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Hepatocellular carcinoma recurrence after liver transplant:An Australian single-centre study

world Journal of Transplantation 2025年第1期15卷 105-114页

作者： Matthew G Garas Luis Calzadilla-Bertot briohny w smith Luc Delriviere Byron Jaques Lingjun Mou Leon A Adams Gerry C MacQuillan George Garas Gary P Jeffrey Michael C wallace Medical School University of Western AustraliaNedlands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Surgery Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia

BACKGROUND Hepatocellular carcinoma(HCC)is a leading cause of cancer-related deaths *** transplantation(LT)offers the most effective *** recurrence is the strongest risk factor that decreases post-LT survival in patients transplanted for *** rate of HCC recurrence is generally reported as 8%-20%in the *** predictors of HCC have already been researched,however,to our knowledge there are no published studies on this topic using Australian *** To determine the rate and identify predictors of HCC recurrence in a contemporary western Australian LT *** we performed a retrospective cohort study of all liver transplants in patients with HCC at Sir Charles Gairdner Hospital between 2006 and *** was collected from various health record databases and included recipient demographics,serum biochemistry,radiology,operation notes,explant histopathology and details of *** survival of HCC patients post-LT,stratified for recurrence,was calculated by Kaplan Meier *** and multivariate Cox regression was used to determine predictors of HCC recurrence *** Between 1/1/2006 and 12/31/2021,119 patients were transplanted with HCC.8.4%of subjects developed recurrent HCC after LT with median follow-up time of 5.4 *** median time to recurrence was 2.9 years±0.75 *** comparing baseline characteristics,a greater proportion of subjects with recurrence had common characteristics on explant histopathology,including>3 viable nodules(P=0.001),vascular invasion(P=0.003)and poorly differentiated HCC(P=0.03).Unadjusted survival curves showed lower 1-year,3-year,5-year and 10-year survival rates in subjects with HCC recurrence compared to those without HCC recurrence(90%vs 92%,70%vs 88%,42%vs 80%,14%vs 76%,respectively;log rank Pwas low at 8.4%in this contemporary Australian cohort,however it significantly impacted post-LT *** studies are requir

关键词： Liver cancer Recurrence Liver transplantation Hepatocellular carcinoma Predictors Post-transplant survival Australian data

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Predictors of survival in autoimmune liver disease overlap syndromes

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world Journal of Hepatology 2024年第9期16卷 1269-1277页

作者： Dujinthan Jayabalan Yi Huang Luis Calzadilla-Bertot Malik Janjua Bastiaan de Boer John Joseph wendy Cheng Simon Hazeldine briohny w smith Gerry C MacQuillan Michael C wallace George Garas Leon A Adams Gary P Jeffrey Medical School University of Western AustraliaNed-lands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Anatomical Pathology PathWest Laboratory MedicineNedlands 6009Western AustraliaAustralia Department of Gastroenterology and Hepatology Royal Perth HospitalPerth 6000Western AustraliaAustralia Department of Gastroenterology and Hepatology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Medical School University of Western AustraliaNedl-ands 6009Western AustraliaAustralia

BACKGROUND Survival in patients with autoimmune liver disease overlap syndromes(AILDOS)compared to those with single autoimmune liver disease is *** To investigate the survival of patients with AILDOS and assess the accuracy of non-invasive serum models for predicting liver-related *** Patients with AILDOS were defined as either autoimmune hepatitis and primary biliary cholangitis overlap(AIH-PBC)or autoimmune hepatitis and primary sclerosing cholangitis overlap(AIH-PSC)and were identified from three tertiary centres for this cohort ***-related death or transplantation(liver-related mortality)was determined using a population-based data linkage *** scores for liver-related death were compared for accuracy[including liver outcome score(LOS),Hepascore,Mayo Score,model for end-stage liver disease(MELD)score and MELD incorporated with serum sodium(MELD-Na)score].RESULTS Twenty-two AILDOS patients were followed for a median of 3.1 years(range,0.35-7.7).Fourteen were female,the median age was 46.7 years(range,17.8 to 82.1)and median Hepascore was 1(range,0.07-1).At five years post enrolment,57%of patients remained free from liver-related mortality(74%AIH-PBC,27%AIH-PSC).There was no significant difference in survival between AIH-PBC and *** was a significant predictor of liver-related mortality(Pwith AIH-PBC(n=14)but not AIH-PSC(n=8).A LOS cut-point of 6 discriminated liver-related mortality in AIH-PBC patients(P=0.012,log-rank test,100%sensitivity,77.8%specificity)(Harrell's C-statistic 0.867).The MELD score,MELD-Na score and Mayo Score were not predictive of liver-related mortality in any *** Survival in the rare,AILDOS is *** current study supports the LOS as a predictor of liver-related mortality in AIH-PBC *** trials investigating predictors of survival in AILDOS are required.

关键词： Autoimmune liver disease overlap syndromes Liver outcome score Liver-related death Hepascore Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.smith Jessica L.williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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PHOSPHORUS REMOVAL USING STEEL SLAG

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Acta Metallurgica Sinica(English Letters) 2006年第6期19卷 449-454页

作者： R.w. smith Metallurgical and Materials Department Nevada University of Reno NV89503 Nevada USA

Steel slag is a byproduct produced in large amounts in the steel-making process. It is an important resource that can be effectively utilized. An experiment was described in which steel slag was tested as an adsorbent for the removal of phosphorus from waste water. Phosphorus removal depended on the amount of steel slag added, the pH value, the contact time, and the initial concentration. Under laboratory conditions when the added slag was 7.5g/L, the contact time 2h, and the pH value was equivalent to 6.5, over 99% of the phosphorus was removed; the experimental data on steel slag adsorption of phosphorus in the water fitted the Freundlich isotherm model. Steel slag was found to be very effective in adsorbing phosphorus.

关键词： steel slag waste water phosphorus removal

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Laboratory Study on the Removal of Fluorine from High Fluorine Bearing Zinc Oxide Ore

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Journal of Materials Science & Technology 2005年第5期21卷 767-769页

作者： Yaozhong LAN Liaoyuan YE Rose w.smith Materials Department Yunnan University Kunming 650091 China Metallurgical and Materials Department Nevada University of Reno NV89503 Nevada USA

An ever increasing demand for zinc has resulted in worldwide efforts to exploit complex and lean grade reserves of zinc oxide ore. In this study experiments were done on zinc recovery from high-fluorine bearing zinc oxide ore. First the effect of different variables on fluorine removal was investigated. Optimum experimental conditions occurred when the temperature was 1173 K, roasting time was 90 min and air flow was at a velocity of 5 m/min, the fluorine removal from the samples reached over 93%. The results obtained indicate that fluorine removal is not enhanced by adding diluted sulfuric acid or water as a binder. Second the roasted materials were leached with a diluted sulfuric acid, neutralized, flocculated and filtrated. The which satisfies the requirement of fluorine residual fluorine content in the leached content in the leached solutions for the solutions was less than 38 mg/L production of electrolytic zinc.

关键词： High-fluorine bearing zinc oxide ore Roasting Leaching Zinc recovery

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The use of environmentally sustainable bio-derived solvents in solvent extraction applications——A review

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Chinese Journal of Chemical Engineering 2016年第2期24卷 215-220页

作者： Zheng Li Kathryn H.smith Geoffrey w.Stevens Particulate Fluids Processing Centre Department of Chemical and Biomolecular EngineeringThe University of Melbourne

Replacement of volatile organic compounds （VOCs） by greener or more environmentally sustainable solvents is becoming increasingly important due to the increasing health and environmental concerns as well as economic pressures associated with VOCs. Solvents that are derived from biomass, namely bio-derived solvents, are a type of green solvent that have attracted intensive investigations in recent years because of their advantages over con- ventional VOCs, such as low toxicity, biodegradability and renewability. This review aims to summarize the use of bio-derived solvents in solvent extraction applications, with special emphasis given to utilization of biodiesels and terpenes. Compared with the conventional VOCs, the overall performance of these bio-derived solvents is comparable in terms of extraction yields and selectivity for natural product extraction and no difference was found for metal extraction. To date most researchers have focused on laboratory scale thermodynamics studies. Future work is required to develop and test new bio-derived solvents and understand the kinetic performance as well as solvent extraction nilnt nlant studies.

关键词： Solvent extraction Bio-derived solvents Green solvents Biodiesels Terpenes

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Creep-fatigue lives prediction and sensitivity study of 316H at 550 ℃

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Acta Metallurgica Sinica(English Letters) 2011年第2期24卷 132-140页

作者： Zhichao FAN David J smith Xuedong CHEN Mike w Spindler Hefei General Machinery Research Institute Hefei 23-0031 China University of Bristol Bristol BS8 1TR UK British Energy Gloucester GL4 3RS UK

In Volume 2/3 of R5 ＂An assessment procedure for the high temperature response of structures＂, the strain based ductility exhaustion method is suggested to calculate the creep damage of stress concentration region, which involves description of creep dwell initial stress, stress drop and creep ductility. Considering lots of uncertainty existed in these assessment, some sensitivity analysis is required in R5 procedure to ensure the conservatism of assessment results. In this paper, laboratory creep-fatigue test data of 316H at 550 ℃ with different loading conditions are selected as a special case to investigate whether the basic R5 approach is conservative, and the different material data combinations of cyclic stress-strain, creep deformation and creep ductility are used to identify those significant parameters affecting the assessment results. The analytical results indicate that the creep deformation model and creep ductility data are more significant to the results comparing with cyclic stress-strain data. If the upper bound of creep deformation law and lower bound of creep ductility data are used to predict their creep-fatigue lives, the degree of conservatism can be as large as a factor of -300, but if the modified creep deformation model and cast specific ductility data are used, very well prediction results can be gained within a factor of ±2.0 although there is slight non-conservatism.

关键词： Creep Fatigue Damage Life prediction Sensitivity study

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Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.smith Liwen Zhou Cameron L.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation wallerian degeneration

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COMPLEXITY OF SYSTEM MAINTAINABILITY ANALYSIS BASED ON THE INTERPRETIVE STRUCTURAL MODELING METHODOLOGY： TRANSDISCIPLINARY APPROACH

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Journal of Systems Science and Systems Engineering 2016年第2期25卷 254-268页

作者： A. Ertas M.w. smith D. Tate w.D. Lawson T.B. Baturalp Department of Mechanical Engineering Texas Tech University Lubbock TX USA 79410 Department of Industrial Design Xi 'an Jiaotong-Liverpool University Suzhou 215123 Jiangsu China Department of Civil Engineering Texas Tech University Lubbock TX USA 79410

This paper outlines a diagnostic approach to quantify the maintainability of a Commercial off-the-Shelf （COTS）-based system by analyzing the complexity of the deployment of the system components. Interpretive Structural Modeling （ISM） is used to demonstrate how ISM supports in identifying and understanding interdependencies among COTS components and how they affect the complexity of the maintenance of the COTS Based System （CBS）. Through ISM analysis we have determined which components in the CBS contribute most significantly to the complexity of the system. with the ISM, architects, system integrators, and system maintainers can isolate the COTS products that cause the most complexity, and therefore cause the most effort to maintain, and take precautions to only change those products when necessary or during major maintenance efforts. The analysis also clearly shows the components that can be easily replaced or upgraded with very little impact on the rest of the system.

关键词： COTS Based System maintainability complexity Interpretive Structural Modeling

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： wenrui Qu Xiangbing wu wei wu Ying wang Yan Sun Lingxiao Deng Melissa walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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