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Immunomodulatory activity of polycaprolactone nanoparticles with calcium phosphate salts against Leishmania infantum infection

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 359-368页

作者： Kübra Kelleci Adil Allahverdiyev Melahat Bağırova Murat Ihlamur EmrahŞefik Abamor Department of Bioengineering Yildiz Technical UniversityIstanbulTurkey V.Akhundov National Scientific Research Medical Prophylactic Institute BakuAzerbaijan Department of Electronics and Automation Biruni UniversityIstanbulTurkey

Objective:To prepare and characterize polycaprolactone(PCL)nanoparticles loaded with sonicator fragmented(SLA)and freeze-thaw Leishmania antigens(FTLA)and to investigate the in vitro immunogenicity of antigen-encapsulated nanoparticles with calcium phosphate ***:The water/oil/water binary emulsion solvent evaporation method was used to synthesize antigen-loaded PCL *** were characterized by scanning electron microscopy and zeta potential *** cytotoxicity in J774 macrophages in vitro was determined by MTT *** addition,the amount of nitric oxide and the level of cytokines produced by macrophages were determined by Griess reaction and ELISA method,*** protective effect of the developed formulations was evaluated by determining the infection index percentage in macrophages infected with Leishmania ***:Compared to the control group,SLA PCL and FTLA PCL nanoparticles with calcium phosphate adjuvant induced a 6-and 7-fold increase in nitric oxide,***,the vaccine formulations promoted the production of IFN-γand *** PCL and FTLA PCL nanoparticles combined with calcium phosphate adjuvant caused an approximately 13-and 11-fold reduction in infection index,respectively,compared to the control ***:The encapsulation of antigens obtained by both sonication and freeze-thawing into PCL nanoparticles and the formulations with calcium phosphate adjuvant show strong in vitro immune stimulating ***,PCL-based antigen delivery systems and calcium phosphate adjuvant are recommended as a potential vaccine candidate against leishmaniasis.

关键词： Leishmaniasis Calcium phosphate Polycaprolactone Nanoparticle Antigen delivery system Adjuvant Vaccine design

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Prevalence and Factors Associated with Dry Eyes Syndrome in Glaucomatous Patients on Anti-Glaucoma Eye Drops Followed up at the Garoua Regional Hospital-Northern Cameroon

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Open Journal of Ophthalmology 2024年第3期14卷 350-360页

作者： Josiane mare Njoya Dodo Balkissou Bimingo Noelle bra’ Eyatcha Viola Dohvoma Yannick Bilong Godefroy Koki Faculty of Medicine and Biomedical Sciences University of Garoua Garoua Cameroon Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon

Background: Dry eye and glaucoma are two common pathologies in the elderly, and are very often associated. This association suggests a link between them and between their treatments. Our purpose for this study is to determine the prevalence of dry eye in our glaucoma patients treated with eye drops and deduce the factors associated with it. Patients and Methods: We conducted a cross-sectional, analytical study from October 2022 to September 2023 in the ophthalmology department of Garoua Regional Hospital in glaucoma patients aged over 15 years able to answer the Ocular Surface Disease Index (OSDI) questionnaires and treated with antiglaucoma eye drops for more than 3 months. These patients underwent a complete ophthalmological examination and a tear film break-up time test. Results: A total of 73 patients (146 eyes) were examined. The average age of the patients was 47.2 ± 16.5 years, with a male predominance of 54.8%. The prevalence of dry eye syndrome in our patients according to the OSDI score was 56.2% (95% CI) (44.8;67.6). The prevalence of dry eye syndrome on clinical examination of the BUT in the right eye was 83.7% (95% CI) (75.1;92.1) and 79.4% (70.2;88.7) in the left eye. The duration of antiglaucoma treatment was the factor associated with dry eye syndrome (p ma patients in our setting. Conclusion: Dry Eye Syndrome is common in glaucoma patients on drops in our setting. Treatment duration of more than 1 year seems to be associated with dry eyes.

关键词： Dry Eyes Glaucoma Conservative Eye Drops Médications Garoua-Cameroon

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Surgical Site Infections in Trauma and Orthopaedics at Bouaké Teaching Hospital (Côte d’Ivoire)

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Open Journal of Orthopedics 2024年第9期14卷 381-390页

作者： Loukou Blaise Yao Koffi Léopold Krah Aya Adelaïde Natacha Kouassi Kouamé Innocent M’bra Kouamé Jean-Eric Kouassi Michel Kodo Department of Trauma and Orthopaedics Bouak Teaching Hospital Bouak Cte dIvoire

Background: Surgical site infections are serious healthcare problems. The aim was to describe the epidemiological, diagnostic, therapeutic, and prognostic aspects of surgical site infections in Trauma and Orthopaedics at Bouaké Teaching Hospital. Method: This retrospective, descriptive, and analytical study was conducted from January 2019 to December 31, 2021. The data studied included prevalence, initial lesions, type of surgical intervention, type of SSI, bacteria involved, treatment, and outcomes. Results: Forty-four (11%) of the 399 patients included in the study developed a surgical site infection. The mean age was 27 years, with 36 male and 8 female. Initial lesions were predominantly open fractures (n = 31;70%), with a mean delay of 48 hours for surgical management. Emergency interventions accounted for 70% (n = 31) of cases. The NNISS infection risk score was 1 in 80% (n = 35) of cases. Superficial infections (n = 34;77%) appeared early, on a mean 6 days postoperatively. Bacteriological analysis primarily identified Pseudomonas aeruginosa (n = 10;23%), sensitive to Imipenem and Chloramphenicol but resistant to Amoxicillin-clavulanic acid, Ceftriaxone, Gentamicin, and Ciprofloxacin. Multidrug-resistant bacteria were found in 89% (n = 8) of cases, with all bacteria resistant to Ceftriaxone. Surgical revision was performed in 10 patients (23%), primarily involving debridement with hardware retention (n = 7;70%). Chloramphenicol was the most commonly used antibiotic post-antibiogram (61%). Outcomes were favourable in 98% of cases. Identified risk factors included the type of lesion according to NRC classification, the delay in managing open fractures, and the NNISS score. Conclusion: The prevalence of surgical site infection was 11%, favoured by the delayed operation of open fractures.

关键词： Surgical Site Infection Open Fractures Pseudomonas aeruginosa Ceftriaxone

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Deep tissue near-infrared imaging for vascular network analysis

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Journal of Innovative Optical Health Sciences 2017年第3期10卷 12-23页

作者： Kübra Seker Mehmet Engin Department of Electrical&Electronics Engineering Faculty of Engineering Ege University Bornova IzmirTurkey35100

Subcutaneous vein network plays important roles to maintain microcirculation that is related to some diagnostic *** developments of optical imaging technologies,still the difficulties about deep skin vascular imaging have been *** the other hand,since hemoglobin con-centration of human blood has key role in the veins imaging by optical manner,the used wavelength in vascular imaging,must be chosen considering absorption of *** this research,we constructed a near infrared(NIR)light source because of lower absorption of hemoglobin in this optical *** obtain vascular image,reflectance geometry was ***,from recorded images,vascular network analysis,such as calculation of width of vascular of interest and complexity of selected region were *** comparing with other modalities,we observed that proposed imaging system has great advantages including nonionized radiation,moderate penetration depth of 0.5-3 mm and diameter of 1 mm,cost-effective and algorit hmic simplicity for analysis.

关键词： Vascular NIR imaging manufacturing liquid and solid phantoms difuse optical imaging image processing and analysis optical imaging system design.

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The movement dynamics of autotomized lizards and their tails reveal functional costs of caudal autotomy

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Integrative Zoology 2020年第6期15卷 511-521页

作者： Irene FERNÁNDEZ-RODRÍGUEZ Florentino braÑA Department of Organisms and Systems Biology(Zoology) University of OviedoOviedoSpain Research Unit of Biodiversity(UMIB UO/CSIC/PA)University of OviedoMieresSpain

Autotomy has evolved independently several times in different animal *** frequently involves immediate functional costs,so regeneration evolved in many instances to restore the functionality of that body *** autotomy is a widespread antipredator strategy in lizards,although it may affect energy storage,locomotion dynamics,or survival in future encounters with ***,we assessed the effect of tail loss on the locomotor performance of wall lizards(Podarcis muralis),as well as the recovery of locomotor functionality of lizards with regenerated tails,and the movement dynamics of shed tails that were either intact or having regenerated *** loss had no effect on locomotion over unhindered spaces,possibly due to compensation between a negative effect on the stride of front limbs,and a positive effect of losing mass and friction *** found a clear negative impact of tail loss on locomotion in spaces with interspersed obstacles,in which tailed lizards jumped larger distances when leaving the ***,lizards that used the tail to push off the ground were able to approach the obstacles from further,so that the tail seemed to be useful when used during *** fully restores lizard’s locomotor capacities,but tail antipredator value,as indicated by the intensity of post-autotomic movements,is only partially *** these results,we propose that,together with the recovery of post-autotomy antipredator capacities,the restoration of the organismal locomotor performance may have been an important,yet frequently neglected factor in the evolution of lizard’s regeneration ability.

关键词： autotomy locomotor performance regeneration tail wall lizard

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Comparison of clinical outcomes of deep anterior lamellar keratoplasty and excimer laser assisted anterior lamellar keratoplasty in keratoconus

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International Journal of Ophthalmology(English edition) 2019年第4期12卷 582-586页

作者： Kübra Serbest Ceylanoglu Bahri Aydin Mehmet Cuneyt Ozmen Department of Ophthalmology Sincan State Hospital Department of Ophthalmology Gazi University Medical School

AIM: To compare and evaluate the clinical outcomes of deep anterior lamellar keratoplasty(DALK) and excimer laser assisted anterior lamellar keratoplasty(ELLK) in eyes with ***: In this study, 57 eyes of 56 patients operated between 2013 to 2017 were included. Thirty-one eyes underwent big-bubble DALK and twenty-six eyes underwent ELLK. Preoperative and at control visits complete ophthalmic examination was performed. RESULTS: The mean patient age at the time of DALK surgery was 27 y and mean follow-up period was 21±5.4 mo. The mean patient age at the time of ELLK surgery was 27 y and mean follow-up period was 40±18 mo. Mean best spectacle corrected visual acuity(BSCVA) at postoperative period was significantly higher for DALK group(0.66±0.11) versus ELLK group(0.4±0.2)(Pbrane microperforation was occurred in 7 patients in DALK group versus in 1 patient in ELLK group. In 4 eyes, interface irregularity was developed in ELLK group. None of the patients in follow-up had graft rejection in both ***: In ELLK group, complication rate is lower, the surgical technique is simpler, faster and safer and also ELLK requires less experience with respect to DALK. Further, DALK can be performed unless satisfactory visual acuity is achieved after ELLK.

关键词： excimer laser assisted lamellar keratoplasty deep anterior lamellar keratoplasty big-bubble technique

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Honey Dressing of Cutaneous Wounds on Limbs in the Traumatology Orthopaedics Department of Bouaké University Hospital

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Open Journal of Orthopedics 2024年第9期14卷 411-420页

作者： Achié Jean-Régis Akobe Aya Adélaide Natacha Kouassi Ibrahim Soumahoro Zolopégué marcel Soro Sedy Louess De Randolphe Akpro Bakary Traoré Almamy Kamate Axel Fabrice Essehin Yao Aboh Ganyn Robert Arnaud Assere Lanciné Kaba Kouamé Innocent M’bra Loukou Blaise Yao Bada Justin Léopold Niaoré Sery Koffi Léopold Krah Michel Kodo Orthopaedics-Traumatology Department of the University Hospital of Bouak Bouak Ivory Coast Plastic and Reconstructive Surgery Department of the University Hospital of Bouak Bouak Ivory Coast

The study evaluated the effectiveness of honey dressings in healing recent skin wounds with soft tissue loss on limbs. Conducted over a year with 60 patients, results showed a significant reduction in wound size and early healing, with complete recovery on average within 29 days. The study supports honey as a viable wound treatment.

关键词： Healing Honey Limbs Loss of Substances

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周期驱动谐振子的一种非厄米哈密顿和经典-量子对应

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中国科学：物理学、力学、天文学 2024年第6期54卷 151-158页

作者：辛俊丽马紫微黄丽运城学院物理与电子工程系运城044000 山西省光电信息科学与技术实验室运城044000

本文构造一非幺正厄米变换算符和广义规范变换,定义了非厄米哈密顿算符双正交基矢的度规算符,证明了周期驱动谐振子的一种非厄米哈密顿是赝厄米哈密顿算符;从双含时薛定谔方程出发将其厄米化,从而得到其解析量子波函数;基于经典正则变换... 详细信息

本文构造一非幺正厄米变换算符和广义规范变换,定义了非厄米哈密顿算符双正交基矢的度规算符,证明了周期驱动谐振子的一种非厄米哈密顿是赝厄米哈密顿算符;从双含时薛定谔方程出发将其厄米化,从而得到其解析量子波函数;基于经典正则变换,得到非厄米哈密顿的经典对应;将系统演化一个周期,得到量子LR相和经典角变化率,以及它们之间的对应关系.本文通过对周期驱动谐振子非厄米哈密顿的分析,得出结论:哈密顿算符的厄米性是其有实数本征值的充分,但非必要条件,非厄米哈密顿算符都可以通过构造一非幺正的厄米变换算符和广义规范变换得到其厄米对应,此结论为研究非厄米系统提供了一种新思路.

关键词：非厄米哈密顿广义规范变换经典-量子对应

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Osteoarticular Lesions of the Shoulder Girdle by Hippopotamus Bite: Highly Septic Lesion

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Open Journal of Orthopedics 2024年第2期14卷 114-121页

作者： Jr Pierre Germain Ochou Achié Jean Régis Akobe Yao Aboh Ganyn Robert Arnaud Assere Kouamé Jean-Eric Kouassi Adelaïde Aya Natacha Kouassi Ibrahim Soumahoro Zolopégué marcel Soro Sédi Loues De Randolphe Akpro Gbalé Yannick Blé Kouamé Innocent M’bra Loukou Blaise Yao Bada Juste Léopold NiaoréSery Koffi Léopold Krah Michel Kodo Department of Orthopaedic and Traumatological Surgery Bouaké University Hospital Bouaké Ivory Coast Raoul Follereau Institute Manikro Centre Bouaké Ivory Coast

Hippopotamus bites are rare in medical consultations, despite several studies exposing their aggressive character. A case of a hippopotamus bite on the shoulder of a fisherman has been reported. In addition to the osteoarticular aspect representing a therapeutic problem, the infectious aspect was marked by sepsis, with a death in less than 48 hours. Based on this observation, a protocol for the initial management of large animal bites was submitted.

关键词： Bite Hippopotamus Septic Shock

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Waste Tire Rubber-based Refrigerants for Solid-state Cooling Devices

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Chinese Journal of Polymer Science 2020年第7期38卷 769-775,I0007页

作者： Nicolau Molina Born Erik Oda Usuda mariana da Silva Gigliotti Denílson Josémarcolino de Aguiar William Imamura Lucas Soares Paixao Alexandre magnus Gomes Carvalho Catalan Institute of Nanoscience and Nanotechnology(ICN2) 08860BellaterraBarcelonaSpain The Institute of Photonic Sciences(ICFO) 08193CastelldefelsBarcelonaSpain Universidade Federal de Sāo Paulo(UNIFESP) 00972-270DiademaSPBrazil Instituto de Física"Gleb Wataghin" Universidade Estadual de Campinas(UNICAMP)13083-970CampinasSPBrazil Universidade Tecnológica Federal do Paraná(UTFPR) 84017-220Ponta GrossaPRBrazil Faculdade de Engenharia Mec(a)nica Universidade Estadual de Campinas(UNICAMP)13083-860CampinasSPBrazil Departamento de Engenharia Mec(a)nica Universidade Estadual de Maringá(UEM)870-900MaringáPRBrazil

management of discarded tires is a compelling environmental issue *** there are several approaches developed to recycle waste tire rubbers,their application in solid-state cooling is still *** the high barocaloric potential verified for elastomers,the use of waste tire rubber(WTR)as a refrigerant in solid-state cooling devices is very ***,we investigated the barocaloric effects in WTR and polymer blends made of vulcanized natural rubber(VNR)and WTR,to evaluate its feasibility for solid-state cooling *** adiabatic temperature changes and the isothermal entropy changes reach giant values,as well as the performance parameters,being comparable or even better than most barocaloric materials in ***,pure WTR and WTR-based samples also present a faster thermal exchange than VNR,consisting of an additional advantage of using these discarded ***,the present findings evidence the encouraging perspectives of employing waste rubbers in solid-state cooling based on barocaloric effects,contributing to both the recycling of polymers and the sustainable energy technology field.

关键词： Waste tire rubber Solid-state cooling Barocaloric effect Tire recycling Sustainable energy

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