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A dynamic model of once-daily 5-aminosalicylic acid predicts clinical efficacy

World Journal of Gastroenterology 2010年第1期16卷 136-137页

作者： Deepak Parakkal Eli D Ehrenpreis Matthew P Thorpe Karson S Putt bruce hannon Department of Gastroenterology North-Shore University Hospital Chief of Gastroenterology and Endoscopy Highland Park HospitalNorthShore University Health System Clinical Associate Professor of Medicine University of Chicago Division of Nutritional Sciences University of Illinois Department of Biochemistry University of Illinois Department of Geography/NCSA University of Illinois

New once daily mesalamine formulations may improve adherence to medication *** to Asacol and other forms of 5-aminosalicyclic acid(5-ASA)is better correlated with tissue concentrations and best predicted by concentrations of the drug within the lumen of the *** group used computer simulation to predict colonic 5-ASA levels after Asacol *** our study,the model simulated Asacol distribution in the healthy colon,and during quiescent and active ulcerative *** Asacol dosage of 800 mg,threetimes a day,was compared to 2400 mg given once a *** ideal conditions,the predicted maximum drug in the total colon and individual colonic segments over 100 d differed by less than 3%between single and multiple *** changes in motility and defection rates,the predicted maximum and average 5-ASA concentrations in the total colon and individual colonic segments differed by less than 10%between dosing *** distribution of 5-ASA in the colon was influenced by frequency of bowel movements and colonic transit *** active colitis,sigmoid 5-ASA concentration becomes *** model supports once daily administration of Asacol as standard treatment for ulcerative colitis.

关键词： Ulcerative colitis 5-aminosalicylate Mesalazine Asacol Once-daily

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Modeling dynamic biological systems

Modeling dynamic biological systems

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1997年

作者： hannon, bruce M.

来源：畅想之星图书光盘版（南... 评论

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全球生态系统服务与自然资本的价值估算

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生态学杂志 1999年第2期18卷 70-78页

作者： Robert Costanza Ralph d'Arge Rudolf de Groot Stephen Farber Monica Grasso bruce hannon Karin Limburg Shahid Naeem Robert V.O'neill Jose Paruelo Robert G.Raskin Paul Sutton Marjan van den Belt 陶大立(译) 美国马里兰大学美国怀俄明大学荷兰瓦格宁根农业大学美国匹次堡大学美国伊利诺大学美国米尔布卢克生态系统研究所美国明尼苏达大学美国橡树岭国家实验室环境科学部阿根廷布依诺斯艾利斯大学美国加里福尼亚喷气推进实验室美国加州大学美国生态经济研究和应用公司不详

编者按：地球上的生态系统是一种复杂的生命支持系统，生态系统对人类的贡献，在生态学研究中经常用“社会效益和经济效益”来表述，是可以用经济价值来估算的。然而，由于其复杂性和不确定性，对这两个效益如何进行估价，一直是困扰生... 详细信息

编者按：地球上的生态系统是一种复杂的生命支持系统，生态系统对人类的贡献，在生态学研究中经常用“社会效益和经济效益”来表述，是可以用经济价值来估算的。然而，由于其复杂性和不确定性，对这两个效益如何进行估价，一直是困扰生态学家和经济学家的重要问题。Ｃｏｓ...

关键词：全球生态系统自然资本价值估算

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Congenital diaphragmatic hernia survival in an English regional ECMO center

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World Journal of Pediatric Surgery 2023年第2期6卷 77-84页

作者： Elizabeth O'connor Ryo Tamura Therese hannon Sundeep Harigopal bruce Jaffray Paediatric surgery The Great North Children's HospitalNewcastle upon TyneTyne&WearUK Fetal medicine and obstetrics Royal Victoria InfirmaryNewcastle upon TyneTyne&WearUK Neonatal medicine Royal Victoria InfirmaryNewcastle upon TyneTyne&WearUK

Introduction Congenital diaphragmatic hernia(CDH)remains a cause of neonatal *** aims are to describe contemporary rates of survival and the variables associated with this outcome,contrasting these with our study of two decades earlier and recent *** and methods A retrospective review of all infants diagnosed in a regional center between January 2000 and December 2020 was *** outcome of interest was *** explanatory variables included side of defect,use of complex ventilatory or hemodynamic strategies(inhaled nitric oxide(iNO),high-frequency oscillatory ventilation(HFOV),extracorporeal membrane oxygenation(ECMO),and Prostin),presence of antenatal diagnosis,associated anomalies,birth weight,and *** changes were studied by measuring outcomes in each of four consecutive 63-month *** A total of 225 cases were *** was 60%(134 of 225).Postnatal survival was 68%(134 of 198 liveborn),and postrepair survival was 84%(134 of 159 who survived to repair).Diagnosis was made antenatally in 66%of *** associated with mortality were the need for complex ventilatory strategies(iNO,HFOV,Prostin,and ECMO),antenatal diagnosis,right-sided defects,use of patch repair,associated anomalies,birth weight,and *** has improved from our report of a prior decade and did not vary during the study *** survival has improved despite fewer *** multivariate analysis,the need for complex ventilation was the strongest predictor of death(OR=50,95%CI 13 to 224,p<0.0001),and associated anomalies ceased to be *** Survival has improved from our earlier report,despite reduced numbers of *** may be related to increased use of complex ventilatory strategies.

关键词： Survival termination sided

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