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Which Are the Factors Associated to Child Mistreatment? Use of a Routinely Collected Specific Dataset for Surveillance in a Belgian Pediatric Unit

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Health 2014年第12期6卷 1396-1407页

作者： Christelle Senterre brigitte Vanthournout Research Centre of Epidemiology Biostatistics and Clinical Research School of Public Health Université Libre de Bruxelles Brussels Belgium SOS enfants ULB CHU Saint Pierre Hospital Brussels Belgium

Introduction: Child abuse is a serious health problem with compelling evidence that the phenomenon is common throughout the world. The Center “SOS enfants ULB” is a specialized team, established in a pediatric ward, which had mission to prevent and to treat the situations of children victims of physical, sexual, psychological abuse or of neglect. Our objectives were to describe the characteristics of 439 children hospitalized for (suspicion of) maltreatment and to investigate different factors potentially associated with the children at risk of neglect or maltreatment, the children victims of neglect and the physically maltreated children. Methods: Chi square test and multinomial logistic regression models with clustered robust standard error were applied to assess the relationship between the three types of mistreatment and the potential associated factors. Results: Maltreatment was observed for almost one in two children (48.7%) and approximately four on ten (41.5%) were considered at risk. Physical abuse was the most prevalent (57.9%) among the maltreated children and neglect was the second most prevalent (37.4%) form of maltreatment. Regarding the criteria leading to hospitalisation, at least one protective criterion was observed for a little more than eight children on ten. The parental criteria have shown that social problems and conjugal conflicts were the most prevalent for this category of hospitalisation criteria. Conclusion: These data, concerning the hospitalized children for which there is (suspicion of) mistreatment, collected by this team make important contribution to describing child maltreatment and its associated factors. Despite the fact that these hospitalized cases may be probably more serious than those who were not reported, every event, however small it may be, should be known for better organizing each level of prevention.

关键词： Child Maltreatment Physical Abuse Neglect Epidemiology Surveillance

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The antiangiogenic phloroglucinol hyperforin inhibits the secretion of proMMP-2, proMMP-9 and VEGF-A during apoptosis of primary acute myeloid leukemia cells

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 588-603页

作者： Faten Merhi Ruoping Tang Ollivier Legrand Florence Nguyen-Khac Santos A.Susin brigitte Bauvois Centre de Recherche des Cordeliers INSERMSorbonne UniversitéUSPCUniversitéParis DescartesUniversitéParis DiderotParis F-75006France Department of Life&Earth Sciences Faculty of Sciences(I)Lebanese UniversityBeirutLebanon Assistance Publique-Hôpitaux de Paris Groupe Hospitalier Saint-AntoineService d’Hématologie CliniqueParis F-75012France Service Génétique des Tumeurs Département de Biologie et de Pathologie MédicaleGustave Roussy Cancer CamusVillejuif F-94805France Assistance Publique-Hôpitaux de Paris Groupe Hospitalier Pitié-SalpêtrièreService d’Hématologie BiologiqueParis F-75013France.

Aim:Angiogenesis is observed in acute myeloid leukemia(AML).AML cells abnormally proliferate and are resistant to *** regulators of angiogenesis,VEGF-A and matrix metalloproteinases(MMPs)2 and 9 are markers of disease status in *** natural phloroglucinol hyperforin(HF)displays antitumoral properties of potential pharmacological ***,we investigated the effects of HF on MMP-2/9 and VEGF-A expression and survival of primary AML ***:Blood and bone marrow samples were collected in 45 patients with distinct subtypes defined by French American British classification,i.e.,M0,M1,M2,M3,M4,and *** of MMPs and VEGF-A in leukemic blood cells and culture supernatants were determined by RT-PCR,ELISA,and gelatin zymography(MMPs).The balance between cell death and survival was assessed by flow cytometry with analysis of phosphatidylserine externalization and caspase-3 ***:The administration of HF promoted a caspase-associated apoptosis in primary AML blasts(from blood and bone marrow),but not normal blood cells and *** addition,HF inhibited the levels of secreted proMMP-2,proMMP-9,and VEGF-A without altering *** induction of apoptosis by HF significantly paralleled the inhibition of MMP-2/9 and VEGF-A release by *** differences were seen in response to the deleterious effects of HF between AML cells of distinct ***:Our results suggest that HF,through its proapoptotic and potential antiangiogenic properties(by inhibiting MMP-2/9 and VEGF-A)on primary AML cells,might be a useful experimental agent,in combination with existing drugs,for new therapeutic approaches in the treatment of this incurable disease.

关键词： Acute myeloid leukemia apoptosis hyperforin matrix metalloproteinase VEGF secretion

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高度吸气,高度均匀分配细小气泡和高效率 SelectaFlot^(TM)脱墨浮选系统

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中华纸业 2004年第2期25卷 24-27页

作者： brigitte Poms

工厂要求的不断提高需要新一代的浮选槽。Andritz公司把理想的浮选条件集成到一个紧凑的、可选择的、高效的浮选脱墨系统。该浮选系统的优化体现在下列方面:多级气泡发生元件产生良好的吸气效果,无论是吸气量还是气泡尺寸;独立浆流,精... 详细信息

工厂要求的不断提高需要新一代的浮选槽。Andritz公司把理想的浮选条件集成到一个紧凑的、可选择的、高效的浮选脱墨系统。该浮选系统的优化体现在下列方面:多级气泡发生元件产生良好的吸气效果,无论是吸气量还是气泡尺寸;独立浆流,精确设计的浮选槽体保证了高效浮选要求的水力特性;运行性和经济性。SelectaFlotTM浮选槽充分考虑了用户的各种需要。

关键词：浮选脱墨系统 SelectaFlot^TM浮选槽造纸制浆设备设备配置技术经济分析工艺设计

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EGFR and HER2 expression in advanced biliary tract cancer

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World Journal of Gastroenterology 2009年第36期15卷 4511-4517页

作者： Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz Department of MedicineⅡ University Medical CenterD-79106 Freiburg Germany Tumorzentrum Ludwig Heilmeyer- Comprehensive Cancer Center Freiburg D-79106 Freiburg Germany Tumorzentrum ZeTuP St.GallenSwitzerland and Department of MedicineⅠUniversity Medical Center D-79106 FreiburgGermany Department of Medicine Gastroenterology and OncologyMunicipal Hospital EsslingenGermany Department of Medical Biometry und Statistics University of FreiburgD-79106 FreiburgGermany Annette Schmitt-Graeff Institute of PathologyUniversity Medical CenterD-79106 Freiburg Germany

AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and *** micrometers sections of paraffin embedded tissue were examined by standard, FDA approved *** with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar *** expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), ***2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising.

关键词： Cholangiocarcinoma Gallbladder cancer Chemotherapy Targeted therapy

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Towards Sustainable Land Uses within the Elbe River Biosphere Reserve in Lower Saxony, Germany by Means of TerraSAR-X Images

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Journal of Geoscience and Environment Protection 2016年第3期4卷 97-121页

作者： Dalia Farghaly Emad Elba brigitte Urban Faculty of Sustainability Sciences Institute of Ecology Subject Area Landscape Change LEUPHANA University of Lüneburg Lüneburg Germany

Floods are one of the major hazards worldwide. They are the source of huge risks in rural and urban areas, resulting in severe impacts on the civil society, industry and the economy. The Elbe River has suffered from many severe floods during recent decades. In this study, the zones flooded during 2011 were analyzed using TerraSAR-X images and a digital elevation model for the area in order to identify possible ways to mitigate flood hazards in the future, regarding sustainable land-use. Two study areas are investigated, around the Walmsburg oxbow and the Wehningen oxbow. These are located between Elbe-Kilometer (505-520) and (533-543), respectively, within the Lower Saxonian Elbe River Biosphere Reserve. Those areas are characterized by several types of land use, with agricultural land use being predominant. The study investigated the possibility of using a Decision-Tree object-based classifier for determining the major land uses and the extent of the inundation areas. The inundation areas identify for 2011 submerged some agricultural fields that must be added to existing flood risk maps, and future cultivation activities there prevented to avoid the possible economic losses. Furthermore, part of the residential area is located within the high flood zone, and must be included in risk maps to avoid the possible human and economic losses, to achieve sustainable land use for the areas studied.

关键词： Elbe River Floods Land Use SAR TerraSAR-X Decision-Tree Object-Based Classification Risk Maps

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肌松剂在早产儿非急诊气管插管前的应用

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实用儿科临床杂志 2009年第24期24卷 1910-1912页

作者：程锐 brigitte Lemyre 南京医科大学附属南京市儿童医院新生儿科南京210008 渥太华大学附属总医院NICU

目的探讨肌松剂-司可林在早产儿(0.05)。结论阿托品、芬太尼、司可林联合用药,安全可靠,能提高一次插管成功率,避免反复插管引起的声门损伤,有利于年轻医师快速掌握气管插管术。

关键词：非急诊气管插管插管前用药婴儿,早产

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T(11;18)(q21;q21)-positive gastrointestinal MALT lymphomas are heterogeneous with respect to the V_H gene mutation status

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World Journal of Gastrointestinal Oncology 2011年第2期3卷 24-32页

作者： Xavier Sagaert Vera Vanhentenrijk Gert De Hertogh Karel Geboes Thomas Tousseyn brigitte Maes Mathijs Baens Eric Van Cutsem Department of Morphology and Molecular Pathology University Hospitals Leuven Department of Morphology and Molecular Pathology University Hospitals Leuven Department of Laboratory Medicine Jessa Hospital Department for Molecular and Developmental Genetics Flanders Institute for Biotechnology (VIB) Department of Human Genetics Catholic University of Leuven Department of Digestive Oncology University Hospitals Leuven

AIM: To investigate how t(11;18)(q21;q21)-positive gastrointestinal MALT lymphomas relate to other marginal zone lymphomas with respect to the somatic mutation pattern of the VH genes and the expression of the marker CD27. METHODS: The VH gene of 7 t(11;18)(q21;q21)-positive gastrointestinal MALT lymphomas was amplif iedby PCR using family specif ic VH primers and a consensus JH primer. PCR products were sequenced and mutation analysis of the CDR and the FR regions was performed. All cases were immunostained for CD27. RESULTS: One case showed unmutated VH genes while the others showed mutated VH genes with mutation frequencies ranging from 1.3 to 14.7% and with evidence of antigen selection in 2 cases. These data suggest that the translocation t(11;18)(q21;q21) can target either B-cells at different stages of differentiation or naive B-cells that retain the capacity to differentiate upon antigen stimulation. All cases but one displayed weak to strong CD27 expression which did not correlate with the VH gene mutation status. CONCLUSION: t(11;18)(q21;q21)-positive gastro- intestinal MALT lymphomas are heterogeneous with respect to the VH mutation status and CD27 is not a marker of somatically mutated B-cells.

关键词： Gastrointestinal MALT lymphoma t(11 18) (q21 q21) VH mutation Marginal zone CD27

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Modeling High Aswan Dam Reservoir Morphology Using Remote Sensing to Reduce Evaporation

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International Journal of Geosciences 2014年第2期5卷 156-169页

作者： Emad Elba Dalia Farghaly brigitte Urban Faculty of Sustainability Sciences Institute of Ecology Division of Landscape Change Leuphana University of Lüneburg Lüneburg Germany

Egypt is considered as an extremely arid country with annual rainfall under 200 mm within coastal zones. High Aswan Dam Reservoir (HADR) experiences high evaporation losses of 15 BCM/year on average. Meanwhile, the water demand is increasing due to rapid population growth. Hence, measurements must be taken to decrease its evaporation losses. This can be achieved through controlling evaporation losses from the shallow lagoons, locally known as khors. The first step in the control process is to model the lake morphology using topographic data. Topographic maps are available for the time span before the construction of the High Aswan DAM (HAD), but they have not been updated. Hence, this study utilized satellite imagery since 1984 to develop a digital elevation model (DEM) that simulated the lake surface area. Correlated water levels were gained from the assembled hydrological database of HADR. This paper reports on the different alternatives for reducing the evaporation losses of two large khors, Kalabsha and El-Alaky, and two small khors, Korosko and Sara. It shows that the developed DEM allows estimation of the different hydrological features of HADR and its khors and recommends some measures to eliminate these khors to save up to 3 BCM by 2100 according to global climate model scenarios.

关键词： El-Alaky Evaporation Losses Kalabsha Korosko Lake Nasser Morphology Remote Sensing GIS

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Observing the Middle Elbe Biosphere in Germany by Means of TerraSAR-X Images

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International Journal of Geosciences 2014年第2期5卷 196-205页

作者： Dalia Farghaly Emad Elba brigitte Urban Faculty of Sustainability Sciences Institute of Ecology Division of Landscape Change Leuphana University of Lüneburg Lüneburg Germany

The Lower Saxonian Elbe Valley Biosphere Reserve is part of the UNESCO Biosphere Reserve “Elbe River Landscape”, and used mainly for agriculture. One of tasks of the Biosphere Reserve Administration is to develop sustainable forms of land use which requires comprehensive updated land cover maps. Land use maps are hard to produce because of surveying costs and time. Nevertheless, these large areas need to be monitored. TerraSAR-X images are used to establish agricultural land use maps. In this study, two areas are selected within the Elbe Biosphere Reserve situated around the oxbows Wehninger Werder and Walmsburger Werder. Multi temporal classification methods were used to identify the different crops using maximum likelihood classifier for the years 2010 and 2011. The crop classifications were used to evaluate the effect of the number of images, the necessity of polarizations, and the consequences of some missing images within the crop calendar. These classifications were analyzed to estimate producer accuracy and Kappa index for each crop besides the overall accuracy for each agricultural land use map. The study shows that using dual polarization imagery enhances producer accuracies for many crops over the single polarization imagery, and demonstrates the importance of using frequent images during the cultivation period.

关键词： Agricultural Land Use Elbe River Multi Temporal Classification TerraSAR-X UNESCO Biosphere Reserves

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What will I be like at eighty? How human values contribute to expected real and ideal self-images in old age in a Germanic/Austrian cultural context

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Advances in Aging Research 2014年第1期3卷 35-42页

作者： Walter Renner brigitte Jenull Irene Strasser Department of Psychology Alpen-Adria-Universitat KlagenfurtKlagenfurtAustria

According to Grawe’s Consistency Theory, congruence between an individual’s aims and reality is fundamental for psychological health. We examined the real and ideal self-images of N = 440 participants in a Germanic/Austrian cultural context as perceived in presence and as anticipated for an age of 80 years and examined their relationship to value orientations as a coping resource. From adjective ratings on the Semantic Differential for the real self-image at presence, two dimensions were extracted, one representing Warmth (W) and one representing Competence (C) in the sense of the Stereotype Content Model. Cluster analysis yielded one type of respondents with a cautiously optimistic, and one with a moderately pessimistic view of the present and the future. A third cluster devalued W and C in favor of Religiosity and Conservatism and had the highest degree of congruence between real and ideal self-images. Thus, hypotheses with regard to Religiosity and Conservatism as coping resources were confirmed.

关键词： Old Age Real vs Ideal Self-Image Stereotype Content Model Human Values Consistency Theory

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