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Hepatocellular carcinoma in patients with chronic hepatitis C virus infection without cirrhosis

World Journal of Gastroenterology 2010年第32期16卷 4061-4065页

作者： Kathryn L Nash Tracy Woodall Ashley sm brown Susan E Davies Graeme JM Alexander Department of Hepatology University of CambridgeAddenbrooke's HospitalHills RoadCambridge CB2 2QQUnited Kingdom Department of Hepatology Mailpoint 255Southampton General HospitalTremona RoadSouthamptonHampshire SO16 6YDUnited Kingdom Liver Unit Department of MedicineSt Mary's HospitalPraed StreetLondon W2 1NYUnited Kingdom Department of Histopathology University of CambridgeAddenbrooke's HospitalHills RoadCambridge CB2 2QQUnited Kingdom

AIM:To investigate and characterise patients with chronic hepatitis C virus(HCV) infection presenting with hepatocellular carcinoma(HCC) in the absence of ***:Patients with chronic hepatitis C infection without cirrhosis presenting with HCC over a 2-year period were *** clinical case notes,blood test results and histological specimens were reviewed to identify whether additional risk factors for the development of HCC were ***:Six patients(five male,one female) with chronic hepatitis C infection without cirrhosis presented to a single centre with HCC over a 2-year *** patients were treated by surgical resection and one patient underwent liver *** of generous histological specimens confirmed the presence of HCC and the absence of cirrhosis in all *** degree of fibrosis of the background liver was staged as mild(n = 1),moderate(n = 4) or bridging fibrosis(n = 1).Review of the clinical case notes revealed that all cases had an additional risk factor for the development of HCC(four had evidence of past hepatitis B virus infection;two had a history of excessive alcohol consumption;a further patient had prolonged exposure to immune suppression).CONCLUSION:HCC does occur in patients with non-cirrhotic HCV infection who have other risk factors for hepatocarcinogenesis.

关键词： Hepatitis C virus Hepatocellular carcinoma Non-cirrhotic Screening

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Interaction between inflammatory bowel disease,physical activity,and myokines:Assessment of serum irisin levels

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World Journal of Gastroenterology 2024年第22期30卷 2923-2926页

作者： Marwan sm Al-Nimer Department of Therapeutics and Clinical Pharmacology College of MedicineUniversity of DiyalaBaqubah 32001Iraq

Inflammatory bowel disease(IBD),including Crohn’s disease and ulcerative colitis,showed a wide spectrum of intestinal and extra-intestinal manifestations,which rendered the patients physically inactive and impaired their quality of *** has been found that physical activity is a non-pharmacological intervention that improves the quality of life for those *** is one member of the myokines secreted by muscle contraction during exercise and could be used as an antiinflammatory biomarker in assessing the physical activity of IBD *** addition,experimental studies showed that exogenous irisin significantly decreased the inflammatory markers and the histological changes of the intestinal mucosa observed in experimental ***,irisin produces changes in the diversity of the ***,endogenous or exogenous irisin,via its anti-inflammatory effects,will improve the health of IBD patients and will limit the barriers to physical activity in patients with IBD.

关键词： Irisin Inflammatory bowel disease Physical activity Myokines Prognostic marker

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视网膜血管弹性调节的新概念

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美国医学会眼科杂志（中文版） 1996年第4期8卷 199-203页

作者： brown,sm 孙文赏

目的:复习视网膜、脉络膜循环局部血管弹性调节的机理。设计:文献复习。结果:血管内皮细胞对化学刺激素如:乙酰胆碱、缓激肽,对血压的变化和血管壁压力的变化,对局部氧含量的变化和其它局部刺激发生反应,可产生一氧化氮、内皮素、前列... 详细信息

目的:复习视网膜、脉络膜循环局部血管弹性调节的机理。设计:文献复习。结果:血管内皮细胞对化学刺激素如:乙酰胆碱、缓激肽,对血压的变化和血管壁压力的变化,对局部氧含量的变化和其它局部刺激发生反应,可产生一氧化氮、内皮素、前列腺素和肾素-血管紧张素产物。这些物质都包含在人们熟悉的最有效的血管收缩剂和血管舒张剂之中。初步研究提示这些物质对视网膜和脉络膜血管系统的内皮自身调节有潜在的作用。结论:对于包括视网膜和脉络膜在内的许多血管床生理性压力变化的反应,血管内皮的激素产物可以为血管自身调节提供最终的共同的通路。此过程的药理学调节,可以提供疾病治疗的用药方式,例如对高血压、糖尿病视网膜病变的治疗。

关键词：视网膜血管弹性调节血管舒张剂

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用P物质和胰岛素样生长因子Ⅰ治疗神经营养性和？…

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美国医学会眼科杂志（中文版） 1998年第2期10卷 104-105页

作者： brown,sm 姜中蓉

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Biomarker bust:meta-analyses reveal unreliability of neuronal extracellular vesicles for diagnosing parkinsonian disorders

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Neural Regeneration Research 2025年第1期20卷 201-202页

作者： Hash brown Taha Leonard Davis School of Gerontology University of Southern CaliforniaLos AngelesCAUSA

A range of neurodegenerative disorders,collectively termed parkinsonian disorders,present with a complex array of both motor and non-motor *** in this group are Parkinson’s disease(PD),dementia with Lewy bodies(DLB),multiple system atrophy(MSA),corticobasal syndrome(CBS),and progressive supranuclear palsy(PSP).These disorders are differentiated neuropathologically by their dominant protein pathologies involvingα-synuclein(α-syn)and/or tau,the types of brain cells affected,such as neurons,oligodendroglia,and astrocytes,and the specific brain regions involved(Tolosa et al.,2021).

关键词： disorders parkin

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PLK1 phosphorylation of ZW10 guides accurate chromosome segregation in mitosis

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Journal of Molecular Cell Biology 2024年第2期16卷 47-62页

作者： sm Faysal Bellah Fangyuan Xiong Zhen Dou Fengrui Yang Xing Liu Xuebiao Yao Xinjiao Gao Liangyu Zhang MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics Hefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of China School of Life SciencesHefei 230027China Anhui Key Laboratory for Cellular Dynamics and Chemical Biology Hefei 230027China

Stable transmission of genetic information during cell division requires faithful chromosome *** evidence has demonstrated that polo-like kinase 1(PLK1)dynamics at kinetochores control correct kinetochore–microtubule attachments and subsequent silencing of the spindle assembly ***,the mechanisms underlying PLK1-mediated silencing of the spindle checkpoint remain ***,we identified a regulatory mechanism by which PLK1-elicited zeste white 10(ZW10)phosphorylation regulates spindle checkpoint silencing in ***10 is a cognate substrate of PLK1,and the phosphorylation of ZW10 at Ser12 enables dynamic ZW10–Zwint1 *** of ZW10 phosphorylation resulted in misaligned chromosomes,while persistent expression of phospho-mimicking ZW10 mutant caused premature anaphase,in which sister chromatids entangled as cells entered *** findings reveal the previously uncharacterized PLK1–ZW10 interaction through which dynamic phosphorylation of ZW10 fine-tunes accurate chromosome segregation in mitosis.

关键词： ZW10 PLK1 kinetochore mitosis phosphorylation

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Flavone improves liver damage in nicotine-exposed rats via the Nrf2/HO-1 pathway

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 341-349页

作者： Nora A.Elsayed Fatma sm Moawed Esraa SA Ahmed Ahmed Hammad Omayma AR Abo-Zaid Biochemistry and Molecular Biology Department Faculty of Vet.Med.Benha UniversityBenha cityEgypt Health Radiation Research National Center for Radiation Research and TechnologyEgyptian Atomic Energy AuthorityCairoEgypt Radiation Biology Department National Center for Radiation Research and TechnologyEgyptian Atomic Energy AuthorityCairoEgypt

Objective:To assess the hepatoprotective effects of flavone on nicotine-induced liver ***:Thirty-six rats were allocated into six groups:the control group,the nicotine group,the flavone alone groups(10 and 25 mg/kg/body weight),and the nicotine groups treated with flavone(10 and 25 mg/kg/body weight).Liver function,oxidative stress,Nrf2 pathway(HO-1,Nrf2,and Keap-1),and inflammatory markers(IL-17,TNF-α,and NF-κB)were ***,a histopathological examination of liver tissues was ***:Nicotine increased liver damage,inflammation,and oxidative ***,flavone suppressed nicotine-induced liver enzymes,oxidative stress,and inflammation,as manifested by increased antioxidants and decreased malondialdehyde level,liver enzymatic activities,and inflammatory ***(10 and 25 mg/kg/body weight)also reduced the level of Keap-1 and increased HO-1 and Nrf2 levels in the liver of nicotine-exposed ***:Flavone has hepatoprotective properties and may slow the progression of liver injury by reducing oxidative stress,liver enzymes,and inflammation possibly via the Nrf2 pathway.

关键词： Flavone Nicotine Liver Nrf2 HO-1 NF-κB

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Projective Hilbert modules and sequential approximations

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Science China Mathematics 2024年

作者： Lawrence G.brown Huaxin Lin Department of Mathematics Purdue University Department of Mathematics East China Normal University Department of Mathematics University of Oregon

We show that when A is a separable C*-algebra, every countably generated Hilbert A-module is projective(with bounded module maps as morphisms). We also study the approximate extensions of bounded module maps. In the case where A is a σ-unital simple C*-algebra with strict comparison, and every strictly positive lower semicontinuous affine function on quasitraces can be realized as the rank of an element in the Cuntz semigroup, we show that the Cuntz semigroup is equivalent to unitarily equivalent classes of countably generated Hilbert A-modules if and only if A has stable rank one.

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Exploring the Social Impact of the Short-Stay Market(Ssm)in Regional Areas:An Empirical Study

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Fudan Journal of the Humanities and Social Sciences 2024年第2期17卷 243-277页

作者： Emeka Ndaguba Kerry brown Dora Marinova Uma Jogulu School of Business and Law Edith Cowan UniversityPerthAustralia Curtin University Sustainability Policy Institute Curtin UniversityPerthAustralia

The discourse on microentrepreneurs and their involvement in the short stay market (Ssm) was non-existent until 2008. While several concepts and constructs have been developed and empirically tested since 2009, many of them relate to economics, leaving the social, cultural, and environmental factors underdeveloped. Thus, this study aimed to fll the gap and identify and assess the social impact of the short-stay market (Ssm) in a regional area. The study included 16 face-to-face interview sessions conducted with 18 participants, and the Leximancer software was employed to analyse the data. The study revealed that the social impact on Ssm is not generic, rather pluralistic, multidimensional, and dynamic. The study also found that the limitation clause instituted by the council is a direct disconnect between the council and property owners/managers. Furthermore, despite ample opportunities provided by the short-stay market (Ssm) in regional areas, encumbrances cannot be overlooked. Therefore, there is a need for a comprehensive approach to understand the social impact on policy frameworks in regional areas.

关键词： Short-stay market Experience economy Long-term rentals Wine economy Regulation

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A review of public health guidelines for postpartum physical activity and sedentary behavior from around the world

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Journal of Sport and Health Science 2024年第4期13卷 472-483,F0003页

作者： Kelly R.Evenson Wendy J.brown Alison K.Brinson Emily Budzynski-Seymour Melanie Hayman Department of Epidemiology Gillings School of Global Public HealthUniversity of North Carolina at Chapel HillChapel HillNC 27599-8050USA Faculty of Health Sciences and Medicine Bond UniversityGold CoastQLD 4226Australia School of Human Movement and Nutrition Sciences The University of QueenslandBrisbaneQLD 4072Australia Department of Anthropology University of North Carolina at Chapel HillChapel HillNC 27599-3115USA Carolina Population Center University of North Carolina at Chapel HillChapel HillNC 27599-8120USA Faculty of Sport Health and Social SciencesSolent UniversitySouthamptonSO140YNUK Appleton Institute School of HealthMedical and Applied SciencesCentral Queensland UniversityRockhamptonQLD 4701Australia

Background:The period following pregnancy is a critical time window when future habits with respect to physical activity(PA) and sedentary behavior(SB) are established;therefore,it warrants *** purpose of this scoping review was to summarize public health-oriented country-specific postpartum PA and SB guidelines ***:To identity guidelines published since 2010,we performed a(a) systematic search of 4 databases(CINAHL,Global Health,PubMed,and SPORTDiscus),(b) structured repeatable web-based search separately for 194 countries,and(c) separate web-based *** the most recent guideline was included for each ***:We identified 22 countries with public health-oriented postpartum guidelines for PA and 11 countries with SB *** continents with guidelines included Europe(n=12),Asia(n=5),Oceania(n=2),Africa(n=1),North America(n=1),and South America(n=1).The most common benefits recorded for PA included weight control/management(n=10),reducing the risk of postpartum depression or depressive symptoms(n=9),and improving mood/well-being(n=8).Postpartum guidelines specified exercises to engage in,including pelvic floor exercises(n=17);muscle strengthening,weight training,or resistance exercises(n=13);aerobics/general aerobic activity(n=13);walking(n=11);cycling(n=9);and swimming(n=9).Eleven guidelines remarked on the interaction between PA and breastfeeding;several guidelines stated that PA did not impact breast milk quantity(n=7),breast milk quality(n=6),or infant growth(n=3).For SB,suggestions included limiting long-term sitting and interrupting sitting with ***:Country-specific postpartum guidelines for PA and SB can help promote healthy behaviors using a culturally appropriate context while providing specific guidance to public health practitioners.

关键词： Breastfeeding Caesarean section Guidelines Postnatal Recommendations

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