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Evaluation of novel fusion proteins derived from extracellular matrix binding domains of ligB as vaccine candidates against leptospirosis in a hamster model

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Evaluation of novel fusion proteins derived from extracellul...

第三届中国兽医临床大会

作者： Syed M.Faisal Sean P.McDonough bruce l.Akey Department of Population medicine and Diagnostic Sciences Cornell UniversityIthacaNY 14853United States Department of Biomedical Sciences College of Veterinary Medicine Cornell UniversityIthacaNY 14853United States

leptospira binds to host extracellular matrix(ECM)through surface exposed outer membrane proteins called adhesin in order to initiate *** various adhesins present on the surface of the spirochete, leptospira-immunoglobulin like proteins(lig proteins)and lipl32 are most abundant,widely distributed among pathogenic serovars and well *** fragments of lig proteins(ligcon4,ligcon4-7.5,ligBcen2) and C-terminus fragment of lipl32 all of that bind to host ECM were fused,expressed and purified in soluble form as *** week hamsters were immunized subcutaneously with various fusion proteins emulsified in EMUlSIGEN-D adjuvant and subsequently boosted at 3 *** protective efficacy of these novel fusion proteins was evaluated against subsequent challenge with highly virulent *** serovar Pomona(MlD50-100).Our results indicate that fusion protein based vaccine induced significant protection against acute infection with respect to PBS-adjuvant vaccinated controls as revealed by enhanced survival and reduced pulmonary ***,the protection mediated by these novel proteins was higher than that of conserved region of lig protein(ligcon,established protective antigen)and correlated to the level of ***32 failed to impart significant protection,however fusing its immunogenic C-terminus domain to lig fragments slightly delayed the morbidity of the infected *** results demonstrate that this novel strategy could be promising in developing effective subunit vaccine to combat this zoonotic infection.

关键词： Fusion protein Extracellular matrix lig proteins leptospira interrogans

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阿片受体对颅脑损伤后作用的实验研究

中华创伤杂志 1993年第3期9卷 148-150页

作者：江基尧朱诚张光霁 bruce G.lyeth Ronald l.Hayes 第二军医大学长征医院神经外科上海200003 Research Institute of Neuosurgeny Medical School of Virginia Univeasity U. S. A.

观察了三种特异性阿片受体(Mu、Delta、Kappa)类似物和拮抗剂对实验性颅脑伤死亡率和伤后神经功能的影响。结果发现:(1)三种阿片受体对颅脑伤死亡率无明显影响;(2)Mu和Delta受体拮抗剂加重伤后神经功能障碍;(3)Kappa受体拮抗剂促进伤后... 详细信息

观察了三种特异性阿片受体(Mu、Delta、Kappa)类似物和拮抗剂对实验性颅脑伤死亡率和伤后神经功能的影响。结果发现:(1)三种阿片受体对颅脑伤死亡率无明显影响;(2)Mu和Delta受体拮抗剂加重伤后神经功能障碍;(3)Kappa受体拮抗剂促进伤后神经功能恢复,而类似物则加重神经功能障碍。研究表明阿片受体在颅脑损伤发病过程中起一定作用,为临床治疗脑损伤提供了实验依据。

关键词：颅脑损伤阿片受体神经功能

The complete guide to the TOEFl test: listening iBT edition 英文影印版

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丛书名：外研社·风向标丛书

2009年

作者： (美) bruce Rogers

本书详细介绍新托福考试，全面收录考试题型，提供科学系统的应试方案和解题技巧；提供大量典型例题、专项强化训练和两套完整的模拟试题；对口语测试的逐步讲解和技巧分析可帮助考生顺利通过个人陈述和双向交流部分的测试；所有练习均... 详细信息

ISBN: (数字)9787560091228

ISBN: (纸本)9787560091228

本书详细介绍新托福考试，全面收录考试题型，提供科学系统的应试方案和解题技巧；提供大量典型例题、专项强化训练和两套完整的模拟试题；对口语测试的逐步讲解和技巧分析可帮助考生顺利通过个人陈述和双向交流部分的测试；所有练习均为模拟训练模式，让考生身临其境，提前备战。精心设置的词汇训练不仅有助于考生记忆词汇，更有助于其改善发音。

关键词：英语

Essentials of business statistics / 影印

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畅想之星图书光盘版（南通市图书馆镜像）

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2012年

作者： bruce l. Bowerman ... [et al.] = 商务统计基础 / 布鲁斯·l. 鲍

本书主要内容包括: 商务统计学导论 ; 描述性统计: 列表和图像法 ; 描述性统计: 数值法 ; 概率、离散随机变量 ; 连续随机变量 ; 抽样分布等。

ISBN: (纸本)9787302277941

本书主要内容包括: 商务统计学导论 ; 描述性统计: 列表和图像法 ; 描述性统计: 数值法 ; 概率、离散随机变量 ; 连续随机变量 ; 抽样分布等。

关键词：商业统计

Patient, Provider and System Factors Impacting on the Diagnosis and Management of lung Cancer Care in Australia

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Journal of Cancer Therapy 2012年第4期3卷 406-411页

作者： Moyez Jiwa Patricia M. davidson Phillip J. Newton Michelle l. Digiacomo Sarah J. McGrath Cornelius J. lotriet Centre for Cardiovascular and Chronic Care Faculty of Health University of Technology Sydney Sydney Australia Curtin Health Innovation Research Institute Curtin University Perth Australia

Background: lung cancer is the leading cause of cancer death in Australia, with only modest improvements in survival. This study aims to identify factors impacting on diagnosis and management of lung cancer with particular reference to Australian primary care. Methods: A sequential mixed method modified approach employing interview and a two-phased survey technique. Following telephonic interviews with 31 health professionals (individuals representing general practitioners, specialized physicians, nurses and allied health practitioners), interview data was analysed using qualitative thematic analysis, and surveys using descriptive statistics. Emergent themes were organised under patient, provider and system factors. Interviews ceased upon saturation of data. Results: Multiple patient, provider and systems issues were seen to contribute to adverse health outcomes. There is a strong relationship between smoking and outcomes, and factors related to higher smoking rates such as a lower socioeconomic status. For smokers, guilt and/or denial was considered a reason for delay in the decision to seek medical care for cough or shortness of breath. Aboriginal people under-report morbidity related to smoking and chronic obstructive pulmonary disease;other patients fail to recognise the significance of their symptoms. Discussion: Despite the poor prognosis of lung cancer diagnosis, increased awareness of presentation and treatment options can address disparities in health outcomes.

关键词： lung Cancer Primary Care General Practice Survival Diagnosis

ESSENTIAlS OF BUSINESS STATISTICS /

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丛书名： The McGraw-Hill/Irwin series: operations and decision sciences

2004年

作者： bruce l. BOWERMAN RICHARD T. O'CONNEll J.B. ORRI

以私人手段解决纠纷、伸张正义的习惯法:对一个无需国家强制的法律与秩序的现代体系的描述

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山东大学学报（哲学社会科学版） 2007年第3期 2-12页

作者：布鲁斯.l.本森尚海涛佛罗里达州立大学经济系佛罗里达州塔拉哈西32306 山东大学法学院山东济南250100

习惯法作为互惠合作的结果,是一种不成文的社会契约,如同语言一样,它是经过长时间的互动自发产生的。在惩罚破坏法律者方面,相较于现代的惩罚方式,民间执行习惯法倾向于恢复原状,并把罚款作为主要的惩罚方式。同时在这一法律体系下有着... 详细信息

习惯法作为互惠合作的结果,是一种不成文的社会契约,如同语言一样,它是经过长时间的互动自发产生的。在惩罚破坏法律者方面,相较于现代的惩罚方式,民间执行习惯法倾向于恢复原状,并把罚款作为主要的惩罚方式。同时在这一法律体系下有着众多的契约安排,以保护私人的财产和安全。私有法院的产生极大地促进了习惯法标准化的进程,同时流放、抵制认可、私有监狱和罚款征收对于习惯法的遵守亦有莫大的帮助。

关键词：习惯法社会契约私人的

Coherent interaction of atoms with a beam of light confined in a light cage

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light(Science & Applications) 2021年第7期10卷 1247-1256页

作者： Flavie davidson-Marquis Julian Gargiulo Esteban Gómez-lópez Bumjoon Jang Tim Kroh Chris Müller Mario Ziegler Stefan A.Maier Harald Kübler Markus A.Schmidt Oliver Benson Department of Physics and IRIS Adlershof Humboldt-Universität zu Berlin12489 BerlinGermany Chair in Hybrid Nanosystems Nanoinstitute MunichFaculty of PhysicsLudwig-Maximilians-Universität München80539 MunichGermany Department of Fiber Photonics Leibniz Institute of Photonic Technology07745 JenaGermany Competence Center for Micro-and Nanotechnologies Leibniz Institute of Photonic Technology Jena07745 JenaGermany Department of Physics Imperial College LondonLondon SW72AZUK Physikalisches Institut and Center for Integrated Quantum Science and Technology University of StuttgartPfaffenwaldring 5770569 StuttgartGermany Otto Schott Institute of Material Research 07743 JenaGermany

Controlling coherent interaction between optical fields and quantum systems in scalable,integrated platforms is essential for quantum ***,warm alkali-vapour cells integrated with on-chip photonic devices represent an attractive system,in particular for delay or storage of a single-photon quantum ***-core fibres or planar waveguides are widely used to confine light over long distances enhancing light-matter interaction in atomic-vapour ***,they suffer from inefficient filling times,enhanced dephasing for atoms near the surfaces,and limited light-matter *** report here on the observation of modified electromagnetically induced transparency for a non-diffractive beam of light in an on-chip,laterally-accessible hollow-core light *** layer deposition of an alumina nanofilm onto the light-cage structure was utilised to precisely tune the high-transmission spectral region of the light-cage mode to the operation wavelength of the atomic transition,while additionally protecting the polymer against the corrosive alkali *** experiments show strong,coherent light-matter coupling over lengths substantially exceeding the Rayleigh ***,the stable non-degrading performance and extreme versatility of the light cage provide an excellent basis for a manifold of quantum-storage and quantumnonlinear applications,highlighting it as a compelling candidate for all-on-chip,integrable,low-cost,vapour-based photon delay.

关键词： vapour interaction quantum

Complete guide to the TOEIC test /

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丛书名：外研社·托业考试培训教程

2003年

作者： Rogers bruce

本书是一本最新的托业考试备考用书,内容翔实,准确。帮助考生循序渐进地掌握应考策略，提高语言技巧。

ISBN: (纸本)7560032036

本书是一本最新的托业考试备考用书,内容翔实,准确。帮助考生循序渐进地掌握应考策略，提高语言技巧。

关键词：英语