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中华医学杂志 2004年第17期84卷 1426-1428页

作者：童茵金洁吴俊峰王云贵王蕾 Juergen Neppert brigitte Flesch 浙江大学医学院附属第一医院血液科杭州310003 浙江省血液中心浙江大学医学院附属第一医院血液病研究所杭州310003 德国基尔大学输血研究所

目的　调查中国浙江人群中FCGR3B的基因频率及基因变异。方法　聚合酶链反应序列特异性引物方法 (PCR SSP)检测FCGR3B基因型。DNA测序分析FCGR3基因变异。结果　来自浙江的 4 87名健康中国人中 ,FCGR3B 1与FCGR3B 2的基因频率分别是 0... 详细信息

目的　调查中国浙江人群中FCGR3B的基因频率及基因变异。方法　聚合酶链反应序列特异性引物方法 (PCR SSP)检测FCGR3B基因型。DNA测序分析FCGR3基因变异。结果　来自浙江的 4 87名健康中国人中 ,FCGR3B 1与FCGR3B 2的基因频率分别是 0 5 6 4及 0 4 2 9,而FCGR3B 3的基因频率为 0 0 0 0。FCGR3B基因缺失 (FCGR3Bnull)的频率为 0 6 2 % (3/487)。 19名中国人中的 7人存在FCGR3基因变异 ,表现为在第 3个外显子的多态性位点 14 1、14 7、2 2 7、2 6 6和2 77中发生 1个或多个单核苷酸改变。结论　在中国浙江人群中 ,FCGR3B 1基因频率高于FCGR3B 2 ,而FCGR3B 3可能缺失。单核苷酸改变所形成的新的基因变异在中国人群中也存在。

关键词：中国浙江 FCGR3B基因型 FCGR3基因变异多态性单核苷酸基因频率

Metabolic Properties of Fibers and Connective Tissue of Four Muscles from Bovine Carcasses

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Food and Nutrition Sciences 2015年第16期6卷 1522-1532页

作者： Marie-Pierre Ellies-Oury Rollande Dumont Didier Micol Yves Durand brigitte Picard Bordeaux Sciences Agro Gradignan Cedex France Institut National de la Recherche Agronomique St-Genès-Champanelle France Clermont Université VetAgro Sup UMR1213 Herbivores Clermont-Ferrand France AgroSup Dijon Dijon Cedex France Institut Charolais Centre Europe Atlantique Charolles France

Meat-grain-size (MGS) assessment is an empirical method for the early prediction of meat quality, a larger grain being synonymous with higher meat tenderness. The objective was to characterize 4 muscles (longissimus thoracis LT;rectus abdominis RA;longus colli LC;diaphragma D) of 5 coarse and 5 fine carcasses in terms of MGS in order to establish a link between muscular physicochemical properties and carcass MGS score. All comparisons were made of samples with similar fat content. The broiled sample hardness (shear force) was significantly higher for the coarse group than for the fine group (7.20 vs 5.89 kg;RA). Higher collagen content (27.94 vs 24.87 mg/g of dry matter in LT muscle;15.86 vs 13.13 mg/g of dry matter in D muscle), higher oxidative metabolism (cytochrome-c oxidase;LT and D) but also higher glycolytic metabolism (lactate dehydrogenase;LT) were also observed in the coarse groups. Not all the muscles react in a similar way depending on the MGS group. Nevertheless, significant results are constant from one muscle to another, the RA being the only muscle for which the difference in hardness between the two groups is significant.

关键词： Meat Grain Tenderness Muscles Collagen Bovine

Virological response and resistance mutations to NS3/4A inhibitors in hepatitis C virus-human immunodeficiency virus coinfection

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World Journal of Hepatology 2015年第18期7卷 2177-2183页

作者： Alissa Naqvi Valérie Giordanengo brigitte Dunais Francine de Salvador-Guillouet Isabelle Perbost Jacques Durant Pascal Pugliese Aline Joulié Pierre Marie Roger Eric Rosenthal Infectious Diseases Department Archet Hospital Centre Hospitalier Universitaire Virology Laboratory Archet Hospital Centre Hospitalier Universitaire Internal Medicine Department Archet Hospital Centre Hospitalier Universitaire

AIM: To evaluate virological response to telaprevir or boceprevir in combination with pegylated interferon and ribavirin and resistance mutations to NS3/4A inhibitors in hepatitis C virus-human immunodeficiency virus(HCV-HIV) coinfected patients in a real life setting. METHODS: Patients with HCV genotype 1-HIV coinfection followed in Nice University Hospital internal medicine and infectious diseases departments who initiated treatment including pegylated interferon and ribavirin(Peg IFN/RBV) + telaprevir or boceprevir, according to standard treatment protocols, between August 2011 and October 2013 entered this observational study. Patient data were extracted from an electronic database(Nadis®). Liver fibrosis was measured by elastometry(Fibroscan®) with the following cut-off values: F0-F1: < 7.1 k Pa, F2: 7.1-9.5 k Pa, F3: 9.5-14.5 k Pa, F4: ≥ 14.5 k Pa. The proportion of patients with sustained virological response(SVR) twelve weeks after completing treatment, frequency and type of adverse events, and NS3/4A protease inhibitor mutations were described. RESULTS: Forty-one patients were included: 13(31.7%) patients were HCV-treatment na?ve, 22(53.7%) had advanced liver fibrosis or cirrhosis(Fibroscan stage F3 and F4); none had decompensated cirrhosis or hepatocellular carcinoma; all were receiving antiretroviral treatment, consisting for most them(83%) in either a nucleoside reverse-transcriptase inhibitor/protease inhibitor or/integrase inhibitor combination; all patients had undetectable HIV-RNA. One patient was lost to follow-up. SVR was achieved by 52.5% of patients. Five patients experienced virological failure during treatment and four relapsed. Seven discontinued treatment due to adverse events. Main adverse events included severe anemia(88%) and rash(25%). NS3/4A protease mutations were analyzed at baseline and at the time of virological failure in the 9 patients experiencing non-response, breakthrough or relapse. No baseline resistance mutation cou

关键词： Telaprevir Boceprevir Hepatitis C virushuman immun

The Simultaneous Repression Of CCR and CAD, Two Enzymes of the Lignin Biosynthetic Pathway, Results in Sterility and Dwarfism in Arabidopsis thaliana

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Molecular Plant 2011年第1期4卷 70-82页

作者： Johanne Thevenin brigitte Pollet Bruno Letarnec Luc Saulnier Lionel Gissot Alessandra Maia-Grondard Catherine Lapierre Lise Jouanin Institut Jean Pierre Bourgin (IJPB) INRA-AgroParisTech UMR1318 78026 Versailles Cedex France Unite de Recherche 1268 Biopolymeres Assemblages Interactions (BIA) INRA BP71627 44316 Nantes Cedex 03 France Laboratoire Commun de Cytologie et d'lmagerie Vegetale IJPB INRA-AgroParisTech UMR1318 78026 Versailles France Plateau technique de Chimie du vegetal IJPB INRA-AgroParisTech UMR1318 78026 Versailles France

Cinnamoyl CoA reductase （CCR） and cinnamyl alcohol dehydrogenase （CAD） catalyze the last steps of mono- lignol biosynthesis. In Arabidopsis, one CCR gene （CCR1, Atlg15950） and two CAD genes （CAD C At3g19450 and CAD D At4g34230） are involved in this pathway. A triple cad c cad d ccrl mutant, named ccc, was obtained. This mutant displays a severe dwarf phenotype and male sterility. The lignin content in ccc mature stems is reduced to 50% of the wild-type level. In addition, stem lignin structure is severely affected, as shown by the dramatic enrichment in resistant inter-unit bonds and incorporation into the polymer of monolignol precursors such as coniferaldehyde, sinapaldehyde, and ferulic acid. Male sterility is due to the lack of lignification in the anther endothecium, which causes the failure of anther de- hiscence and of pollen release. The cc~ hypolignified stems accumulate higher amounts of flavonol glycosides, sinapoyl malate and feruloyl malate, which suggests a redirection of the phenolic pathway. Therefore, the absence of CAD and CCR, key enzymes of the monolignol pathway, has more severe consequences on the phenotype than the individual absence of each of them. Induction of another CCR （CCR2, Atlg80820） and another CAD （CAD1, At4g39330） does not compensate the absence of the main CCR and CAD activities. This lack of CCR and CAD activities not only impacts lignification, but also severely affects the development of the plants. These consequences must be carefully considered when trying to reduce the lignin content of plants in order to facilitate the lignocellulose-to-bioethanol conversion process.

关键词： Arabidopsis auxin Cinnamyl Alcohol Dehydrogenase (CAD) Cinnamoyl CoA Reductase (CCR) cell wall dwarfism lignins phenolics sterility.

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组织承诺影响因素的模拟实验研究

中国管理科学 2002年第6期10卷 97-100页

作者：刘小平王重鸣 brigitte Charle-Pauvers 中山大学管理学院广州510275 浙江大学管理学院杭州310028 法国南特大学企业管理学院

与传统问卷调查的研究方法不同 ,本研究采用情景模拟实验的方法来探讨影响组织承诺的各种因素 ,以及组织承诺对离职等各种结果变量的影响。本研究的结果和方法进一步加深了人们对组织承诺以及情景模拟实验的理解。

关键词：影响因素组织承诺组织支持情景模拟实验企业员工管理情感承诺

A Pilot Study on Health Care Utilization: Outpatient Aftercare for Geriatric Patients and Their Relatives

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International Journal of Clinical Medicine 2012年第2期3卷 92-97页

作者： Richard R. Gaugeler brigitte B. Jenull Ingrid I. Salem Department of Psychology Alps-Adria University Klagenfurt Austria Public Hospital Waiern Feldkirchen Austria

Increasing life expectancy correlating highly with polymorbidity, frequently causes recurring inpatient stays at Geriatric hospital wards. After discharge from hospital, an offer for physical and psychological after-care seems necessary for most patients. Purpose of this project was the development, implementation and primary assessment of an out-patient after-care intervention program for elderly, multimorbid patients and their relatives. During a period of eight months an interdisciplinary team offered psychological interventions as well as medical advice, nursing care and social casework. Primary goal was the investigation of health care utilization conduct and effectiveness of this after-care service in regard to sustainable stabilization of former inpatients. Preliminary results show higher demand of psychological and psychotherapeutic groups, whereas medical questions and nursing care problems were of minor concern to the patients. Contrary to our presumptions, even geriatric patients with a diagnosis of depression or anxiety disorder, showed to be reliable and constructive participants in psychological group settings. Situation and problems of (nursing) relatives could be identified accurately, although they represented an independent target group, possibly in need of more specific interventions.

关键词： Aftercare Interdisciplinarity Geriatric Patient

火星上的探测车——有maxon电动机的地方就有一条道路

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现代制造 2006年第26期 52-53页

作者： brigitte Michel maxon motor公司

maxon电动机公司的RE8直流电动机被选为2005年“最优产品”。但是该公司的一些其他的尖端的驱动装置甚至离开了地球。

关键词：直流电动机火星表面探测车道路驱动装置探测工作公司

Do intra-operative fluids influence the need for post-operative cardiotropic support after a PDA ligation？

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中国当代儿科杂志 2011年第1期13卷 1-7页

作者： brigitte LEMYRE 刘玲 Gregory Paul MOORE Sarah Linda LAWRENCE Nicholas J.BARROWMAN Department of Pediatrics University of Ottawa Department of Neonatology Children's Hospital of Guiyang

Objective To investigate the effect of intra-operative intravenous fluids on post-operative hemodynamic *** We performed a retrospective cohort study of 98 preterm infants who underwent a patent ductus arteriosus(PDA) ligation in one NICU between 2001 and *** primary outcome was the need for cardiotropic support within 24 hrs of *** Twenty-seven infants(28%) required post-operative cardiotropic *** amount of intra-operative fluids varied between 0 and 50.4 mL/kg(median:10.2 mL/kg).No intra-operative fluid was recorded in 26 *** were not associated with the need for post-operative cardiotropic support(P=0.10).Using a multivariate logistic regression model,age at ligation,weight at ligation and pre-operative FiO2 were significant predictors of post-operative cardiotropic *** Intra-operative fluids do not appear to be associated with the need for post-operative cardiotropic support.A prospective cohort study may help identify modifiable risk factors and improve outcomes in this population.

关键词：《中国当代儿科杂志》期刊摘要编辑部 PDA