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A nove. e.pre.se. prostatic se.re.ion(e.S)-urine.me.abolomic signature.for the.diagnosis of clinically significant prostate.cance.

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Cance. Biology & Me.icine 2021年第2期18卷 604-615页

作者： De.ise.Drago Annapaola Andolfo e.tore.Mosca Ale.sandro Orro Luigi Noce.a Vito Cucchiara Matte.Be.lone.France.co Montorsi Albe.to briganti ProMe.a Proteomics and Metabolomics FacilityCenter for Omics Sciences(COSR)IRCCS San Raffaele Scientific InstituteMilan 20132Italy Institute.of Biome.ical Te.hnologie. National Research Council(CNR)Milan 20090Italy De.artme.t of Urology and Division of e.pe.ime.tal Oncology Urological Research Institute(URI)IRCCS San Raffaele Scientific InstituteMilan 20132Italy Division of Immunology Transplantation and Infectious DiseasesIRCCS San Raffaele Scientific InstituteMilan 20132Italy

Obje.tive.Significant e.forts are.curre.tly be.ng made.to ide.tify nove. biomarke.s for the.diagnosis and risk stratification of prostate.cance.(PCa).Me.abolomics can be.a ve.y use.ul approach in biomarke. discove.y be.ause.me.abolite. are.an important re.d-out of the.dise.se.whe. characte.ize. in biological *** aime. to de.e.mine.a me.abolomic signature.which can accurate.y distinguish me. with clinically significant PCa from those.affe.te. by be.ign prostatic hype.plasia(BPH).Me.hods:We.first pe.forme. untarge.e. me.abolomics using ultrahigh-pe.formance.liquid chromatography tande. mass spe.trome.ry on e.pre.se. prostatic se.re.ion urine.e.S-urine.from 25 patie.ts affe.te. by BPH and 25 me. with clinically significant PCa(de.ine. as Gle.son score.3+4).Diagnosis was histologically confirme. afte. surgical *** e.S-urine.me.abolomic approach was the. applie. to a large.,prospe.tive.cohort of 92 conse.utive.patie.ts unde.going multiparame.ric magne.ic re.onance.imaging for clinical suspicion of PCa prior to ***:We.e.tablishe. a nove. me.abolomic signature.capable.of accurate.y distinguishing PCa from be.ign tissue.A me.abolomic signature.was associate. with clinically significant PCa in all subgroups of the.Prostate.Imaging Re.orting and Data Syste.(PI-RADS)classification(100%and 89.13%of accuracy whe. the.PI-RADS was in range.of 1–2 and 4–5,re.pe.tive.y,and 87.50%in the.more.critical case. whe. the.PI-RADS was 3).Conclusions:A combination of me.abolite. and clinical variable. can e.fe.tive.y he.p in ide.tifying PCa patie.ts that might be.ove.looke. by curre.t imaging *** from e.S-urine.should he.p in de.ining the.diagnostic pathway of PCa,thus improving PCa de.e.tion and de.re.sing the.numbe. of unne.e.sary prostate.biopsie..

关键词： Prostate cance. e.S-urine me.abolomics pre.iction diagnosis

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Primary lymphomas of the.ge.itourinary tract:A population-base. study

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Asian Journal of Urology 2020年第4期7卷 332-339页

作者： Carlotta Palumbo e.io Mazzone.France.co A.Mistre.ta Sophie.Knippe. Zhe.Tian Paul Pe.rotte.France.co Montorsi Shahrokh F.Shariat Fre. Saad Claudio Sime.ne.Albe.to briganti Ale.sandro Antone.li Pie.re.I.Karakie.icz Cance. Prognostics and He.lth Outcome. Unit University of Montreal Health CenterMontrealQuebecCanada Urology Unit ASST Spedali Civili of BresciaDepartment of Medical and Surgical SpecialtiesRadiological Science and Public HealthUniversity of BresciaBresciaItaly Division of e.pe.ime.tal Oncology Unit of UrologyUrological Research Institute(URI)IRCCS San Raffaele Scientific InstituteMilanItaly Vita-Salute.San Raffae.e.Unive.sity MilanItaly De.artme.t of Urology European Institute of OncologyMilanItaly Martini Klinik University Medical Center Hamburg-EppendorfHamburgGermany Division of Urology University of Montreal Hospital Center(CHUM)MontrealQuebecCanada De.artme.t of Urology Comprehensive Cancer CenterMedical University of ViennaViennaAustria De.artme.t of Urology Weill Cornell Medical CollegeNew YorkNYUSA De.artme.t of Urology University of Texas SouthwesternDallasTXUSA De.artme.t of Urology Second Faculty of MedicineCharles UniversityPragCzech Republic Institute.for Urology and Re.roductive.He.lth I.M.Sechenov First Moscow State Medical UniversityMoscowRussia

Obje.tive.We.pe.forme. a population-base. analysis focusing on primary e.tranodal lymphoma of e.the. te.tis,kidne.,bladde. or prostate.PGUL).Me.hods:We.ide.tifie. all case. of localize. te.tis,re.al,bladde. and prostate.primary lymphomas(PL)ve.sus primary te.tis,kidne.,bladde. and prostate.cance.s within the.Surve.llance.e.ide.iology,and e.d Re.ults database.1998e.015).e.timate. annual proportion change.me.hodology(e.PC),multivariable.logistic re.re.sion mode.s,cumulative.incide.ce.plots and multivariable.compe.ing risks re.re.sion mode.s we.e.***:The.rate. of te.tis-PL,re.al-PL,bladde.-PL and prostate.PL we.e.3.04%,0.22%,0.18%and 0.01%,*** with PGUL we.e.olde. and more.fre.ue.tly *** rate. significantly de.re.se. for re.al-PL(e.PC:5.6%;pZ0.004)and prostate.PL(e.PC:3.6%;pZ0.03).In multivariable.logistic re.re.sion mode.s,olde. age. inde.e.de.tly pre.icte. te.tis-PL(odds ratio[OR]:16.4;pe.al-PL(OR:3.5;pe.fe.ale.ge.de. inde.e.de.tly pre.icte. bladde.-PL(OR:5.5;pe.te. patie.ts,cumulative.incide.ce.plots showe. significantly highe. 10-ye.r cance.-spe.ific mortality(CSM)rate. for te.tis-PL,re.al-PL and prostate.PL ve.sus the.r primary ge.itourinary *** multivariable.compe.ing risks re.re.sion mode.s,only te.tis-PL(hazard ratio[HR]:16.7;pe.al-PL(HR:2.52;pe.e.de.tly pre.icte. highe. CSM ***:PGUL rate. are.e.tre.e.y low and on the.de.re.se.in kidne. and prostate.but stable.in te.tis and *** to primary ge.itourinary tumors,PGUL are.associate. with worse.CSM for te.tis-PL and re.al-PL but not for bladde.-PL and prostate.PL,e.e. afte. adjustme.t for othe.-cause.mortality.

关键词： Bladde. lymphoma Ge.itourinary ne.plasm Ge.itourinary Primary e.tranodal lymphoma Prostate.lymphoma Re.al lymphoma Te.tis lymphoma Survival

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附:关于“正弦波与沃尔什函数”一文的评论

系统工程与电子技术 1980年第12期 58-59页

作者： H.F.Harmuth ,e.briganti ,J.e.Gibbs ,于霆

在“正弦波与沃尔什函数”一文中,Blachman试图指出,“对于平滑信号的长取样来说,用沃尔什表达式,项数要用得很多,而且要求其系数有较高的精度;甚至对于不连续信号来说,沃尔什级数也可能要求很多项”。显而易见,这种结果取决于显然的还... 详细信息

在“正弦波与沃尔什函数”一文中,Blachman试图指出,“对于平滑信号的长取样来说,用沃尔什表达式,项数要用得很多,而且要求其系数有较高的精度;甚至对于不连续信号来说,沃尔什级数也可能要求很多项”。显而易见,这种结果取决于显然的还是隐含的假设。现在让我们来对它们进行研究。

关键词：沃尔什函数乘积带宽瓦尔什函数正弦波余弦函数级数

脑胶质瘤分级的定量评估:一项多参数MRI研究

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国际医学放射学杂志 2014年第5期 485-485页

作者： M.Caulo V.Panara D.Tortora P.A.Matte. C.briganti e.Pravatà 黄育斌 De.artme.t of Ne.roscie.ce.and Imaging and ITAB-Institute.of Advance. Biome.ical Te.hnologie. University G.d’AnnunzioVia Dei Vestini 3366100 ChietiItaly

摘要目的基于脑胶质瘤在MR影像上表现的异质性,利用多参数MR成像的定量分析方法对脑胶质瘤进行分级,并采用最普遍的放射学报告方法比较这些结果。材料与方法

关键词：脑胶质瘤异质性 MRI 多参数含量比值