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The gut microbiome: an orchestrator of xenobiotic metabolism

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Acta Pharmaceutica Sinica B 2020年第1期10卷 19-32页

作者： Stephanie L.Collins Andrew d.patterson department of Biochemistry Microbiologyand Molecular Biologythe Pennsylvania State UniversityUniversity ParkPA 16802USA department of Veterinary and Biomedical Science the Pennsylvania State UniversityUniversity ParkPA 16802USA

Microbes inhabiting the intestinal tract of humans represent a site for xenobiotic *** gut microbiome,the collection of microorganisms in the gastrointestinal tract,can alter the metabolic outcome of pharmaceuticals,environmental toxicants,and heavy metals,thereby changing their *** chemical modification of xenobiotics by the gut microbiome,either through the intestinal tract or re-entering the gut via enterohepatic circulation,can lead to increased metabolism or bioactivation,depending on the enzymatic activity within the microbial *** enzymes encoded within the microbiome include those that reverse the modifications imparted by host detoxification ***,the microbiome can limit xenobiotic absorption in the small intestine by increasing the expression of cell-cell adhesion proteins,supporting the protective mucosal layer,and/or directly sequestering ***,host gene expression is regulated by the microbiome,including CYP450s,multi-drug resistance proteins,and the transcription factors that regulate *** the microbiome affects the host and pharmacokinetics of the xenobiotic,xenobiotics can also influence the viability and metabolism of the *** understanding of the complex interconnectedness between host,microbiome,and metabolism will advance with new modeling systems,technology development and refinement,and mechanistic studies focused on the contribution of human and microbial metabolism.

关键词： Gut microbiome Xenobiotic metabolism Absorption Gastrointestinal tract Pharmacokinetics Enterohepatic circulation Bioactivation

An annotated checklist of mammals of Kenya

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动物学研究 2019年第1期

作者： Simon Musila Ara Monadjem Paul W.Webala bruce d.patterson Rainer Hutterer Yvonne A.de Jong Thomas M.Butynski Geoffrey Mwangi Zhong-Zheng Chen Xue-Long Jiang

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掩膜对不准测量用的电压对比度测试结构

功能材料与器件学报 2013年第3期19卷 136-141页

作者： Oliver d.patterson Stephen R.Fox Roland Hahn IBM semiconductor research and development center KLA-Tencor Corporation

由于目前最先进CMOS器件的尺寸非常小,对准要求变得极具挑战性。测量触点至栅极对准的方法涉及用SEM扫描触点阵列,每次与接地栅极的重叠部分数量不同。电压对比信号表明哪些触点正在触及栅极。把样品晶圆数据与光学对准数据进行了比较... 详细信息

由于目前最先进CMOS器件的尺寸非常小,对准要求变得极具挑战性。测量触点至栅极对准的方法涉及用SEM扫描触点阵列,每次与接地栅极的重叠部分数量不同。电压对比信号表明哪些触点正在触及栅极。把样品晶圆数据与光学对准数据进行了比较。阐述了更充分比较二种技术的精度必须要做的后续工作。

关键词：光学对准触点栅条栅极晶圆掩膜测试结构电压

One-dimensional Nonlinear Laplacians under a 3-Point Boundary Condition

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Acta Mathematica Sinica,English Series 2010年第9期26卷 1641-1652页

作者： bruce d.CALVERT department of Mathematics University of Auckland

We consider a three-point boundary value problem for operators such as the one-dimensional p-Laplacian, and show when they have solutions or not, and how many. The inverse operators are given by various formulas involving zeros of a real-valued function. They are shown to be orderpreserving, for some parameter values, and non-singleton valued for others. The operators are shown to be m-dissipative in the space of continuous functions.

关键词： Boundary value problems nonlinear o.d.e.s p-Laplacian three-point boundary value problem m-dissipative

Intersection of autophagy with pathways of antigen presentation

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Protein & Cell 2012年第12期3卷 911-920页

作者： Natalie L.patterson Justine d.Mintern department of Biochemistry and Molecular Biology The University of MelbourneParkvilleVictoria 3010Australia

Traditionally,macroautophagy(autophagy)is viewed as a pathway of cell *** ensures the elimination of damaged or unwanted cytosolic components and provides a source of cellular nutrients during periods of ***,autophagy can also directly intersect with,and impact,other major pathways of cellular ***,we will review the contribution of autophagy to pathways of antigen *** autophagy machinery acts to modulate both MHCⅠ and MHCⅡ antigen *** such autophagy is an important participant in pathways that elicit host cell immunity and the elimination of infectious pathogens.

关键词： autophagy antigen presentation antigen presenting cells dendritic cells MHCⅠ MHCⅡ

Experience on offshore cathodic protection retrofitting in the northern South China Sea

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Acta Oceanologica Sinica 2003年第4期22卷 679-688页

作者： L. patterson A. Amorelli d. Condanni B. Bazzoni CACT Operators Group ENI S.P.A.-Exploration & Production DivisionENI S.P.A.-Exploration & Production DivisionENI S.P.A.-Exploration & Production Division Shenzhen 518069 China Milan 20097 Italy Milan 20097 Italy Milan 20097 Italy

Platforms I and II are steel structures located in offshore areas southeast of the Zhujiang (Pearl) River delta, the northern South China Sea,. in about 110 in water depth. The jackets, with aluminum sacrificial anodes for cathodic protection (CP) of the immersed zone, were launched in March 1995. In May 096 a CP survey showed that, after almost one year of service, a low polarization level had been achieved and some extended unprotected zones existed; mainly in the deepest part of the Platform II. Further to this, a joint activity was decided in order to assess the need of a possible retrofitting of the CP systems. The results of the activity carried out are dealt with, including technical and economical comparisons amongst several retrofitting options, both with sacrificial anodes and with impressed current systems. The adopted solution is illustrated and data are reported on the level of protection presently achieved.

关键词： cathodic protection retrofitting offshore the South China Sea

Moving towards the chemo-free treatment of lymphoma:hype or reality?

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 631-636页

作者： bruce d.Cheson Scientific Advisor Lymphoma Research FoundationNew YorkNY 10005USA

A new generation of novel,effective targeted drugs and cellular therapies include monoclonal antibodies directed at the cell surface,such as the anti-Cd-19 tafasitamab which,combined with lenalidomide,is the first therapy approved by the Food and drug Administration for second-line treatment of diffuse large B-cell *** agents interfere with pro-survival intracellular signaling pathways including drugs that inhibit Bruton tyrosine kinase,phosphatidylinositol-3 kinase(PI3-kinase),and *** increasing number of therapies impact the microenvironment,notably checkpoint inhibitors and bispecific *** antigen receptor-T cell therapy has improved the outcome of patients with a variety of histologies of *** in the past,such therapies would be used inrelapsed and refractory settings,they are now being evaluated as initial treatment in selected *** an improved ability to individualize treatment approaches,chemo-free will be a reality for lymphoma patients.

关键词： Lymphoma targeted therapies chemo-free bispecifics BTK inhibitors PI3k inhibitors CAR-T cell

Effectiveness of hand self-shiatsu to improve sleep following sport-related concussion in young athletes: a proof-of-concept study

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Journal of Integrative Medicine 2019年第1期17卷 24-29页

作者： Pei Qin bruce d.dick Ada Leung Cary A.Brown Faculty of Rehabilitation Medicine University of Alberta department of Anesthesiology and Pain Medicine Faculty of Medicine and Dentistry University of Alberta department of Occupational Therapy Faculty of Rehabilitation Medicine University of Alberta

Objective: The prevalence of sport-related concussion(SRC) is high and results in a number of serious health consequences. One area that has received minimal research is the relationship between SRC and sleep. The literature shows that sleep deficiency is a frequent negative consequence of SRC. At the same time, sleep deficiency delays recovery from SRC and contributes added risk of symptom recurrence.A 2014 study of chronic pain patients who learned to apply the complementary and alternative medicine intervention hand self-shiatsu(HSS) had promising, sleep-promoting results that warrant further investigation with other populations. This proof-of-concept study explored the feasibility of HSS as an intervention to promote sleep onset and continuity for young adults with ***: This study employed a prospective case-series design, where participants act as their own controls. Baseline and follow-up data included standardized self-reported assessment tools and sleep ***: Seven athletes, aged between 18 and 25 years, participated in the study. Although statistically significant improvement in actigraphy sleep scores between baseline and follow-up was not achieved,metrics for sleep quality and daytime fatigue showed significant ***: These findings support the hypothesis that HSS has the potential to improve sleep and reduce daytime fatigue in young postconcussion athletes. This pilot study provides guidance to refine research protocols and lays a foundation for further, large-sample, controlled studies.

关键词： Concussion Insomnia Youth Complementary and alternative medicine Self-management

Crystal structure of HLA-B^(*)5801 with a TW10 HIV Gag epitope reveals a novel mode of peptide presentation

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Cellular & Molecular Immunology 2017年第7期14卷 631-634页

作者： Xiaolong Li Pedro A Lamothe bruce d Walker Jia-huai Wang department of Medical Oncology and Cancer Biology Dana-Farber Cancer InstituteHarvard Medical SchoolBostonMA 02215USA Ragon Institute of Massachusetts General Hospital Massachusetts Institute of TechnologyHarvard UniversityBostonMA 02139USA Howard Hughes Medical Institute Chevy ChaseMD 20815USA Institute for Medical and Engineering Sciences Massachusetts Institute of TechnologyCambridgeMA 02139USA department of Pediatrics and department of Biological Chemistry and Molecular Pharmacology Harvard Medical SchoolBostonMA 02215USA

The major histocompatibility complex(MHC)is encoded by a set of genes that play a key role in the vertebrate adaptive immune *** humans,these genes encode proteins termed human leukocyte antigens(HLAs).

关键词： leukocyte antigens Crystal