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西北工业大学学报 1991年第2期9卷 125-130页

作者： brock.,r 达人

A new database of building-space-specific internal loads and load schedules for performance based code compliance modeling of commercial buildings

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Building Simulation 2024年第6期17卷 877-892页

作者： Yunyang Ye Cary A.Faulkner Wooyoung Jung Jian Zhang Eli brock Pacific Northwest National Laboratory RichlandWA99354USA University of Pittsburgh PittsburghPA15260USA

Building-level loads and load schedules prescribed by current modeling rules save modelers time and provide standards during whole building performance ***,recent studies show that they sometimes insufficiently capture the entire building performance due to the varied loads and load schedules for different space *** a solution to this issue,this paper presents a database of default building-space-specific loads and load schedules for use in energy modeling,and in particular code compliance modeling for commercial *** existing sets of default loads and load schedules are reviewed and the challenges behind using them for specific research topics are ***,the proposed method to develop the building-space-specific loads and load schedules is *** that,the database for these building-space-specific loads and load schedules is *** addition,one case is studied to demonstrate the applications of these loads and load *** this case study,three methods are used to develop building energy models:space-specific(using knowledge of the distribution and location of space types and applying the space-specific data in the developed database),building-level(assuming a lack of knowledge of the space types and using the building-level data in the developed database),and calculated-ratio(assuming knowledge of the distribution of space types but not their locations and calculating weighted average values based on the space-specific data in the developed database).The energy results simulated by using these three methods are compared,which shows building-level methods can produce significantly different absolute energy and energy savings results than the results using space-specific ***,this paper discusses the application scope and maintenance of this new database.

关键词： load load schedule space specific building energy modeling code compliance

Modelling the impact of antimalarial quality on the transmission of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum

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Infectious Disease Modelling 2017年第2期2卷 161-187页

作者： Aleisha r.brock Joshua V.ross Scott Greenhalgh David P.Durham Alison Galvani Sunil Parikh Adrian Esterman School of Nursing&Midwifery University of South AustraliaAdelaideSAAustralia School of Mathematical Sciences The University of AdelaideAdelaideSAAustralia Department of Mathematics and Statistics Queen's UniversityKingstonONCanada Center for Infectious Disease Modeling and Analysis Yale School of Public HealthNew HavenCTUSA Yale School of Public Health New HavenCTUSA Sansom Institute for research Health University of South AustraliaAdelaideSAAustralia Australian Institute of Tropical Health and Medicine James Cook UniversityCairnsQLDAustralia

Background:The use of poor quality antimalarial medicines,including the use of nonrecommended medicines for treatment such as sulfadoxine-pyrimethamine(SP)monotherapy,undermines malaria control and elimination ***,the use of subtherapeutic doses of the active ingredient(s)can theoretically promote the emergence and transmission of drug resistant ***:We developed a deterministic compartmental model to quantify the impact of antimalarial medicine quality on the transmission of SP resistance,and validated it using sensitivity analysis and a comparison with data from Kenya collected in *** modelled human and mosquito population dynamics,incorporating two Plasmodium falciparum subtypes(SP-sensitive and SP-resistant)and both poor quality and good quality(artemether-lumefantrine)antimalarial ***:The model predicted that an increase in human malaria cases,and among these,an increase in the proportion of SP-resistant infections,resulted from an increase in poor quality SP antimalarial use,whether it was full-or half-dose SP ***:Our findings suggest that an increase in poor quality antimalarial use predicts an increase in the transmission of *** highlights the need for stricter control and regulation on the availability and use of poor quality antimalarial medicines,in order to offer safe and effective treatments,and work towards the eradication of malaria.

关键词： Deterministic compartmental model Falsified antimalarial medicine Substandard antimalarial treatments Antimalarial quality Plasmodium falciparum malaria Drug resistance

The Thermal Decomposition of Ammonium Meta-Vanadate under restricted Flow Conditions

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American Journal of Analytical Chemistry 2017年第1期8卷 35-50页

作者： Lori r. brock Jeff W. Keister Michelle France Nathan Fierro Thomas C. DeVore Department of Chemistry James Madison University Harrisonburg VA USA

The products obtained during the thermal decomposition of ammonium meta-vanadate depend on the configuration of the container, the mass of the sample, the heating rate and the composition of the carrier gas. The decomposition in an uncapped container produced (NH4)2V4O11, NH4V3O8, and V2O5 as the apparent stable products while the products in a capped container were NH4V3O8, and V2Ox where x was between 4 and 5. These differences are attributed to the different amounts of the evolved gases in the cell. EGA-FTIr clearly established that the reduced final product in the capped cell resulted from a reaction between NH3 and the V2O5 formed during the decomposition. A pre-equilibrium kinetics model where the rate of the reverse reaction depends on the partial pressure of the gaseous products in the cell could explain the different reaction intermediates. This model provides a possible explanation for the different apparent activation energies that have been reported for the thermal decomposition of other compounds where a reversible step could occur in the decomposition mechanism.

关键词： Ammonium Meta-Vanadate Thermal Decomposition Kinetics Activation Energy

适用于混合动力车及起动-停车系统的带有聚合物涂层的发动机轴承

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汽车与新动力 2013年第5期45卷 22-27页

作者： George J W brock r 朱炳全

内燃机零部件禁止使用铅作为合金元素的法规和降低发动机排放的法规相继实施,对轴瓦的设计和功能产生了十分重要的影响。现已证明,由于制造商趋向于采用起动-停车系统、混合动力、发动机小型化和低黏度机油等各种技术来降低发动机的燃... 详细信息

内燃机零部件禁止使用铅作为合金元素的法规和降低发动机排放的法规相继实施,对轴瓦的设计和功能产生了十分重要的影响。现已证明,由于制造商趋向于采用起动-停车系统、混合动力、发动机小型化和低黏度机油等各种技术来降低发动机的燃油耗和排放,轴瓦的工作环境变得更具挑战性。发动机轴承通常是在液力润滑状态下工作的,但是,在采用上述技术的同时,要在不危及轴承系统耐久性的情况下延长轴承使用寿命,就不得不在混合润滑或边界润滑状态下工作。可以认为,商用车领域也将开始采用这些技术策略来达到规定的目标。针对这种颇具挑战性的轴承工作环境,Mahle公司开发了一种获专利的无铅聚合物轴瓦表面涂层。这种涂层的基体材料是一种高强度、耐高温、耐化学腐蚀的聚合物。在添加固态润滑剂、金属填充物、黏合增进剂和固化剂后,能使轴瓦具备理想的性能。试验台和发动机试验的结果证实,与传统无表面涂层的轴瓦材料相比,新开发的聚合物涂层材料具有良好的耐磨性和耐疲劳性。这种涂料适用于涂覆在被广泛使用的铝基和铜基底材上。着重阐述新技术对轴瓦工作环境的影响,并介绍一种能改善轴承系统可靠性和完整性的无铅聚合物涂层解决方案。

关键词：轴瓦无铅聚合物涂层轴承可靠性

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第七届国际人类遗传学会会议报告

国际遗传学杂志 1988年第3期11卷 143-144页

作者： Williamson r ,brock DJH ,李光明

分子遗传学本文主要介绍有关分子生物学进展的一些特点和印象。绝大多数遗传学家都知道,染色体的物理图与遗传图之间的“差距”正在受到人们的极大关注。Lehrach组织了一次很有趣的会议,内容是探讨分析大于克隆(即多于50 000bp)和小于厘... 详细信息

分子遗传学本文主要介绍有关分子生物学进展的一些特点和印象。绝大多数遗传学家都知道,染色体的物理图与遗传图之间的“差距”正在受到人们的极大关注。Lehrach组织了一次很有趣的会议,内容是探讨分析大于克隆(即多于50 000bp)和小于厘摩[1cM约等于100万bp或一个巨碱基(megabase,mb)]的人类基因组长度的技术。这些技术包括脉冲场凝胶电泳,由于应用限制酶切割DNA很少出现大的片段,所以这些片段可以用与琼

关键词： AFP CVS 位点 HD 人类神经管缺损母体血清基因疗法基因治疗生物疗法会议

Molar ratio induced crystal transformation from coordination complex to coordination polymers

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Chinese Chemical Letters 2024年第4期35卷 539-543页

作者： Peng Meng Qian-Cheng Luo Aidan brock Xiaodong Wang Mahboobeh Shahbazi Aaron Micallef John McMurtrie Dongchen Qi Yan-Zhen Zheng Jingsan Xu School of Chemistry and Physics&Centre for Materials Science Queensland University of TechnologyBrisbaneQLD 4000Australia Frontier Institute of Science and Technology Xi'an Jiaotong UniversityXi'an 710054China Central Analytical research Facility Institute for Future EnvironmentsQueensland University of TechnologyBrisbaneQLD 4000Australia

Coordination complex of a copper cyanurate(Cu(Ⅱ)-CA) was transformed into coordination polymers upon the stimulus of extra Cu(Ⅱ) through “directed Ostwald ripening”. By increasing the molar ratio of Cu(Ⅱ) to CA, we obtained two coordination polymers with selective coordination sites: Cu(Ⅱ)-κ N(HCA)κ NCu(Ⅱ) and Cu(Ⅱ)-κ N(HCA)κ O-Cu(Ⅱ), which display disparate magnetic interactions.

关键词： Molar ratio dependent crystal transformation Copper cyanurate Ostwald ripening Molecular magnetism One-dimensional chain

Surgical management of the diabetic foot:The current evidence

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World Journal of Orthopedics 2024年第5期15卷 404-417页

作者： richard Henry randall roberts Gareth rhys Davies-Jones James brock Vaishnav Satheesh Greg AJ robertson Department of Trauma and Orthopaedics Wrexham Maelor HospitalWrexham LL137TDUnited Kingdom Department of Trauma and Orthopaedics The Robert Jones and Agnes Hunt Orthopaedic HospitalOswestry SY107AGUnited Kingdom

The prevalence of diabetes mellitus and its associated complications,particularly diabetic foot pathologies,poses significant healthcare challenges and economic burdens *** review synthesises current evidence on the surgical management of the diabetic foot,focusing on the interplay between neuropathy,ischemia,and infection that commonly culminates in ulcers,infections,and,in severe cases,*** escalating incidence of diabetes mellitus underscores the urgency for effective management strategies,as diabetic foot complications are a leading cause of hospital admissions among diabetic patients,significantly impacting morbidity and mortality *** review explores the pathophysiological mechanisms underlying diabetic foot complications and further examines diabetic foot ulcers,infections,and skeletal pathologies such as Charcot arthropathy,emphasising the critical role of early diagnosis,comprehensive management strategies,and interdisciplinary care in mitigating adverse *** addressing surgical interventions,this review evaluates conservative surgeries,amputations,and reconstructive procedures,highlighting the importance of tailored approaches based on individual patient profiles and the specific characteristics of foot *** integration of advanced diagnostic tools,novel surgical techniques,and postoperative care,including offloading and infection control,are discussed in the context of optimising healing and preserving limb function.

关键词： Diabetes Diabetic foot Charcot Osteomyelitis Amputation Diabetic foot attack Conservative surgery

Supramolecular Bonding Competition Enabled Nanostructure Evolution and Mechanical reinforcement

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CCS Chemistry 2024年第1期6卷 157-164页

作者： Yuting Wang Peng Meng Aidan brock Yanan Xu Hang Meng Zixuan Liu Kan Zhang John McMurtrie Jingsan Xu School of Chemistry and Physics and Centre for Materials Science Queensland University of TechnologyBrisbaneQueensland 4000 Central Analytical research Facility Institute for Future EnvironmentsQueensland University of TechnologyBrisbaneQueensland 4000 State Key Laboratory of Superhard Materials Department of Materials Science and Key Laboratory of Automobile MaterialsMOEJilin UniversityChangchun 130012

In this work,competition between different supramolecular interactions is investigated based on a fibrous crystal composed of hydrogen-bonded cyanuric acid(CA)and amidinothiourea(ADT).Melamine(M)is found to prevail over ADT and bond to CA due to its stronger triple H-bonding affiliation,forming hollow microtubes assembled by oriented CAM crystalline arrays,as guided by the directionality of peripheral hydrogen ***,competitive interaction between hydrogen bonding and ionic/covalent bonding is demonstrated by mixing Ag+ions with the CA-ADT fibers,where sulfur atoms are abstracted from ADT molecules to produce Ag_(2)S *** in situ-formed Ag_(2)S serves as a binding glue to generate CA-ADT/Ag_(2)S composites with significantly enhanced mechanical strength compared to the pristine CA-ADT fiber pellet.

关键词： supramolecular interaction hydrogen bonds chemical bond competition hollow crystal array organic-inorganic composite

Epigenetic silencing of BEND4,a novel DNA damage repair gene,is a synthetic lethal marker for ATM inhibitor in pancreatic cancer

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Frontiers of Medicine 2024年第4期18卷 721-734页

作者： Yuanxin Yao Honghui Lv Meiying Zhang Yuan Li James G.Herman Malcolm V.brock Aiai Gao Qian Wang Francois Fuks Lirong Zhang Mingzhou Guo Department of Gastroenterology and Hepatology the First Medical CenterChinese PLA General HospitalBeijing100853China Department of Pharmacology School of Basic Medical SciencesZhengzhou UniversityZhengzhou450001China Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou450001China UPMC Hillman Cancer Center University of Pittsburgh Medical CenterPittsburghPA15213USA Department of surgery School of MedicineJohns Hopkins School of MedicineBaltimoreMD21287USA Laboratory of Cancer Epigenetics Faculty of MedicineULB-Cancer Research Center(U-CRC)Universite Libre de Bruxelles(ULB)Brussels1070Belgium National Key Laboratory of Kidney Diseases the First Medical CenterChinese PLA General HospitalBeijing100853China

Synthetic lethality is a novel model for cancer *** understand the function and mechanism of BEN domain-containing protein 4(BEND4)in pancreatic cancer,eight cell lines and a total of 492 cases of pancreatic neoplasia samples were included in this ***-specific polymerase chain reaction,CrISPr/Cas9,immunoprecipitation assay,comet assay,and xenograft mouse model were ***4 is a new member of the BEN domain *** expression of BEND4 is regulated by promoter region *** is methylated in 58.1%(176/303)of pancreatic ductal adenocarcinoma(PDAC),33.3%(14/42)of intraductal papillary mucinous neoplasm,31.0%(13/42)of pancreatic neuroendocrine tumor,14.3%(3/21)of mucinous cystic neoplasm,4.3%(2/47)of solid pseudopapillary neoplasm,and 2.7%(1/37)of serous cystic ***4 methylation is significantly associated with late-onset PDAC(>50 years,Pr differentiation(Pr prognostic marker(Pr-suppressive roles in vitro and in ***,BEND4 involves non-homologous end joining signaling by interacting with Ku80 and promotes DNA damage *** of BEND4 increased the sensitivity of PDAC cells to ATM ***,the present study revealed an uncharacterized tumor suppressor BEND4 and indicated that methylation of BEND4 may serve as a potential synthetic lethal marker for ATM inhibitor in PDAC treatment.

关键词： BEND4 DNA methylation synthetic lethality NHEJ pathway