determine the ability and feasibility of constructing a 3-D model to aid in surgical planning and to predict graft weight prior to an in situ division of the donor liver. METHODS： Over 11 months, 3-D volumetric reconstruction of 4 deceased donors was performed using Pathfinder Scout liver volumetric software. Demographic, laboratory, operative, perioperative and survival data for these patients along with donor demographic data were collected prospectively and analyzed retrospectively. RESULTS： The average predicted weight of the grafts from the adult donors obtained from an in situ split procedure were 1130 g （930-1458 g） for the extended right lobe donors and 312 g （222-396 g） for left lateral segment grafts. Actual adult graft weight was 92% of the predicted weight for both the extended right grafts and the left lateral segment grafts. The predicted and actual graft weights for the pediatric donors were 176 g and 210 g for the left lateral segment grafts and 308 g and 280 g for the extended right lobe grafts,respectively. All grafts were transplanted except for the right lobe from the pediatric donors due to the small graft ***： On-site volumetric assessment of donors provides useful information for the planning of an in situ split and for selection of recipients. This information may expand the donor pool to recipients previously felt to be unsuitable due to donor and/or recipient weight.

关键词： split liver transplantation reduced-size liver transplantation 3-D reconstruction