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MicroRNAs in nasopharyngeal carcinoma

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Chinese Journal of Cancer 2014年第11期33卷 539-544页

作者： Jeff p.bruce Fei-Fei Liu princess Margaret Cancer Centre University Health NetworkTorontoONCanada Department of Radiation Oncology Princess Margaret Cancer CentreUniversity Health NetworkTorontoONCanada Department of Radiation Oncology University of TorontoTorontoONCanada Department of Medical Biophysics University of TorontoTorontoONCanada

MicroRNAs(miRNAs) provide insight into both the biology and clinical behavior of many human cancers, including nasopharyngeal carcinoma(NpC). The dysregulation of miRNAs in NpC results in a variety of tumor-promoting effects. Furthermore, several miRNAs are prognostic markers for NpC. In addition to cellular miRNAs, NpC samples also often contain miRNAs encoded by Epstein-Barr virus, and these miRNAs may impact NpC biology by targeting both cellular and viral genes. Given their numerous putative roles in NpC development and progression, a thorough understanding of the impact of miRNA dysregulation in NpC is expected to shed light on useful biomarkers and therapeutic targets for the clinical management of this disease. In this review, we describe the efforts to date to identify and characterize such miRNAs in the context of NpC.

关键词： microRNA 鼻咽癌 Epstein-Barr病毒 miRNA 生物标志物微RNA 临床管理 NpC

From physics to fixtures to food:current and potential LED efficacy

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Horticulture Research 2020年第1期7卷 2271-2279页

作者： paul Kusuma p.Morgan pattison bruce Bugbee Crop physiology Laboratory Utah State UniversityLogan 84341 UTUSA Solid State Lighting Services Johnson City 37604 TNUSA

Overview Light-emitting diodes(LEDs)have enabled a historic increase in the conversion of electric energy to photons,but this is approaching a physical *** theoretical maximum efficiency occurs when all input energy is converted to energy in photosynthetic *** LEDs can be 93%efficient,phosphor-converted“whites”76%efficient,and red LEDs 81%*** improvements open new opportunities for horticultural lighting.

关键词： diodes phosphor approaching

Night-time Rise in Rat pineal N-Acetyltransferase due to Carbaryl Administration Is Reduced by propranolol Treatment

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Biomedical and Environmental Sciences 1995年第1期8卷 45-53页

作者： AHMED M. ATTIA MOSTAFA H. MOSTAFA bruce A. RICHARDSON AND RUSSEL J. reiter(Department of Environmental Studies, Institute of Graduate Studies and Research, p.O.Box 832, Alexandria, Egypt Department of Cellular and Structural Biology, University of Texas, Department of Environmental Studies Institute of Graduate Studies and Research Alexandria Egypt.

The purpose of the present study was to examine the effects of administration of sublethal doses of carbaryl on nighttime rat pineal melatonin synthesis in the presence and absence of propranolol, a β-adrenergic receptor antagonist. Two groups of adult male albino rats were administered orally N-methyl-l-naphthylcarbamate (carbaryl) (8. 33mg/kg BW daily in corn oil) for six successive days; another two groups received corn oil *** the last day of carbaryl treatment, half of the animals received an intraperitoneal injection of propranolol (20 mg/kg body weight, one hour before lights off). The other two groups were given a saline injection. Four hours after darkness onset, pineal N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT) activities as well as pineal concentrations of 5-hydroxytryptophan (5HTp), serotonin (5HT),5-hydroxyindole acetic acid (5HIAA) and pineal and serum melatonin levels were measured. Nocturnal NAT activity was increased due to carbaryl administration but the pesticide was ineffective in stimulating NAT activity in rats treated with *** 5HT was decreased due to carbaryl administration but 5HTp and 5HIAA levels were unaffected. pineal and serum melatonin levels were decreased due to propranolol treatment. The results indicate that carbaryl may influence pineal NAT activity by a mechanism that involves β-adrenergic neural transmission.

关键词： time Night-time Rise in Rat pineal N-Acetyltransferase due to Carbaryl Administration Is Reduced by propranolol Treatment

A dynamic model of once-daily 5-aminosalicylic acid predicts clinical efficacy

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World Journal of Gastroenterology 2010年第1期16卷 136-137页

作者： Deepak parakkal Eli D Ehrenpreis Matthew p Thorpe Karson S putt bruce Hannon Department of Gastroenterology North-Shore University Hospital Chief of Gastroenterology and Endoscopy Highland Park HospitalNorthShore University Health System Clinical Associate professor of Medicine University of Chicago Division of Nutritional Sciences University of Illinois Department of Biochemistry University of Illinois Department of Geography/NCSA University of Illinois

New once daily mesalamine formulations may improve adherence to medication *** to Asacol and other forms of 5-aminosalicyclic acid(5-ASA)is better correlated with tissue concentrations and best predicted by concentrations of the drug within the lumen of the *** group used computer simulation to predict colonic 5-ASA levels after Asacol *** our study,the model simulated Asacol distribution in the healthy colon,and during quiescent and active ulcerative *** Asacol dosage of 800 mg,threetimes a day,was compared to 2400 mg given once a *** ideal conditions,the predicted maximum drug in the total colon and individual colonic segments over 100 d differed by less than 3%between single and multiple *** changes in motility and defection rates,the predicted maximum and average 5-ASA concentrations in the total colon and individual colonic segments differed by less than 10%between dosing *** distribution of 5-ASA in the colon was influenced by frequency of bowel movements and colonic transit *** active colitis,sigmoid 5-ASA concentration becomes *** model supports once daily administration of Asacol as standard treatment for ulcerative colitis.

关键词： Ulcerative colitis 5-aminosalicylate Mesalazine Asacol Once-daily

A new perspective on quiet Sun magnetism

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Science China(physics,Mechanics & Astronomy) 2009年第11期52卷 1660-1664页

作者： LITES bruce William High Altitude Observatory National Center for Atmospheric ResearchP.O. Box 3000 Boulder CO 80307 USA

The Hinode mission has provided us with a new, quantitative view of the magnetism of the quiet Sun. It has revealed that the quiet internetwork areas are blanketed by horizontal fields that appear at first sight to have more flux than the vertical fields resolved on the same 0.3 size scale. These measurements point to the possibility that the horizontal fields might be the primary source of the "hidden turbulent flux" of the quiet Sun anticipated from Hanle effect depolarization. In this paper, evidence is presented suggesting that the "seething" horizontal fields observed by Harvey in 2007 and the horizontal fields revealed by Hinode are the same phenomenon. Because the seething fields appear to be of uniform fluctuation over the whole disk, the phenomenon is most likely not associated with the dynamo source of solar activity. Thus, the small-scale "hidden turbulent flux" lends support to the notion of a local solar dynamo acting on granular sizes and time scales.

关键词： Sun magnetism fields granulation

One-Dimensional Nonlinear Laplacians under a 3-point Boundary Condition

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Acta Mathematica Sinica,English Series 2010年第9期26卷 1641-1652页

作者： bruce D.CALVERT Department of Mathematics University of Auckland

We consider a three-point boundary value problem for operators such as the one-dimensional p-Laplacian, and show when they have solutions or not, and how many. The inverse operators are given by various formulas involving zeros of a real-valued function. They are shown to be orderpreserving, for some parameter values, and non-singleton valued for others. The operators are shown to be m-dissipative in the space of continuous functions.

关键词： Boundary value problems nonlinear o.d.e.s p-Laplacian three-point boundary value problem m-dissipative

Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia

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World Journal of Gastroenterology 2011年第21期17卷 2646-2651页

作者： Cezary Chojnacki Tomasz poplawski Grazyna Klupinska Janusz Blasiak Jan Chojnacki Russel J reiter Department of Gastroenterology Medical University of Lodz90-647 LodzPoland Department of Molecular Genetics University of Lodz90-131 LodzPoland Department of Cellular and Structural Biology University of Texas Health Science CenterSan AntonioTX 78229-3901United States

To evaluate blood concentration of melatonin and urinary excretion of its metabolite, 6-sulfatoxymelatonin （6-OHMS）, in functional dyspepsia （FD）. METHODS： Ninety individuals were enrolled in the study： 30 in each study group： patients with postprandial distress syndrome （pDS）, epigastric pain syndrome （EpS）, and controls. Blood samples were drawn at 02：00 and 09：00 h and 24-h urine collection was performed. Serum melatonin and urinary 6-OHMS concentrations were measured by enzyme-linked immunosorbent assay. RESULTS： Serum melatonin concentration at night and in the morning was significantly （p 〈 0.001） higher inpDS patients [at 02：00 h-93.3 pg/mL, quartile range （QR）： 79.8-116.2; at 09.00 h-14.3 pg/mL, QR： 7.06-19.0] than in EpS （57.2 pg/mL, QR： 42.6-73.1, 8.1 pg/mL, QR： 4.2-9.3） and control patients （57.7 pg/mL, QR： 51.2-62.5; 8.1 pg/mL, QR： 5.4-10.3）. A similar relationship was observed for urinary 6-OHMS excretion. patients with severe pDS symptoms had a higher melatonin concentration than these with moderate syndromes, whereas patients with severe EpS had a lower urinary 6-OHMS excretion than patients with moderate ***： Evaluation of melatonin serum concentrations and 24-h urinary 6-OHMS excretion are useful methods for differential diagnosis of various clinical forms of FD.

关键词： Functional dyspepsia postprandial distress syndrome Epigastric pain syndrome Melatonin 6-sulfatoxymelatonin

Effects of porosity heterogeneity on chemical dissolution-front instability in fluid-saturated rocks

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Journal of Central South University 2017年第3期24卷 720-725页

作者： ZHAO Chong-bin peter SCHAUBS bruce HOBBS Computational Geosciences Research Centre Central South University Changsha 410083 China CSIRO Mineral Resource National Research Flagship R O. Box 1130 Bentley WA 6102 Australia School of Earth and Environment The University of Western Australia Crawley WA 6009 Australia

Homogeneity and heterogeneity are two totally different concepts in *** the particle length scale,rocks exhibit strong heterogeneity in their constituents and *** the heterogeneity of porosity obeys the random uniform distribution,both the mean value and the variance of porosities in the heterogeneous porosity field can be used to reflect the overall heterogeneous characteristics of the porosity *** main purpose of this work is to investigate the effects of porosity heterogeneity on chemical dissolution front instability in fluid-saturated rocks by the computational simulation *** related computational simulation results have demonstrated that:1) since the propagation speed of a chemical dissolution front is inversely proportional to the difference between the final porosity and the mean value of porosities in the initial porosity field,an increase in the extent of the porosity heterogeneity can cause an increase in the mean value of porosities in the initial porosity field and an increase in the propagation speed of the chemical dissolution front.2) An increase in the variance of porosities in the initial porosity field can cause an increase in the instability probability of the chemical dissolution front in the fluid-saturated rock.3) The greater the mean value of porosities in the initial porosity field,the quicker the irregular morphology of the chemical dissolution front changes in the supercritical chemical dissolution *** means that the irregular morphology of a chemical dissolution front grows quicker in a porosity field of heterogeneity than it does in that of homogeneity when the chemical dissolution system is at a supercritical stage.

关键词： porosity heterogeneity chemical dissolution front instability computational simulation porous rocks

The integration of geophysical and enhanced Moderate Resolution Imaging Spectroradiometer Normalized Difference Vegetation Index data into a rule-based, piecewise regression-tree model to estimate cheatgrass beginning of spring growth

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International Journal of Digital Earth 2015年第2期8卷 118-132页

作者： Stephen p.Boyte bruce K.Wylie Donald J.Major Jesslyn F.Brown Stinger Ghaffarian Technologies Inc.Contractor to the USGS Earth Resources Observation and Science(EROS)CenterSioux FallsSDUSA USGS Earth Resources Observation and Science(EROS)Center Sioux FallsSDUSA U.S.Bureau of Land Management-Great Basin Restoration Initiative BoiseIDUSA

Cheatgrass exhibits spatial and temporal phenological variability across the Great Basin as described by ecological models formed using remote sensing and other spatial *** developed a rule-based,piecewise regression-tree model trained on 99 points that used three data-setslatitude,elevation,and start of season time based on remote sensing input datato estimate cheatgrass beginning of spring growth(BOSG)in the northern Great *** model was then applied to map the location and timing of cheatgrass spring growth for the entire *** model was strong(R^(2)=0.85)and predicted an average cheatgrass BOSG across the study area of 29 March–4 *** early cheatgrass BOSG areas,65% occurred at elevations below 1452 *** highest proportion of cheatgrass BOSG occurred between mid-April and late *** cheatgrass BOSG in this study matched well with previous Great Basin cheatgrass green-up studies.

关键词： remote sensing invasive species ecological model Great Basin phenology