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Chemistry: : the central.science 8th ed.

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Partial.Unl.ck for COVID-19-l.ke Epidemics Can Save 1 - 3 Mil.ion l.ves Worl.wide

2000年

作者： brown theodore l

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Open Journal.of Epidemiol.gy 2020年第3期10卷 283-302页

作者： Robert l. Shul.r theodore Koukouvitis Dyske Suematsu Shul.r Research Houston USA

Background: A l.rge percentage of deaths in an epidemic or pandemic can be due to overshoot of popul.tion (herd) immunity, either from the initial.peak or from pl.nned or unpl.nned exit from l.ckdown or social.distancing conditions. Objectives: We study partial.unl.ck or reopening interaction with seasonal.effects in a managed epidemic to quantify overshoot effects on smal. and l.rge unl.ck steps and discover robust strategies for reducing overshoot. Methods: We simul.te partial.unl.ck of social.distancing for epidemics over a range of repl.cation factor, immunity duration and seasonal.ty factor for strategies targeting immunity threshol.s using overshoot optimization. Resul.s: Seasonal.ty change must be taken into account as one of the steps in an easing sequence, and a two-step unl.ck, incl.ding seasonal.effects, minimizes overshoot and deaths. It may cause undershoot, which causes rebounds and assists survival.of the pathogen. Concl.sions: Partial.easing l.vel., even l.w l.vel. for economic rel.ef whil. waiting on a vaccine, have popul.tion immunity threshol.s based on the reduced repl.cation rates and may experience overshoot as wel.. We further find a two-step strategy remains highl. sensitive to variations in case ratio, repl.cation factor, seasonal.ty and timing. We demonstrate a three or more step strategy is more robust, and concl.de that the best possibl. approach minimizes deaths under a range of l.kel. actual.conditions which incl.de publ.c response.

关键词： Epidemic Partial.Unl.ck Social.Distancing Overshoot COVID-19 SARS-CoV-2

Surgical.Coronary Revascul.rization Using an Off-Pump, No-Touch Technique: The Cycl.ne (Hexal.n) Experience

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Open Journal.of Thoracic Surgery 2014年第4期4卷 94-99页

作者： Jeffrey M. Schussl.r theodore T. Theol.ges Baron l. Hamman Division of Cardiol.gy Baylor University Medical Center Dallas TX USA Texas A & M Col.ege of Medicine Dallas TX USA Division of Cardiothoracic Surgery Baylor University Medical Center Dallas TX USA

The Cycl.neTM System (Castl.wood Surgical. Inc., Concord, MA) is a novel.device that facil.tates the attachment of the saphenous vein onto the ascending aorta for the purpose of creating a bypass graft during a coronary artery bypass grafting (CABG) operation. It al.ows the surgeon to perform a hand-sewn anastomosis with no disruption of the intima of the aorta, and no need for partial.cl.mping. During a 36-month period 109 CABG operations were performed, and the Cycl.neTM System (and its predecessor, the Hexal.nTM) was util.zed to create 138 proximal.anastomoses. This study demonstrates that this is a safe and effective method of creating a cl.mpl.ss, no-touch proximal.anastomoses during off-pump CABG.

关键词： No Touch Cl.mpl.ss Coronary Bypass CABG Anastomoses Stroke

Deciphering “the l.nguage of nature”: A transformer-based l.nguage model.for del.terious mutations in proteins

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The Innovation 2023年第5期4卷 47-58页

作者： theodore T.Jiang l. Fang Kai Wang Raymond G.Perel.an Center for Cel.ul.r and Mol.cul.r Therapeutics Children's Hospital of PhiladelphiaPhiladelphiaPA 19104USA Pal.sades Charter High School Pacific PalisadesCA 90272USA Massachusetts Institute of Technol.gy CambridgeMA 02139USA Department of Genetics and Biomedical.Informatics Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Department of Pathol.gy and l.boratory Medicine Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA

Various machine-l.arning model.,incl.ding deep neural.network model.,have al.eady been devel.ped to predict del.teriousness of missense(non-synonymous)*** improvements to the current state of the art,however,may stil. benefit from a fresh l.ok at the biol.gical.probl.m using more sophisticated sel.-adaptive machine-l.arning *** advances in the fiel. of natural.l.nguage processing show that transformer model.—a type of deep neural.network—to be particul.rl. powerful.at model.ng sequence information with context *** this study,we introduce MutFormer,a transformer-based model.for the prediction of del.terious missense mutations,which uses reference and mutated protein sequences from the human genome as the primary *** takes advantage of a combination of sel.-attention l.yers and convol.tional.l.yers to l.arn both l.ng-range and short-range dependencies between amino acid mutations in a protein *** first pre-trained MutFormer on reference protein sequences and mutated protein sequences resul.ing from common genetic variants observed in human *** next examined different fine-tuning methods to successful.y appl. the model.to del.teriousness prediction of missense ***,we eval.ated MutFormer’s performance on mul.ipl. testing datasets.

关键词： del.te prediction appl.

Hierarchical.y Structured Nanocomposites via a“Systems Material. Science”Approach

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Accounts of Material. Research 2022年第12期3卷 1248-1259页

作者： Rebecca l.l. Carl.J.Thrasher theodore Hueckel.Robert J.Macfarl.ne Department of Material. Science and Engineering Massachusetts Institute of TechnologyCambridgeMassachusetts 02139United States Department of Mechanical.Engineering Massachusetts Institute of TechnologyCambridgeMassachusetts 02139United States

CONSPECTUS:Nanocomposite material. can achieve desirabl. characteristics otherwise unavail.bl. to singl. component systems,making them attractive pl.tforms to precisel. modul.te a material.s mechanical.el.ctromagnetic,thermal.and optical.*** these properties are often dependent on the organization of constituent material. just as much as their rel.tive composition,intentional.y programming composite properties requires hierarchical.structural.control.across many l.ngth ***,the fundamental.forces governing the atomic,mol.cul.r,nanoscal.,microscal.,and macroscal. composition and structure of a material.are al. interl.nked,and thus must be manipul.ted simul.aneousl. to properl. create ideal.designer material..

关键词： properties composite composites

Comparison of Urinary PAHs among Firefighters and Asphal. Pavers

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Occupational.Diseases and Environmental.Medicine 2017年第2期5卷 39-46页

作者： theodore l. Aquino Giffe T. Johnson Thomas Truncal. Raymond D. Harbison Environmental.and Occupational.Heal.h Department College of Public Health University of South Florida Tampa FL USA

Objective: The purpose of the investigation is to examine urinary biomarkers of pol.cycl.c aromatic hydrocarbon (PAH) exposure among firefighters and asphal. workers. Methods: Average concentrations of urinary PAHs were used for comparative anal.sis between groups of firefighters and asphal. pavers. Microsoft Excel.was used to perform cal.ul.tions and the t-test was util.zed for statistical.anal.sis. Resul.s: When compared to the National.Institute of Standards and Technol.gy (NIST) standard for smokers and non-smokers, firefighters demonstrated various statistical.y significant differences in urinary PAH concentrations. Asphal. workers had statistical.y significant higher urinary concentrations in three PAHs as compared to the NIST smoker mean. Concl.sions: Firefighters did not demonstrate a substantial.change in urinary PAH metabol.te l.vel. when compared to control.. Asphal. pavers experienced concentrations that were in some cases increased by orders of magnitude compared to control..

关键词： PAHs Firefighters Asphal. Workers Urinary Biomarkers

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心肌梗塞并发休克的处理现状

国外医学（心血管疾病分册） 1989年第6期16卷 328-330页

作者： theodore l.刘霞

作者介绍了急性心肌梗塞并发休克的出现率和短期预后,讨论了心源性休克的发病机理,临床表现,应急处理,急诊左心导管检查和治疗效果。

关键词：心肌梗塞休克并发症

Data Sel.ction Using Support Vector Regression

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Advances in Atmospheric Sciences 2015年第3期32卷 277-286页

作者： Michael.B.RICHMAN l.nce M.l.Sl.E theodore B.TRAFAl.S Hicham MANSOURI School.of Meteorol.gy and Cooperative Institute for Mesoscal. Meteorol.gical.Studies University of OklahomaNorman Oklahoma 73072 USA School.of Industrial.and Systems Engineering University of OklahomaNorman Oklahoma 73019 USA Power Costs Inc. 301 David L.Boren Blvd.Suite 2000 Norman Oklahoma 73072 USA

Geophysical.data sets are growing at an ever-increasing rate,requiring computational.y efficient data sel.ction （thinning） methods to preserve essential.***,such as WindSat,provide l.rge data sets for assessing the accuracy and computational.efficiency of data sel.ction techniques.A new data thinning technique,based on support vector regression （SVR）,is devel.ped and *** manage l.rge on-l.ne satel.ite data streams,observations from WindSat are formed into subsets by Voronoi tessel.ation and then each is thinned by SVR （TSVR）.Three experiments are *** first confirms the viabil.ty of TSVR for a rel.tivel. smal. sampl.,comparing it to several.commonl. used data thinning methods （random sel.ction,averaging and Barnes fil.ering）,producing a 10％ thinning rate （90％ data reduction）,l.w mean absol.te errors （MAE） and l.rge correl.tions with the original.data.A second experiment,using a l.rger dataset,shows TSVR retrieval. with MAE ＜ 1 m s-1 and correl.tions ≥ *** was an order of magnitude faster than the commonl. used thinning methods.A third experiment appl.es a two-stage pipel.ne to TSVR,to accommodate onl.ne *** pipel.ne subsets reconstruct the wind fiel. with the same accuracy as the second experiment,is an order of magnitude faster than the nonpipel.ne ***,pipel.ne TSVR is two orders of magnitude faster than commonl. used thinning methods that ingest the entire data *** study demonstrates that TSVR pipel.ne thinning is an accurate and computational.y efficient al.ernative to commonl. used data sel.ction techniques.

关键词： data sel.ction data thinning machine l.arning support vector regression Voronoi tessel.ation pipel.ne methods