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Treat to target in Crohn’s disease:A practical guide for clinicians

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World Journal of Gastroenterology 2024年第1期30卷 50-69页

作者： Ashish r Srinivasan Department of Gastroenterology Austin HealthVictoriaMelbourne 3083Australia Department of Gastroenterology Eastern HealthVictoriaMelbourne 3128Australia Department of Medicine University of MelbourneVictoriaMelbourne 3052Australia

A treat-to-target(T2T)approach applies the principles of early intervention and tight disease control to optimise long-term outcomes in Crohn's *** Selecting Therapeutic Targets in Inflammatory Bowel Disease(STrIDE)-II guidelines specify short,intermediate,and long-term treatment goals,documenting specific treatment targets to be achieved at each of these *** appraisal of Crohn’s disease activity against pre-defined treatment targets at these timepoints remains central to determining whether current therapy should be continued or *** treatment targets in Crohn’s disease comprise combination clinical and patient-reported outcome remission,in conjunction with biomarker normalisation and endoscopic *** the STrIDE-II guidelines endorse the pursuit of endoscopic healing,clinicians must consider that this may not always be appropriate,acceptable,or achievable in all *** underscores the need to engage patients at the outset in an effort to personalise care and individualise treatment *** use of non-invasive biomarkers such as faecal calprotectin in conjunction with cross-sectional imaging techniques,particularly intestinal ultrasound,holds great promise;as do emerging treatment targets such as transmural *** randomised clinical trials,namely,CALM and STArDUST,have evaluated the efficacy of a T2T approach in achieving endoscopic endpoints in patients with Crohn’s *** from these studies reflect that patient subgroups and Crohn’s disease characteristics likely to benefit most from a T2T approach,remain to be ***,outside of clinical trials,data pertaining to the real-world effectiveness of a T2T approach remains scare,highlighting the need for pragmatic real-world *** the obvious promise of a T2T approach,a lack of guidance to support its integration into real-world clinical practice has the potential to limit its *** highlights the need to describe st

关键词： Treat to target Inflammatory bowel disease Crohn’s disease Treatment targets Endoscopic remission Transmural healing Time to response Intestinal ultrasound

Control system design for a pressure-tube-type supercritical water-cooled nuclear reactor via a higher order sliding mode method

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Nuclear Science and Techniques 2024年第1期35卷 145-154页

作者： M.Hajipour G.r.Ansarifar Department of Nuclear Engineering Faculty of PhysicsUniversity of IsfahanIsfahan 81746-73441Iran

Nuclear power plants exhibit non-linear and time-variable ***,designing a control system that sets the reactor power and forces it to follow the desired load is complicated.A supercritical water reactor(SCWr)is a fourth-generation conceptual *** an SCWr,the non-linear dynamics of the reactor require a controller capable of control-ling the *** this study,a pressure-tube-type SCWr was controlled during reactor power maneuvering with a higher order sliding mode,and the reactor outgoing steam temperature and pressure were controlled *** an SCWr,the temperature,pressure,and power must be maintained at a setpoint(desired value)during power *** point kinetics equations with three groups of delayed neutrons were used in the ***-order and classic sliding mode controllers were separately manufactured to control the plant and were compared with the PI controllers speci-fied in previous *** controlled parameters were reactor power,steam temperature,and ***,for these parameters,the PI controller had certain instabilities in the presence of *** classic sliding mode controller had a higher accuracy and stability;however its main drawback was the chattering *** was highly accurate and stable and had a small computational *** reality,it followed the desired values without oscillations and chattering.

关键词： Supercritical water nuclear reactor Higher order sliding mode controller Steam temperature Steam pressure Point kinetics model

南极格罗夫山火星陨石GrV 99027的宇宙射线暴露年龄

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中国科学（D辑） 2007年第8期37卷 1020-1023页

作者：孔屏 D.Fabel r.brown S.Freeman 中国科学院地质与地球物理研究所岩石圈演化国家重点实验室中国科学院青藏高原研究所北京100085 Department of Geographical and Earth Sciences University of GlasgowGlasgowG12 8QQScotlandUK Scottish Universities Environmental research Centre Rankine AvenueScottish Enterprise Technology ParkEast Kilbride G75 0QFScotlandUK

中国第16次南极考察队回收的GrV 99027的宇宙成因核素10Be和26Al的含量分别为(14.1±0.6)和(67.5±3.4)dpm/kg,从10Be的含量计算出GrV 99027的宇宙线暴露年龄为(4.4±0.6)Ma,而其过高的26Al的含量表明来自太阳射线的影响.幔源火星陨石Gr... 详细信息

中国第16次南极考察队回收的GrV 99027的宇宙成因核素10Be和26Al的含量分别为(14.1±0.6)和(67.5±3.4)dpm/kg,从10Be的含量计算出GrV 99027的宇宙线暴露年龄为(4.4±0.6)Ma,而其过高的26Al的含量表明来自太阳射线的影响.幔源火星陨石GrV 99027,LEW 88516,Y-793605,NWA 1950和ALHA77005具有非常相近的宇宙线暴露年龄,再加上极为相似的矿物学和地球化学特征,说明它们极有可能来自火星上的同一次撞击事件.

关键词： GrV 99027 火星陨石宇宙线暴露年龄火星

Simple collective model for nuclear chiral mode

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Frontiers of physics 2024年第2期19卷 1-5页

作者： r.V.Jolos E.A.Kolganova D.r.Khamitova Joint Institute for Nuclear research 141980 DubnaMoscow regionRussia Dubna State University 141982 DubnaMoscow RegionRussia

A simple semi-analytical collective model that takes into account the limitations of the variation interval of the collective variable is suggested to describe the chiral dynamics in triaxial odd−odd nuclei with a fixed particle−hole *** collective Hamiltonian is constructed with the potential energy obtained using the postulated ansatz for the wave function symmetric with respect to chiral *** diagonalizing the collective Hamiltonian the wave functions of the lowest states are obtained and the evolution of the energy splitting of the chiral doublets in transition from chiral vibration to chiral rotation regime is demonstrated.

关键词： collective model nuclear chiral

Tolerance of Winter Wheat (Triticum aestivumL.) and Under Seeded red Clover (Trifolium pretenseL.) to Fall Applied Post-Emergent Broadleaf Herbicides

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American Journal of Plant Sciences 2014年第9期5卷 1265-1271页

作者： Kristen E. McNaughton Lynette r. brown Peter H. Sikkema University of Guelph Ridgetown Campus Ridgetown Canada

The fall application of post-emergent (POST) herbicides on winter wheat provided effective control of emerged winter annual, biennial, and perennial broadleaf weeds. In recent years, wheat producers have seen a shift to these weeds, due in part, to the adoption of reduced-and no-tillage practices and the use of non-residual herbicides such as glyphosate in the preceding soybean and corn crops. The tolerance of winter wheat to ten herbicides, applied POST in the fall, was evaluated between 2008 and 2011 at Exeter and ridgetown, Ontario. Winter wheat yield was not reduced by applications of MCPA ester, dicamba/ MCPA/ mecoprop, clopyralid, bromoxynil/ MCPA, thifensulfuron /tribenuron +MCPA ester, fluroxypyr +MCPA ester, and pyrasulfotole/ bromoxynil. In contrast, 2,4-D ester and dichlorprop/2,4-D, caused visible injury in June and July of the following year and consistently decreased winter wheat yield by at least 10%. Applications of 100 g a.i. ha-1 saflufenacil also decreased winter wheat yield in two of the four harvest years examined. None of the herbicide options examined were safe on red clover when it was under seeded the spring following winter wheat planting. All herbicides significantly decreased red clover dry biomass one month after wheat harvest.

关键词： 2 4-D Clopyralid Pyrasulfotole Saflufenacil Winter Wheat

BFMT： A Simple Biometric Facial recognition System

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Computer Technology and Application 2011年第8期2卷 579-590页

作者： Gene r. brown Murray E. Jennex Theophilus B.A. Addo On Assignment Inc. 9095 Rio San Diego Drive Suite 300 San Diego CA 92108 USA Management Information Systems Department College of Business Administration San Diego State University San Diego CA 92182 USA

This study describes the development of a simple biometric facial recognition system, BFMT, which is designed for use in identifying individuals within a given population. The system is based on digital signatures derived from facial images of human subjects. The results of the study demonstrate that a particular set of facial features from a simple two-dimensional image can yield a unique digital signature which can be used to identify a subject from a limited population within a controlled environment. The simplicity of the model upon which the system is based can result in commercial facial recognition systems that are more cost-effective to develop than those currently on the market.

关键词：面部识别系统生物识别数字签名面部图像二维图像成本效益

Weed Control in Winter Wheat (Triticum aestivumL.) with Preplant Applications of Glyphosate plus Mesotrione or Saflufenacil

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Agricultural Sciences 2015年第6期6卷 594-600页

作者： Nader Soltani Lynette r. brown Christy Shropshire Peter H. Sikkema University of Guelph ridgetown Campus Ridgetown Canada

There is limited information on weed control with glyphosate plus mesotrione or saflufenacil when applied prior to seeding winter wheat in the autumn. A total of 12 field trials (six for each herbicide tankmix) were conducted over a three-year (2010-2012) at two locations (ridgetown and Exeter, Ontario) to evaluate the effect of glyphosate plus mesotrione or saflufenacil at various rates for broadleaf weed control and red clover establishment in winter wheat. Glyphosate (900 g ae ha-1) and tankmixes of glyphosate (900 g ae ha-1) plus mesotrione or saflufenacil at 12.5, 25, 50, 75, 100, 150 and 200 g ai ha-1 applied preplant (PP) in the autumn resulted in minimal visible injury (0% - 2%) in the autumn and on May 1 and June 1 of the following spring in winter wheat. The PP application of glyphosate alone or in combination with mesotrione or saflufenacil provided only 1% - 30% control of common ragweed in the following spring. The PP application of glyphosate in combination with mesotrione or saflufenacil provided 74% - 100% control of wild mustard at 2 and 4 weeks after emergence (WAE) in autumn but the control was only 0% - 35% on June 1 of the following spring. Glyphosate plus mesotrione or saflufenacil did not have any effect on seed moisture content and yield of winter wheat compared to glyphosate alone. Clover establishment was reduced with glyphosate plus mesotrione at the two highest rates but was not affected with glyphosate plus saflufenacil compared to glyphosate alone. Based on these results, glyphosate alone and in combination with mesotrione or saflufenacil applied PP in the autumn at rates evaluated did not provide adequate residual control of common ragweed, common lambsquarters and wild mustard in the spring of the following year in winter wheat.

关键词： Cereals Injury Height Herbicide Tolerance Yield

Efficacy of POST glyphosate applications in combination with other POST herbicides in glyphosate-resistant corn (Zea mays L.)

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Agricultural Sciences 2014年第1期5卷 1-8页

作者： Kristen E. McNaughton Lynette r. brown Peter H. Sikkema University of Guelph Ridgetown Campus Ridgetown Canada

The use of glyphosate-resistant corn has facilitated a shift from a reliance on preemergence residual herbicides to postemergence (POST) herbicides, and in some cases exclusively glyphosate. Glyphosate is a non-selective herbicide that is relatively slow-acting, which may allow weeds to continue to compete with corn after application and potentially decrease crop yield. The addition of several POST corn herbicides, with some residual control, to an early-season glyphosate application was examined to determine if the tankmix combination would improve the speed of weed control compared to glyphosate applied alone. Seven field trials were conducted over three years (2009, 2010 and 2011) near ridgetown and Exeter, Ontario. The control of common ragweed was improved 3 days after application (DAA) with three POST glyphosate tankmixes compared to glyphosate alone. However control was still less than 55%. Depending on the weed species examined, at 28 DAA two of the glyphosate tankmix treatments tested provided better common ragweed, common lambsquarters, or green foxtail control than glyphosate alone. Treatments providing better weed control at 28 DAA also typically decreased weed density compared to glyphosate alone.

关键词： Glyphosate Weed Control Glyphosate-resistant Corn POST Application

Changes in snow cover extent in the Central Taurus Mountains from 1981 to 2021 in relation to temperature, precipitation, and atmospheric teleconnections

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Journal of Mountain Science 2024年第1期21卷 49-67页

作者： Ecmel ErLAT Fulya AYDIN-KANDEMİr Department of Geography Ege UniversityIzmir 35100Türkiye Climate Change and Zero Waste Department Antalya Metropolitan MunicipalityAntalya 07310Türkiye Hydropolitics Association Ankara 06680Türkiye

The snow cover over the Taurus Mountains affects water supply, agriculture, and hydropower generation in the region. In this study, we analyzed the monthly Snow Cover Extent(SCE) from November to April in the Central Taurus Mountains(Bolkar, Aladaglar, Tahtali and Binboga Mountains) from 1981 to 2021. Linear trends of snow cover season(November to April) over the last 41 years showed decreases in SCE primarily at lower elevations. The downward trend in SCE was found to be more pronounced and statistically significant for only November and March. SCE in the Central Taurus Mountains has declined about-6.3% per decade for 2500-3000 m in November and about-6.0% per decade for 1000-1500 m and 3000+ m in March over the last 41 years. The loss of SCE has become evident since the 2000s, and the lowest negative anomalies in SCE have been observed in 2014, 2001, and 2007 in the last 41 years, which are consistent with an increase in air temperature and decreased precipitation. SCE was correlated with both mean temperature and precipitation, with temperature having a greater relative importance at all elevated gradients. results showed that there is a strong linear relationship between SCE and the mean air temperature(r =-0.80) and precipitation(r = 0.44) for all elevated gradients during the snow season. The Arctic Oscillation(AO), the North Atlantic Oscillation(NAO), and the Mediterranean Oscillation(MO) winter indices were used to explain the year-to-year variability in SCE over the Central Taurus Mountains. The results showed that the inter-annual variability observed in the winter SCE on the Central Taurus Mountains was positively correlated with the phases of the winter AO, NAO and MO, especially below 2000 m elevation.

关键词： Snow cover extent Atmospheric teleconnection Central Taurus Mountains Air temperature and precipitation Geographic Information Systems Türkiye