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A study of process-induced grain structures during steady state and non-steady state electron-beam welding of a titanium alloy

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Journal of Materials Science & Technology 2022年第18期113卷 117-127页

作者： Yu Lu Richard Turner Jeffery brooks Hector Basoalto School of Metallurgy and Materials University of BirminghamBirminghamB152TTUnited Kingdom Department of Materials Science and Engineering The University of SheffieldMappin StreetSheffieldS13JDUnited Kingdom

A detailed microstructural characterisation of the emerging weld-line grain structure,for bead-upon-plate welds in Ti-6Al-4V(Ti64)of differing plate thickness,was *** microstructure studied was formed during both steady state and non-steady state sections within the weld path,with the non-steady state portion being taken from the end of the plate as the weld bead and heat source overhang the edge of the *** allows for the effects of welding process conditions on the microstructural evolution to be *** weld pool geometry and 3D tomography of the weld-induced defects have been *** characterisation of microstructure and texture for different welding parameters and for steady and non-steady states have been used to identify physical parameters for the microstructure predictions that are difficult to obtain *** different states significantly affect the weld crown shape and formation,weld toe,weld bead depth and ***,the heat affected zone(HAZ)re-mains *** the microstructural evolution,both the steady and non-steady states have similar microstructure and *** defects were observed in the steady state section of welds,but sub-surface spherical pores have been observed in the non-steady state section of a *** element modelling to simulate the thermal-metallurgical-mechanical fields within the steady and non-steady state sections of the welds was considered,and the cooling rates predicted within steady state and non-steady sections were interrogated to improve the theoretical understanding of the microstructure and defect formation differences in these Ti64 EB weld regions.

关键词： Electron-beam fusion welding Processing Microstructure Ti-6Al-4V

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Stability and orientation of cecropin P1 on maleimide self-assembled monolayer(SAM) surfaces and suggested functional mutations

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Chinese Chemical Letters 2015年第4期26卷 485-490页

作者： Shuai Wei Charles L.brooks Ⅲ Department of Chemistry University of Michigan Department of Biophysics University of Michigan

One of the main challenges of biosensor design is to understand the protein or peptide stability on the chip in high resolution structural detail. Since conventional experimental methods are limited by the resolution for their applications on surface tethered peptides/proteins, a recently developed coarse grained simulation method is employed to explore the peptide/surface interaction in residue-level resolution. This work shows how the coarse grained model successfully describes peptide-surface interactions by evaluating thermal stability of the peptide cecropin PI in bulk solution and on surfaces by physical adsorption and chemical tethering. The simulation also reproduces observations of peptide orientations on the self-assembled monolayer surface from earlier experimental work. Additionally, using knowledge obtained from the simulations, specific mutations are suggested and the desired structure and pose on the surface is obtained. In summary, this work sheds a light on the reasonable biosensor design that is ~uided by simulations.

关键词： Coarse grained simulationKB Go-like modelPeptide-surface interactionThermal stabilityOrientationMutation

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The impact of acetylation and deacetylation on the p53 pathway

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Protein & Cell 2011年第6期2卷 456-462页

作者： Christopher L.brooks Wei Gu Stemline Therapeutics Inc.New YorkNY 10128USA Institute for Cancer Genetics and Department of Pathology College of Physicians&SurgeonsColumbia UniversityNew YorkNY 10032USA

The p53 tumor suppressor is a sequence-specific transcription factor that undergoes an abundance of post-translational modifications for its regulation and *** of p53 is an important reversible enzymatic process that occurs in response to DNA damage and genotoxic stress and is indispensible for p53 transcriptional activity.p53 was the first non-histone protein shown to be acetylated by histone acetyl transferases,and a number of more recent in vivo models have underscored the importance of this type of modification for p53 ***,we review the current knowledge and recent findings of p53 acetylation and deacetylation and discuss the implications of these processes for the p53 pathway.

关键词： p53 Mdm2 acetylation deacetylation destabilization ubiquitination transcriptional activation and stability

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Conceptus elongation in ruminants: roles of progesterone, prostaglandin, interferon tau and cortisol

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Journal of Animal Science and Biotechnology 2015年第2期6卷 151-162页

作者： Kelsey brooks Greg Burns Thomas E Spencer Department of Animal Science and Center for Reproductive Biology Washington State University

The majority of pregnancy loss in ruminants occurs during the first three weeks after conception, particularly during the period of conceptus elongation that occurs prior to pregnancy recognition and implantation. This review integrates established and new information on the biological role of ovarian progesterone （P4）, prostaglandins （PGs）, interferon tau （IFNT） and cortisol in endometrial function and conceptus elongation. Progesterone is secreted by the ovarian corpus luteum （CL） and is the unequivocal hormone of pregnancy. Prostaglandins （PGs） and cortisol are produced by both the epithelial cells of the endometrium and the trophectoderm of the elongating conceptus. In contrast, IFNT is produced solely by the conceptus trophectoderm and is the maternal recognition of pregnancy signa that inhibits production of luteolytic pulses of PGF2α by the endometrium to maintain the CL and thus production of P4. Available results in sheep support the idea that the individual, interactive, and coordinated actions of P4, PGs, IFNT and cortisol regulate conceptus elongation and implantation by controlling expression of genes in the endometrium and/or trophectoderm. An increased knowledge of conceptus-endometrial interactions during early pregnancy in ruminants is necessary to understand and elucidate the causes of infertility and recurrent early pregnancy loss and provide new strategies to improve fertility and thus reproductive efficiency.

关键词： Conceptus Cortisol Endometrium Interferon Prostaqlandin Ruminant

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Effects of particle size and concentration on bubble coalescence and froth formation in a slurry bubble column

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Particuology 2018年第1期16卷 82-95页

作者： A.R. Sarhan J. Naser G. brooks Department of Mechanical and Product Design Engineering Swinburne University of Technology Hawthorn Victoria 3122 Australia Department of Mechanical Engineering University ofAnbar Ramadi Anbar 31001 lraq

A new approach for simulating the formation of a froth layer in a slurry bubble column is proposed. Froth is considered a separate phase, comprised of a mixture of gas, liquid, and solid. The simulation was carried out using commercial flow simulation software （FIRE v2014） for particle sizes of 60-150 μm at solid concentrations of 0-40vol%, and superficial gas velocities of 0.02-0.034m/s in a slurry bubble column with a hydraulic diameter of 0.2 m and height of 1.2 m. Modelling calculations were conducted using a Eulerian-Eulerian multiphase approach with k-ε turbulence. The population balance equations for bubble breakup, bubble coalescence rate, and the interfacial exchange of mass and momentum were included in the computational fluid dynamics code by writing subroutines in Fortran to track the number density of different bubble sizes. Flow structure, radial gas holdup, and Sauter mean bubble diameter distributions at different column heights were predicted in the pulp zone, while froth volume fraction and density were predicted in the froth zone. The model was validated using available experimental data, and the predicted and experimental results showed reasonable agreement. To demonstrate the effect of increasing solid concentration on the coalescence rate, a solid-effect multiplier in the coalescence effi- ciency equation was used. The solid-effect multiplier decreased with increasing slurry concentration, causing an increase in bubble coalescence efficiency. A slight decrease in the coalescence efficiency was also observed owing to increasing particle size, which led to a decrease in Sauter mean bubble diam- eter. The froth volume fraction increased with solid concentration. These results provide an improved understanding of the dynamics of slurry bubble reactors in the presence of hydrophilic particles.

关键词： Computational fluid dynamics Slurry concentration Gas holdup Particle size Froth Coalescence efficiency

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Two case reports of novel syndrome of bizarre performance of gastrointestinal endoscopy due to toxic encephalopathy of endoscopists among 181767 endoscopies in a 13-year-university hospital review: Endoscopists, first do no harm!

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World Journal of Gastroenterology 2020年第9期26卷 984-991页

作者： mitchell S Cappell Division of Gastroenterology & Hepatology William Beaumont Hospital Oakland University William Beaumont School of Medicine

BACKGROUND Although deficient procedures performed by impaired physicians have been reported for many specialists,such as surgeons and anesthesiologists,systematic literature review failed to reveal any reported cases of deficient endoscopies performed by gastroenterologists due to toxic *** gastroenterologists,like any individual,can rarely suffer acute-changes-inmental-status from medical disorders,and these disorders may first manifest while performing gastrointestinal endoscopy because endoscopy comprises so much of their *** SUMMARIES Among 181767 endoscopies performed by gastroenterologists at William-Beaumont-Hospital at Royal-Oak,two endoscopies were performed by normally highly qualified endoscopists who manifested bizarre endoscopic interpretation and technique during these endoscopies due to toxic ***-1-endoscopist repeatedly insisted that gastric polyps were colonic polyps,and absurdly“pressed”endoscopic steering dials to“take”endoscopic photographs;Case-2-endoscopist repeatedly insisted that had intubated duodenum when intubating antrum,and wildly turned steering dials and bumped endoscopic tip forcefully against antral *** nurses recognized endoscopists as impaired and informed *** called Chief-of-Gastroenterology who advised endoscopists to terminate their esophagogastroduodenoscopies(fulfilling ethical imperative of“physician,firstdo-no-harm”),and go to emergency room for medical *** endoscopists ***-hospital-work-up revealed toxic encephalopathy in both from:case-1-urosepsis and left-ureteral-impacted-nephrolithiasis;and case-2-dehydration and accidental ingestion of suspected illicit drug given by unidentified *** rapidly recovered with medical *** This rare syndrome(0.0011%of endoscopies)may manifest abruptly as bizarre endoscopic interpretation and technique due to impairment of endoscopists by toxic encephalopathy.

关键词： Endoscopy Iatrogenic injury Medical ethics Hippocratic Oath Quality improvement Medical malpractice Morbidity and mortality

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CFD model simulation of bubble surface area flux in flotation column reactor in presence of minerals

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International Journal of Mining Science and Technology 2018年第6期28卷 999-1007页

作者： A.R.Sarhan J.Naser G.brooks Department of Mechanical and Product Design Engineering Swinburne University of TechnologyHawthornVictoria 3122Australia Department of Mechanical Engineering University of Anbar RamadiAnbar 31001Iraq

Bubble surface area flux(S_b) is one of the main design parameter in flotation column that typically employed to describe the gas dispersion properties, and it has a strong correlation with the flotation rate constant. There is a limited information available in the literature regarding the effect of particle type,density, wettability and concentration on Sb. In this paper, computational fluid dynamics(CFD) simulations are performed to study the gas–liquid–solid three-phase flow dynamics in flotation column by employing the Eulerian–Eulerian formulation with k-e turbulence model. The model is developed by writing Fortran subroutine and incorporating then into the commercial CFD code AVL FIRE, *** paper studies the effects of superficial gas velocities and particle type, density, wettability and concentration on Sband bubble concentration in the flotation column. The model has been validated against published experimental data. It was found that the CFD model was able to predict, where the response variable as indicated by R-Square value of 0.98. These results suggest that the developed CFD model is reasonable to describe the flotation column reactor. From the CFD results, it is also found that Sb decreased with increasing solid concentration and hydrophobicity, but increased with increasing superficial gas velocity. For example, approximately 28% reduction in the surface area flux is observed when coal concentration is increased from 0 to 10%, by volume. While for the same solid concentration and gas flow rate, the bubble surface area flux is approximately increased by 7% in the presences of sphalerite.A possible explanation for this might be that increasing solid concentration and hydrophobicity promotes the bubble coalescence rate leading to the increase in bubble size. Also, it was found that the bubble concentration would decrease with addition of hydrophobic particle(i.e., coal). For instance, under the same operating conditions, approximately 23% reduc

关键词： CFD Froth flotation Bubble surface area flux Solid properties Bubble concentration

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Brains, bacteria and behaviors: the role of interferon-gamma in the pathogenesis of pneumococcal meningitis

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Neural Regeneration Research 2021年第1期16卷 125-126页

作者： Lay Khoon Too Andrew mitchell Molecular Immunopathology Unit Bosch Institute and School of Medical SciencesSave Sight InstituteFaculty of Medicine and HealthUniversity of SydneySydneyNSWAustralia Materials Characterisation and Fabrication Platform Department of Chemical EngineeringThe University of MelbourneMelbourneVictoriaAustralia

of bacterial meningitis that occurs following brain infection by the Gram-positive cocci Streptococcus *** only does it cause acute mortality,but pneumococcal meningitis also accounts for the highest proportion of survivors living with neurological sequelae,including behavioral disorders,cognitive deficits,hearing loss,motor impairment and *** than 90 distinct pneumococcal serotypes have been identified worldwide based on their capsular compositions and serological *** replacement continually poses great challenge to costly vaccination programs in developed countries(Koelman et al.,2020),this has therefore emphasized the need to develop new treatment strategies in addition to improving vaccine coverage.

关键词： meningitis epilepsy mortality

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Modulation of antioxidant status in streptozotocin-induced diabetic male wistar rats following intake of red palm oil and/or rooibos

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Asian Pacific Journal of Tropical Medicine 2014年第7期7卷 536-544页

作者： Ademola Ayeleso Nicole brooks Oluwafemi Oguntibeju Oxidative Stress Research Centre.Department of Biomedical Sciences Faculty of Health & Wellness SciencesCape Peninsula University of Technology Department of Wellness Sciences.Faculty of Health & Wellness Sciences Cape Peninsula University of Technology

Objective:To investigate the role of red palm oil(RPO),rooibos tea extract(RTE)and their combined treatment(RPO+RTE)on antioxidant status in streptozotocin(STZ)-induced diabetic ***:Diabetes mellitus was induced by a single administration of streptozotocin(50 mg/kg)and the rats were treated for 7 *** enzymes[calalase(CAT),glutathione peroxidase(GPx),superoxide dismutase(SOD)],antioxidant capacity[trolox equivalence antioxidant capacity(TEAC),oxygen radical absorbance capacity(ORAC)]as well as total protein,albumin,globulin,total glutathione,conjugated diene and thiobarbituric acid reactive substances(TBARS)were ***:Treatment with RPO,RTE and RPO+RTE significantly(p>0.05)improved liver SOD and plasma ORAC in the diabetic ***,diabetic rats treated with RTE and RPO+RTE enhanced liver GPx.A significant(P<0.05)increase in the plasma TBARS in the diabetic control group was observed when compared with the normal control *** of diabetic rats with RTE and RPO+RTE reduced plasma TBARS to a level not significantly different at P<0.05 from the normal control ***:The results revealed the anti-oxidative potentials of red palm oil,rooibos and their combination in diabetic conditions and hence,they could be useful in the management of diabetes and its complications.

关键词： Red palm oil Rooibos Antioxidant Streptozotocin Diabetes Rats

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True polar wander in the Earth system

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Science China Earth Sciences 2023年第6期66卷 1165-1184页

作者： Chong WANG Ross N.mitchell State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

True polar wander(TPW),or planetary reorientation,is the rotation of solid Earth(crust and mantle)about the liquid outer core in order to stabilize Earth’s rotation due to mass *** TPW is well-documented on Earth presently with satellites and for multiple planets and moons in the Solar System,the prevalence of TPW in Earth history remains *** a history of controversy,both the physical plausibility of TPW on Earth and an empirical basis for it are now *** resistance to the old idea likely stems from the fact that,like plate tectonics,TPW may influence much of the Earth system,thus acknowledging its existence requires rethinking how many different datasets are *** review summarizes the development of TPW as a concept and provides a framework for future research that no longer regards TPW like a ghost process that may or may not exist,but as an integral part of the Earth system that can relate shallow and deep processes that are otherwise only mysteriously ***,we focus on the temporal regularity of large TPW,and discuss its relationship with the supercontinent-megacontinent cycle based on previous *** suggest the assembly of megacontinents has a close linkage to large ***,supercontinent tenure and breakup have a close linkage to fast *** effects of TPW on sea level changes,paleoclimate,biological diversity,and other facets of the Earth system are presented and require interdisciplinary tests in the future.

关键词： True polar wander(TPW) Planetary reorientation Apparent polar wander(APW) Mantle convection Supercontinent cycle Megacontinent

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