检索结果-南通市图书馆

Journal of Systems Science and Systems Engineering 2016年第2期25卷 254-268页

作者： A. Ertas M.w. smith D. Tate w.D. Lawson T.B. Baturalp Department of Mechanical Engineering Texas Tech University Lubbock TX USA 79410 Department of Industrial Design Xi 'an Jiaotong-Liverpool University Suzhou 215123 Jiangsu China Department of Civil Engineering Texas Tech University Lubbock TX USA 79410

This paper outlines a diagnostic approach to quantify the maintainability of a Commercial off-the-Shelf （COTS）-based system by analyzing the complexity of the deployment of the system components. Interpretive Structural Modeling （ISM） is used to demonstrate how ISM supports in identifying and understanding interdependencies among COTS components and how they affect the complexity of the maintenance of the COTS Based System （CBS）. Through ISM analysis we have determined which components in the CBS contribute most significantly to the complexity of the system. with the ISM, architects, system integrators, and system maintainers can isolate the COTS products that cause the most complexity, and therefore cause the most effort to maintain, and take precautions to only change those products when necessary or during major maintenance efforts. The analysis also clearly shows the components that can be easily replaced or upgraded with very little impact on the rest of the system.

关键词： COTS Based System maintainability complexity Interpretive Structural Modeling

Caspase-3 activation as a bifurcation point between plasticity and cell death

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2012年第1期28卷 14-24页

作者： Shikha Snigdha Erica D smith G Aleph Prieto Carl w Cotman Institute for Memory Impairments and Neurological Disorders University of CaliforniaIrvineIrvineCalifornia 92697-4540USA

Death-mediating proteases such as caspases and caspase-3 in particular, have been implicated in neurodegenerative processes, aging and Alzheimer＇s disease. However, emerging evidence suggests that in addition to their classical role in cell death, caspases play a key role in modulating synaptic function. It is remarkable that active caspases-3, which can trigger widespread damage and degeneration, aggregates in structures as delicate as synapses and persists in neurons without causing acute cell death. Here, we evaluate this dichotomy, and discuss the hypothesis that caspase-3 may be a bifurcation point in cellular signaling, able to orient the neuronal response to stress down either pathological/apoptotic pathways or towards physiological cellular remodeling. we propose that temporal, spatial and other regulators of caspase activity are key determinants of the ultimate effect of caspase-3 activation in neurons. This concept has implications for differential roles of caspase-3 activation across the lifespan. Specifically, we propose that limited caspase-3 activation is critical for synaptic function in the healthy adult brain while chronic activation is involved in degenerative processes in the aging brain.

关键词： caspase-3 neurodegeneration cognition memory synaptic function

Investigation of role of cartilage surface polymer brush border in lubrication of biological joints

在线全文

学校读者我要写书评

暂无评论

Friction 2022年第1期10卷 110-127页

作者： JinJing LIAO David w.smith Saeed MIRAMINI Bruce S.GARDINER Lihai ZHANG Department of Infrastructure Engineering.The University of Melbourne.Victoria 3010 Australia Faculty of Engineering and Mathematical Sciences The University of Western AustraliaWA 6009Australia College of Science Health.Engineering and Education.Murdoch UniversityWA 6150Australia

Although experimental evidence has suggested that the polymer brush border(PBB)on the cartilage surface is important in regulating fluid permeability in the contact gap,the current theoretical understanding of joint lubrication is still *** address this research gap,a multiscale cartilage contact model that includes PBB,in particular its effect on the fluid permeability of the contact gap,is developed in this *** modeling is employed to estimate the permeability of the contact *** permeability is classified into two categories:For a gap size>1μm,the flow resistance is assumed to be dominated by the cartilage roughness;for gap sizew resistance is assumed to be dominated by the surface polymers extending beyond the collagen network of the articular *** gap sizes of less than 1μm,the gap permeability decreases exponentially with increasing aggrecan concentration,whereas the aggrecan concentration varies inversely with the gap ***,the gap permeability is employed in a macroscale cartilage contact model,in which both the contact gap space and articular cartilage are modeled as two interacting poroelastic *** fluid exchange between these two media is achieved by imposing pressure and normal flux continuity boundary *** model results suggest that PBB can substantially enhance cartilage lubrication by increasing the gap fluid load support(e.g.,by 26 times after a 20-min indentation compared with the test model without a PBB).Additionally,the fluid flow resistance of PBB sustains the cartilage interstitial fluid pressure for a relatively long period,and hence reduces the vertical deformation of the ***,it can be inferred that a reduction in the PBB thickness impairs cartilage lubrication ability.

关键词： assumed polymer hence

在线全文

学校读者我要写书评

暂无评论

流动的艺术Blue Table巧克力店

室内设计与装修 2024年第9期 148-149页

作者： [美国]Arch&Type Kim smith(摄影) 夕阳(编译) Arch&Type

Arch&Type受邀为Blue Table巧克力店打造一处结合制作与销售的综合场所。设计师Seth Amman与Adam McCullough在思考如何透过建筑空间来提升巧克力的制作及消费体验时,巧克力店负责人Ben Johnson向团队提供了一张未经调温程序的巧克力影... 详细信息

Arch&Type受邀为Blue Table巧克力店打造一处结合制作与销售的综合场所。设计师Seth Amman与Adam McCullough在思考如何透过建筑空间来提升巧克力的制作及消费体验时,巧克力店负责人Ben Johnson向团队提供了一张未经调温程序的巧克力影像,其融化、丝滑、流动的样貌,成为设计团队的初始灵感。于是,设计团队以数字建模的方式,打造了一个由CNC铣削、手工组装并经过油漆处理的天花板。

关键词：消费体验数字建模巧克力设计团队天花板

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： wenrui Qu Xiangbing wu wei wu Ying wang Yan Sun Lingxiao Deng Melissa walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

EFFECT OF THE HEAT OF REACTION DURING THE ALUMINOTHERMIC PROCESS OF ILMENITE

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2005年第2期18卷 173-176页

作者： Y.Z.Lan J.Liu R.w.smith MaterialsDepartment YunnanUniversityKunming650091China MetallurgicalandMaterialsDepartment NevadaUniversityofRenoNV89503NevadaUSA

The influence of the heat of reaction during the aluminothermic process for the production of ferrotitanium was investigated. The effect of the variation of the heat of reaction on FeTi and Ti recovery and the topographical analysis of slag produced showed that FeTi and Ti recovery increased and Al content in the alloy decreased with the increase of the absolute value of ΔH when │ΔH│wever, when │ΔH│>2584.24K·J/kg, FeTi and Ti recovery decreased with an increase of the absolute value of ΔH. Therefore, the heat of reaction in the aluminothermic process of ilmenite should be strictly controlled to -2584.24K·J/kg.

关键词： ilmenite Al reduction the heat of reaction

Co-deposition of Co-Ni alloys and their microstructure analysis by PoSAP

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1997年第23期42卷 2013-2014页

作者： R.A.D.Mackenzie G.D.w.smith Department of Materials University of Oxford Parks Road Oxford OX1 3PH UKDepartment of Materials University of Oxford Parks Road Oxford OX1 3PH UK

PULSED-co-electrodeposition （PCD） is a new and promising technique for producing alloymaterials of nanometer grain size. In this letter, Co-Ni alloys were produced by PCD, and theeffect of CO+2 ion concentration in the depositing baths on the Co content and the microstruc-ture in the corresponding deposit was studied by the position sensitive atom probe （PoSAP）,TEM and X-ray diffraction. The Co-Ni phase diagram shows that, at room temperature,there are two phases in Co-Ni alloys, one is εCo with hcp lattice, the other is αCo of fcc lat-tice. A Co-Ni alloy with a Ni content below 27% consists of single εCo, beyond 36% consistsof single αCo, in between consists of εCo + αCo. The examination results of TEM, SEM andX-ray diffraction indicated that the Co-Ni deposits with average grain size of 70 nm and thick-

关键词： Co-deposition of Co-Ni alloys and their microstructure analysis by PoSAP Ni

在线全文

学校读者我要写书评

暂无评论

万物皆AI?那自行车运动呢?

中国自行车 2024年第4期 96-99页

作者：尼古拉·史密斯不详

在万物皆可AI(人工智能)的当下,能利用AI的力量来改善自行车运动吗?AI可以快速处理大量数据来探寻变化趋势,能在一定程度上预测未来,并且它正在渗透到我们生活的各个领域,自行车运动也避免不了它的进入。自行车运动员或者爱好者可以利... 详细信息

在万物皆可AI(人工智能)的当下,能利用AI的力量来改善自行车运动吗?AI可以快速处理大量数据来探寻变化趋势,能在一定程度上预测未来,并且它正在渗透到我们生活的各个领域,自行车运动也避免不了它的进入。自行车运动员或者爱好者可以利用这一新兴技术来提高他们的表现,享受更加舒适的骑行,或者只是为了让骑行更安全,你已经在不知不觉中应用到了AI技术。

关键词：自行车运动人工智能 AI技术快速处理新兴技术骑行预测未来万物

维普期刊数据库博看期刊

Utilization of RNA sequencing to investigate olfactory dysfunction in chronic rhinosinusitis without nasal polyps:A pilot study

在线全文

学校读者我要写书评

暂无评论

world Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 29-36页

作者： Jorge A.Gutierrez III Jeremy L.Barth Rodney J.Schlosser Thomas S.Edwards Timothy L.smith Zachary M.Soler Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Regenerative Medicine&Cell Biology Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Otolaryngology-Head and Neck Surgery Oregon Health&Science UniversityPortlandOregonUSA

Objectives:Prior research on olfactory dysfunction in chronic rhinosinusitis(CRS)has focused on patients with polyps and suggests that direct inflammation of the olfactory cleft mucosa plays a contributory *** purpose of this study was to evaluate gene expression in superior turbinate mucosal specimens,comparing normosmic and dysosmic CRS patients without polyps(CRSsNP).Methods:Tissue samples were obtained from the superior turbinates of patients with CRSsNP at the time of endoscopic sinus *** subsequently underwent RNA sequencing and functional analysis to investigate biological pathways associated with differentially expressed genes between dysosmic(n=7)and normosmic(n=4)***:Differential gene expression analysis comparing dysosmic and normosmic CRSsNP patients showed upregulation of 563 genes and downregulation of 327 *** stringent criteria for multiple comparisons,one upregulated gene(Immediate Early Response 3[IER3])had an false discovery rate(FDR)correction adjustedP value considered statistically significant(Pways significantly different between dysosmic and normosmic patients(Pwith CRSsNP can provide valuable information regarding biological pathways and genes involved in olfactory *** study supports literature suggesting that Type 2 inflammation may play a role in olfactory dysfunction in at least some patients with *** study also prompts questions regarding the role of IL-10,rhodopsin-like receptors,andIER3 in the pathogenesis of olfactory dysfunction.

关键词： chronic rhinosinusitis without nasal polyps olfactory dysfunction RNA sequencing

Functional-trait ecology of the plateau pika Ochotona curzoniae in the Qinghai-Tibetan Plateau ecosystem

在线全文

学校读者我要写书评

暂无评论

Integrative Zoology 2019年第1期14卷 87-103页

作者： Andrew T.smith BADINGQIUYING Maxwell C.wILSON Brigitte w.HOGAN School of Life Sciences Arizona State UniversityTempeArizonaUSA School of Geographical Sciences Qinghai Normal UniversityXiningChina

Understanding a species’functional traits allows for a directed and productive perspective on the role a species plays in nature,and thus its relative importance to conservation *** functionaltrait ecology of the plateau pika Ochotona curzoniae is examined to better understand the resilience and sustainability of the high alpine grasslands of the Qinghai-Tibetan Plateau(QTP).The key functional traits of plateau pikas are their abundance and behavior of digging extensive burrow *** pikas have been poisoned over a significant part of their original geographic distribution across the QTP,allowing comparison of ecological communities with and without *** all mammalian and avian carnivores,most of which are obligate predators on pikas,have been lost in regions where pikas have been *** endemic birds on the QTP nest in pika burrows;when pikas are poisoned,burrows collapse,and these birds are greatly reduced in *** to the biopedturbation resulting from their burrows,regional plant species richness is higher in areas with pikas than *** presence of pika burrows allows higher rates of infiltration during heavy monsoon rains compared to poisoned areas,possibly mitigating runoff and the potential for serious downslope erosion and ***,the functional traits of plateau pikas enhance native biodiversity and other important ecosystem functions;these traits are *** plateau pikas are not natural colonizers,active reintroduction programs are needed to restore pikas to areas from which they have been poisoned to restore the important functional ecological traits of pikas.

关键词： ecosystem engineer functional-trait ecology keystone species Ochotona curzoniae re-introduction