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Dog10K: the International Consortium of Canine Genome Sequencing

National Science Review 2019年第4期6卷 611-613页

作者： Guo-Dong Wang Greger Larson Jeffrey m.Kidd bridgett m.von holdt Elaine A.Ostrander Ya-Ping Zhang State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Palaeogenomics and Bio-Archaeology Research Network School of Archaeology University of Oxford Department of Human Genetics and Department of Computational medicine and Bioinformatics University of Michigan Medical School Ecology & Evolutionary Biology Princeton University National Human Genome Research Institute National Institutes of Health

Dogs (Canis lupus familiaris) were the first species to enter into a domestic relationship with people [1] and are a source of fascination all over the world, not only due to their history of domestication and dispersal along with human beings [2],but also because of their diverse phenotypes and behaviors, driven by both artificial and natural selection [3]. Dogs

关键词： the International Consortium of Canine Genome Sequencing Dog10K

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Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health

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National Science Review 2019年第4期6卷 810-824页

作者： Elaine A.Ostrander Guo-Dong Wang Greger Larson bridgett m.von holdt Brian W.Davis Vidhya Jagannathan Christophe Hitte Robert K.Wayne Ya-Ping Zhang National Human Genome Research Institute National Institutes of Health State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Palaeogenomics and Bio-Archaeology Research Network School of Archaeology University of Oxford Department of Ecology and Evolutionary Biology Princeton University College of Veterinary medicine and Biomedical Sciences Texas A&M University Institute of Genetics Vetsuisse Faculty University of Bern IGDR CNRS University of Rennes Department of Ecology and Evolutionary Biology University of CaliforniaLos Angeles the Dog10K Consortium

Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across well-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the world's canid populations. The Dog10 K Consortium(http://***10 ***) is an international collaboration of researchers from across the globe who will generate 20× whole genomes from 10 000 canids in 5 *** effort will capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids worldwide. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and de novo assemblies of multiple canids are being constructed. This unprecedented dataset will address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. more generally, this effort will advance our understanding of human and canine health.

关键词： genomics genome-wide association studies(GWAS) breed selection variation evolution

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Parkinson’s Disease: Examining the Role of the Pedunculopontine Nucleus via Animal models

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Advances in Parkinson's Disease 2017年第1期6卷 39-44页

作者： bridgett Boxley Department of Behavioral Brain Sciences University of Texas at Dallas Richardson USA

Parkinson’s disease is a neurodegenerative disease that spreads rapidly through the brain, and can influence a number of vital systems. The cause of this disease appears to be brought on by the progressive inability to produce adequate dopamine in the brain. People that suffer with Parkinson’s have reported REm sleep disruption at the onset of the condition. This paper reviews several animal model lesion studies related to the Pedunculopontine Nucleus, and how it plays a role in sleep regulation following a decline in dopamine production in those with parkinsonian conditions. The goal of this paper is to elucidate the functioning of the PPN and explain the nuclei’s possible role in the onset and progression of parkinsonian conditions in animal models.

关键词： Parkinson’s Disease Neurodegeneration REm Sleep Change Dopamine Substantia Nigra Systems PPN PTN Pedunculopontine

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