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Predictors of clinical outcomes after non-operative management of symptomatic full-thickness rotator cuff tears

World Journal of Orthopedics 2021年第4期12卷 223-233页

作者： Christopher Bush Joel J Gagnier James Carpenter Asheesh Bedi bruce miller Department of Orthopaedic Surgery University of MichiganAnn ArborMI 48106United States

BACKGROUND Previous studies have shown that non-surgical management can be an effective treatment strategy for many patients with rotator cuff *** the prevalence of rotator cuff disease,few studies have examined the patient and tear related factors that predict outcomes of nonsurgical management in this cohort of *** To identify factors that are associated with changes in patient reported outcomes over time in individuals with full-thickness rotator cuff tears treated without *** A cohort of 59 patients who underwent non-surgical management of full thickness rotator cuff tears with a minimum of 1-year follow-up were identified from our institutional *** demographics,comorbidities and tear characteristics were collected at initial *** measures were collected at baseline and at each clinical follow-up,which included Western Ontario Rotator Cuff(WORC)index,American Shoulder and Elbow Surgeons score,Visual Analog Scale for pain and Single Assessment Numerical ***-and univariate regression analyses were used to determine the impact of each patient and tear related variable on final WORC scores and change in WORC scores throughout the *** In this non-surgical cohort,all patient-reported outcome measures significantly improved compared to baseline at 1 and 2-year *** was no significant difference in outcomes between 1 and 2 *** average improvement surpassed the published minimal clinically important differences values for WORC,American Shoulder and Elbow Surgeons,Visual Analog Scale pain and Single Assessment Numerical Evaluation *** analysis identified female gender(β=-19.88,P=0.003),smoking(β=-29.98,P=0.014)and significant subscapularis fatty infiltration(β=-15.35,P=0.024)as predictors of less favorable WORC scores at 1 year,and female gender(β=-19.09,P=0.015)alone as a predictor of lower WORC scores at 2 *** with symptom duration greater than 1

关键词： Rotator cuff tear Conservative treatment Patient reported outcome measures Shoulder injuries Shoulder pain

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Evaluation of utility in shoulder pathology:Correlating the American Shoulder and Elbow Surgeons and Constant scores to the EuroQoL

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World Journal of Orthopedics 2012年第3期3卷 20-24页

作者： Blaine T Bafus Richard E Hughes bruce S miller James E Carpenter Department of Orthopaedic Surgery Cleveland Clinic Foundation Cleveland OH 44115-2325 United States Department of Orthopaedic Surgery University of Michigan Ann Arbor MI 48109-2200 United States

AIM: To study whether health utility scores can be derived from shoulder-specific ***: Authors investigated two questions:(1) do the American Shoulder and Elbow Surgeons(ASES) score and the Constant score correlate with the EuroQo L(EQ-5D), a measure of health utility?(2) can the ASES and Constant scores be obtained from a complete study sample without bias? Thirty subjects with various shoulder diagnoses completed ASES, Constant, and EQ-5D instruments. Pearson correlations were calculated to assess the associations between EQ-5D score and ASES and Constant ***: The correlation between EQ-5D score and ASES score was 0.60(P < 0.001); it was 0.54 for EQ-5D and Constant scores(P < 0.003). A multiple regression model containing ASES score, Constant score, age, and gender failed to adequately predict EQ-5D. Moreover, 25% of patients meeting the inclusion criteria did not complete the ASES questionnaire because they did not feel that specific questions, such as "do usual sport-list" and "throw ball overhand," applied to ***: Authors' results do not support the use of the ASES and Constant scores in predicting EuroQ ol health utility values. However, the Constant score was more suitable for this patient population because all patients were able to complete it.

关键词： Utility EuroQoL American Shoulder and Elbow Surgeons score Constant score Shoulder Outcomes

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在慢性阻塞性肺疾病患者中使用救援吸入器传感器、电子症状问卷和体育活动监测器

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英国医学杂志中文版 2019年第6期22卷 363-363页

作者： Russell Bowler Matthew Allinder Sean Jacobson Andrew miller bruce miller Ruth Tal-Singer Nicholas Locantore 崔晓霞(译) 不详北京协和医院呼吸科

来源期刊简介:BMJ Open Respiratory Research杂志是呼吸和重症医学领域的同行评议、开放获取期刊。该刊是英国胸科学会和BMJ集团共有期刊,是Thorax杂志的姐妹刊。与研究新颖性和影响力相比,该刊刊文更注重研究方法的可靠性和学术的严谨性.

关键词：慢性阻塞性肺疾病体育活动传感器吸入器监测器救援患者症状

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先天性心脏病患儿肝素效应与凝血酶抑制因子水平的临床检测

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麻醉与镇痛 2008年第2期4卷 23-30页

作者： Nina A. Guzzetta bruce E. miller Kathy Todd Fania Szlam, MMSc Renee H. Moore Keith K. Brosius Elizabeth C. Wilson Anna M. Cohen Steven R. Tosone 陈蕾(译) 徐美英(校) Department of Anesthesiology Emory University School of Medicine Cardiac Research Department Children's Healthcare of Atlanta at Egleston Department of Biostatistics Emory University Atlanta Georgia 不详

本研究观察了体外循环（CPB）下行心脏手术的先天性心脏病患儿3种凝血酶抑制因子[抗凝血酶Ⅲ（ATⅢ）、肝素辅助因子Ⅱ（HCⅡ）、α-2-巨球蛋白（α2M）]水平与临床不同检测肝素效应方法间的关系。118例患儿分为6个年龄组：〈1个月龄．1... 详细信息

本研究观察了体外循环（CPB）下行心脏手术的先天性心脏病患儿3种凝血酶抑制因子[抗凝血酶Ⅲ（ATⅢ）、肝素辅助因子Ⅱ（HCⅡ）、α-2-巨球蛋白（α2M）]水平与临床不同检测肝素效应方法间的关系。118例患儿分为6个年龄组：〈1个月龄．1～3个月龄，3—6个月龄，6～12个月龄，12～24个月龄，〉10岁。测定基础ATⅢ、HCⅡ、α2M数值。同时测定白陶土法活化凝血时间（k-ACT）、硅藻土法活化凝血时间（c-ACT）的基础值并在应用标准剂量400U／kg肝素3分钟后再次测定k-ACT和c-ACT。计算每例患儿应用肝素前、后ACT的差值和肝素量-效关系。给予肝素后k-ACT较c-ACT的变异性小。与既往在成人中证实的结果不同，ATⅢ以及其他凝血酶抑制因子与肝素效应的临床检测间无正性相关；而且〈1个月龄组患儿不仅ATⅢ、HCⅡ水平低．α2M水平也较低。研究结果对肝素是否能在新生儿体外循环手术中发挥充分的抗凝效应提出了疑义，并对ACT延长作为反映抗凝程度的精确性提出了挑战。

关键词：肝素辅助因子Ⅱ 抗凝血酶Ⅲ 先天性心脏病临床检测抑制因子患儿活化凝血时间水

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Fracturing,caving propagation and influence of mining on groundwater above longwall panels–a review of predictive models

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International Journal of Mining Science and Technology 2020年第1期30卷 49-54页

作者： bruce Hebblewhite School of Minerals and Energy Resources Engineering University of New South WalesSydney 2052Australia

Historically there have been a number of different hypotheses and empirical models developed in an attempt to describe the nature of fracturing above longwall panels in underground coal *** motivation for suchmodels varies,ranging fromunderstanding the impact ofmining on surface subsidence,to back-analysis of caving behaviour in the immediate roof behind the longwall *** of the most critical motivating factors that is taking on increased importance in many coalfields,is the need for better understanding,and hence prediction of the impact of mining on overlying strata,particularly strata units acting as aquifers for different groundwater *** paper reviews some of the major prediction models in the context of observed behaviour of strata displacement and fracturing above longwall panels in the southern coalfields of New South Wales,south of *** paper discusses the parameter often referred to as"height of fracturing"in terms of the critical parameters that influence it,and the relevance and appropriateness of this terminology in the context of overlying sub-surface subsidence and groundwater *** paper proposes an alternative terminology for this parameter that better reflects what it is and how it is *** paper also addresses the potential role of major bedding shear planes mobilised by mining and their potential influence on overlying subsidence and groundwater interference.

关键词： Longwall mining Subsidence Groundwater Caving Underground coal mining

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The art and science of species delimitation

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Current Zoology 2015年第5期61卷 846-853页

作者： bruce RANNALA Department of Evolution and Ecology University of California Davis Davis CA 95616 USA

DNA-based approaches to systematics have changed dramatically during the last two decades with the rise of DNA barcoding methods and newer multi-locus methods for species delimitation. During the last half-decade, partly driven by the new sequencing technologies, the focus has shifted to multi-locus sequence data and the identification of species within the frame-work of the multi-species coalescent （MSC）. In this paper, I discuss model-based Bayesian methods for species delimitation that have been developed in recent years using the MSC. Several approximate methods for species delimitation （and their limitations） are also discussed. Explicit species delimitation models have the advantage of clarifying more precisely what is being delimited and what assumptions we are making in doing so. Moreover, the methods can be very powerful when applied to large multi-locus datasets and thus take full advantage of data generated using today＇s technologies [Current Zoology 61 （5）： 846-853,2015].

关键词： Bayesian species delimitation Species concepts Multi-species coalescent

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New microsome-associated HT-family proteins from Nicotiana respond to pollination and define an HT/NOD-24 protein family

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Molecular Plant 2008年第4期1卷 634-644页

作者： Katsuhiko Kondo bruce McClure Department of Biochemistry Interdisciplinary Plant Group and the Christopher S. Bond Life Sciences Center University of Missouri MI USA

HT-family proteins have been identified in Nicotiana, Solanum, and Petunia. HT-B-type proteins are implicated in S-RNase-based self-incompatibility, but the functions of other family members are unknown. Screening for cDNA sequences with an expression pattern similar to HT-B in Nicotiana alata revealed a new group of small HT-family proteins, designated HT-M. HT-M proteins resemble HT-B in several respects： their pistil-specific expression pattern is indistinguishable from HT-B, they pellet with a microsome fraction, and their abundance decreases after pollination. Unlike HT-B, there is no S-specificity to this response, and RNAi experiments show that HT-M proteins are not necessary for self-incompatibility. Identification of a third group of pistil-specific HT-family proteins helps better define the characteristics of the family and allowed identification of putative new family members. By searching the databases with only the most conserved HT- family sequence elements, the signal sequence and cysteine motifs, we identified nodulin-24-1ike proteins and several small glycine-rich proteins as putative HT-family members. Like HT-M and HT-B, nodulin-24 is membrane associated. We propose that the conserved features in HT-family proteins are important for targeting or modification and refer to the broader family that includes both HT- and nodulin-24-1ike proteins as the HT/NOD-24-family.

关键词： New microsome-associated HT-family pollination an HT/NOD-24 protein family

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Study of Electron Beam Surfi-sculpt during Composite Materials Joining

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稀有金属材料与工程 2011年第S4期40卷 292-296页

作者： bruce Dance The Welding Institute(TWI) Cambridge CB1 6ALUK

Electron beam surfi-sculpt is a new metal surface processing technology,which is widely used in the areas of materials surface treatment,composite materials manufacturing,and so *** this paper,comeld technology,which was an application technology of electron beam surfi-sculpt during composite materials area,was *** tensile experiments results and failure forms of Ti6Al4V/Carbon fibre single step joints were compared with different joining methods,such as slick embedding,adhesive bonding,riveting and *** was found that comeld joint had more advantage of tensile property than other joining *** the same time,tensile process of comeld joint was analyzed with numerical simulation,and key factors of protrusions influenced tensile property were obtained,which was of importance to structure design and joint property improvement.

关键词： electron beam surfi-sculpt comeld joining methods tensile experiments numerical simulation

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A review of the geomechanics aspects of a double fatality coal burst at Austar Colliery in NSW,Australia in April 2014

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International Journal of Mining Science and Technology 2017年第1期27卷 3-7页

作者： Hebblewhite bruce Calvin Jim School of Mining Engineering UNSWSydney 2052Australia

A coal burst occurred on 15 April, 2014 at the Austar Coal Mine, located west of Newcastle, NSW,Australia. The burst resulted in fatal injuries to two men working as part of the mining crew at the development face. At the time, a continuous miner was being used to mine a longwall development gate road through heavily structured coal, at a depth of approximately 550 m. A number of pre-cursor bumps had occurred on previous shifts, emanating from the coal ribs of the roadway, in proximity to the coal *** paper reviews the geological, geotechnical and mining conditions and circumstances leading up to the coal burst event; and presents and discusses the available evidence and possible interpretations relating to the geomechanical behaviour mechanisms that may have been critical factors in this incident. The paper also discusses some key technical and operational considerations of ground support systems and mining practices and strategies needed for operating in such conditions in the future.

关键词： Underground coal mining Roadway development Strata controlCoal burst Coal geology Mine safety

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Biology Past and Biology Future:Where have we been and where are we going?

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Neural Regeneration Research 2013年第25期8卷 2309-2316页

作者： bruce Alberts President of National Academy of Sciences Presented at the 2nd International Neural Regeneration Symposium(INRS2012) Shenyang

bruce Alberts, a prominent biochemist with a strong commitment to the improvement of science and mathematics education, serves as Editor-in-Chief of Science and as one of President Obama＇s first three Science Envoys. Alberts is also Professor Emeritus in the Department of Biochemistry and Biophysics at the University of California, San Francisco, to which he returned after serving two six-year terms as the president of the National Academy of Sciences （NAS）.

关键词： Biology Past and Biology Future

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