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RASSF10 Suppresses Colorectal Cancer Growth by Activating P53 Signaling and Sensitizes Colorectal Cancer Cell to Docetaxel

RASSF10 Suppresses Colorectal Cancer Growth by Activating P5...

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遵循诊疗规范、鼓励临床试验——第八届中国肿瘤内科大会、第三届中国肿瘤医师大会、中国抗癌协会肿瘤临床化疗专业委员会2014年学术年会

作者：郭静杨雅阁杨云生詹启敏 James G.Herman Malcolm V.brock 张炳勇郭明洲中国人民解放军总医院消化内科郑州大学第一附属医院中国医学科学院 Johns Hopkins University 河南省人民医院

Objective;To further understand the methylation status,expression,function,and mechanism of RASSFIO in colorectal ***;Eight colorectal cancer cell lines,89 cases of primary colorectal cancer,and 5 cases of normal colorectal mucosa were involved in this *** specific PCR,western blot,colony formation,siRNA,gene expression array,and xenograft mice were ***;Loss of RASSFIO expression and complete methylation were found in LOVO,RKO,and *** or reduced expression and partial methylation were found in LS180,DLD1,HT29,SW480,and SW620 *** or increased expression of RASSFIO was found in these colorectal cancer cells by 5-aza-2’-deoxycytidine *** was methylated in 60.7%(54/89)of primary colorectal cancer *** was associated with tumor stage(P<0.05)and metastasis(P<0.05).Re-expression of RASSFIO inhibited cell proliferation and induced apoptosis and G2/M phase arrest in RKO and HCT116 ***116 cells tumor xenograft was suppressed by *** expression of MDM2 was revealed by comparison of gene expression profile in RASSFIO expressed and unexpressed RKO *** result was confirmed by RT-PCR and western *** activated P53 signaling in RKO and HCT116 cells after UV ***10 sensitized RKO and HCT116 cells to ***;RASSF10 is frequently methylated in human colorectal cancer and the expression is regulated by promoter region *** of RASSF10 is associated with late tumor stage and ***10 suppresses human colorectal cancer growth by activating P53 signaling in colorectal ***10 sensitizes colorectal cancer to docetaxel.

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华南澄江及南澳Emu Bay Shale化石群中的开腔骨类新发现（英文）

华南澄江及南澳Emu Bay Shale化石群中的开腔骨类新发现（英文）

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中国古生物学会第十二次全国会员代表大会暨第29届学术年会

作者：贠浩张兴亮 Glenn brock 李洛阳 State Key Laboratory of Continental Dynamics and Shaanxi Key Laboratory of Early Life and Environments Department of GeologyNorthwest University Department of Biological Sciences Macquarie University

Three chancelloriid species,Allonnia phrixothrix Bengtson and Hou,2001,*** Yun et al.,2018 and *** Cong et al.,2018 from the Erjie section,a new locality of the Chengjiang fossil Lagerst?tte(Cambrian Series 2,Stage 3),South China are described,based on over 450 specimens preserved in mudstones composed of clay minerals and highlighted by reddish iron *** Allonnia sclerites in the scleritome are morphologically classified into two groups:common 3+0 form sclerites and modified single-rayed *** common sclerites of *** and ***,especially the latter,are densely arranged,while the sclerites are extremely sparsely distributed in *** modified sclerites are generally palisaded around the apical orifice of the body,forming an obvious tuft *** body wall integuments of *** and *** are ornamented by locally-distributed wrinkle-like stripes and microscopic nodes,manifesting the complexity and plasticity of the epidermal *** contrast,the integument of *** is usually *** australilonga *** the Emu Bay Shale(EBS,Cambrian Series 2,Stage 4) represents the first described chancelloriid scleritome from East *** new species has a typical sac-like body,equipped with dozens of distinctive rosette-like *** sclerite comprises one central ray and six or seven lateral rays(6–7+1 form),and is characterized by a pair of remarkably long and subparallel adapical *** exceptionally-preserved chancelloriid scleritomes enriched the biodiversity of Chengjiang and EBS KonservatLagerst?tten,especially with regard to the sessile benthic *** also provided support for the idea that chancelloriids could inhabit a broad spectrum of environments.

关键词： chancelloriids scleritome Konservat-Lagerst?tten Cambrian

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专家全方位解读:数字印刷之路如何走?

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今日印刷 2013年第9期 12-24页

作者：陈毅莹 Masto Atoda Maureen brock 潘晓东吕理哲张建民王大伟赢船公司(InfoTreds Inc.) Memjet Lables公司亚太区业务开发部上海数字印刷行业协会中国印刷及设备器材工业协会数码与网络印刷分会惠普Indigo/Inkjet

数字印刷在全球印刷市场的迅速发展让更多的中国印刷人开始着眼于这方领域的开垦,越来越多的印刷企业纷纷瞄准这一看似广阔的市场大势发力。然而,看似极其诱人的数字印刷市场,获得成功的企业却少之又少。我们看到现有的大多数数字印刷... 详细信息

数字印刷在全球印刷市场的迅速发展让更多的中国印刷人开始着眼于这方领域的开垦,越来越多的印刷企业纷纷瞄准这一看似广阔的市场大势发力。然而,看似极其诱人的数字印刷市场,获得成功的企业却少之又少。我们看到现有的大多数数字印刷企业仍在摸索徘徊,前行乏力。数字印刷到底是蛋糕还是鸡肋?数字印刷发展的现

关键词：数字印刷传统印刷可变数据传统胶印按需印刷印刷业印刷厂印刷工业加工厂数字印刷机印刷企业专家

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IFOSFAMIDE AND MESNA IN ADVANCED MALIGNANCIES

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中华医学杂志(英文版) 1988年第3期101卷 220-220页

作者： G C Li N brock J Q Li Z Z Guan Y J He Department of Oncology and Liver Cancer Research Unit Sun Yat-sen University of Medical Sciences Guangzhou D-4800 Bielefeld 14/F.R. Germany 140129 Department of Abdominal Surgery Affiliated Tumor Hospital (ATH) Sun Yat-sen University of Medical Sciences Guangzhou Department of Medical Oncology ATH

Fifty-seven patients with advanced malignancies, including 8 cases of soft tissue sarcomas, 9 ovarian carcinomas, 5 non-seminomatous testicular tumor, 11 bronchogenic carcinoma, 3 renal carcinoma, 7 non-Hogkin’s lymphoma, 2 skeletal fibrosarcoma, 2 breast carcinoma and one each of Ewing’s tumor, prostatic carcinoma, seminoma, plasma cell tumor, multiple myeloma, malignant teratoma, nasopharyngeal carcinoma, Wilms’s tumor, neuroblastoma and mycosis fungoides, were treated with Ifosfamide and Mesna. In 53 evaluable cases of this series, there were 5 complete remissions and 20 partial remissions, a total response rate of 47.2%. The overall median survival time was 7.5 months. Non-seminomatous testicular tumor, non-Hogkin’s lymphoma and ovarian carcinoma showed high response rates. The side effects of this regimen included dyspepsia, nausea, vomiting, myelodepression, dizziness and alopecia and were mostly grades l-2. Hemorrhagic cystitis can be prevented nearly completely by concomitant administration of Mesna.

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Assessing the value of information in residential building simulation: Comparing simulated and actual building loads at the circuit leve

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建筑节能(中英文) 2017年第10期 132-132页

作者： brock Glasgo Chris Hendrickson Inês Lima Azevedo

Building energy simulation tools are now being used in a number of new roles such as building operation optimization,performance verification for efficiency programs,and-recently-building energy code analysis,design, and compliance verification in the residential sector. But increasing numbers of studies show major differences between the results of these simulations and the actual measured performance of the buildings they are intended to model. The accuracy and calibration of building simulations have been studied extensively in the commercial sector,but these new applications have created a need to better understand the performance of home energy *** this paper,we assess the ability of the DOE's EnergyPlus software to simulate the energy consumption of 106 homes using audit records,homeowner survey records,and occupancy estimates taken from monitored *** compare the results of these simulations to device-level monitored data from the actual homes to provide a first measure of the accuracy of the EnergyPlus condensing unit, central air supply fan, and other energy consumption model estimates in a large number of *** then conduct sensitivity analysis to observe which physical and behavioral characteristics of the homes and homeowners most influence the accuracy of the *** show that EnergyPlus models do not accurately or consistently estimate occupied whole-home energy *** some models accurately predict annual energy consumption to within1%of measured data, none of the modeled homes meet ASHRAE criteria for a calibrated model when looking at hourly interval data. The majority of this error is due to appliance and lighting energy overestimates,f ollowed by AC condensing unit use. These inaccuracies are due to factors such as occupant behaviors and differences in appliance and lighting stocks which are not well-captured in traditional energy audit *** identify a number of factors which must be specified for an accu

关键词： EnergyPlus Residential Simulation Energy code

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应用PPD或特异性抗原ESAT-6和CFP-10诊断结核病的全血IFN-γ试验

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国际结核病与肺部疾病杂志 2001年第2期 88-92页

作者： I.brock M.E.Munk A.Kok-Jensen P.Andersen 邢青 Department of Tuberculosis Immunology Statens Serum Institute Department of Pulmonary Medicine Rigshospitalet Copenhagen Denmark

目的:为了评价QuantiFERON-TB试验在已接种BCG疫苗、未接种BCG疫苗及结核病患者人群中的作用,并且应用结核分支杆菌特异性抗原ESAT-6和CFP-10的全血试验,比较它的诊断性能。设计:用PPD,ESAT-6或CFP-10刺激已接种BCG疫苗、未接种BCG疫... 详细信息

目的:为了评价QuantiFERON-TB试验在已接种BCG疫苗、未接种BCG疫苗及结核病患者人群中的作用,并且应用结核分支杆菌特异性抗原ESAT-6和CFP-10的全血试验,比较它的诊断性能。设计:用PPD,ESAT-6或CFP-10刺激已接种BCG疫苗、未接种BCG疫苗及结核病患者的全血,分析其IFN-τ应答水平,评价该试验的敏感性及特异性。结果:没有一个未接种BCG疫苗者对***-PPD,ESAT-6或CFP-10产生阳性应答。在已接种BCG疫苗的19人中,有9人(9/19,47％)对***-PPD产生应答,而只有2人(2/19,10.5％)对ESAT-6或CFP-10产生应答。在QuantiFERON-TB试验中,利用不同抗原,所得到的敏感性水平相似,其中对***-PPD的敏感性为79％,对ESAT-6或CFP-10的敏感性为72％。结论:结果表明,利用***-PPD的全血试验不能有效的区分BCG疫苗接种者和结核病患者。***特异性的新的重组抗原ESAT-6或CFP-10.能够提高全血试验的特异性,并且能够区分TB感染,非典型分支杆菌反应性及BCG疫苗接种。这个试验,将为控制和消灭结核病提供一个优于目前所采用的结核菌素皮肤试验的量化的方法。

关键词：结核分支杆菌结核病结核病诊断全血试验 IFN-γ

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贴错标签的孩子

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作者： (美)布罗克·艾德(brock Eide) (美)费尔内特·艾德(Fernette Eide)

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澳大利亚南部寒武系Ajax组黑珊瑚化石的发现

澳大利亚南部寒武系Ajax组黑珊瑚化石的发现

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中国古生物学会化石藻类专业委员会第十九次学术年会、中国古生物学会微体学分会第十一届会员代表大会暨第十八次学术年会、江苏省古生物学会2020年学术年会

作者：郝文静宋希坤 Glenn A.brock 张志亮孙洁 Bernhard Ruthensteiner 韩健西北大学地质学系大陆动力学国家重点实验室陕西省早期生命与环境重点实验室厦门大学海洋与地球科学学院海洋环境科学国家重点实验室 Department of Biological Sciences Macquarie University SNSB-Zoologische Staatssammlung München

黑珊瑚是一种主要生活在深海的六射珊瑚,与其他六射珊瑚的不同之处在于(1)其珊瑚虫具有六个触手;(2)群居生活;(3)具有灰色或黑色的几丁质骨骼。黑珊瑚唯一已知的化石记录来自于中国南部湖北省早奥陶世分乡组(470 Ma)。本文我们报告了来... 详细信息

黑珊瑚是一种主要生活在深海的六射珊瑚,与其他六射珊瑚的不同之处在于(1)其珊瑚虫具有六个触手;(2)群居生活;(3)具有灰色或黑色的几丁质骨骼。黑珊瑚唯一已知的化石记录来自于中国南部湖北省早奥陶世分乡组(470 Ma)。本文我们报告了来自南澳大利亚寒武纪阿加西组(约515Ma)的黑珊瑚化石星射狼牙棒虫(Kanabopathes stellatus gen. et sp. nov)。化石具有中空的轴,沿着中轴具有五列三角形的尖刺,横截面呈现同心环形结构。这是目前已知最早的六射珊瑚。结合它们与寒武纪古杯礁共同保存这一特征,我们推测,(1)寒武纪黑珊瑚生活在一个清洁、温暖、强波浪的大陆架环境中。(2)它们的几丁质骨架可能适应支持螅肉附着,竞争海底下层微型食物。(3)在随后地史时期,黑珊瑚很可能逐渐迁入深海。(4)现生黑珊瑚与化石极为相似,表明黑珊瑚的演化异常缓慢。(5)包括黑珊瑚在内的六射珊瑚化石应该出现在寒武纪第四期或更早,而不是出现在二叠纪-三叠纪界线之后。

关键词：古杯寒武纪黑珊瑚珊瑚纲

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